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Adv Pharm Bull. 2015;5(4): 507-514. doi: 10.15171/apb.2015.069
PMID: 26819923        PMCID: PMC4729356

Original Research

A Combination of Prebiotic Inulin and Oligofructose Improve Some of Cardiovascular Disease Risk Factors in Women with Type 2 Diabetes: A Randomized Controlled Clinical Trial

Akbar Aliasgharzadeh 1, Mohammad Khalili 2, Elham Mirtaheri 3, Bahram Pourghassem Gargari 3, Farnaz Tavakoli 1, Mahdieh Abbasalizad Farhangi 4, Hossein Babaei 5, Parvin Dehghan 6 *

Cited by CrossRef: 66


1- Valenlia K, Morshedi M, Saghafi-Asl M, Shahabi P, Abbasi M. Beneficial impacts of Lactobacillus plantarum and inulin on hypothalamic levels of insulin, leptin, and oxidative markers in diabetic rats. Journal of Functional Foods. 2018;46:529 [Crossref]
2- Mitchell C, Davy B, Ponder M, McMillan R, Hughes M, Hulver M, Neilson A, Davy K. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients. 2021;13(9):3235 [Crossref]
3- Zhou P, Wang Y, Li S, Zhao Y, Deng K, Chao D, Jin C, Zhuo Y, Che L, Li J, Lin Y, Xu S, Feng B, Fang Z, Wu D. Effects of prebiotic inulin addition to low- or high-fat diet on maternal metabolic status and neonatal traits of offspring in a pregnant sow model. Journal of Functional Foods. 2018;48:125 [Crossref]
4- Shafie M, Homayouni Rad A, Mirghafourvand M. Effects of prebiotic-rich yogurt on menopausal symptoms and metabolic indices in menopausal women: a triple-blind randomised controlled trial. International Journal of Food Sciences and Nutrition. 2022;73(5):693 [Crossref]
5- Chaimala A, Jogloy S, Vorasoot N, Holbrook C, Kvien C. The Roles of Net Photosynthetic Rate and Transpiration Efficiency on Economic Yield of Jerusalem artichoke (Helianthus tuberosus L.) Genotypes under Different Drought Durations during the Terminal Growth Stages. Agronomy. 2023;13(7):1882 [Crossref]
6- Ning C, Wang X, Gao S, Mu J, Wang Y, Liu S, Zhu J, Meng X. Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro. Molecular Nutrition Food Res. 2017;61(8) [Crossref]
7- Becerril-Alarcón Y, Campos-Gómez S, Valdez-Andrade J, Campos-Gómez K, Reyes-Barretero D, Benítez-Arciniega A, Valdés-Ramos R, Soto-Piña A. Inulin Supplementation Reduces Systolic Blood Pressure in Women with Breast Cancer Undergoing Neoadjuvant Chemotherapy. Cardiovascular Therapeutics. 2019;2019:1 [Crossref]
8- Li Z, Zhang T, Liu Y, Huang Y, Liu J, Wang S, Sun P, Nie Y, Han Y, Li F, Xu H. A review in two classes of hypoglycemic compounds (prebiotics and flavonoids) intervening in type 2 diabetes mellitus: Unveiling their structural characteristics and gut microbiome as key mediator. Food Bioscience. 2024;61:105010 [Crossref]
9- Yang S, Sun X, Jiang X, Wang L, Tian J, Li L, Zhao M, Zhong Q. Characterization of the Tibet plateau Jerusalem artichoke (Helianthus tuberosus L.) transcriptome by de novo assembly to discover genes associated with fructan synthesis and SSR analysis. Hereditas. 2019;156(1) [Crossref]
10- Jiménez-Avalos J, Arrevillaga-Boni G, González-López L, García-Carvajal Z, González-Avila M. Classical methods and perspectives for manipulating the human gut microbial ecosystem. Critical Reviews in Food Science and Nutrition. 2021;61(2):234 [Crossref]
11- Li L, Zhang L, Zhou L, Jin M, Xu L. Chain length‐dependent inulin alleviates diet‐induced obesity and metabolic disorders in mice. Food Science & Nutrition. 2021;9(7):3470 [Crossref]
12- Zhou X, Wang S, Xu C, Li J, Liu H, He L, Zhong S, Li K. The Leap of Inulin Fructans from Food Industry to Medical Application. Chemistry & Biodiversity. 2023;20(6) [Crossref]
13- Khursheed R, Singh S, Wadhwa S, Kapoor B, Gulati M, Kumar R, Ramanunny A, Awasthi A, Dua K. Treatment strategies against diabetes: Success so far and challenges ahead. European Journal of Pharmacology. 2019;862:172625 [Crossref]
