ISSN: 2228-5881 eISSN: 2251-7308

Adv Pharm Bull. 2018;8(1): 77-84. doi: 10.15171/apb.2018.010

PMID: 29670842 PMCID: PMC5896398

Research Article

Investigation of Effective Parameters on Size of Paclitaxel Loaded PLGA Nanoparticles

Fatemeh Madani ^1,2, Seyedeh Sara Esnaashari ¹, Basil Mujokoro ³, Farid Dorkoosh ⁴, Masood Khosravani ¹, Mahdi Adabi ¹ *

Cited by CrossRef: 64

1- Maleki H, Naghibzadeh M, Amani A, Adabi M, Khosravani M. Preparation of Paclitaxel and Etoposide Co-loaded mPEG-PLGA Nanoparticles: an Investigation with Artificial Neural Network. J Pharm Innov. 2021;16(1):11 [Crossref]

2- Tahir A, Plengsuriyakarn T, Chittasupho C, Na-Bangchang K. Potential of Alpha-Mangostin-Loaded PLGA Nanoparticles for Cholangiocarcinoma Treatment. Polymers. 2022;14(20):4444 [Crossref]

3- Song M, Dong S, An X, Zhang W, Shen N, Li Y, Guo C, Liu C, Li X, Chen S. Erythrocyte-biomimetic nanosystems to improve antitumor effects of paclitaxel on epithelial cancers. Journal of Controlled Release. 2022;345:744 [Crossref]

4- Pudineh Moarref M, Alimolaei M, Emami T, Koohi M. Development and evaluation of cell membrane-based biomimetic nanoparticles loaded by Clostridium perfringens epsilon toxin: a novel vaccine delivery platform for Clostridial -associated diseases . Nanotoxicology. 2023;17(5):420 [Crossref]

5- Aldawsari H, Fahmy U, Abd-Allah F, Ahmed O. Formulation and Optimization of Avanafil Biodegradable Polymeric Nanoparticles: A Single-Dose Clinical Pharmacokinetic Evaluation. Pharmaceutics. 2020;12(6):596 [Crossref]

6- Ho Hoang N, Nguyen Van Anh T, Ho Nguyen Anh T, Le Thi Thanh N, Le Hoang H. PREPARATION AND CHARACTERIZATION OF POLYMERIC NANOPARTICLES CONTAINING METRONIDAZOLE. JMP. 2020;:99 [Crossref]

7- Doroudian M, O’Neill A, O’Reilly C, Tynan A, Mawhinney L, McElroy A, Webster S, MacLoughlin R, Volkov Y, E Armstrong M, A. O’Toole G, Prina-Mello A, C Donnelly S. Aerosolized Drug-Loaded Nanoparticles Targeting Migration Inhibitory Factors Inhibit Pseudomonas Aeruginosa -Induced Inflammation and Biofilm Formation . Nanomedicine (Lond). 2020;15(30):2933 [Crossref]

8- Diab T, AlKafaas S, Shalaby T, Hessien M. Dexamethasone simulates the anticancer effect of nano-formulated paclitaxel in breast cancer cells. Bioorganic Chemistry. 2020;99:103792 [Crossref]

9- Ullah F, Iqbal Z, Khan A, Khan S, Ahmad L, Alotaibi A, Ullah R, Shafique M. Formulation Development and Characterization of pH Responsive Polymeric Nano-Pharmaceuticals for Targeted Delivery of Anti-Cancer Drug (Methotrexate). Front Pharmacol. 2022;13 [Crossref]

10- Dudhat K, Patel H, Mori D. Design, Development, and In Vitro Characterization of Pirfenidone-Loaded Biodegradable Nanoparticles for Idiopathic Pulmonary Fibrosis. J Pharm Innov. 2023;18(4):1908 [Crossref]

11- Ahmadi H, Haddadi-Asl V, Mohammadloo H. Advancing anticorrosion and antibacterial performance of mg AZ31 implants using novel pH-responsive polymeric surfactant for preparing PLGA nanoparticles. Surface and Coatings Technology. 2024;482:130738 [Crossref]

