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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2017;7(4): 603-609. doi: 10.15171/apb.2017.072
PMID: 29399550        PMCID: PMC5788215

Research Article

Strategies for Improving siRNA-Induced Gene Silencing Efficiency

Fatemeh Safari 1,2,3 * , Solmaz Rahmani Barouji 4, Ali Mohammad Tamaddon 5

Cited by CrossRef: 19

1- Shrivastava N, Verma P, Singh G, Singh J, Kumar A, Yadav S, Sonkar A, Ansari M, S Saeedan A, Akhter Y, A. Aldossary S, Kaithwas G. Optimizing siRNA Therapeutics Targeting HIF-1α: Computational Design, Screening, and Molecular Dynamics Simulation Studies. Mol Pharmaceutics. 2025;22(6):3179 [Crossref]
2- Long R, Guo Z, Han D, Liu B, Yuan X, Chen G, Heng P, Zhang L. siRNADiscovery: a graph neural network for siRNA efficacy prediction via deep RNA sequence analysis. 2024;25(6) [Crossref]
3- Safari F, Zare K, Negahdaripour M, Barekati-Mowahed M, Ghasemi Y. CRISPR Cpf1 proteins: structure, function and implications for genome editing. Cell Biosci. 2019;9(1) [Crossref]
4- Mehmood A, Ali W, Din Z, Song S, Sohail M, Shah W, Guo J, Guo R, Ilahi I, Shah S, Al‐Shaebi F, Zeb L, Asiamah E, Al‐Dhamin Z, Bilal H, Li B. Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson's disease. Brain and Behavior. 2021;11(8) [Crossref]
5- Safari F, Sharifi M, Farajnia S, Akbari B, Karimi Baba Ahmadi M, Negahdaripour M, Ghasemi Y. The interaction of phages and bacteria: the co-evolutionary arms race. Critical Reviews in Biotechnology. 2020;40(2):119 [Crossref]
6- Golovkin I, Shatkovskii D, Serov N. Two-Stage Probability-Enhanced Regression on Property Matrices and LLM Embeddings Enables State-of-the-Art Prediction of Gene Knockdown by Modified siRNAs. IJMS. 2025;26(24):11791 [Crossref]
7- Islam R, Shahriar A, Uddin M, Fatema N. Immunoinformatic and molecular docking approaches: siRNA prediction to silence cell surface binding protein of monkeypox virus. Beni-Suef Univ J Basic Appl Sci. 2024;13(1) [Crossref]
8- Yasmin T, Adiba M, Saba A, Nabi A. In Silico Design of siRNAs for Silencing CLEC5A Receptor as a Potential Therapeutic Approach Against Dengue and Japanese Encephalitis Virus Infection in Human. Bioinform Biol Insights. 2022;16 [Crossref]
9- Zare R, ArabSolghar R, Behbahni A, Zare F, Kheirandish A, Safari F. Exploring Caspase-3 overexpression in pheochromocytoma cells: Implications for cancer therapy. Tissue and Cell. 2025;93:102720 [Crossref]
10- Moaveni A, Amiri M, Shademan B, Farhadi A, Behroozi J, Nourazarian A. Advances and challenges in gene therapy strategies for pediatric cancer: a comprehensive update. Front Mol Biosci. 2024;11 [Crossref]
11- Liu Q, Zhang Y, Huang J, Xu Z, Li X, Yang J, Huang H, Tang S, Chai Y, Lin J, Yang C, Liu J, Lin S. Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing. J Nanobiotechnol. 2022;20(1) [Crossref]
12- Islam R, Shahriar A, Fatema N, Uddin M, Acharjee M, Shepon M, Sarkar A, Aurin K. In silico prediction of siRNA to silence the SARS-CoV-2 omicron variant targeting BA.4, BA.5, BQ.1, BQ1.1. and XBB: an alternative to traditional therapeutics. Futur J Pharm Sci. 2023;9(1) [Crossref]
13- Friedrich M, Aigner A. Therapeutic siRNA: State-of-the-Art and Future Perspectives. BioDrugs. 2022;36(5):549 [Crossref]
14- Luo Y, Liu L, He Z, Zhang S, Huo P, Wang Z, Jiaxin Q, Zhao L, Wu Y, Zhang D, Bu D, Chen R, Zhao Y. TREAT: Therapeutic RNAs exploration inspired by artificial intelligence technology. Computational and Structural Biotechnology Journal. 2022;20:5680 [Crossref]
15- Bondue T, van den Heuvel L, Levtchenko E, Brock R. The potential of RNA-based therapy for kidney diseases. Pediatr Nephrol. 2023;38(2):327 [Crossref]
16- Tuo D, Zhou P, Yan P, Cui H, Liu Y, Wang H, Yang X, Liao W, Sun D, Li X, Shen W. A cassava common mosaic virus vector for virus-induced gene silencing in cassava. Plant Methods. 2021;17(1) [Crossref]
17- Romero-López C, Ramos-Lorente S, Berzal-Herranz A. In Vitro Methods to Decipher the Structure of Viral RNA Genomes. Pharmaceuticals. 2021;14(11):1192 [Crossref]
18- Opdensteinen P, Caparco A, Steinmetz N. Protein-based spherical nanoparticles for dsRNA delivery to nematodes – A platform technology for RNA silencing. Materials Today. 2025;88:117 [Crossref]
19- Aigner A. RNA drugs and nonviral nanocarriers in oncology – present status and emerging concepts. Biochemical and Biophysical Research Communications. 2025;781:152512 [Crossref]
20- Safari F, Farajnia S, Behzad Behbahani A, Zarredar H, Barekati-Mowahed M, Dehghani H. Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability. Biol Res. 2020;53(1) [Crossref]
21- Safari F, Hatam G, Behbahani A, Rezaei V, Barekati‑Mowahed M, Petramfar P, Khademi F. CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson’s Disease. Cell Mol Neurobiol. 2020;40(4):477 [Crossref]
22- González R, Simões S, Ferreira L, Carvalho A. Designing Cell Delivery Peptides and SARS-CoV-2-Targeting Small Interfering RNAs: A Comprehensive Bioinformatics Study with Generative Adversarial Network-Based Peptide Design and In Vitro Assays. Mol Pharmaceutics. 2023;20(12):6079 [Crossref]
23- Aydeğer C. SMAD7 as a hub regulator in the pathophysiology of bone autograft healing and specific siRNA design: An in silico study. 2026;(1):15 [Crossref]