Original Research
Doxorubicin Changes Bax /Bcl-xL Ratio, Caspase-8 and 9 in Breast Cancer Cells
Simin Sharifi 1,2, Jaleh Barar 1,3, Mohammad Saeid Hejazi 1,4 * , Nasser Samadi 3,4,5 *
Cited by CrossRef: 98
1- Kumari S, Badana A, Mohan G, Shailender Naik G, Malla R. Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomedicine & Pharmacotherapy. 2017;91:436 [Crossref]
2- Liang L, Fu J, Wang S, Cen H, Zhang L, Mandukhail S, Du L, Wu Q, Zhang P, Yu X. MiR-142-3p enhances chemosensitivity of breast cancer cells and inhibits autophagy by targeting HMGB1. Acta Pharmaceutica Sinica B. 2020;10(6):1036 [Crossref]
3- Tupal A, Sabzichi M, Ramezani F, Kouhsoltani M, Hamishehkar H. Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer. Journal of Microencapsulation. 2016;33(4):372 [Crossref]
4- El-Gamal R, Elfarrash S, EL-Nablaway M, Salem A, Zaraei S, Anbar H, Shoma A, El-Gamal M. Anti-proliferative activity of RIHMS-Qi-23 against MCF-7 breast cancer cell line is through inhibition of cell proliferation and senescence but not inhibition of targeted kinases. BMC Cancer. 2023;23(1) [Crossref]
5- Kieda J, Appak-Baskoy S, Jeyhani M, Navi M, Chan K, Tsai S. Microfluidically-generated Encapsulated Spheroids (μ-GELS): An All-Aqueous Droplet Microfluidics Platform for Multicellular Spheroids Generation. ACS Biomater Sci Eng. 2023;9(2):1043 [Crossref]
6- Liu P, Shi C, Qiu L, Shang D, Lu Z, Tu Z, Liu H. Menin signaling and therapeutic targeting in breast cancer. Current Problems in Cancer. 2024;51:101118 [Crossref]
7- Zhang Z, Lin G, Yan Y, Li X, Hu Y, Wang J, Yin B, Wu Y, Li Z, Yang X. Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells. Oncogene. 2018;37(25):3456 [Crossref]
8- Saleh T, Al Shboul S, Awad H, El-Sadoni M, Alhesa A, Alsharaiah E, Abu Shahin N, Alotaibi M, Battah A, Azab B. Characterization of BCL-XL, MCL-1, and BAX Protein Expression in Response to Neoadjuvant Chemotherapy in Breast Cancer. 2024;32(4):189 [Crossref]
9- Ren R, Yuan Z, Xu Z. miRNA-144 targeting DNAJC3-AS1 reverses the resistance of the breast cancer cell line Michigan Cancer Foundation-7 to doxorubicin. Bioengineered. 2021;12(2):9885 [Crossref]
10- Noorian M, Chamani E, Salmani F, Rezaei Z, Khorsandi K. Effects of doxorubicin and apigenin on chronic myeloid leukemia cells (K562) in vitro: anti-proliferative and apoptosis induction assessments. Natural Product Research. 2023;37(19):3335 [Crossref]
11- Zhang B, Wu J, Guo P, Wang Y, Fang Z, Tian J, Yu Y, Teng W, Yingbin L, Li Y. Down-Regulation of SREBP via PI3K/AKT/mTOR Pathway Inhibits the Proliferation and Invasion of Non-Small-Cell Lung Cancer Cells
. OTT. 2020;Volume 13:8951 [Crossref]
12- Shen T, Wang H, Zhang S, Dong X, Zhang W, Liu C, Qian J. Safe, simple and multifunctional hydroxyapatite nanoparticles for efficient overcoming of tumor multidrug resistance. Applied Materials Today. 2024;40:102394 [Crossref]
13- Gangrade A, Mandal B. Injectable Carbon Nanotube Impregnated Silk Based Multifunctional Hydrogel for Localized Targeted and On-Demand Anticancer Drug Delivery. ACS Biomater Sci Eng. 2019;5(5):2365 [Crossref]
14- Ismail M, Abdelwahab G, Hamama W, Abdel‐Latif E, El‐Senduny F, El‐Sayed W. Synthesis of new thienylnicotinamidines: Proapoptotic profile and cell cycle arrest of HepG2 cells. Archiv der Pharmazie. 2022;355(9) [Crossref]