12- Eftekhari R, Maghsoudnia N, Samimi S, Zamzami A, Dorkoosh F. Co-Delivery Nanosystems for Cancer Treatment: A Review. PNT. 2019;7(2):90 [Crossref]

13- Dhuri A, Sriram A, Aalhate M, Mahajan S, Parida K, Singh H, Gupta U, Maji I, Guru S, Singh P. Chitosan functionalized PCL nanoparticles bearing tyrosine kinase inhibitor osimertinib mesylate for effective lung cancer therapy. Pharmaceutical Development and Technology. 2023;28(5):460 [Crossref]

14- Wusiman A, Jiang W, Yu L, Zhu T, He J, Liu Z, Bo R, Liu J, Wang D. Cationic polymer-modified Alhagi honey polysaccharide PLGA nanoparticles as an adjuvant to induce strong and long-lasting immune responses. International Journal of Biological Macromolecules. 2021;177:370 [Crossref]

15- Nassireslami E, Ajdarzade M. Gold Coated Superparamagnetic Iron Oxide Nanoparticles as Effective Nanoparticles to Eradicate Breast Cancer Cells via Photothermal Therapy. Adv Pharm Bull. 2018;8(2):201 [Crossref]

16- Khodaverdi S, Jafari A, Movahedzadeh F, Madani F, Yousefi Avarvand A, Falahatkar S. Evaluating Inhibitory Effects of Paclitaxel and Vitamin D3 Loaded Poly Lactic Glycolic Acid Co-Delivery Nanoparticles on the Breast Cancer Cell Line. Adv Pharm Bull. 2019;10(1):30 [Crossref]

17- Ahmed O, Badr-Eldin S. Biodegradable self-assembled nanoparticles of PEG-PLGA amphiphilic diblock copolymer as a promising stealth system for augmented vinpocetine brain delivery. International Journal of Pharmaceutics. 2020;588:119778 [Crossref]

18- Wu W, Liu R, Guo J, Hu Z, An C, Zhang Y, Liu T, Cen L, Pan Y. Modulation of immunosuppressive effect of rapamycin via microfluidic encapsulation within PEG-PLGA nanoparticles. J Biomater Appl. 2024;38(7):821 [Crossref]

19- Öztürk A, Yenilmez E, Özarda M. Clarithromycin-Loaded Poly (Lactic-co-glycolic Acid) (PLGA) Nanoparticles for Oral Administration: Effect of Polymer Molecular Weight and Surface Modification with Chitosan on Formulation, Nanoparticle Characterization and Antibacterial Effects. Polymers. 2019;11(10):1632 [Crossref]

20- Firdaus S, Hassan N, Mirza M, Ara T, El-Serehy H, Al-Misned F, Iqbal Z. FbD directed fabrication and investigation of luliconazole based SLN gel for the amelioration of candidal vulvovaginitis: a 2 T (thermosensitive & transvaginal) approach. Saudi Journal of Biological Sciences. 2021;28(1):317 [Crossref]

21- Ayoub A, Atya M, Abdelsalam A, Schulze J, Amin M, Engelhardt K, Wojcik M, Librizzi D, Yousefi B, Nasrullah U, Pfeilschifter J, Bakowsky U, Preis E. Photoactive Parietin-loaded nanocarriers as an efficient therapeutic platform against triple-negative breast cancer. International Journal of Pharmaceutics. 2023;643:123217 [Crossref]

22- Alonso-González M, Fernández-Carballido A, Quispe-Chauca P, Lozza I, Martín-Sabroso C, Isabel Fraguas-Sánchez A. DoE-based development of celecoxib loaded PLGA nanoparticles: In ovo assessment of its antiangiogenic effect. European Journal of Pharmaceutics and Biopharmaceutics. 2022;180:149 [Crossref]

23- Mujokoro B, Madani F, Esnaashari S, Khosravani M, Adabi M. Combination and Co-delivery of Methotrexate and Curcumin: Preparation and In Vitro Cytotoxic Investigation on Glioma Cells. J Pharm Innov. 2020;15(4):617 [Crossref]

