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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2017;7(4): 579-584. doi: 10.15171/apb.2017.069
PMID: 29399547        PMCID: PMC5788212

Research Article

Caffeine Neuroprotective Mechanism Against β-Amyloid Neurotoxicity in SHSY5Y Cell Line: Involvement of Adenosine, Ryanodine, and N-Methyl-D-Aspartate Receptors

Mojtaba Keshavarz 1 * , Majid Reza Farrokhi 1, Atena Amiri 1

Cited by CrossRef: 7

1- Gupta S, Dasmahapatra A. Caffeine destabilizes preformed Aβ protofilaments: insights from all atom molecular dynamics simulations. Phys Chem Chem Phys. 2019;21(39):22067 [Crossref]
2- 蒋 单. Advances in Sleep Induction by Adenosine Activation of A1 and A2A Receptors. ACM. 2023;13(02):2083 [Crossref]
3- Londzin P, Zamora M, Kąkol B, Taborek A, Folwarczna J. Potential of Caffeine in Alzheimer’s Disease—A Review of Experimental Studies. Nutrients. 2021;13(2):537 [Crossref]
4- Castillo C, Ballesteros-Yáñez I, León-Navarro D, Albasanz J, Martín M. Early Effects of the Soluble Amyloid β25-35 Peptide in Rat Cortical Neurons: Modulation of Signal Transduction Mediated by Adenosine and Group I Metabotropic Glutamate Receptors. IJMS. 2021;22(12):6577 [Crossref]
5- Gomaa A, Farghaly H, Ahmed A, El-Mokhtar M, Hemida F. Advancing combination treatment with cilostazol and caffeine for Alzheimer's disease in high fat-high fructose-STZ induced model of amnesia. European Journal of Pharmacology. 2022;921:174873 [Crossref]
6- Jawad M, Uthirapathy S, Altalbawy F, Oghenemaro E, Rizaev J, Lal M, Eldesoqui M, Sharma N, Pramanik A, AL-Hamairy A. Examining the role of antioxidant supplementation in mitigating oxidative stress markers in Alzheimer’s disease: a comprehensive review. Inflammopharmacol. 2025;33(2):573 [Crossref]
7- Naik R, Mir M, Malik I, Bhardwaj R, Alshabrmi F, Mahmoud M, Alhomrani M, Alamri A, Alsanie W, Hjazi A, Ghatak T, Poeggeler B, Singh M, TS G, Singh S. The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease. Front Biosci (Landmark Ed). 2025;30(2) [Crossref]
8- Pritam P, Deka R, Bhardwaj A, Srivastava R, Kumar D, Jha A, Jha N, Villa C, Jha S. Antioxidants in Alzheimer’s Disease: Current Therapeutic Significance and Future Prospects. Biology. 2022;11(2):212 [Crossref]
9- Rodrigues Salles G, Granato A, Viero F, Pacheco-Soares C, Ferreira S, Porcionatto M, Ulrich H. Self-assembly and 3D Bioprinting of Neurospheres and Evaluation of Caffeine and Photobiomodulation Effects in an Alzheimer’s Disease In Vitro Model. Stem Cell Rev and Rep. 2025; [Crossref]
10- Badshah H, Ikram M, Ali W, Ahmad S, Hahm J, Kim M. Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. Biomolecules. 2019;9(11):719 [Crossref]