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Adv Pharm Bull. 2017;7(3): 375-380. doi: 10.15171/apb.2017.045
PMID: 29071219        PMCID: PMC5651058

Research Article

Two Active Compounds from Caesalpinia sappan L. in Combination with Cisplatin Synergistically Induce Apoptosis and Cell Cycle Arrest on WiDr Cells

Sri Handayani 1,2, Ratna Asmah Susidarti 2, Riris Istighfari Jenie 2, Edy Meiyanto 2 *

Cited by CrossRef: 19


1- Son S, Lee H, Moeng S, Kuh H, Choi S, Park J. Participation of MicroRNAs in the Treatment of Cancer with Phytochemicals. Molecules. 2020;25(20):4701 [Crossref]
2- Widodo N, Puspitarini S, Widyananda M, Alamsyah A, Wicaksono S, Masruri M, Jatmiko Y. Anticancer activity of Caesalpinia sappan by downregulating mitochondrial genes in A549 lung cancer cell line. F1000Res. 2022;11:169 [Crossref]
3- Jamaddar S, Sarkar C, Akter S, Mubarak M, El-Nashar H, El-Shazly M, Islam M. Brazilin: An updated literature-based review on its promising therapeutic approaches and toxicological studies. South African Journal of Botany. 2023;158:118 [Crossref]
4- Hasibuan P, Harahap U, Sitorus P, Satria D. The anticancer activities of Vernonia amygdalina Delile. Leaves on 4T1 breast cancer cells through phosphoinositide 3-kinase (PI3K) pathway. Heliyon. 2020;6(7):e04449 [Crossref]
5- He D, Tan X, Li L, Gao W, Tian X, Zeng P. Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway. Chin J Integr Med. 2024; [Crossref]
6- Jenie R, Handayani S, Susidarti R, Udin L, Meiyanto E. The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubicin on MCF-7/HER2 Cells. Adv Pharm Bull. 2018;8(3):507 [Crossref]
7- Nava-Tapia D, Cayetano-Salazar L, Herrera-Zúñiga L, Bello-Martínez J, Mendoza-Catalán M, Navarro-Tito N. Brazilin: Biological activities and therapeutic potential in chronic degenerative diseases and cancer. Pharmacological Research. 2022;175:106023 [Crossref]
8- Liao X, Tao L, Liu J, Gu Y, Xie J, Chen Y, Lin M, Liu T, Wang D, Guo H, Mo S. Matrine combined with cisplatin synergistically inhibited urothelial bladder cancer cells via down-regulating VEGF/PI3K/Akt signaling pathway. Cancer Cell Int. 2017;17(1) [Crossref]
9- Satria D, Hasibuan P, Muhammad M, Waruwu S, Utomo R, Ghoran S. Cytotoxic and apoptotic effect of Vernonia amygdalina Delile. fractions against Hs578t triple-negative breast cancer cell lines. Phytomedicine Plus. 2024;4(4):100640 [Crossref]
10- Marina Herawati M, Petra Wibisono A, Wijaya Setiawan A, Pudjihartati E, Buot I, Luqman A. The increase of steviol glycosides in stevia (Stevia rebaudiana Bertoni) through artificial polyploidy. BIO Web Conf. 2024;101:01004 [Crossref]
11- Widodo N, Puspitarini S, Widyananda M, Alamsyah A, Wicaksono S, Masruri M, Jatmiko Y. Anticancer activity of Caesalpinia sappan by downregulating mitochondrial genes in A549 lung cancer cell line. F1000Res. 2022;11:169 [Crossref]
12- Yang X, Liang Y, Zhao L, Chen L, Yang Y, Wang J, Yan L, Zhang S, Liu X, Zhang H. Brazilin Inhibits the Invasion and Metastasis of Breast Cancer. Biological & Pharmaceutical Bulletin. 2023;46(6):773 [Crossref]
13- Raptania C, Zakia S, Fahira A, Amalia R. Article review: Brazilin as potential anticancer agent. Front Pharmacol. 2024;15 [Crossref]
14- Zheng X, Shi Z, Qiu C, Hong Z, Wang C, Zhuang H, Chen Z, Pan J. Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression. Integr Cancer Ther. 2020;19:153473542097247 [Crossref]
15- Yang S, Shergalis A, Lu D, Kyani A, Liu Z, Ljungman M, Neamati N. Design, Synthesis, and Biological Evaluation of Novel Allosteric Protein Disulfide Isomerase Inhibitors. J Med Chem. 2019;62(7):3447 [Crossref]
16- Saleh P, Hosseini M, Piri R, Ghaffari M, Mohammadi S, Naghavi-Behzad M. Association of Lung Cancer and Tuberculosis: A Cross Sectional Study from Northwest of Iran. Int J Cancer Manag. 2019;12(6) [Crossref]
17- Correia Soeiro M, Vergoten G, Bailly C. Molecular docking of brazilin and its analogs to barrier‐to‐autointegration factor 1 (BAF1). Annals of the New York Academy of Sciences. 2022;1511(1):154 [Crossref]
18- Nazliniwaty N, Hanafiah O, Pertiwi D, Muhammad M, Satria D. The Activity of Combination of Ethanol Extract of Artocarpus lacucha Buch.-Ham and Anredera cordifolia Steenis Leaves to Increase Wound Healing Process on NIH-3T3 Cell Line. Open Access Maced J Med Sci. 2022;10(A):807 [Crossref]
19- Jenie R, Amalina N, Hermawan A, Suzery M, Putra A, Meiyanto E. Caesalpinia sappan reduces the stemness of breast cancer stem cells involving the elevation of intracellular reactive oxygen species. 2023;18(6):708 [Crossref]
20- Bailly C. A world tour in the name of natural products. Phytomedicine. 2022;100:154080 [Crossref]
21- Chaisri W, Suebsakwong P, Pandith H, Panya A, Taynawa K, Pikulkaew S, Suriyasathaporn W, Okonogi S, Khonkarn R. Effects of Encapsulation of Caesalpinia sappan L. with Cyclodextrins for Bovine Mastitis. AAPS PharmSciTech. 2023;24(8) [Crossref]