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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2017;7(3): 399-408. doi: 10.15171/apb.2017.048
PMID: 29071222        PMCID: PMC5651061

Research Article

Pharmaceutical Cocrystal of Piroxicam: Design, Formulation and Evaluation

Prabhakar Panzade 1 * , Giridhar Shendarkar 1, Sarfaraj Shaikh 2, Pavan Balmukund Rathi 2

Cited by CrossRef: 39

1- Arshad M, Mujeeb M, Zafar S, Khan W, Patel M, Yousef B, Chang M, Sayed E, Ahmad Z. EHDA engineering of Piroxicam-PVP components for pharmaceutical dosages. Journal of Drug Delivery Science and Technology. 2022;78:103927 [Crossref]
2- Hussein L. Utilization of co-crystallization technology to enhance the solubility and the dissolution profiles of famotidine. Epitheorese Klin Farmakol Farmakokinet. 2024;42(Sup1):53 [Crossref]
3- Sengel-Turk C, Ozkan E, Bakar-Ates F. Box-Behnken design optimization and in vitro cell based evaluation of piroxicam loaded core-shell type hybrid nanocarriers for prostate cancer. Journal of Pharmaceutical and Biomedical Analysis. 2022;216:114799 [Crossref]
4- Salih Z, Al-Khedairy E. Designing and evaluation of ebastine–benzamide cocrystals. F1000Res. 2023;12:1449 [Crossref]
5- Pantwalawalkar J, Kale N, Nangare S, Patil S, Pawar S, Jadhav N. Pharmaceutical cocrystals: Unlocking the potential of challenging drug candidates. Journal of Drug Delivery Science and Technology. 2025;104:106572 [Crossref]
6- Alsuraifi A, Lin P, Curtis A, Lamprou D, Hoskins C. A Novel PAA Derivative with Enhanced Drug Efficacy in Pancreatic Cancer Cell Lines. Pharmaceuticals. 2018;11(4):91 [Crossref]
7- V, Kumar A, Kumar M, Lokanath N, Naveen S, Murthy P, Suchetan P. N-1,3-thiazole-2-ylacetamide: An efficient novel cocrystal former with carboxylic acids. Journal of Molecular Structure. 2025;1342:142706 [Crossref]
8- Radha-Rani E, Venkata-Radha G. Engineering cocrystals of Paliperidone with enhanced solubility and dissolution characteristics. Arhiv za farmaciju. 2021;71(5):393 [Crossref]
9- Rathi R, Kaur S, Singh I. A Review on Co-crystals of Herbal Bioactives for Solubility Enhancement: Preparation Methods and Characterization Techniques. Crystal Growth & Design. 2022;22(3):2023 [Crossref]
10- Burman J, Manchanda K, Bhakhar K, Boharupi A, Gohlke H, Bharatam P. A comparative electronic structure analysis of reactive metabolites of oxicams. Computational and Theoretical Chemistry. 2024;1237:114648 [Crossref]
11- Budziak-Wieczorek I, Maciołek U. Synthesis and Characterization of a (−)-Epicatechin and Barbituric Acid Cocrystal: Single-Crystal X-ray Diffraction and Vibrational Spectroscopic Studies. ACS Omega. 2021;6(12):8199 [Crossref]
12- Jadhav S, Ahire S, Shewale V, Patil C, Pagar R, Sonawane D, Mahajan S, Mahajan S. Formulation of Tablet of Nifedipine Co-Crystal for Enhancement of Solubility and Other Physical Properties. Biosci, Biotech Res Asia. 2025;22(1):191- [Crossref]
13- MALIK J, SACHDEVA H, KHATKAR A, NANDA A. DESIGN AND CHARACTERIZATION OF GLIBENCLAMIDE-CAFFEIC ACID COCRYSTALS VIA CRYSTAL ENGINEERING. Int J App Pharm. 2025;:365 [Crossref]
14- Panzade P, Shendarkar G. Pharmaceutical cocrystal: a game changing approach for the administration of old drugs in new crystalline form. Drug Development and Industrial Pharmacy. 2020;46(10):1559 [Crossref]
15- Sohn J, Kim E, Park J, Choi J. Piroxicam ternary solid dispersion system for improvement of dissolution (%) and in vitro anti-inflammation effects. Materials Science and Engineering: B. 2020;261:114651 [Crossref]