24- Pulingam T, Foroozandeh P, Chuah J, Sudesh K. Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles. Nanomaterials. 2022;12(3):576 [Crossref]

25- Sagoe P, Velázquez E, Espiritusanto Y, Gilbert A, Orado T, Wang Q, Jain E. Fabrication of PEG-PLGA Microparticles with Tunable Sizes for Controlled Drug Release Application. Molecules. 2023;28(18):6679 [Crossref]

26- Otroj M, Taymouri S, Varshosaz J, Mirian M. Preparation and characterization of dry powder containing sunitinib loaded PHBV nanoparticles for enhanced pulmonary delivery. Journal of Drug Delivery Science and Technology. 2020;56:101570 [Crossref]

27- Diab T, Alkafaas S, Shalaby T, Hessien M. Paclitaxel Nanoparticles Induce Apoptosis and Regulate TXR1, CYP3A4 and CYP2C8 in Breast Cancer and Hepatoma Cells. ACAMC. 2020;20(13):1582 [Crossref]

28- Bödder J, Kok L, Fauerbach J, Flórez-Grau G, de Vries I. Tailored PGE2 Immunomodulation of moDCs by Nano-Encapsulated EP2/EP4 Antagonists. IJMS. 2023;24(2):1392 [Crossref]

29- Cui Y, Sun J, Hao W, Chen M, Wang Y, Xu F, Gao C. Dual-Target Peptide-Modified Erythrocyte Membrane-Enveloped PLGA Nanoparticles for the Treatment of Glioma. Front Oncol. 2020;10 [Crossref]

30- Xu J, Fang Q, Yang L, Gao J, Xue Y, Wang X, Tang R. pH-sensitive deoxycholic acid dimer for improving doxorubicin delivery and antitumor activity in vivso. Colloids and Surfaces B: Biointerfaces. 2020;196:111319 [Crossref]

31- Dandamudi M, McLoughlin P, Behl G, Rani S, Coffey L, Chauhan A, Kent D, Fitzhenry L. Chitosan-Coated PLGA Nanoparticles Encapsulating Triamcinolone Acetonide as a Potential Candidate for Sustained Ocular Drug Delivery. Pharmaceutics. 2021;13(10):1590 [Crossref]

32- Esnaashari S, Muhammadnejad S, Amanpour S, Amani A. A Combinational Approach Towards Treatment of Breast Cancer: an Analysis of Noscapine-Loaded Polymeric Nanoparticles and Doxorubicin. AAPS PharmSciTech. 2020;21(5) [Crossref]

33- Casciaro B, d’Angelo I, Zhang X, Loffredo M, Conte G, Cappiello F, Quaglia F, Di Y, Ungaro F, Mangoni M. Poly(lactide-co-glycolide) Nanoparticles for Prolonged Therapeutic Efficacy of Esculentin-1a-Derived Antimicrobial Peptides against Pseudomonas aeruginosa Lung Infection: in Vitro and in Vivo Studies. Biomacromolecules. 2019;20(5):1876 [Crossref]

34- Ataabadi F, Oveissi F, Etebari M, Taheri A. Preparation of chitosan nanoparticles for simultaneous drug delivery of dacarbazine and enoxaparin in melanoma. Carbohydrate Polymers. 2023;316:121041 [Crossref]

35- Jafarbeglou M, Meimandi-Parizi A, Derakhshandeh A, Khodakaram-Tafti A, Bigham-Sadegh A, Arkan P, Jafarbeglou M. Silk fibroin/chitosan thiourea hydrogel scaffold with vancomycin and quercetin-loaded PLGA nanoparticles for treating chronic MRSA osteomyelitis in rats. International Journal of Pharmaceutics. 2024;666:124826 [Crossref]

36- Beltran O, Luna M, Gastelum M, Costa-Santos A, Cambón A, Taboada P, López-Mata M, Topete A, Juarez J. Novel Gold Nanorods@Thiolated Pectin on the Killing of HeLa Cells by Photothermal Ablation. Pharmaceutics. 2023;15(11):2571 [Crossref]

