Adv Pharm Bull. 2015;5(2): 141-149. doi: 10.15171/apb.2015.021
PMID: 26236651        PMCID: PMC4517092

Mini Review

The Effect of Hypoxia on Mesenchymal Stem Cell Biology

Mostafa Ejtehadifar 1, Karim Shamsasenjan 1,2 * , Aliakbar Movassaghpour 1, Parvin Akbarzadehlaleh 3, Nima Dehdilani 1, Parvaneh Abbasi 1, Zahra Molaeipour 1, Mahshid Saleh 1

Cited by CrossRef: 24

1- Sun X, Jin Y, Liang Q, Tang J, Chen J, Yu Q, Li F, Li Y, Wu J, Wu S. Altered expression of circular RNAs in human placental chorionic plate‐derived mesenchymal stem cells pretreated with hypoxia. J Clin Lab Anal. 2019;33(3):e22825 [Crossref]
2- Ferreira J, Teixeira G, Santos S, Barbosa M, Almeida-Porada G, Gonçalves R. Mesenchymal Stromal Cell Secretome: Influencing Therapeutic Potential by Cellular Pre-conditioning. Front Immunol. 2018;9 [Crossref]
3- Ramasamy S. Structure and Functions of Blood Vessels and Vascular Niches in Bone. Stem Cells International. 2017;2017:1 [Crossref]
4- Choi J, Yong K, Wan Safwani W. Effect of hypoxia on human adipose-derived mesenchymal stem cells and its potential clinical applications. Cell Mol Life Sci. 2017;74(14):2587 [Crossref]
5- Farahzadi R, Fathi E, Mesbah-Namin S, Zarghami N. Anti-aging protective effect of L-carnitine as clinical agent in regenerative medicine through increasing telomerase activity and change in the hTERT promoter CpG island methylation status of adipose tissue-derived mesenchymal stem cells. Tissue and Cell. 2018;54:105 [Crossref]
6- Baumann R, Depping R, Delaperriere M, Dunst J. Targeting hypoxia to overcome radiation resistance in head & neck cancers: real challenge or clinical fairytale?. Expert Review of Anticancer Therapy. 2016;16(7):751 [Crossref]
7- Ezquer F, Ezquer M, Vicencio J, Calligaris S. Two complementary strategies to improve cell engraftment in mesenchymal stem cell-based therapy: Increasing transplanted cell resistance and increasing tissue receptivity. Cell Adhesion & Migration. 2017;11(1):110 [Crossref]
8- Wang J, Qiu Y, Fu Y, Liu J, He Z, Huang Z. Transplantation with hypoxia-preconditioned mesenchymal stem cells suppresses brain injury caused by cardiac arrest-induced global cerebral ischemia in rats. J Neuro Res. 2017;95(10):2059 [Crossref]
9- Wang Q, Gao S, Luo Y, Kang Q. Compound anisodine affects the proliferation and calcium overload of hypoxia-induced rat retinal progenitor cells and brain neural stem cells via the p-ERK1/2/HIF-1α/VEGF pathway. 2017;14(1):600 [Crossref]
10- Teti G, Focaroli S, Salvatore V, Mazzotti E, Ingra’ L, Mazzotti A, Falconi M. The Hypoxia-Mimetic Agent Cobalt Chloride Differently Affects Human Mesenchymal Stem Cells in Their Chondrogenic Potential. Stem Cells International. 2018;2018:1 [Crossref]
11- Qiu Y, Chen Y, Zeng T, Guo W, Zhou W, Yang X. EGCG ameliorates the hypoxia-induced apoptosis and osteogenic differentiation reduction of mesenchymal stem cells via upregulating miR-210. Mol Biol Rep. 2016;43(3):183 [Crossref]
12- Rivera-Cruz C, Shearer J, Figueiredo Neto M, Figueiredo M. The Immunomodulatory Effects of Mesenchymal Stem Cell Polarization within the Tumor Microenvironment Niche. Stem Cells International. 2017;2017:1 [Crossref]
13- Li Q, Zhang B, Kasoju N, Ma J, Yang A, Cui Z, Wang H, Ye H. Differential and Interactive Effects of Substrate Topography and Chemistry on Human Mesenchymal Stem Cell Gene Expression. IJMS. 2018;19(8):2344 [Crossref]
14- Gugliandolo A, Diomede F, Scionti D, Bramanti P, Trubiani O, Mazzon E. The Role of Hypoxia on the Neuronal Differentiation of Gingival Mesenchymal Stem Cells: A Transcriptional Study. Cell Transplant. 2019;:096368971881447 [Crossref]
15- Gugliandolo A, Bramanti P, Mazzon E. Mesenchymal stem cell therapy in Parkinson's disease animal models. Current Research in Translational Medicine. 2017;65(2):51 [Crossref]
16- Marrazzo P, Angeloni C, Freschi M, Lorenzini A, Prata C, Maraldi T, Hrelia S. Combination of Epigallocatechin Gallate and Sulforaphane Counteracts In Vitro Oxidative Stress and Delays Stemness Loss of Amniotic Fluid Stem Cells. Oxidative Medicine and Cellular Longevity. 2018;2018:1 [Crossref]
