Effect of Daily Caper Fruit Pickle Consumption on Disease Regression in Patients with Non-Alcoholic Fatty Liver Disease: a Double-Blinded Randomized Clinical Trial

Narjes Khavasi ¹, Mohammad hosein Somi ², Ebrahim Khadem ³, Elnaz Faramarzi ², Mohammad Hossein Ayati ³, Seyyed Muhammad Bagher Fazljou ¹, Mohammadali Torbati ⁴ *

Cited by CrossRef: 16

1- Rosqvist F, Rydell A, Iggman D. The Effects of Foods on Blood Lipids in Non-alcoholic Fatty Liver Disease (NAFLD)—A Systematic Review and Meta-Analysis. Front Nutr. 2020;7 [Crossref]

2- Li S, Xu Y, Guo W, Chen F, Zhang C, Tan H, Wang N, Feng Y. The Impacts of Herbal Medicines and Natural Products on Regulating the Hepatic Lipid Metabolism. Front Pharmacol. 2020;11 [Crossref]

3- Li H, Gan R, Shang A, Mao Q, Sun Q, Wu D, Geng F, He X, Li H, Zhang G. Plant‐Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application. Oxidative Medicine and Cellular Longevity. 2021;2021(1) [Crossref]

4- Olas B. The Current State of Knowledge about the Biological Activity of Different Parts of Capers. Nutrients. 2023;15(3):623 [Crossref]

5- Esmaeili S, Keramatian B, Kashafroodi H, Choopani R, Hajimehdipoor H. Capparis spinosa L. tablet: from traditional to modern dosage form. J Med Plants. 2022;21(82):56 [Crossref]

6- Mohaddab M, Genva M, Fakiri M, El-Goumi Y, Zeroual A, Fauconnier M. Capparis spinosa: A rich source of phenolic compounds - A comprehensive review of its phytochemistry, health benefits, and biotechnological applications. Biocatalysis and Agricultural Biotechnology. 2024;61:103409 [Crossref]

7- Sardari S, Fallahi F, Emadi F, Khavasi N, Esmaeili S. Capparis; A Candidate for Therapy in Patients with Hepatopulmonary Syndrome. Iran Red Crescent Med J. 2018;20(5) [Crossref]

8- Wan C, Langyan S, Echeverría J, Devkota H, Tewari D, Moosavi M, Ezzat S, Perez-Vazquez A, Fraga-Corral M, Cravotto G, Prieto M, Belwal T, li M. Edible fruits and berries as a source of functional polyphenols: current scene and future perspectives. Phytochem Rev. 2023; [Crossref]

9- Ayati M, Pourabbasi A, Namazi N, Zargaran A, Kheiry Z, Kazemi A, Larijani B. The necessity for integrating traditional, complementary, and alternative medicine into medical education curricula in Iran. Journal of Integrative Medicine. 2019;17(4):296 [Crossref]

10- Karimi-Sales E, Jeddi S, Alipour M. trans-Chalcone inhibits transforming growth factor-β1 and connective tissue growth factor-dependent collagen expression in the heart of high-fat diet-fed rats. Archives of Physiology and Biochemistry. 2022;128(5):1221 [Crossref]

11- Pourali G, Hosseini Z, Maftooh M, Nazari E, Khazaei M, Nassiri M, Hassanian S, Ghayour-Mobarhan M, Ferns G, Kiani M, Avan A. Therapeutic Potential of Herbal Medicine against Non-alcoholic Fatty Liver Disease. CDT. 2023;24(4):300 [Crossref]

12- Perna S, Rafique A, Rondanelli M, Allehdan S, Riso P, Marino M. Effect of caper fruit (Capparis spinosa L.) consumption on liver enzymes, lipid profile, fasting plasma glucose, and weight loss. A systematic review and a preliminary meta-analysis of randomized controlled trials. Biomedicine & Pharmacotherapy. 2023;168:115638 [Crossref]

13- Fakhri M, Fakheri H, Azadbakht M, Moosazadeh M, Yousefi S. Effect of Medicinal Plants and Natural Products on Liver Enzymes in Non-alcoholic Fatty Liver Patients in Iran. 2022;13(1):87 [Crossref]

14- Mahmoodpoor F, Hosseini S, Ahmadian E, Ardalan M, Kamali K, Zununi Vahed S, Sardari S, Khavasi N. The Histopathological Evaluation of the Effects of Capparis spinosa Seed Hydroalcoholic Extract on Cisplatin- induced-Nephrotoxicity in Rats. J Adv Med Biomed Res. 2023;31(144):73 [Crossref]

15- Liu X, Aimaier A, Wang W, Dong Y, Han P, He J, Mu L, Wang X, Li J. Quality variation and biosynthesis of anti-inflammatory compounds for Capparis spinosa based on the metabolome and transcriptome analysis. Front Plant Sci. 2023;14 [Crossref]

16- Heydari S, Hosseini S, Kamali K, Sardari S, Parsamanesh N, Khavasi N. Evaluation of the Effect of Capparis spinosa L. on Cisplatin-Induced Liver Injury in Male Rats based on Persian Medicine. J Adv Med Biomed Res. 2023;31(147):398 [Crossref]

17- Shafiezadeh R, Alavian S, Namdar H, Gholami-Fesharaki M, Esmaeili S. Evaluating the Efficacy of Carum Copticum Seeds on the Treatment of Patients with Nonalcoholic Fatty Liver Disease: A Multi-Center, Randomized, Triple–Blind, Placebo-Controlled Clinical Trial Study. Hepat Mon. 2021;20(12) [Crossref]

18- Assadi S, Shafiee S, Erfani M, Akmali M. Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats. Biomedicine & Pharmacotherapy. 2021;138:111391 [Crossref]