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Adv Pharm Bull. 2015;5(2): 201-208. doi: 10.15171/apb.2015.028
PMID: 26236658        PMCID: PMC4517083

Original Research

Adenovirus-Mediated Over-Expression of Nrf2 Within Mesenchymal Stem Cells (MSCs) Protected Rats Against Acute Kidney Injury

Mohammad Mohammadzadeh-Vardin, Mehryar Habibi Roudkenar * , Ali Jahanian-Najafabadi

Cited by CrossRef: 16


1- Kahroba H, Davatgaran-Taghipour Y. Exosomal Nrf2: From anti-oxidant and anti-inflammation response to wound healing and tissue regeneration in aged-related diseases. Biochimie. 2020;171-172:103 [Crossref]
2- Moubarak M, Pagano Zottola A, Larrieu C, Cuvellier S, Daubon T, Martin O. Exploring the multifaceted role of NRF2 in brain physiology and cancer: A comprehensive review. 2024;6(1) [Crossref]
3- Rendra E, Crigna A, Daniele C, Sticht C, Cueppers M, Kluth M, Ganss C, Frank M, Gretz N, Bieback K. Clinical-grade human skin-derived ABCB5+ mesenchymal stromal cells exert anti-apoptotic and anti-inflammatory effects in vitro and modulate mRNA expression in a cisplatin-induced kidney injury murine model. Front Immunol. 2024;14 [Crossref]
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6- Mirzaei S, Mohammadi A, Gholami M, Hashemi F, Zarrabi A, Zabolian A, Hushmandi K, Makvandi P, Samec M, Liskova A, Kubatka P, Nabavi N, Aref A, Ashrafizadeh M, Khan H, Najafi M. Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance. Pharmacological Research. 2021;167:105575 [Crossref]
7- Liu Y, Fang J, Mareschi K. Mesenchymal Stem Cells as Therapeutic Agents and Novel Carriers for the Delivery of Candidate Genes in Acute Kidney Injury. Stem Cells International. 2020;2020:1 [Crossref]
8- Mard S, Hoseinynejad K, Nejaddehbashi F. Gallic Acid Improves Therapeutic Effects of Mesenchymal Stem Cells Derived from Adipose Tissue in Acute Renal Injury Following Rhabdomyolysis Induced by Glycerol. Inflammation. 2022;45(6):2294 [Crossref]
9- Večerić-Haler Ž, Cerar A, Perše M. (Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity. Stem Cells International. 2017;2017:1 [Crossref]
10- Kahroba H, Shirmohamadi M, Hejazi M, Samadi N. The Role of Nrf2 signaling in cancer stem cells: From stemness and self-renewal to tumorigenesis and chemoresistance. Life Sciences. 2019;239:116986 [Crossref]
11- Kingsley S, Bhat B. Could stem cells be the future therapy for sepsis?. Blood Reviews. 2016;30(6):439 [Crossref]
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13- Fu Z, Zhang Y, Geng X, Chi K, Liu C, Song C, Cai G, Chen X, Hong Q. Optimization strategies of mesenchymal stem cell-based therapy for acute kidney injury. Stem Cell Res Ther. 2023;14(1) [Crossref]
14- Zhao L, Hu C, Zhang P, Jiang H, Chen J. Preconditioning strategies for improving the survival rate and paracrine ability of mesenchymal stem cells in acute kidney injury. J Cellular Molecular Medi. 2019;23(2):720 [Crossref]
15- Sabzevari R, Mohammadi Roushandeh A, Alijani -Ghazyani Z, Jahanian-Najafabadi A, Habibi Roudkenar M. SA/G hydrogel containing NRF2-engineered HEK-293-derived CM improves wound healing efficacy of WJ-MSCs in a rat model of excision injury. Journal of Tissue Viability. 2021;30(4):527 [Crossref]
16- Ni W, Zhang Y, Yin Z. The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis. Regenerative Therapy. 2021;18:255 [Crossref]
17- Roushandeh A, Bahadori M, Roudkenar M. Mesenchymal Stem Cell-based Therapy as a New Horizon for Kidney Injuries. Archives of Medical Research. 2017;48(2):133 [Crossref]
18- Hejazian S, Hosseiniyan Khatibi S, Barzegari A, Pavon-Djavid G, Razi Soofiyani S, Hassannejhad S, Ahmadian E, Ardalan M, Zununi Vahed S. Nrf-2 as a therapeutic target in acute kidney injury. Life Sciences. 2021;264:118581 [Crossref]
19- Zhang S, Jiang W, Ma L, Liu Y, Zhang X, Wang S. Nrf2 transfection enhances the efficacy of human amniotic mesenchymal stem cells to repair lung injury induced by lipopolysaccharide. J of Cellular Biochemistry. 2018;119(2):1627 [Crossref]