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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2017;7(4): 651-654. doi: 10.15171/apb.2017.078
PMID: 29399556        PMCID: PMC5788221

Short Communication

Role of Essential Oil of Mentha Spicata (Spearmint) in Addressing Reverse Hormonal and Folliculogenesis Disturbances in a Polycystic Ovarian Syndrome in a Rat Model

Mahmood Sadeghi Ataabadi 1, Sanaz Alaee 1 * , Mohammad Jafar Bagheri 2, Soghra Bahmanpoor 2

Cited by CrossRef: 25

1- Fatima S, Mohapatra L, Mishra D, Tripathi A, Khan A. Nipecotic Acid Ameliorates Letrozole Induced Poly Cystic Ovarian Syndrome in Female Virgin Wistar Rats by Modulating Hypothalamic-Pituitary-Gonadal (HPG) Axis Regulated by GABA. Reprod Sci. 2025;32(2):382 [Crossref]
2- Jiang L, Xiao J, Xie L, Zheng F, Ge F, Zhao X, Qiang R, Fang J, Liu Z, Xu Z, Chen R, Wang D, Liu Y, Xia Q. The emerging roles of N6-methyladenosine (m6A) deregulation in polycystic ovary syndrome. J Ovarian Res. 2025;18(1) [Crossref]
3- Malik S, Saeed S, Saleem A, Khan M, Khan A, Akhtar M. Alternative treatment of polycystic ovary syndrome: pre-clinical and clinical basis for using plant-based drugs. Front Endocrinol. 2024;14 [Crossref]
4- Szczuko M, Kikut J, Szczuko U, Szydłowska I, Nawrocka-Rutkowska J, Ziętek M, Verbanac D, Saso L. Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review. Nutrients. 2021;13(7):2452 [Crossref]
5- Mahendran G, Verma S, Rahman L. The traditional uses, phytochemistry and pharmacology of spearmint (Mentha spicata L.): A review. Journal of Ethnopharmacology. 2021;278:114266 [Crossref]
6- Mekkaoui M, Bouidida E, Naceiri Mrabti H, Ouaamr A, Lee L, Bouyahya A, Cherrah Y, Alaoui K. Investigation of Chemical Compounds and Evaluation of Toxicity, Antibacterial, and Anti-Inflammatory Activities of Three Selected Essential Oils and Their Mixtures with Moroccan Thyme Honey. Foods. 2022;11(19):3141 [Crossref]
7- Zhang J, Huang H, Xiao M, Jiang X, Yang Y, Huang M, Wang S, Zhu B, Zhao M. Erchen Decoction ameliorates the rat model of polycystic ovary syndrome by regulating the steroid biosynthesis pathway. Phytomedicine. 2025;143:156852 [Crossref]
8- Ashkar F, Rezaei S, Salahshoornezhad S, Vahid F, Gholamalizadeh M, Dahka S, Doaei S. The Role of medicinal herbs in treatment of insulin resistance in patients with Polycystic Ovary Syndrome: A literature review. 2020;11(1):57 [Crossref]
9- Yuan J, Li Z, Yu Y, Wang X, Zhao Y. Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential. Front Nutr. 2025;12 [Crossref]
10- Han J, Manzoor M, Siddique R, Manzoor H, Moazzam S, Bazmi R, Hussain L, Han L. Pharmacological Appraisal of Phyllanthus emblica in Letrozole‐Induced Polycystic Ovarian Syndrome Female Rats Model. Journal of Food Biochemistry. 2025;2025(1) [Crossref]
11- Ainehchi N, Khaki A, Farshbaf-Khalili A, Hammadeh M, Ouladsahebmadarek E. The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to Be Pregnant: A Randomized Clinical Trial. Biomolecules. 2019;9(6):215 [Crossref]
12- Barbhuiya P, Pathak M. Myrtenol: A promising terpene with potent pharmacological properties. Pharmacological Research - Natural Products. 2024;4:100067 [Crossref]
13- MALAKHED S. MOLECULAR DOCKING OF SPEARMINT PHYTOCOMPOUNDS AGAINST CYP21A2: IMPLICATIONS FOR PCOS THERAPY. Innovare J Med Sci. 2024;:1 [Crossref]