15- Kamath P, Joseph M, Abdul Salam A, T. Therakathinal S, Sunil D, Biswas S, Pai K. Retracted: Bisindole‐oxadiazole hybrids, T3P®‐mediated synthesis, and appraisal of their apoptotic, antimetastatic, and computational Bcl‐2 binding potential. J Biochem & Molecular Tox. 2017;31(11) [Crossref]
16- Yu H, Wen K, Zhou X, Zhang Y, Yan Z, Fu H, Zhu J, Zhu Y. Role of unfolded protein response in genital malformation/damage of male mice induced by flutamide. Hum Exp Toxicol. 2020;39(12):1690 [Crossref]
17- Ismail M, El‐Shafeai H, Arafa R, Abdel‐Rhman M, Abdel‐Latif E, El‐Sayed W. Synthesis, Antiproliferative Activity, Apoptotic Profiling, and In‐silico ADME of New Thienylbenzamidine Derivatives. ChemistrySelect. 2021;6(30):7644 [Crossref]
18- Younis N, Ghanim A, Saber S. Mebendazole augments sensitivity to sorafenib by targeting MAPK and BCL-2 signalling in n-nitrosodiethylamine-induced murine hepatocellular carcinoma. Sci Rep. 2019;9(1) [Crossref]
19- Alhowail A. Pioglitazone ameliorates DOX-induced cognitive impairment by mitigating inflammation, oxidative stress, and apoptosis of hippocampal neurons in rats. Behavioural Brain Research. 2024;457:114714 [Crossref]
20- Mahmoud A, El-Sayed W. The Anti-Proliferative Activity of Anisosciadone: A New Guaiane Sesquiterpene from Anisosciadium lanatum. ACAMC. 2019;19(9):1114 [Crossref]
21- Zhang W, Liu Y, Jiang J, Tang Y, Tang Y, Liang X. Extracellular vesicle long non–coding RNA‐mediated crosstalk in the tumor microenvironment: Tiny molecules, huge roles. Cancer Science. 2020;111(8):2726 [Crossref]
22- Mansoori-Kermani A, Khalighi S, Akbarzadeh I, Niavol F, Motasadizadeh H, Mahdieh A, Jahed V, Abdinezhad M, Rahbariasr N, Hosseini M, Ahmadkhani N, Panahi B, Fatahi Y, Mozafari M, Kumar A, Mostafavi E. Engineered hyaluronic acid-decorated niosomal nanoparticles for controlled and targeted delivery of epirubicin to treat breast cancer. Materials Today Bio. 2022;16:100349 [Crossref]
23- Xie L, Chen Y, Chen J, Zhang H, Liao Y, Zhou Y, Zhou L, Qing C. Anti-tumor effects and mechanism of GA-13315, a novel gibberellin derivative, in human lung adenocarcinoma: an in vitro and in vivo study. Cell Mol Biol Lett. 2019;24(1) [Crossref]
24- Kim M, Park W, Kim H, Park S, Lim W, Song G, Park S. Dimethyl Fumarate Ameliorates the Endometriosis Through Anti‐Inflammatory and Anti‐Proliferation Mechanisms In Vitro and In Vivo. Advanced Therapeutics. 2024;7(11) [Crossref]
25- Fouad M, Sayed-Ahmed M, Huwait E, Hafez H, Osman A. Epigenetic immunomodulatory effect of eugenol and astaxanthin on doxorubicin cytotoxicity in hormonal positive breast Cancer cells. BMC Pharmacol Toxicol. 2021;22(1) [Crossref]
26- Fourie C, Davis T, Kriel J, Engelbrecht A. The paracrine effects of fibroblasts on Doxorubicin-treated breast cancer cells. Experimental Cell Research. 2019;381(2):280 [Crossref]
27- Jabbari N, Zarei L, Esmaeili Govarchin Galeh H, Mansori Motlagh B. Assessment of synergistic effect of combining hyperthermia with irradiation and calcium carbonate nanoparticles on proliferation of human breast adenocarcinoma cell line (MCF-7 cells). Artificial Cells, Nanomedicine, and Biotechnology. 2018;46(sup2):364 [Crossref]
