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Adv Pharm Bull. 2018;8(1): 123-130. doi: 10.15171/apb.2018.015

PMID: 29670847 PMCID: PMC5896387

Research Article

Changes of Insulin Resistance and Adipokines Following Supplementation with Glycyrrhiza Glabra L. Extract in Combination with a Low-Calorie Diet in Overweight and Obese Subjects: a Randomized Double Blind Clinical Trial

Mohammad Alizadeh ¹, Nazli Namazi ^1,2 * , Elham Mirtaheri ¹, Nafiseh Sargheini ³, Sorayya Kheirouri ⁴

Cited by CrossRef: 11

1- Giri S, Sahoo J, Roy A, Kamalanathan S, Naik D. Treatment on Nature’s lap: Use of herbal products in the management of hyperglycemia. World J Diabetes. 2023;14(4):412 [Crossref]

2- Hooshmandi H, Ghadiri-Anari A, Ranjbar A, Fallahzadeh H, Hosseinzadeh M, Nadjarzadeh A. Effects of licorice extract in combination with a low-calorie diet on obesity indices, glycemic indices, and lipid profiles in overweight/obese women with polycystic ovary syndrome (PCOS): a randomized, double-blind, placebo-controlled trial. J Ovarian Res. 2024;17(1) [Crossref]

3- Al Anei S, Abu Raghif A, Almoayed H. Therapeutic potential of Glycyrrhiza glabra (licorice) in modulating metabolic and inflammatory parameters in women with PCOS. FM. 2026;68(1) [Crossref]

4- Luo W, Xu G, Song Z, Mu W, Wen J, Hui S, Zhao J, Zhan X, Bai Z, Xiao X. Licorice extract inhibits the cGAS-STING pathway and protects against non-alcoholic steatohepatitis. Front Pharmacol. 2023;14 [Crossref]

5- Kumari D, Gautam J, Sharma V, Gupta S, Sarkar S, Jana P, Singhal V, Babele P, Kamboj P, Bajpai S, Tandon R, Kumar Y, Dikshit M. Effect of herbal extracts and Saroglitazar on high-fat diet-induced obesity, insulin resistance, dyslipidemia, and hepatic lipidome in C57BL/6J mice. Heliyon. 2023;9(11):e22051 [Crossref]

6- Kaur N, Ruiz-Velasco A, Raja R, Howell G, Miller J, Abouleisa R, Ou Q, Mace K, Hille S, Frey N, Binder P, Smith C, Fachim H, Soran H, Swanton E, Mohamed T, Müller O, Wang X, Chernoff J, Cartwright E, Liu W. Paracrine signal emanating from stressed cardiomyocytes aggravates inflammatory microenvironment in diabetic cardiomyopathy. iScience. 2022;25(3):103973 [Crossref]

7- Li X, Sun R, Liu R. Natural products in licorice for the therapy of liver diseases: Progress and future opportunities. Pharmacological Research. 2019;144:210 [Crossref]

8- Watanabe M, Risi R, Masi D, Caputi A, Balena A, Rossini G, Tuccinardi D, Mariani S, Basciani S, Manfrini S, Gnessi L, Lubrano C. Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review. Nutrients. 2020;12(9):2873 [Crossref]

9- Abubakar M, Yusuf A, Usman D, Abubakar I, Katsayal B, Sadiq I, Hassan S, Forcados G, Ibrahim K, Hudu S, Muhammad A. Potential benefits and challenges on the use of phytochemicals for obese COVID-19 patients: A review. Phytomedicine Plus. 2024;4(2):100526 [Crossref]

10- Hu Y, Hou J, Cai Y, Ni C, Xing Z, Li J, Zhou Z, Xu G, Zeng X, Jia J, Li L. Therapeutic potential of glycyrrhizic acid in inflammation-related diseases: from HMGB1-oriented molecular insights to preclinical application. Arch Pharm Res. 2026; [Crossref]

11- Shi J, Hu H, Harnett J, Zheng X, Liang Z, Wang Y, Ung C. An evaluation of randomized controlled trials on nutraceuticals containing traditional Chinese medicines for diabetes management: a systematic review. Chin Med. 2019;14(1) [Crossref]