16- Kenguva G, Rekha Rout S, Shaikh T, Baidya D, Shelke N, Sanphui P, Dandela R. Exploring novel cocrystals of milrinone: a cardioprotective drug combined with nutraceuticals and an NSAID. CrystEngComm. 2025;27(2):138 [Crossref]
17- Charoenchaitrakool M, Roubroum T, Sudsakorn K. Processing of a novel mefenamic acid−paracetamol−nicotinamide cocrystal using gas anti-solvent process. Journal of CO2 Utilization. 2022;62:102080 [Crossref]
18- Kumbhar P, Kolekar K, Khot C, Dabhole S, Salawi A, Sabei F, Mohite A, Kole K, Mhatre S, Jha N, Manjappa A, Singh S, Dua K, Disouza J, Patravale V. Co-crystal nanoarchitectonics as an emerging strategy in attenuating cancer: Fundamentals and applications. Journal of Controlled Release. 2023;353:1150 [Crossref]
19- Shaik A, Bhagwat P, Palanisamy P, Chhabria D, Dubey P, Kirubakaran S, Thiruvenkatam V. Novel pharmaceutical co-crystals of gefitinib: synthesis, dissolution, cytotoxicity, and theoretical studies. CrystEngComm. 2023;25(17):2570 [Crossref]
20- Dhoot A, Fernandes G, Naha A, Rathnanand M, Kumar L. Design of Experiments in Pharmaceutical Development. Pharm Chem J. 2019;53(8):730 [Crossref]
21- Huang S, Venables D, Lawrence S. Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions. Crystal Growth & Design. 2022;22(11):6504 [Crossref]
22- Panzade P, Somani P, Rathi P. Nevirapine Pharmaceutical Cocrystal: Design, Development and Formulation. DDL. 2019;9(3):240 [Crossref]
23- Rathod N, Borkhataria C, Manek R, Patel V, Patel N, Patel K, Paun J, Sakhiya D. Study on the Correlation Between Nimodipine (BCS Class II) Solubility, Dissolution Improvement, and Brain Tissue Concentration Through Cocrystallization. J Pharm Innov. 2023;18(4):2235 [Crossref]
24- Saikia B, Pathak D, Sarma B. Variable stoichiometry cocrystals: occurrence and significance. CrystEngComm. 2021;23(26):4583 [Crossref]
25- Hasmukh Mehta C, Pooja Srinivas P, SB A, Fathy Mahany K, Koteshwara K, Yogendra Nayak U. Computational and Experimental Insights in Design and Development of Aceclofenac Co-Crystals. RJPT. 2022;:3709 [Crossref]
26- NANDA A, ANAND R. FORMULATION AND EVALUATION OF COCRYSTALS OF A BCS CLASS II DRUG USING GLYCINE AS COFORMER. Int J App Pharm. 2022;:68 [Crossref]
27- Wichianphong N, Charoenchaitrakool M. Application of Box–Behnken design for processing of mefenamic acid–paracetamol cocrystals using gas anti-solvent (GAS) process. Journal of CO2 Utilization. 2018;26:212 [Crossref]
28- Feng Q, Huan W, Wang J, Guo F, Lu J, Diao G, Shan Y. Cocrystal Assembled by Pyrene Derivative and 1,4-Diiodotetrafluorobenzene via a C=O···I Halogen Bond. Crystals. 2018;8(10):392 [Crossref]
29- Aitipamula S, Das S. Cocrystal formulations: A case study of topical formulations consisting of ferulic acid cocrystals. European Journal of Pharmaceutics and Biopharmaceutics. 2020;149:95 [Crossref]
30- Raheem Thayyil A, Juturu T, Nayak S, Kamath S. Pharmaceutical Co-Crystallization: Regulatory Aspects, Design, Characterization, and Applications. Adv Pharm Bull. 2020;10(2):203 [Crossref]
31- Thakkar H, Modi K, Shah D, Patel D. Formulation and Evaluation of Raloxifene Hydrochloride Co-Crystals with Bioenhancer – a Potential Approach for Solubility and Bioavailability Enhancement. J Pharm Innov. 2025;20(3) [Crossref]