14- Cai X, Yu H, Liu L, Lu T, Li J, Ji Y, Le Z, Bao L, Ma W, Xiao R, Yang Y. Milk Powder Co‐Supplemented with Inulin and Resistant Dextrin Improves Glycemic Control and Insulin Resistance in Elderly Type 2 Diabetes Mellitus: A 12‐Week Randomized, Double‐Blind, Placebo‐Controlled Trial. Molecular Nutrition Food Res. 2018;62(24) [Crossref]
15- Merkevičius K, Kundelis R, Maleckas A, Veličkienė D. Microbiome Changes after Type 2 Diabetes Treatment: A Systematic Review. Medicina. 2021;57(10):1084 [Crossref]
16- Vesnina A, Prosekov A, Atuchin V, Minina V, Ponasenko A. Tackling Atherosclerosis via Selected Nutrition. IJMS. 2022;23(15):8233 [Crossref]
17- Golzarand M, Bahadoran Z, Mirmiran P, Azizi F. Inulin intake and the incidence of cardiometabolic diseases: a prospective cohort study. Food Funct. 2022;13(20):10516 [Crossref]
18- Zhao J, Zhang J. Using Genetics to Assess the Role of Acetate in Ischemic Heart Disease, Diabetes, and Sex-Hormone-Related Cancers: A Mendelian Randomization Study. Nutrients. 2024;16(21):3674 [Crossref]
19- Hoving L, Katiraei S, Pronk A, Heijink M, Vonk K, Amghar-el Bouazzaoui F, Vermeulen R, Drinkwaard L, Giera M, van Harmelen V, Willems van Dijk K. The prebiotic inulin modulates gut microbiota but does not ameliorate atherosclerosis in hypercholesterolemic APOE*3-Leiden.CETP mice. Sci Rep. 2018;8(1) [Crossref]
20- Rao M, Gao C, Xu L, Jiang L, Zhu J, Chen G, Law B, Xu Y. Effect of Inulin-Type Carbohydrates on Insulin Resistance in Patients with Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis. Journal of Diabetes Research. 2019;2019:1 [Crossref]
21- Hosseinifard E, Bavafa-Valenlia K, Saghafi-Asl M, Morshedi M. Antioxidative and Metabolic Effects of Lactobacillus plantarum, Inulin, and Their Synbiotic on the Hypothalamus and Serum of Healthy Rats. Nutr Metab Insights. 2020;13 [Crossref]
22- Akram W, Pandey V, Sharma R, Joshi R, Mishra N, Garud N, Haider T. Inulin: Unveiling its potential as a multifaceted biopolymer in prebiotics, drug delivery, and therapeutics. International Journal of Biological Macromolecules. 2024;259:129131 [Crossref]
23- Skidan I, Gulyaev A, Belmer S. Prebiotic components of breast milk and the possibility of repeating their effects in infant formulas. Ross vestn perinatol pediatr. 2019;64(3):37 [Crossref]
24- Li L, Li P, Xu L. Assessing the effects of inulin‐type fructan intake on body weight, blood glucose, and lipid profile: A systematic review and meta‐analysis of randomized controlled trials. Food Science & Nutrition. 2021;9(8):4598 [Crossref]
25- Major N, Perković J, Palčić I, Bažon I, Horvat I, Ban D, Goreta Ban S. The Phytochemical and Nutritional Composition of Shallot Species (Allium × cornutum, Allium × proliferum and A. cepa Aggregatum) Is Genetically and Environmentally Dependent. Antioxidants. 2022;11(8):1547 [Crossref]
26- Bakr A, Farag M. Soluble Dietary Fibers as Antihyperlipidemic Agents: A Comprehensive Review to Maximize Their Health Benefits. ACS Omega. 2023;8(28):24680 [Crossref]
27- Wu X, Wang J, Shi Y, Chen S, Yan Q, Jiang Z, Jing H. N-Acetyl-chitobiose ameliorates metabolism dysfunction through Erk/p38 MAPK and histone H3 phosphorylation in type 2 diabetes mice. Journal of Functional Foods. 2017;28:96 [Crossref]
28- Tan H, Chen W, Liu Q, Yang G, Li K. Pectin Oligosaccharides Ameliorate Colon Cancer by Regulating Oxidative Stress- and Inflammation-Activated Signaling Pathways. Front Immunol. 2018;9 [Crossref]
29- Durazzo A, Nazhand A, Lucarini M, Atanasov A, Souto E, Novellino E, Capasso R, Santini A. An Updated Overview on Nanonutraceuticals: Focus on Nanoprebiotics and Nanoprobiotics. IJMS. 2020;21(7):2285 [Crossref]
30- Juhász A, Greff D, Teutsch B, Gede N, Hegyi P, Horváth E, Deák P, Nyirády P, Ács N, Juhász R. Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: a systematic review and network meta-analysis. The American Journal of Clinical Nutrition. 2023;117(2):266 [Crossref]