17- Okawa H, Kayashima H, Sasaki J, Miura J, Kamano Y, Kosaka Y, Imazato S, Yatani H, Matsumoto T, Egusa H. Scaffold-Free Fabrication of Osteoinductive Cellular Constructs Using Mouse Gingiva-Derived Induced Pluripotent Stem Cells. Stem Cells International. 2016;2016:1 [Crossref]
18- Sassoli C, Pierucci F, Tani A, Frati A, Chellini F, Matteini F, Vestri A, Anderloni G, Nosi D, Zecchi-Orlandini S, Meacci E. Sphingosine 1-Phosphate Receptor 1 Is Required for MMP-2 Function in Bone Marrow Mesenchymal Stromal Cells: Implications for Cytoskeleton Assembly and Proliferation. Stem Cells International. 2018;2018:1 [Crossref]
19- Coffman L, Pearson A, Frisbie L, Freeman Z, Christie E, Bowtell D, Buckanovich R. Ovarian Carcinoma-Associated Mesenchymal Stem Cells Arise from Tissue-Specific Normal Stroma. Stem Cells. 2019;37(2):257 [Crossref]
20- Fathi E, Farahzadi R. Zinc Sulphate Mediates the Stimulation of Cell Proliferation of Rat Adipose Tissue-Derived Mesenchymal Stem Cells Under High Intensity of EMF Exposure. Biol Trace Elem Res. 2018;184(2):529 [Crossref]
21- Bora P, Majumdar A. Adipose tissue-derived stromal vascular fraction in regenerative medicine: a brief review on biology and translation. Stem Cell Res Ther. 2017;8(1) [Crossref]
22- Abu-El-Rub E, Sequiera G, Sareen N, Yan W, Moudgil M, Sabbir M, Dhingra S. Hypoxia-induced 26S proteasome dysfunction increases immunogenicity of mesenchymal stem cells. Cell Death Dis. 2019;10(2) [Crossref]
23- Zhilai Z, Biling M, Sujun Q, Chao D, Benchao S, Shuai H, Shun Y, Hui Z. Preconditioning in lowered oxygen enhances the therapeutic potential of human umbilical mesenchymal stem cells in a rat model of spinal cord injury. Brain Research. 2016;1642:426 [Crossref]
24- Elabd C, Ichim T, Miller K, Anneling A, Grinstein V, Vargas V, Silva F. Comparing atmospheric and hypoxic cultured mesenchymal stem cell transcriptome: implication for stem cell therapies targeting intervertebral discs. J Transl Med. 2018;16(1) [Crossref]
25- Cortini M, Avnet S, Baldini N. Mesenchymal stroma: Role in osteosarcoma progression. Cancer Letters. 2017;405:90 [Crossref]
26- Hudson K, Bonassar L. Hypoxic Expansion of Human Mesenchymal Stem Cells Enhances Three-Dimensional Maturation of Tissue-Engineered Intervertebral Discs. Tissue Engineering Part A. 2017;23(7-8):293 [Crossref]
27- Ciapetti G, Granchi D, Fotia C, Savarino L, Dallari D, Del Piccolo N, Donati D, Baldini N. Effects of hypoxia on osteogenic differentiation of mesenchymal stromal cells used as a cell therapy for avascular necrosis of the femoral head. Cytotherapy. 2016;18(9):1087 [Crossref]
28- Andreeva E, Matveeva D. Multipotent Mesenchymal Stromal Cells and Extracellular Matrix: Regulation under Hypoxia. Hum Physiol. 2018;44(6):696 [Crossref]
29- Melrose J. Strategies in regenerative medicine for intervertebral disc repair using mesenchymal stem cells and bioscaffolds. Regenerative Medicine. 2016;11(7):705 [Crossref]
30- Farahzadi R, Fathi E, Mesbah-Namin S, Zarghami N, Saretzki G. Zinc sulfate contributes to promote telomere length extension via increasing telomerase gene expression, telomerase activity and change in the TERT gene promoter CpG island methylation status of human adipose-derived mesenchymal stem cells. PLoS ONE. 2017;12(11):e0188052 [Crossref]
31- Ko S, Choi G, Oh J, Lee H, Kim J, Chae C, Choi D, Han H. Succinate promotes stem cell migration through the GPR91-dependent regulation of DRP1-mediated mitochondrial fission. Sci Rep. 2017;7(1) [Crossref]
32- Yoon D, Choi Y, Lee J. Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53–SIRT1 axis. Cell Death Dis. 2016;7(2):e2093 [Crossref]
33- Antebi B, Rodriguez L, Walker K, Asher A, Kamucheka R, Alvarado L, Mohammadipoor A, Cancio L. Short-term physiological hypoxia potentiates the therapeutic function of mesenchymal stem cells. Stem Cell Res Ther. 2018;9(1) [Crossref]
34- Li Q, Gao Z, Chen Y, Guan M. The role of mitochondria in osteogenic, adipogenic and chondrogenic differentiation of mesenchymal stem cells. Protein Cell. 2017;8(6):439 [Crossref]
35- Phelps J, Sanati-Nezhad A, Ungrin M, Duncan N, Sen A. Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics. Stem Cells International. 2018;2018:1 [Crossref]

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eISSN: 2251-7308 
pISSN: 2228-5881 
Freq.: Quarterly

 

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