14- Shabbir S, Khurram E, Moorthi V, Eissa Y, Kamal M, Butler A. The interplay between androgens and the immune response in polycystic ovary syndrome. J Transl Med. 2023;21(1) [Crossref]
15- Aslam M, Shauket R, Yousaf Z, Tehzeeb K. Nutraceutical Intervention of Seeds in the Treatment of Poly Cystic Ovarian Syndrome; A Systematic Review. PBMJ. 2021;4(2) [Crossref]
16- Lee J, An S, Kim Y, Choi L, Kim D, Kim M. Comparative advantage and efficacy of natural products for polycystic ovary syndrome. J Ovarian Res. 2025;18(1) [Crossref]
17- Mehraban M, Jelodar G, Rahmanifar F. A combination of spearmint and flaxseed extract improved endocrine and histomorphology of ovary in experimental PCOS. J Ovarian Res. 2020;13(1) [Crossref]
18- Alesi S, Ee C, Moran L, Rao V, Mousa A. Nutritional Supplements and Complementary Therapies in Polycystic Ovary Syndrome. Advances in Nutrition. 2022;13(4):1243 [Crossref]
19- Sharma A, Bansal K, Bajpai M. The Role of Different Medicinal Herbs in Treatment of Polycystic Ovary Syndrome: A Review. NPJ. 2024;14(1) [Crossref]
20- Xu S, Liu Y, Zhang Y, Wang L, Ling N, Xu H, Zhou Y. Astaxanthin: a novel antioxidant for polycystic ovary syndrome?. Discov Med. 2024;1(1) [Crossref]
21- A. Devade O, D. Londhe R, V. Sokate N, R. Randave U, A. Ranpise P. A Review on: Polycystic Ovarian Disorder. AJPS. 2022;:219 [Crossref]
22- V Gadhave P, V Sutar G, Sajane S, Redasani V, Das K, Prasad P D, Alobid S, Ibrahim Almoteer A, Imam Rabbani S, Yasmin F, Gilkaramenthi R, Abdulrazaq AlAnazi M, Jameel Alshamrani H, Asdaq S. Protective effects of vanillic acid on letrozole-induced polycystic ovarian syndrome: A comprehensive study in female wistar rats. Saudi Pharmaceutical Journal. 2024;32(2):101953 [Crossref]
23- Islam R, Ghosh A, Ghosh S, Sarkar S, Saha T. Oral administration of the methanolic extract of Abutilon indicum (L.) Sweet seed proves effective in reducing cystic follicles and restoring the metabolic profile of Wistar albino rats with letrozole-induced polycystic ovarian syndrome. Pharmacological Research - Modern Chinese Medicine. 2024;10:100389 [Crossref]
24- Shirke P, Sayyad N, Devade O, Purane L, Redasani V. A Review on Polycystic Ovarian Syndrome. AJPS. 2025;:250 [Crossref]
25- Alaee S, Mirani M, Derakhshan Z, Koohpeyma F, Bakhtari A. Thymoquinone improves folliculogenesis, sexual hormones, gene expression of apoptotic markers and antioxidant enzymes in polycystic ovary syndrome rat model. Veterinary Medicine & Sci. 2023;9(1):290 [Crossref]
26- Cowan S, Lim S, Alycia C, Pirotta S, Thomson R, Gibson-Helm M, Blackmore R, Naderpoor N, Bennett C, Ee C, Rao V, Mousa A, Alesi S, Moran L. Lifestyle management in polycystic ovary syndrome – beyond diet and physical activity. BMC Endocr Disord. 2023;23(1) [Crossref]
27- Zhang J, Arshad K, Siddique R, Xu H, Alshammari A, Albekairi N, Bazmi R, Hussain L, Lv G. Phytochemicals-based investigation of Rubia cordifolia pharmacological potential against letrozole-induced polycystic ovarian syndrome in female adult rats: In vitro, in vivo and mechanistic approach. Heliyon. 2024;10(14):e34298 [Crossref]
28- Kumar G, Garg K, Soni A, Dalal M. A Comprehensive Review of Preclinical Models for Polycystic Ovary Syndrome. CDTH. 2024;19(4):426 [Crossref]