31- Talukdar J, Cooper M, Lyutvyn L, Zeraatkar D, Ali R, Berbrier R, Janes S, Ha V, Darling P, Xue M, Chu A, Chowdhury F, Harnack H, Huang L, Malik M, Powless J, Lavergne F, Zhang X, Ehrlich S, Jenkins D, Sievenpiper J, Banfield L, Mbuagbaw L, de Souza R. The effects of inulin-type fructans on cardiovascular disease risk factors: systematic review and meta-analysis of randomized controlled trials. The American Journal of Clinical Nutrition. 2024;119(2):496 [Crossref]
32- Shayista H, Prasad M, Raj S, Ranjini H, Manju K, Baker S. Mechanistic overview of gut microbiota and mucosal pathogens with respect to cardiovascular diseases. The Microbe. 2024;5:100160 [Crossref]
33- Ahn H, Kim M, Seo C, Yoo H, Lee S, Lee J. The effects of Jerusalem artichoke and fermented soybean powder mixture supplementation on blood glucose and oxidative stress in subjects with prediabetes or newly diagnosed type 2 diabetes. Nutr & Diabetes. 2018;8(1) [Crossref]
34- Azamian Y, Abdollahzad H, Rezaeian S, Rouhani M, Fatehi M. The effect of synbiotic supplementation on plasma levels of advanced glycation end products and cardiovascular risk factors in hemodialysis patients: A double‐blind clinical trial. Food Science & Nutrition. 2024;12(9):6864 [Crossref]
35- Wu W, Xie J, Zhang H. Dietary fibers influence the intestinal SCFAs and plasma metabolites profiling in growing pigs. Food Funct. 2016;7(11):4644 [Crossref]
36- Wu H, Chiou J. Potential Benefits of Probiotics and Prebiotics for Coronary Heart Disease and Stroke. Nutrients. 2021;13(8):2878 [Crossref]
37- Dehghan P, Farhangi M, Tavakoli F, Aliasgarzadeh A, Akbari A. Impact of prebiotic supplementation on T-cell subsets and their related cytokines, anthropometric features and blood pressure in patients with type 2 diabetes mellitus: A randomized placebo-controlled Trial. Complementary Therapies in Medicine. 2016;24:96 [Crossref]
38- Khezri S, Dehghan P, Mahmoudi R, Jafarlou M. Fig Juice Fermented with Lactic Acid Bacteria as a Nutraceutical Product. Pharm Sci. 2016;22(4):260 [Crossref]
39- Eliana F, Pranoto B. A randomized controlled clinical trial of carbohydrate mix-fortified nutrition in type 2 diabetes mellitus patients. Med J Indones. 2020;29(3):275 [Crossref]
40- Tawfick M, Xie H, Zhao C, Shao P, Farag M. Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics. International Journal of Biological Macromolecules. 2022;208:948 [Crossref]
41- Gupta J, Abosaoda M, Shukla M, Ballal S, Kumar A, Chahar M, Saini S, Kapila I, Hadpoori A. Effect of soluble fiber supplementation on lipid parameters in subjects with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Prostaglandins & Other Lipid Mediators. 2025;176:106939 [Crossref]
42- Colantonio A, Werner S, Brown M. The Effects of Prebiotics and Substances with Prebiotic Properties on Metabolic and Inflammatory Biomarkers in Individuals with Type 2 Diabetes Mellitus: A Systematic Review. Journal of the Academy of Nutrition and Dietetics. 2020;120(4):587 [Crossref]
43- Fathi S, Borzouei S, Goodarzi M, Poorolajal J, Ahmadi-Motamayel F. Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Type 2 Diabetes Mellitus: A Retrospective Cohort Study. EMIDDT. 2020;20(4):584 [Crossref]
44- Kaul R, Paul P, Harfouche M, Saliba R, Chaari A. Microbiome‐modulating nutraceuticals ameliorate dyslipidemia in type 2 diabetes: A systematic review, meta‐analysis, and meta‐regression of clinical trials. Diabetes Metabolism Res. 2024;40(2) [Crossref]
45- Farhangi M, Javid A, Sarmadi B, Karimi P, Dehghan P. A randomized controlled trial on the efficacy of resistant dextrin, as functional food, in women with type 2 diabetes: Targeting the hypothalamic–pituitary–adrenal axis and immune system. Clinical Nutrition. 2018;37(4):1216 [Crossref]
