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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2017;7(1): 123-130. doi: 10.15171/apb.2017.016
PMID: 28507946        PMCID: PMC5426725

Research Article

Conditioned Medium of Wharton's Jelly Derived Stem Cells Can Enhance the Cartilage Specific Genes Expression by Chondrocytes in Monolayer and Mass Culture Systems

Maryam Hassan Famian 1, Soheila Montazer Saheb 2, Azadeh Montaseri 2 *

Cited by CrossRef: 26

1- saghebasl S, Davaran S, Rahbarghazi R, Montaseri A, Salehi R, Ramazani A. Synthesis andin vitroevaluation of thermosensitive hydrogel scaffolds based on (PNIPAAm-PCL-PEG-PCL-PNIPAAm)/Gelatin and (PCL-PEG-PCL)/Gelatin for use in cartilage tissue engineering. Journal of Biomaterials Science, Polymer Edition. 2018;29(10):1185 [Crossref]
2- Adibkia K, Ehsani A, Jodaei A, Fathi E, Farahzadi R, Barzegar-Jalali M. Silver nanoparticles induce the cardiomyogenic differentiation of bone marrow derived mesenchymal stem cells via telomere length extension. Beilstein J Nanotechnol. 2021;12:786 [Crossref]
3- Eftekhari A, Maleki Dizaj S, Ahmadian E, Przekora A, Hosseiniyan Khatibi S, Ardalan M, Zununi Vahed S, Valiyeva M, Mehraliyeva S, Khalilov R, Hasanzadeh M. Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration. Materials. 2021;14(11):2939 [Crossref]
4- Safari S, Eidi A, Mehrabani M, Fatemi M, Sharifi A. Conditioned Medium of Adipose-Derived Mesenchymal Stem Cells as a Promising Candidate to Protect High Glucose-Induced Injury in Cultured C28I2 Chondrocytes. Adv Pharm Bull. 2022;12(3):632 [Crossref]
5- Fathi E, Montazersaheb S, Vandghanooni S, Farahzadi R, Vietor I. Adipose Tissue-Mesenchymal Stem Cells Caused to Change the Methylation Status of hTERT Gene Promoter CpG Islands of Molt-4 Leukemia Cells as Cell-based Therapy. CMM. 2023;23(3):266 [Crossref]
6- Calixto R, Freitas G, Souza P, Ramos J, Santos I, de Oliveira F, Almeida A, Rosa A, Beloti M. Effect of the secretome of mesenchymal stem cells overexpressing BMP‐9 on osteoblast differentiation and bone repair. Journal Cellular Physiology. 2023;238(11):2625 [Crossref]
7- Arifka M, Wilar G, Elamin K, Wathoni N. Polymeric Hydrogels as Mesenchymal Stem Cell Secretome Delivery System in Biomedical Applications. Polymers. 2022;14(6):1218 [Crossref]
8- Vizoso F, Eiro N, Cid S, Schneider J, Perez-Fernandez R. Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine. IJMS. 2017;18(9):1852 [Crossref]
9- Aghaei Z, Karbalaei N, Namavar M, Haghani M, Razmkhah M, Ghaffari M, Nemati M, Ballini A. Neuroprotective Effect of Wharton’s Jelly-Derived Mesenchymal Stem Cell-Conditioned Medium (WJMSC-CM) on Diabetes-Associated Cognitive Impairment by Improving Oxidative Stress, Neuroinflammation, and Apoptosis. Stem Cells International. 2023;2023:1 [Crossref]
10- Fathi E, Farahzadi R, Valipour B. Alginate/gelatin encapsulation promotes NK cells differentiation potential of bone marrow resident C-kit+ hematopoietic stem cells. International Journal of Biological Macromolecules. 2021;177:317 [Crossref]