28- Pearce M, Gamble J, Kopparapu P, O'Donnell E, Mueller M, Jang H, Greenwood J, Satterthwait A, Tanguay R, Zhang X, Kolluri S. Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells. Oncotarget. 2018;9(40):26072 [Crossref]
29- Fotouhi P, Sohrabi S, Nosrati N, Vaziri A, Khaleghi S, Narmani A, Jafari H, Mohammadnejad J. Surface modified and rituximab functionalized PAMAM G4 nanoparticle for targeted imatinib delivery to leukemia cells: In vitro studies. Process Biochemistry. 2021;111:221 [Crossref]
30- Wang H, He L, Zhang P, Zhang J, Chen Z, Ren X, Mei X. Folate-modified hydroxyapatite nanorods induce apoptosis in MCF-7 cells through a mitochondrial-dependent pathway. New J Chem. 2019;43(37):14728 [Crossref]
31- Mi H, Wang X, Wang F, Li L, Zhu M, Wang N, Xiong Y, Gu Y. miR-381 induces sensitivity of breast cancer cells to doxorubicin by inactivation of MAPK signaling via FYN. European Journal of Pharmacology. 2018;839:66 [Crossref]
32- Kumari M, Purohit M, Patnaik S, Shukla Y, Kumar P, Gupta K. Curcumin loaded selenium nanoparticles synergize the anticancer potential of doxorubicin contained in self-assembled, cell receptor targeted nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics. 2018;130:185 [Crossref]
33- Ismail M, Negm A, Arafa R, Abdel-Latif E, El-Sayed W. Anticancer activity, dual prooxidant/antioxidant effect and apoptosis induction profile of new bichalcophene-5-carboxamidines. European Journal of Medicinal Chemistry. 2019;169:76 [Crossref]
34- Jafarinejad-Farsangi S, Hashemi M, Yazdi Rouholamini S, Gharbi S, Ansari-Asl Z, Jafari E, Shiralizadeh Dezfuli A, Shahrokhi-Farjah M. Curcumin loaded on graphene nanosheets induced cell death in mammospheres from MCF-7 and primary breast tumor cells. Biomed Mater. 2021;16(4):045040 [Crossref]
35- Alhowail A, Aldubayan M. Doxorubicin impairs cognitive function by upregulating AMPAR and NMDAR subunit expression and increasing neuroinflammation, oxidative stress, and apoptosis in the brain. Front Pharmacol. 2023;14 [Crossref]
36- Azadpour A, Hajrasouliha S, Khaleghi S. Green synthesized-silver nanoparticles coated with targeted chitosan nanoparticles for smart drug delivery. Journal of Drug Delivery Science and Technology. 2022;74:103554 [Crossref]
37- Cordeiro A, Feuser P, Araújo P, dos Santos D, Ourique F, Hübner L, Pedrosa R, Sayer C. Doxorubicin and 4-nitrochalcone loaded in beeswax-based nanostructured lipid carriers: In vitro antitumoral screening and evaluation of synergistic effect on HepG-2 cells. International Journal of Pharmaceutics. 2024;666:124788 [Crossref]
38- Khatibi Z, Kazemi N, Khaleghi S. Targeted and biocompatible NMOF as efficient nanocomposite for delivery of methotrexate to colon cancer cells. Journal of Drug Delivery Science and Technology. 2022;73:103441 [Crossref]
39- Kim J, Lee D, Na Y, Kim B, Jeong Y, Lee S, Kang S, Joung S, Lee S, Oh S, Min B. Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells. Tumor Biol. 2016;37(7):9709 [Crossref]
40- Karimabad M, Mahmoodi M, Jafarzadeh A, Darehkordi A, Hajizadeh M, Khorramdelazad H, Falahati-pour S, Hassanshahi G. The novel Indole-3-formaldehyde (2-AITFEI-3-F) is involved in processes of apoptosis induction?. Life Sciences. 2017;181:31 [Crossref]