37- Messerschmidt V, Chintapula U, Kuriakose A, Laboy S, Truong T, Kydd L, Jaworski J, Pan Z, Sadek H, Nguyen K, Lee J. Notch Intracellular Domain Plasmid Delivery via Poly(Lactic-Co-Glycolic Acid) Nanoparticles to Upregulate Notch Pathway Molecules. Front Cardiovasc Med. 2021;8 [Crossref]

38- Hernández-Giottonini K, Rodríguez-Córdova R, Gutiérrez-Valenzuela C, Peñuñuri-Miranda O, Zavala-Rivera P, Guerrero-Germán P, Lucero-Acuña A. PLGA nanoparticle preparations by emulsification and nanoprecipitation techniques: effects of formulation parameters. RSC Adv. 2020;10(8):4218 [Crossref]

39- Ramezanpour S, Tavatoni P, Akrami M, Navaei-Nigjeh M, Shiri P, Premkumar T. Potential Wound Healing of PLGA Nanoparticles Containing a Novel L‐Carnitine–GHK Peptide Conjugate. Journal of Nanomaterials. 2022;2022(1) [Crossref]

40- Dahiya P, Zafar A, Ahmad F, Khalid M, Ali A. Development of Forskolin and rutin-loaded polymeric nanoparticles for enhancement of topical ocular delivery: Optimization, in-vitro, ex-vivo, and toxicity evaluation. Journal of Drug Delivery Science and Technology. 2023;82:104292 [Crossref]

41- Mahmood A, Khan L, Ijaz M, Nazir I, Naseem M, Tahir M, Aamir M, Rehman M, Asim M. Enhanced Intestinal Permeability of Cefixime by Self-Emulsifying Drug Delivery System: In-Vitro and Ex-Vivo Characterization. Molecules. 2023;28(6):2827 [Crossref]

42- Singh R, Khan S, Basu S, Chauhan M, Sarviya N, Giri J. Fabrication, Characterization, and Biological Evaluation of Airbrushed Gelatin Nanofibers. ACS Appl Bio Mater. 2019;2(12):5340 [Crossref]

43- Garcia L, Palma-Florez S, Espinosa V, Soleimani Rokni F, Lagunas A, Mir M, García-Celma M, Samitier J, Rodríguez-Abreu C, Grijalvo S. Ferulic acid-loaded polymeric nanoparticles prepared from nano-emulsion templates facilitate internalisation across the blood–brain barrier in model membranes. Nanoscale. 2023;15(17):7929 [Crossref]

44- Miraghaie S, Zandi A, Davari Z, Mousavi‐kiasary M, Saghafi Z, Gilani A, Kordehlachin Y, Shojaeian F, Mamdouh A, Heydari Z, Dorkoosh F, Kaffashi B, Abdolahad M. Targeted Delivery of Anticancer Drug Loaded Charged PLGA Polymeric Nanoparticles Using Electrostatic Field. Macromolecular Bioscience. 2023;23(9) [Crossref]

45- Casciaro B, Ghirga F, Quaglio D, Mangoni M. Inorganic Gold and Polymeric Poly(Lactide-co-glycolide) Nanoparticles as Novel Strategies to Ameliorate the Biological Properties of Antimicrobial Peptides. CPPS. 2020;21(4):429 [Crossref]

46- Razuvaeva E, Kalinin K, Sedush N, Nazarov A, Volkov D, Chvalun S. Structure and cytotoxicity of biodegradable poly(d,l-lactide-co-glycolide) nanoparticles loaded with oxaliplatin. Mendeleev Communications. 2021;31(4):512 [Crossref]

47- Qi P, Bu R, Zhang H, Yin J, Chen J, Zhang A, Gou J, Yin T, Zhang Y, He H, Wang P, Tang X, Wang Y. Goserelin Acetate Loaded Poloxamer Hydrogel in PLGA Microspheres: Core–Shell Di-Depot Intramuscular Sustained Release Delivery System. Mol Pharmaceutics. 2019;16(8):3502 [Crossref]

48- Bao Y, Maeki M, Ishida A, Tani H, Tokeshi M. Effect of Organic Solvents on a Production of PLGA-Based Drug-Loaded Nanoparticles Using a Microfluidic Device. ACS Omega. 2022;7(37):33079 [Crossref]

