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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2017;7(4): 603-609. doi: 10.15171/apb.2017.072
PMID: 29399550        PMCID: PMC5788215

Research Article

Strategies for Improving siRNA-Induced Gene Silencing Efficiency

Fatemeh Safari 1,2,3 * , Solmaz Rahmani Barouji 4, Ali Mohammad Tamaddon 5

Cited by CrossRef: 19

1- Shrivastava N, Verma P, Singh G, Singh J, Kumar A, Yadav S, Sonkar A, Ansari M, S Saeedan A, Akhter Y, A. Aldossary S, Kaithwas G. Optimizing siRNA Therapeutics Targeting HIF-1α: Computational Design, Screening, and Molecular Dynamics Simulation Studies. Mol Pharmaceutics. 2025;22(6):3179 [Crossref]
2- Moaveni A, Amiri M, Shademan B, Farhadi A, Behroozi J, Nourazarian A. Advances and challenges in gene therapy strategies for pediatric cancer: a comprehensive update. Front Mol Biosci. 2024;11 [Crossref]
3- Long R, Guo Z, Han D, Liu B, Yuan X, Chen G, Heng P, Zhang L. siRNADiscovery: a graph neural network for siRNA efficacy prediction via deep RNA sequence analysis. 2024;25(6) [Crossref]
4- Liu Q, Zhang Y, Huang J, Xu Z, Li X, Yang J, Huang H, Tang S, Chai Y, Lin J, Yang C, Liu J, Lin S. Mesoporous silica-coated silver nanoparticles as ciprofloxacin/siRNA carriers for accelerated infected wound healing. J Nanobiotechnol. 2022;20(1) [Crossref]
5- Safari F, Zare K, Negahdaripour M, Barekati-Mowahed M, Ghasemi Y. CRISPR Cpf1 proteins: structure, function and implications for genome editing. Cell Biosci. 2019;9(1) [Crossref]
6- Islam R, Shahriar A, Fatema N, Uddin M, Acharjee M, Shepon M, Sarkar A, Aurin K. In silico prediction of siRNA to silence the SARS-CoV-2 omicron variant targeting BA.4, BA.5, BQ.1, BQ1.1. and XBB: an alternative to traditional therapeutics. Futur J Pharm Sci. 2023;9(1) [Crossref]
7- Friedrich M, Aigner A. Therapeutic siRNA: State-of-the-Art and Future Perspectives. BioDrugs. 2022;36(5):549 [Crossref]
8- Luo Y, Liu L, He Z, Zhang S, Huo P, Wang Z, Jiaxin Q, Zhao L, Wu Y, Zhang D, Bu D, Chen R, Zhao Y. TREAT: Therapeutic RNAs exploration inspired by artificial intelligence technology. Computational and Structural Biotechnology Journal. 2022;20:5680 [Crossref]
9- Mehmood A, Ali W, Din Z, Song S, Sohail M, Shah W, Guo J, Guo R, Ilahi I, Shah S, Al‐Shaebi F, Zeb L, Asiamah E, Al‐Dhamin Z, Bilal H, Li B. Clustered regularly interspaced short palindromic repeats as an advanced treatment for Parkinson's disease. Brain and Behavior. 2021;11(8) [Crossref]
10- Bondue T, van den Heuvel L, Levtchenko E, Brock R. The potential of RNA-based therapy for kidney diseases. Pediatr Nephrol. 2023;38(2):327 [Crossref]
11- Tuo D, Zhou P, Yan P, Cui H, Liu Y, Wang H, Yang X, Liao W, Sun D, Li X, Shen W. A cassava common mosaic virus vector for virus-induced gene silencing in cassava. Plant Methods. 2021;17(1) [Crossref]
12- Romero-López C, Ramos-Lorente S, Berzal-Herranz A. In Vitro Methods to Decipher the Structure of Viral RNA Genomes. Pharmaceuticals. 2021;14(11):1192 [Crossref]
13- Safari F, Sharifi M, Farajnia S, Akbari B, Karimi Baba Ahmadi M, Negahdaripour M, Ghasemi Y. The interaction of phages and bacteria: the co-evolutionary arms race. Critical Reviews in Biotechnology. 2020;40(2):119 [Crossref]
14- Opdensteinen P, Caparco A, Steinmetz N. Protein-based spherical nanoparticles for dsRNA delivery to nematodes – A platform technology for RNA silencing. Materials Today. 2025; [Crossref]
15- Safari F, Farajnia S, Behzad Behbahani A, Zarredar H, Barekati-Mowahed M, Dehghani H. Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability. Biol Res. 2020;53(1) [Crossref]
16- Islam R, Shahriar A, Uddin M, Fatema N. Immunoinformatic and molecular docking approaches: siRNA prediction to silence cell surface binding protein of monkeypox virus. Beni-Suef Univ J Basic Appl Sci. 2024;13(1) [Crossref]
17- Safari F, Hatam G, Behbahani A, Rezaei V, Barekati‑Mowahed M, Petramfar P, Khademi F. CRISPR System: A High-throughput Toolbox for Research and Treatment of Parkinson’s Disease. Cell Mol Neurobiol. 2020;40(4):477 [Crossref]
18- González R, Simões S, Ferreira L, Carvalho A. Designing Cell Delivery Peptides and SARS-CoV-2-Targeting Small Interfering RNAs: A Comprehensive Bioinformatics Study with Generative Adversarial Network-Based Peptide Design and In Vitro Assays. Mol Pharmaceutics. 2023;20(12):6079 [Crossref]
19- Yasmin T, Adiba M, Saba A, Nabi A. In Silico Design of siRNAs for Silencing CLEC5A Receptor as a Potential Therapeutic Approach Against Dengue and Japanese Encephalitis Virus Infection in Human. Bioinform Biol Insights. 2022;16 [Crossref]
20- Zare R, ArabSolghar R, Behbahni A, Zare F, Kheirandish A, Safari F. Exploring Caspase-3 overexpression in pheochromocytoma cells: Implications for cancer therapy. Tissue and Cell. 2025;93:102720 [Crossref]