41- Zeng Y, Mao J, Wang X, Yin B, Shen Z, Di C, Gu W, Wu M. Mechanism for ginsenoside Rh2-induced apoptosis of triple-negative breast cancer MDA-MB-231 cells. Clin Exp Obstet Gynecol. 2020;47(1) [Crossref]
42- Habibi Khorassani S, Ghodsi F, Arezomandan H, Shahraki M, Omidikia N, Hashemzaei M, Heidari Majd M. In Vitro Apoptosis Evaluation and Kinetic Modeling onto Cyclodextrin-Based Host–Guest Magnetic Nanoparticles Containing Methotrexate and Tamoxifen. BioNanoSci. 2021;11(3):667 [Crossref]
43- Mohammadizadeh F, Mahmoodi M, Rezaei A, Mohamadi M, Hajizadeh M, Mirzaei M, Falahati-pour S. A new copper complex enhanced apoptosis in human breast cancerous cells without considerable effects on normal cells. Gene Reports. 2019;17:100475 [Crossref]
44- Esmaeili Govarchin Ghaleh H, Zarei L, Mansori Motlagh B, Jabbari N. Using CuO nanoparticles and hyperthermia in radiotherapy of MCF-7 cell line: synergistic effect in cancer therapy. Artificial Cells, Nanomedicine, and Biotechnology. 2019;47(1):1396 [Crossref]
45- Shahi S, Zununi Vahed S, Fathi N, Sharifi S. Polymerase chain reaction (PCR)-based methods: Promising molecular tools in dentistry. International Journal of Biological Macromolecules. 2018;117:983 [Crossref]
46- Sampson V, Vetter N, Kamara D, Collier A, Gresh R, Kolb E, Loeb D. Vorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK Pathways. PLoS ONE. 2015;10(11):e0142704 [Crossref]
47- Al-Aamri H, Irving H, Bradley C, Meehan-Andrews T. Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment. BMC Cancer. 2021;21(1) [Crossref]
48- Kurtdede E, Alçığır M, Şahin Y. THE COMBINED EFFECTS OF 5-FLUOROURASIL AND TURKISH PROPOLIS EXRACT ON EPGF AND KRAS EXPERSSIONS AND APOPTOTIC CASCADE CHANGING IN RAT COLON CANCER MODEL. 2024; [Crossref]
49- Zhang Z, Xiang S, Cui R, Peng H, Mridul R, Xiang M. ILP-2: A New Bane and Therapeutic Target for Human Cancers. Front Oncol. 2022;12 [Crossref]
50- Gul S, Korkut A, Aydemir E. Combined Effect of Sertraline and Capecitabine on Breast Cancer Cell Lines In Vitro and In Silico Evidence for Synergistic Interaction. Sci Pharm. 2024;92(3):38 [Crossref]
51- Eisvand F, Imenshahidi M, Ghasemzadeh Rahbardar M, Tabatabaei Yazdi S, Rameshrad M, Razavi B, Hosseinzadeh H. Cardioprotective effects of alpha‐mangostin on doxorubicin‐induced cardiotoxicity in rats. Phytotherapy Research. 2022;36(1):506 [Crossref]
52- Guerriero E, Sorice A, Capone F, Storti G, Colonna G, Ciliberto G, Costantini S. Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. 2017;50(2):468 [Crossref]
53- Pahlavan Y, Samadi N, Ansarin K, Khabbazi A. Phosphorylation Modulates Survivin Function in Behcet’s Disease. Adv Pharm Bull. 2020;10(2):278 [Crossref]
54- Kesharwani P, Md S, Alhakamy N, Hosny K, Haque A. QbD Enabled Azacitidine Loaded Liposomal Nanoformulation and Its In Vitro Evaluation. Polymers. 2021;13(2):250 [Crossref]
55- Zununi Vahed S, Salehi R, Davaran S, Sharifi S. Liposome-based drug co-delivery systems in cancer cells. Materials Science and Engineering: C. 2017;71:1327 [Crossref]
56- Mondol A, Töpfer N, Rüger J, Neugebauer U, Popp J, Schie I. New perspectives for viability studies with high-content analysis Raman spectroscopy (HCA-RS). Sci Rep. 2019;9(1) [Crossref]