11- Morrovati F, Karimian Fathi N, Soleimani Rad J, Montaseri A. Mummy Prevents IL-1β-Induced Inflammatory Responses and Cartilage Matrix Degradation via Inhibition of NF-қB Subunits Gene Expression in Pellet Culture System. Adv Pharm Bull. 2018;8(2):283 [Crossref]
12- Soetjahjo B, Adriansyah D, Riawan W. A potential role of arcadia in conditioned media - umbilical cord derived mesenchymal stem cell on  cartilage repair. F1000Res. 2022;11:972 [Crossref]
13- Shin S, Lee S, Choi S, Park N, Kwon Y, Jeong J, Ju S, Chang Y, Park K, Ha C, Lee C. Characterization of the Secretome of a Specific Cell Expressing Mutant Methionyl-tRNA Synthetase in Co-Culture Using Click Chemistry. IJMS. 2022;23(12):6527 [Crossref]
14- ARIYOSHI W, USUI M, SANO K, KAWANO A, OKINAGA T, NAKASHIMA K, NAKAZAWA K, NISHIHARA T. 3D spheroid culture models for chondrocytes using polyethylene glycol-coated microfabricated chip. Biomed Res. 2020;41(4):187 [Crossref]
15- Thangprasert A, Bernhardt A, Gossla E, Kilian D, Klaiklay S, Meesane J, Srithep P, Gelinsky M, Pasitsuparoad P. Bio-design material as scaffold module proposed for surgical application in osteoarthritis: fabrication, characterization, biological evaluation of in vitro testing. Biomed Mater. 2025;20(4):045022 [Crossref]
16- Lee Y, Park Y, Choi N, Kim Y, Koh Y, Jones E. Proteomic Analysis Reveals Commonly Secreted Proteins of Mesenchymal Stem Cells Derived from Bone Marrow, Adipose Tissue, and Synovial Membrane to Show Potential for Cartilage Regeneration in Knee Osteoarthritis. Stem Cells International. 2021;2021:1 [Crossref]
17- Rosochowicz M, Lach M, Richter M, Suchorska W, Trzeciak T. Conditioned Medium – Is it an Undervalued Lab Waste with the Potential for Osteoarthritis Management?. Stem Cell Rev and Rep. 2023;19(5):1185 [Crossref]
18- Arrigoni C, D’Arrigo D, Rossella V, Candrian C, Albertini V, Moretti M. Umbilical Cord MSCs and Their Secretome in the Therapy of Arthritic Diseases: A Research and Industrial Perspective. Cells. 2020;9(6):1343 [Crossref]
19- Pinto-Cardoso R, Pereira-Costa F, Pedro Faria J, Bandarrinha P, Bessa-Andrês C, Correia-de-Sá P, Bernardo Noronha-Matos J. Adenosinergic signalling in chondrogenesis and cartilage homeostasis: Friend or foe?. Biochemical Pharmacology. 2020;174:113784 [Crossref]
20- Lin F. Cell Therapy for Osteoarthritis. JSRT. 2017;3(2) [Crossref]
21- Camões S, Bulut O, Yazar V, Gaspar M, Simões S, Ferreira R, Vitorino R, Santos J, Gursel I, Miranda J. 3D-MSCs A151 ODN-loaded exosomes are immunomodulatory and reveal a proteomic cargo that sustains wound resolution. Journal of Advanced Research. 2022;41:113 [Crossref]
22- Soetjahjo B, Adriansyah D, Riawan W. A potential role of arcadia in conditioned media - umbilical cord derived mesenchymal stem cell on  cartilage repair. F1000Res. 2024;11:972 [Crossref]
23- Eyvazi M, Farahzadi R, Karimian Fathi N, Karimipour M, Soleimani Rad J, Montaseri A. Mummy Material Can Promote Differentiation of Adipose Derived Stem Cells into Osteoblast through Enhancement of Bone Specific Transcription Factors Expression. Adv Pharm Bull. 2018;8(3):457 [Crossref]
24- Udalamaththa V, Kaluarachchi A, Wijeratne S, Udagama P. Therapeutic uses of post-partum tissue-derived mesenchymal stromal cell secretome. 2020;152(6):541 [Crossref]