46- Jahangiry L, Farhangi M, Rezaei F. Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome. J Health Popul Nutr. 2017;36(1) [Crossref]
47- Megur A, Daliri E, Baltriukienė D, Burokas A. Prebiotics as a Tool for the Prevention and Treatment of Obesity and Diabetes: Classification and Ability to Modulate the Gut Microbiota. IJMS. 2022;23(11):6097 [Crossref]
48- Dixon S, Mishra S, Dietsche K, Jain S, Mabundo L, Stagliano M, Krenek A, Courville A, Yang S, Turner S, Meyers A, Estrada D, Yadav H, Chung S. The effects of prebiotics on gastrointestinal side effects of metformin in youth: A pilot randomized control trial in youth-onset type 2 diabetes. Front Endocrinol. 2023;14 [Crossref]
49- Nechchadi H, Nadir Y, Benhssaine K, Alem C, Sellam K, Boulbaroud S, Berrougui H, Ramchoun M. Hypolipidemic activity of phytochemical combinations: A mechanistic review of preclinical and clinical studies. Food Chemistry. 2024;459:140264 [Crossref]
50- Shamasbi S, Ghanbari-Homayi S, Mirghafourvand M. The effect of probiotics, prebiotics, and synbiotics on hormonal and inflammatory indices in women with polycystic ovary syndrome: a systematic review and meta-analysis. Eur J Nutr. 2020;59(2):433 [Crossref]
51- Hoving L, De Vries M, De Jong R, Katiraei S, Pronk A, Quax P, Van Harmelen V, Willems van Dijk K. The Prebiotic Inulin Aggravates Accelerated Atherosclerosis in Hypercholesterolemic APOE*3-Leiden Mice. Nutrients. 2018;10(2):172 [Crossref]
52- Paul P, Kaul R, Abdellatif B, Arabi M, Upadhyay R, Saliba R, Sebah M, Chaari A. The Promising Role of Microbiome Therapy on Biomarkers of Inflammation and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative Review. Front Nutr. 2022;9 [Crossref]
53- Ghavidel F, Amiri H, Tabrizi M, Alidadi S, Hosseini H, Sahebkar A. The Combinational Effect of Inulin and Resveratrol on the Oxidative Stress and Inflammation Level in a Rat Model of Diabetic Nephropathy. Current Developments in Nutrition. 2024;8(1):102059 [Crossref]
54- Gholizadeh Shamasbi S, Dehghan P, Mohammad-Alizadeh Charandabi S, Aliasgarzadeh A, Mirghafourvand M. Effect of Prebiotic on Anthropometric Indices in Women with Polycystic Ovarian Syndrome: A Triple-Blind, Randomized, Controlled Clinical Trial. Iran Red Crescent Med J. 2018;In Press(In Press) [Crossref]
55- Farhangi M, Dehghan P, Namazi N. Prebiotic supplementation modulates advanced glycation end-products (AGEs), soluble receptor for AGEs (sRAGE), and cardiometabolic risk factors through improving metabolic endotoxemia: a randomized-controlled clinical trial. Eur J Nutr. 2020;59(7):3009 [Crossref]
56- Kouchakkhani H, Dehghan P, Moosavy M, Sarmadi B. Occurrence, Molecular Detection and Antibiotic Resistance Profile of Escherichia coli O157:H7 Isolated from Ready-to-Eat Vegetable Salads in Iran. Pharm Sci. 2016;22(3):195 [Crossref]
57- Chu N, Chan J, Chow E. A diet high in FODMAPs as a novel dietary strategy in diabetes?. Clinical Nutrition. 2022;41(10):2103 [Crossref]
58- Li L, Lietz G, Seal C. Effects of Quinoa Intake on Markers of Cardiovascular Risk: A Systematic Literature Review and Meta-Analysis. Food Reviews International. 2024;40(1):1 [Crossref]
59- Farhangi M, Javid A, Dehghan P. The effect of enriched chicory inulin on liver enzymes, calcium homeostasis and hematological parameters in patients with type 2 diabetes mellitus: A randomized placebo-controlled trial. Primary Care Diabetes. 2016;10(4):265 [Crossref]
60- Zhu D, Yan Q, Liu J, Wu X, Jiang Z. Can functional oligosaccharides reduce the risk of diabetes mellitus?. The FASEB Journal. 2019;33(11):11655 [Crossref]
61- Pourrajab B, Fatahi S, Sohouli M, Găman M, Shidfar F. The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition. 2022;62(2):490 [Crossref]
62- Chanmuang S, Nguyen Q, Kim H. Current Research on the Effects of Non-Digestible Carbohydrates on Metabolic Disease. Applied Sciences. 2022;12(8):3768 [Crossref]