57- de Mello L, Souza G, Winter E, Silva A, Pittella F, Creczynski-Pasa T. Knockdown of antiapoptotic genes in breast cancer cells by siRNA loaded into hybrid nanoparticles. Nanotechnology. 2017;28(17):175101 [Crossref]
58- Jayawardena T, Lee W, Fernando I, Sanjeewa K, Wang L, Lee T, Park Y, Ko C, Jeon Y. Antiproliferative and apoptosis-inducing potential of 3β-hydroxy-Δ5-steroidal congeners purified from the soft coral Dendronephthya putteri. J Ocean Limnol. 2019;37(4):1382 [Crossref]
59- Jabłońska-Trypuć A, Świderski G, Krętowski R, Lewandowski W. Newly Synthesized Doxorubicin Complexes with Selected Metals—Synthesis, Structure and Anti-Breast Cancer Activity. Molecules. 2017;22(7):1106 [Crossref]
60- Ashour F, Awwad M, Sharawy H, Kamal M. Estrogen receptor positive breast tumors resist chemotherapy by the overexpression of P53 in Cancer Stem Cells. Journal of the Egyptian National Cancer Institute. 2018;30(2):45 [Crossref]
61- QUISBERT-VALENZUELA E, CALAF G. Apoptotic effect of noscapine in breast cancer cell lines. 2016;48(6):2666 [Crossref]
62- Huyut Z, Alp H, Yaman T, Keleş Ö, Yener Z, Türkan F, Ayengin K. Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity. Andrologia. 2021;53(2) [Crossref]
63- Hasnawati H, Wahyuono S, Susidarti R, Santosa D, Arfan A. A New Diterpenoid of Indonesian Scoparia dulcis Linn: Isolation and Cytotoxic Activity against MCF-7 and T47D Cell Lines. Molecules. 2023;28(16):5960 [Crossref]
64- Tavangar F, Sepehri H, Saghaeian Jazi M, Asadi J. Amphotericin B potentiates the anticancer activity of doxorubicin on the MCF-7 breast cancer cells. J Chem Biol. 2017;10(3):143 [Crossref]
65- Rahdar A, Sargazi S, Barani M, Shahraki S, Sabir F, Aboudzadeh M. Lignin-Stabilized Doxorubicin Microemulsions: Synthesis, Physical Characterization, and In Vitro Assessments. Polymers. 2021;13(4):641 [Crossref]
66- Deihimi M, Moghbelinejad S, Najafipour R, Parivar K, Nassiri-Asl M. The Effects of Rutin on the Gene Expression of Dazl, Bcl2, and Caspase3 in Idarubicin-induced Testicular Damages in Mice. Iran Red Crescent Med J. 2017;19(4) [Crossref]
67- A, Patel S, Patle R, Parameswaran P, Jain A, Shard A. Design, computational studies, synthesis and biological evaluation of thiazole-based molecules as anticancer agents. European Journal of Pharmaceutical Sciences. 2019;134:20 [Crossref]
68- Şahin Y, Üstüner E, Tutun H, Yildirim E, Eroğlu O, Kurtdede E, Ozkabadayi Y, Güncüm E, Kutluca K, Bilge A. Effects of edaravone on testicular torsion–detorsion injury in rats. Andrology. 2024;12(8):1918 [Crossref]
69- Wardhani B, Louisa M, Watanabe Y, Setiabudy R, Kato M. TGF-β-Induced TMEPAI Promotes Epithelial–Mesenchymal Transition in Doxorubicin-Treated Triple-Negative Breast Cancer Cells via SMAD3 and PI3K/AKT Pathway Alteration. BCTT. 2021;Volume 13:529 [Crossref]
70- Narmani A, Ganji S, Amirishoar M, Jahedi R, Kharazmi M, Jafari S. Smart chitosan-PLGA nanocarriers functionalized with surface folic acid ligands against lung cancer cells. International Journal of Biological Macromolecules. 2023;245:125554 [Crossref]