32- Feng Y, Meng Y, Tan F, Lv L, Li Z, Wang Y, Yang Y, Gong W, Yang M. Effect of Surfactants and Polymers on the Dissolution Behavior of Supersaturable Tecovirimat-4-Hydroxybenzoic Acid Cocrystals. Pharmaceutics. 2021;13(11):1772 [Crossref]
33- Saha A, Ahangar A, Dar A, Thirunahari S, Parambil J. Pharmaceutical Cocrystals: A Perspective on Development and Scale-up of Solution Cocrystallization. Crystal Growth & Design. 2023;23(11):7558 [Crossref]
34- Yadav V, Kumar R, Sharma M, Dhir A, Bhardwaj V. Pharmaceutical cocrystals: An overview of synthesis, characterization, and applications. Journal of Molecular Structure. 2026;1349:143682 [Crossref]
35- Shen Y, Cruz-Cabeza A, Azzouz O, Edkins K. Using Prenucleation Aggregation of Caffeine-Benzoic Acid as a Rapid Indication of Co-crystallization from Solutions. Mol Pharmaceutics. 2023;20(4):1942 [Crossref]
36- Nugrahani I, Parwati R. Challenges and Progress in Nonsteroidal Anti-Inflammatory Drugs Co-Crystal Development. Molecules. 2021;26(14):4185 [Crossref]
37- Doloking H, Syamsi Dhuha N, Nurjannah N. Formation, Characterization and In vitro Dissolution studies of Piroxicam-Malic Acid Cocrystals. RJPT. 2024;:3061 [Crossref]
38- Nijhawan M, Jidige B, Aleti R, Gunnam S, Saxena T. Development and characterization of voriconazole-oxalic acid dihydrate cocrystals for enhanced pharmaceutical performance. Prosp Pharm Sc. 2025;22(4):199 [Crossref]
39- Saikia J, Devi T, Karlo T. A combined spectroscopic and quantum chemical approach to study the molecular interaction between anti-inflammatory drug Hydrocortisone and amino acid l-Phenylalanine. Journal of Molecular Structure. 2023;1286:135546 [Crossref]
40- Pessoa A, Aguiar G, Vladimir Oliveira J, Bortoluzzi A, Paulino A, Lanza M. Precipitation of resveratrol-isoniazid and resveratrol-nicotinamide cocrystals by gas antisolvent. The Journal of Supercritical Fluids. 2019;145:93 [Crossref]
41- Ngilirabanga J, Samsodien H. Pharmaceutical co‐crystal: An alternative strategy for enhanced physicochemical properties and drug synergy. Nano Select. 2021;2(3):512 [Crossref]
42- Nugrahani I, Jessica M. Amino Acids as the Potential Co-Former for Co-Crystal Development: A Review. Molecules. 2021;26(11):3279 [Crossref]
43- Thimmasetty J, Ghosh T, Nayak N, Raheem A. Oral Bioavailability Enhancement of Paliperidone by the use of Cocrystalization and Precipitation Inhibition. J Pharm Innov. 2021;16(1):160 [Crossref]
44- Otsuka Y, Goto S. Dry and Wet Mechanochemical Synthesis of Piroxicam and Saccharin Co-Crystals and Evaluation by Powder X-Ray Diffraction, Thermal Analysis and Mid- and Near- Infrared Spectroscopy. Journal of Pharmaceutical Sciences. 2022;111(1):88 [Crossref]
45- Rajbhar K, Karodadeo G, Kumar V, Barethiya V, Lahane A, Kale S, Thakre V, Dixit G, Kohale N, Hiradeve S, Rarokar N. Comparative assessment of solubility enhancement of itroconazole by solid dispersion and co-crystallization technique: Investigation of simultaneous effect of media composition on drug dissolution. Annales Pharmaceutiques Françaises. 2023;81(5):843 [Crossref]
46- Saha A, Dalvi S, Dar A, Parambil J. Ternary phase diagram and investigation of slurry conversion of 1:1 sulfamethazine-acetylsalicylic acid cocrystal. Chemical Engineering Research and Design. 2024;210:71 [Crossref]
47- Panzade P, Shendarkar G, Kulkarni D. Hot Melt Extrusion: an Emerging Green Technique for the Synthesis of High-Quality Pharmaceutical Cocrystals. J Pharm Innov. 2022;17(2):283 [Crossref]