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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2018;8(1): 141-147. doi: 10.15171/apb.2018.017
PMID: 29670849        PMCID: PMC5899783

Research Article

Ameliorative Activity of Ethanolic Extract of Artocarpus heterophyllus Stem Bark on Alloxan-induced Diabetic Rats

Basiru Olaitan Ajiboye 1 * , Oluwafemi Adeleke Ojo 1, Oluwatosin Adeyonu 1, Oluwatosin Imiere 1, Babatunji Emmanuel Oyinloye 1, Oluwafemi Ogunmodede 2

Cited by CrossRef: 23

1- Rebecca Roy J, Julius A, Chinnapan V. Health benefits and Future prospects of Artocarpus heterophyllus. RJPT. 2023;:4443 [Crossref]
2- Ojo O, Osukoya O, Ekakitie L, Ajiboye B, Oyinloye B, Agboinghale P, Kappo A. Gongronema latifolium leaf extract modulates hyperglycaemia, inhibits redox imbalance and inflammation in alloxan-induced diabetic nephropathy. J Diabetes Metab Disord. 2020;19(1):469 [Crossref]
3- Ojo O, Okesola M, Ekakitie L, Ajiboye B, Oyinloye B, Agboinghale P, Onikanni A. Gongronema latifolium Benth. leaf extract attenuates diabetes‐induced neuropathy via inhibition of cognitive, oxidative stress and inflammatory response. J Sci Food Agric. 2020;100(12):4504 [Crossref]
4- Ajiboye B, Omojolomoloju T, Salami S, Onikanni S, Hosseinzadeh H, Mopuri R, Oyinloye B. Effect of Dalbergiella welwitschi alkaloid-rich extracts on neuroprotective in streptozotocin-induced diabetic rats. Metab Brain Dis. 2024;39(7):1353 [Crossref]
5- Ajiboye B, Ojo O, Okesola M, Oyinloye B, Kappo A. Ethyl acetate leaf fraction ofCnidoscolus aconitifolius(Mill.) I. M. Johnst: antioxidant potential, inhibitory activities of key enzymes on carbohydrate metabolism, cholinergic, monoaminergic, purinergic, and chemical fingerprinting. International Journal of Food Properties. 2018;21(1):1697 [Crossref]
6- Ye S, Imran A, Agar O, Yadav D, Moore C, Suleria H. Jackfruit (Artocarpus heterophyllus Lam.): nutritional profile, polysaccharide analysis, and opportunities for product development. 2025;60(1) [Crossref]
7- Ojo O, Ojo A, Ajiboye B, Imiere O, Oyinloye B. Antihyperlipidemic Activities and Hematological Properties of Ethanol Extract of Blighia Sapida Koenig Bark in Alloxan-Induced Diabetic Rats. 2020;21(1):11 [Crossref]
8- Azadbakht Z, Fanaei H, Karajibani M, Montazerifar F. Effect of type 1 diabetes during pregnancy and lactation on neonatal hypoxia‐ischemia injury and apoptotic gene expression. Intl J of Devlp Neuroscience. 2023;83(4):346 [Crossref]
9- Subekti I, Sujono T, Suhendi A. Antioxidant Activity of DPPH and ABTS Methods, from Jackfruit Leaf Extract and Fraction (Artocarpus heterophyllus) with ELISA Reader . pharmacon. 2025;:27 [Crossref]
10- Chaurasia S, Pandey A. Phytochemistry and Pharmacology of Genus Artocarpus: A Review on Current Status of Knowledge. Russ J Bioorg Chem. 2023;49(3):481 [Crossref]
11- Hajare B, Bhutada D, Khare A, Radhakrishnan S, Kulkarni M. Review on conversion of jackfruit (Artocarpus heterophyllus) waste for making value added polymers. Biomass Conv Bioref. 2024;14(19):23245 [Crossref]
12- Gang R, Matsabisa M, Okello D, Kang Y. Ethnomedicine and ethnopharmacology of medicinal plants used in the treatment of diabetes mellitus in Uganda. Appl Biol Chem. 2023;66(1) [Crossref]
13- Ansari P, Islam S, Ali A, Masud M, Reberio A, Khan J, Hannan J, Flatt P, Abdel-Wahab Y. Insulinotropic and Beta-Cell Proliferative Effects of Unripe Artocarpus heterophyllus Extract Ameliorate Glucose Dysregulation in High-Fat-Fed Diet-Induced Obese Mice. Diabetology. 2025;6(8):83 [Crossref]
14- Gupta A, Marquess A, Pandey A, Bishayee A. Jackfruit ( Artocarpus heterophyllus Lam.) in health and disease: a critical review . Critical Reviews in Food Science and Nutrition. 2023;63(23):6344 [Crossref]
15- Khan A, Ema I, Faruk M, Tarapder S, Khan A, Noreen S, Adnan M. A Review on Importance of Artocarpus heterophyllus L. (Jackfruit). J Multidiscip Appl Nat Sci. 2021;1(2):106 [Crossref]
16- Suo H, Xiao S, Wang B, Cai Y, Wang J. Waste to Wealth: Dynamics and metabolic profiles of the conversion of jackfruit flake into value-added products by different fermentation methods. Food Chemistry: X. 2024;21:101164 [Crossref]
17- Ekakitie L, Oyinloye B, Ajiboye B. The ameliorative activity of Chrysobalanus orbicularis in streptozotocin-induced type II diabetes mellitus rat model. Heliyon. 2021;7(4):e06596 [Crossref]
18- Okesola M, Ojo O, Onikanni S, Ajiboye B, Oyinloye B, Agboinghale P, Kappo A. Ameliorative effect of Gongronema latifolium leaf extract on alloxan-induced diabetic cardiomyopathy in Wistar rats model. Comp Clin Pathol. 2020;29(4):865 [Crossref]
19- Rao A, Naik K, Unnikrishnan A, Joseph J. Efficacy of green jackfruit flour as a medical nutrition therapy replacing rice or wheat in patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Nutr Diabetes. 2021;11(1) [Crossref]
20- Yani Br. Tambunan I, Siringo-Ringo E, Julianti Butar-Butar M, Gurning K. GC-MS analysis of bioactive compounds and antibacterial activity of nangka leaves (Artocarpus heterophyllus Lam). PHAR. 2023;70(1):67 [Crossref]
21- Ukwenya V, Alese M, Ogunlade B, Folorunso I, Omotuyi O. Anacardium occidentale leaves extract and riboceine mitigate hyperglycemia through anti-oxidative effects and modulation of some selected genes associated with diabetes. J Diabetes Metab Disord. 2022;22(1):455 [Crossref]
22- Singh S, Gupta A, Gupta N. Bioactive Potential of Artocarpus heterophyllus Lam.: PRISMA Based Review. CTM. 2023;9(6) [Crossref]
23- Ajiboye B, Diayi A, Agunbiade S, Akinyemi A, Adewale O, Ojo O. Ameliorating activity of polyphenolic-rich extracts of Basella rubra L. leaves on pancreatic β-cell dysfunction in streptozotocin-induced diabetic rats. 2022;19(2):335 [Crossref]