71- Hallajian F, Ghasmi M, Abedi S, Behzadi R, Hayati E, Sadeghzadeh N, Rezazadeh F, Karimi H. Evaluation of the Effect of Resveratrol and Doxorubicin on 99mTc-MIBI Uptake in Breast Cancer Cell Xenografts in Mice. Cancer Biotherapy and Radiopharmaceuticals. 2018;33(9):403 [Crossref]
72- du Z. BAX, a novel cell pro-apoptotic protein, involved in hemocytes early antiviral immune response in fresh water crayfish, Procambarus clarkii. Fish & Shellfish Immunology. 2016;55:384 [Crossref]
73- Sesarman A, Tefas L, Sylvester B, Licarete E, Rauca V, Luput L, Patras L, Porav S, Banciu M, Porfire A. Co-delivery of curcumin and doxorubicin in PEGylated liposomes favored the antineoplastic C26 murine colon carcinoma microenvironment. Drug Deliv and Transl Res. 2019;9(1):260 [Crossref]
74- Chu B, Peng F, Wang H, Su Y, He Y. Synergistic effects between silicon nanowires and doxorubicin at non-toxic doses lead to high-efficacy destruction of cancer cells. J Mater Chem B. 2018;6(45):7378 [Crossref]
75- Dou Y, Jiang X, Xie H, He J, Xiao S. The Jun N-terminal kinases signaling pathway plays a “seesaw” role in ovarian carcinoma: a molecular aspect. J Ovarian Res. 2019;12(1) [Crossref]
76- Tanveer Ahmed M, Sarkar S, Shukla R, Banerjee R. Etoposide‐Entrapped Progesterone‐Cationic Lipid Nanoaggregates as Selective Therapeutics against Etoposide‐Resistant Colorectal Cancer Cells. ChemBioChem. 2023;24(12) [Crossref]
77- Pardo-Mora D, Murillo O, Rey-Buitrago M, Losada-Barragán M, Uribe J, Santiago K, Conti B, Cardoso E, Conte F, Gutiérrez R, García O, Sforcin J. Apoptosis-related gene expression induced by Colombian propolis samples in canine osteosarcoma cell line. Vet World. 2021;14(4):964 [Crossref]
78- Sadeghi S, Mohammadnejad J, Eidi A, Jafary H. Biocompatible PLGA-PCL nanobeads for efficient delivery of curcumin to lung cancer. Cancer Nano. 2024;15(1) [Crossref]
79- Ayna E, Huyut Z, Kele&; O, Yener Z, Bal R. Protective Effect of Urtica dioica Seeds’ Extract in Experimental Chronic Aflatoxicosis in Broiler Chickens. International J of Poultry Science. 2021;20(6):256 [Crossref]
80- Adeyemi D, Obembe O, Hamed M, Akhigbe R. Sodium acetate ameliorates doxorubicin-induced cardiac injury via upregulation of Nrf2/HO-1 signaling and downregulation of NFkB-mediated apoptotic signaling in Wistar rats. Naunyn-Schmiedeberg's Arch Pharmacol. 2024;397(1):423 [Crossref]
81- El-Metwally S, Khalil A, El-Sayed W. Design, molecular modeling and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as inhibitors of topoisomerase II. Bioorganic Chemistry. 2020;94:103492 [Crossref]
82- Wang X, Pei X, Guo G, Qian X, Dou D, Zhang Z, Xu X, Duan X. Exosome‐mediated transfer of long noncoding RNA H19 induces doxorubicin resistance in breast cancer. Journal Cellular Physiology. 2020;235(10):6896 [Crossref]
83- Sun Y, Wang H, Li H. Elucidating the interaction of propofol as an intravenous anesthetic drug with blood components: IgG and peripheral blood mononuclear cell as targets. Arabian Journal of Chemistry. 2021;14(2):102965 [Crossref]
84- Afacan B, Budak U, Altınyürek E, Özden C, Çevik Ö, Köse T, Emingil G. Gingival crevicular fluid Bax, Bcl‐xl, interleukin‐22, and transforming growth factor beta 1 levels in stage III periodontitis. Journal of Periodontology. 2024; [Crossref]