49- Malekpour M, Hosseindoost S, Madani F, Kamali M, khosravani M, Adabi M. Combination nanochemotherapy of brain tumor using polymeric nanoparticles loaded with doxorubicin and paclitaxel: An in vitro and in vivo study. European Journal of Pharmaceutics and Biopharmaceutics. 2023;193:175 [Crossref]

50- Pan X, Liu S, Ju L, Xi J, He R, Zhao Y, Zhuang R, Huang J. Preparation, evaluation, and in vitro cytotoxicity studies of artesunate-loaded glycyrrhetinic acid decorated PEG-PLGA nanoparticles. Drug Development and Industrial Pharmacy. 2020;46(11):1889 [Crossref]

51- Karimi Z, Taymouri S, Minaiyan M, Mirian M. Evaluation of thermosensitive chitosan hydrogel containing gefitinib loaded cellulose acetate butyrate nanoparticles in a subcutaneous breast cancer model. International Journal of Pharmaceutics. 2022;624:122036 [Crossref]

52- Mishra R, Jain N, Kaul S, Nagaich U. Central composite design–based optimization, fabrication, and pharmacodynamic assessment of sulfasalazine-loaded lipoidal nanoparticle-based hydrogel for the management of rheumatoid arthritis. Drug Deliv and Transl Res. 2023;13(4):994 [Crossref]

53- Souza R, Dantas A, Melo C, Felício I, Oliveira E. Nanotechnology as a tool to improve the biological activity of carvacrol: A review. Journal of Drug Delivery Science and Technology. 2022;76:103834 [Crossref]

54- Xu W, Kumar V, Cui C, Li X, Whittaker A, Xu Z, Smith M, Woodruff T, Han F. Success in Navigating Hurdles to Oral Delivery of a Bioactive Peptide Complement Antagonist through Use of Nanoparticles to Increase Bioavailability and In Vivo Efficacy. Advanced Therapeutics. 2022;5(12) [Crossref]

55- Seo H, Kim J. Ultrasound-assisted fractional precipitation of paclitaxel from Taxus chinensis cell cultures. Process Biochemistry. 2019;87:238 [Crossref]

56- Xiao P, Qi P, Chen J, Song Z, Wang Y, He H, Tang X, Wang P. The effect of polymer blends on initial release regulation and in vitro-in vivo relationship of peptides loaded PLGA-Hydrogel Microspheres. International Journal of Pharmaceutics. 2020;591:119964 [Crossref]

57- Razuvaeva E, Sedush N, Shirokova E, Moskvichev S, Streltsov D, Chvalun S. Effect of preparation conditions on the size of nanoparticles based on poly(D,L-lactide-co-glycolide) synthesized with bismuth subsalicylate. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022;648:129198 [Crossref]

58- Radwan R, Abdelkader A, Fathi H, Elsabahy M, Fetih G, El-Badry M. Development and Evaluation of Letrozole-Loaded Hyaluronic Acid/Chitosan-Coated Poly(d,l-lactide-co-glycolide) Nanoparticles. J Pharm Innov. 2022;17(2):572 [Crossref]

59- Hu D, Yang Y, Jiao T. Tennis Rehabilitation Training-Assisted Paclitaxel Nanoparticles in Treatment of Lung Tumor. Journal of Chemistry. 2020;2020:1 [Crossref]

60- Yun D, Liu D, Liu J, Feng Y, Chen H, Chen S, Xie Q. In Vitro/In Vivo Preparation and Evaluation of cRGDyK Peptide-Modified Polydopamine-Bridged Paclitaxel-Loaded Nanoparticles. Pharmaceutics. 2023;15(11):2644 [Crossref]

61- Messerschmidt V, Chintapula U, Bonetesta F, Laboy-Segarra S, Naderi A, Nguyen K, Cao H, Mager E, Lee J. In vivo Evaluation of Non-viral NICD Plasmid-Loaded PLGA Nanoparticles in Developing Zebrafish to Improve Cardiac Functions. Front Physiol. 2022;13 [Crossref]