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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2016;6(2): 267-270. doi: 10.15171/apb.2016.037
PMID: 27478791        PMCID: PMC4961987

Short Communication

Fisetin Protects DNA Against Oxidative Damage and Its Possible Mechanism

Tingting Wang, Huajuan Lin, Qian Tu, Jingjing Liu, Xican Li *

Cited by CrossRef: 13

1- Thangsiri S, Kespanyarak R, Pitchakarn P, Buacheen P, Inthachat W, Temviriyanukul P, Suttisansanee U. Unveiling purple Capsicum frutescens Chili: First report on metabolomic composition, antioxidant capacity, and synergistic enzyme inhibition. Applied Food Research. 2026;6(1):102190 [Crossref]
2- Shen T, Wang X, Zhang X, Pei J, Wang Z, Li Q, Zhao L. Engineering of Flavonoid 3′-O-Methyltransferase for Improved Biomodification of Fisetin in Escherichia coli. J Agric Food Chem. 2025;73(18):11132 [Crossref]
3- Quraishi S, Hojaisa S, Kumari K, Marboh E, Aguan K, Jha A, Singha Roy A. Construing the Interaction of Antioxidant Coumarin Derivative Daphnetin with Double-Stranded Calf Thymus Deoxyribonucleic Acid: Insights into the Binding Mechanism and Effects on Oxidative DNA Damage. J Phys Chem B. 2025;129(21):5119 [Crossref]
4- Almaliki A, Abdul-Jabar R, Abood A. A comprehensive phytochemical evaluation of fisetin by in vitro antioxidant assays, anti-inflammatory activity, antidiabetic activity, antiproliferative assays, and DNA protection assay. JABC. 2026;69 [Crossref]
5- Naeimi A, Alizadeh M. Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies. Trends in Food Science & Technology. 2017;70:34 [Crossref]
6- Khan S, Khan M, Khan B, Ahmad U, Khan S. Fisetin as a multifunctional bioactive flavonoid: A comprehensive review of its pharmacology, mechanism of action, safety profile, clinical trials, and future directions in therapeutics. Food Bioscience. 2025;73:107620 [Crossref]
7- Antika L, Dewi R. Pharmacological aspects of fisetin. 2021;11(1):1 [Crossref]
8- Christodoulou M, Villa F, Pinto A, Cappitelli F. Correlation between Perturbation of Redox Homeostasis and Antibiofilm Capacity of Phytochemicals at Non-Lethal Concentrations. Antioxidants. 2022;11(12):2451 [Crossref]
9- Soycan S, Yıldırım D, Akyürek F, Güven H, Ünlükal N, Atay S, Serin H. Evaluation of the Relationships of Fisetin and Atorvastatin with Adipokine, Hepatokine, Myokine Profiles and Metabolic Parameters in Rats Fed with High-Fat Diet. Bratisl Med J. 2026; [Crossref]
10- Hassan S, Samanta S, Dash R, Karpiński T, Habibi E, Sadiq A, Ahmadi A, Bungau S. The neuroprotective effects of fisetin, a natural flavonoid in neurodegenerative diseases: Focus on the role of oxidative stress. Front Pharmacol. 2022;13 [Crossref]
11- Proshkina E, Shaposhnikov M, Moskalev A. Genome-Protecting Compounds as Potential Geroprotectors. IJMS. 2020;21(12):4484 [Crossref]
12- Łodyga-Chruscińska E, Pilo M, Zucca A, Garribba E, Klewicka E, Rowińska-Żyrek M, Symonowicz M, Chrusciński L, Cheshchevik V. Physicochemical, antioxidant, DNA cleaving properties and antimicrobial activity of fisetin-copper chelates. Journal of Inorganic Biochemistry. 2018;180:101 [Crossref]
13- Ahmad A, Ali T, Rehman S, Kim M. Phytomedicine-Based Potent Antioxidant, Fisetin Protects CNS-Insult LPS-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment. JCM. 2019;8(6):850 [Crossref]
14- Monyatovsky H, Anderson T, Nadeau J. Synthesis and Characterization of Highly Stable Fisetin Encapsulated in Lecithin-Chitosan-Savie Nanoparticles. ACS Omega. 2025;10(46):55964 [Crossref]
15- Imai K, Nakanishi I, Ohkubo K, Ohno A, Mizuno M, Fukuzumi S, Matsumoto K, Fukuhara K. Synthesis and radical-scavenging activity of C-methylated fisetin analogues. Bioorganic & Medicinal Chemistry. 2019;27(8):1720 [Crossref]
16- Mishra J, Swain J, Mishra A. Probing the temperature-dependent changes of the interfacial hydration and viscosity of Tween20 : cholesterol (1 : 1) niosome membrane using fisetin as a fluorescent molecular probe. Phys Chem Chem Phys. 2018;20(19):13279 [Crossref]
17- Wang R, Li J, Niu D, Xu F, Zeng X. Protective effect of baicalein on DNA oxidative damage and its binding mechanism with DNA: An in vitro and molecular docking study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2021;253:119605 [Crossref]
18- Rosiak N, Tykarska E, Cielecka-Piontek J. Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity. IJMS. 2024;25(7):3648 [Crossref]
19- Wang R, Hu X, Pan J, Zhang G, Gong D. Interaction of isoeugenol with calf thymus DNA and its protective effect on DNA oxidative damage. Journal of Molecular Liquids. 2019;282:356 [Crossref]
20- Çelikel P, Şimşek Derelioğlu S, Şengül F, Okkay U. The Role of Graphene and BiodentineTM on Proliferation and Odontoblastic Differentiation of Pulp Stem Cells. 2024;34(4):291 [Crossref]
21- Chahal S, Kabra A, Saeedan A, Ansari M. Fisetin: a multitarget flavonol bridging oxidative stress, inflammation, aging, and cancer. Naunyn-Schmiedeberg's Arch Pharmacol. 2026;399(6):7877 [Crossref]