85- Zununi Vahed S, Barzegari A, Rahbar Saadat Y, Goreyshi A, Omidi Y. Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-κB/AKT/PTEN/MAPK pathways. Biomedicine & Pharmacotherapy. 2017;94:1094 [Crossref]
86- Zununi Vahed S, Fathi N, Samiei M, Maleki Dizaj S, Sharifi S. Targeted cancer drug delivery with aptamer-functionalized polymeric nanoparticles. Journal of Drug Targeting. 2019;27(3):292 [Crossref]
87- Cheemanapalli S, C.M. A, Pakala S, Chitta S. Design and screening of syringic acid analogues as BAX activators-An in silico approach to discover “BH3 mimetics”. Computational Biology and Chemistry. 2018;74:49 [Crossref]
88- Moammeri A, Abbaspour K, Zafarian A, Jamshidifar E, Motasadizadeh H, Dabbagh Moghaddam F, Salehi Z, Makvandi P, Dinarvand R. pH-Responsive, Adorned Nanoniosomes for Codelivery of Cisplatin and Epirubicin: Synergistic Treatment of Breast Cancer. ACS Appl Bio Mater. 2022;5(2):675 [Crossref]
89- Boussada M, Dias T, Crisóstomo L, Akacha A, Ali R, El May M, Alves M, Oliveira P. A new thiocyanoacetamide (2-cyano-2-p-nitrophenyl-N-benzylthioamide) reduces doxorubicin-induced in vitro toxicity in Sertoli cells by decreasing apoptosis and autophagy. Theriogenology. 2019;140:188 [Crossref]
90- Choupani J, Alivand M, M. Derakhshan S, Zaeifizadeh M, S. Khaniani M. Oleuropein inhibits migration ability through suppression of epithelial‐mesenchymal transition and synergistically enhances doxorubicin‐mediated apoptosis in MCF‐7 cells. Journal Cellular Physiology. 2019;234(6):9093 [Crossref]
91- Pilco-Ferreto N, Calaf G. Influence of doxorubicin on apoptosis and oxidative stress in breast cancer cell lines. 2016;49(2):753 [Crossref]
92- Shokooh Saremi S, Nikpoor A, Sadri K, Mehrabian A, Karimi M, Mansouri A, Jafari M, Badiee A. Development of a stable and high loaded liposomal formulation of lapatinib with enhanced therapeutic effects for breast cancer in combination with Caelyx®: In vitro and in vivo evaluations. Colloids and Surfaces B: Biointerfaces. 2021;207:112012 [Crossref]
93- Živanović M, Gazdić Janković M, Ramović Hamzagić A, Virijević K, Milivojević N, Pecić K, Šeklić D, Jovanović M, Kastratović N, Mirić A, Đukić T, Petrović I, Jurišić V, Ljujić B, Filipović N. Combined Biological and Numerical Modeling Approach for Better Understanding of the Cancer Viability and Apoptosis. Pharmaceutics. 2023;15(6):1628 [Crossref]
94- Bhosale P, Kim H, Abusaliya A, Jeong S, Park M, Kim H, Seong J, Ahn M, Park K, Heo J, Kim Y, Kim G. Inhibition of Cell Proliferation and Cell Death by Apigetrin through Death Receptor-Mediated Pathway in Hepatocellular Cancer Cells. Biomolecules. 2023;13(7):1131 [Crossref]
95- Chan Z, Leong K, Kareem H, Norazit A, Noor S, Ariffin A. Activation of death receptor, DR5 and mitochondria-mediated apoptosis by a 3,4,5-trimethoxybenzyloxy derivative in wild-type and p53 mutant colorectal cancer cell lines. Naunyn-Schmiedeberg's Arch Pharmacol. 2020;393(3):405 [Crossref]
96- Akbarzadeh I, Tavakkoli Yaraki M, Ahmadi S, Chiani M, Nourouzian D. Folic acid-functionalized niosomal nanoparticles for selective dual-drug delivery into breast cancer cells: An in-vitro investigation. Advanced Powder Technology. 2020;31(9):4064 [Crossref]