Venlafaxine-Induced Cytotoxicity Towards Isolated Rat Hepatocytes Involves Oxidative Stress and Mitochondrial/Lysosomal Dysfunction

Elham Ahmadian ^1,2,3,4, Hossein Babaei ^2,3, Alireza Mohajjel Nayebi ³, Aziz Eftekhari ^3,4, Mohammad Ali Eghbal ^2,3 *

Cited by CrossRef: 46

1- Parnia F, Yazdani J, Maleki Dizaj S. Applications of Mesenchymal Stem Cells in Sinus Lift Augmentation as a Dental Implant Technology. Stem Cells International. 2018;2018:1 [Crossref]

2- Kaur S, Kaur A, Jaswal N, Aniqa A, Sadwal S, Bharati S. Selenium attenuates venlafaxine hydrochloride‐induced testicular damage in mice via modulating oxidative stress and apoptosis. Andrologia. 2021;53(6) [Crossref]

3- Wan C, Liu X, Chen M, Ma H, Wu G, Qiao L, Cai Y, Zhang S. Tanshinone IIA ameliorates Aβ transendothelial transportation through SIRT1-mediated endoplasmic reticulum stress. J Transl Med. 2023;21(1) [Crossref]

4- Asgharzadeh F, Mostafapour A, Ebrahimi S, Amerizadeh F, Sabbaghzadeh R, Hassanian S, Fakhraei M, Farshbaf A, Ferns G, Giovannetti E, Avan A, Khazaei M. Inhibition of angiotensin pathway via valsartan reduces tumor growth in models of colorectal cancer. Toxicology and Applied Pharmacology. 2022;440:115951 [Crossref]

5- Zhang Q, Liu Y, Wang H, Ma L, Xia H, Niu J, Sun T, Zhang L. The preventive effects of taurine on neural tube defects through the Wnt/PCP-Jnk-dependent pathway. Amino Acids. 2017;49(9):1633 [Crossref]

6- Eftekhari A, Heidari R, Ahmadian E, Eghbal M. Cytoprotective Properties of Carnosine against Isoniazid-Induced Toxicity in Primary Cultured Rat Hepatocytes. Pharm Sci. 2018;24(4):257 [Crossref]

7- Heidari R, Ahmadi A, Mohammadi H, Ommati M, Azarpira N, Niknahad H. Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance. Biomedicine & Pharmacotherapy. 2018;107:834 [Crossref]

8- Heidari R, Behnamrad S, Khodami Z, Ommati M, Azarpira N, Vazin A. The nephroprotective properties of taurine in colistin-treated mice is mediated through the regulation of mitochondrial function and mitigation of oxidative stress. Biomedicine & Pharmacotherapy. 2019;109:103 [Crossref]

9- Madrigal-Bujaidar E, Paniagua-Pérez R, Rendón-Barrón M, Morales-González J, Madrigal-Santillán E, Álvarez-González I. Investigation of the DNA Damage and Oxidative Effect Induced by Venlafaxine in Mouse Brain and Liver Cells. Toxics. 2022;10(12):737 [Crossref]

10- Huang X, Han C, Zhong J, Hu J, Jin Y, Zhang Q, Luo W, Liu R, Ling F. Low expression of the dynamic network markers FOS/JUN in pre-deteriorated epithelial cells is associated with the progression of colorectal adenoma to carcinoma. J Transl Med. 2023;21(1) [Crossref]

11- Paulis M, Hafez E, El-Tahawy N, Aly M. Toxicological Assessment of Venlafaxine: Acute and Subchronic Toxicity Study in Rats. Int J Toxicol. 2018;37(4):327 [Crossref]

12- Liu Y, Zeng Z, Jiang O, Li Y, Xu Q, Jiang L, Yu J, Xu D. Green synthesis of CuO NPs, characterization and their toxicity potential against HepG2 cells. Mater Res Express. 2021;8(1):015011 [Crossref]

13- Mehdi H, Bragg L, Servos M, Craig P. Multiple Stressors in the Environment: The Effects of Exposure to an Antidepressant (Venlafaxine) and Increased Temperature on Zebrafish Metabolism. Front Physiol. 2019;10 [Crossref]

14- Zhang H, Xia N, Tang T, Nie S, Zha L, Zhang M, Lv B, Lu Y, Jiao J, Li J, Cheng X. Cholesterol suppresses human iTreg differentiation and nTreg function through mitochondria-related mechanisms. J Transl Med. 2023;21(1) [Crossref]

15- Sommerfeld-Klatta K, Jiers W, Rzepczyk S, Nowicki F, Łukasik-Głębocka M, Świderski P, Zielińska-Psuja B, Żaba Z, Żaba C. The Effect of Neuropsychiatric Drugs on the Oxidation-Reduction Balance in Therapy. IJMS. 2024;25(13):7304 [Crossref]

16- Emadi E, Abdoli N, Ghanbarinejad V, Mohammadi H, Mousavi Mobarakeh K, Azarpira N, Mahboubi Z, Niknahad H, Heidari R. The potential role of mitochondrial impairment in the pathogenesis of imatinib-induced renal injury. Heliyon. 2019;5(6):e01996 [Crossref]

17- Meng H, Li R, Xie Y, Mo Z, Zhai H, Zhang G, Liang G, Shi X, Zhou B. Nanoparticles Mediated circROBO1 Silencing to Inhibit Hepatocellular Carcinoma Progression by Modulating miR-130a-5p/CCNT2 Axis. IJN. 2023;Volume 18:1677 [Crossref]

18- Eftekhari A, Ahmadian E, Azami A, Johari‐Ahar M, Eghbal M. Protective effects of coenzyme Q10 nanoparticles on dichlorvos‐induced hepatotoxicity and mitochondrial/lysosomal injury. Environmental Toxicology. 2018;33(2):167 [Crossref]

19- Li Y, Wang Y, Zhang N, Zhou S, Peng Y, Zheng J. Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxinein vitroandin vivo. Xenobiotica. 2021;51(11):1303 [Crossref]

20- Tang Y, Chen K, Xiao Z, Hong G, Hu L, Cai J, Lu Z. A novel mechanism of Dimethyl ester of Alpha-ketoglutarate in suppressing Paraquat-induced BEAS-2B cell injury by alleviating GSDME dependent pyroptosis. Phytomedicine. 2023;112:154698 [Crossref]

21- Eftekhari A, Dizaj S, Chodari L, Sunar S, Hasanzadeh A, Ahmadian E, Hasanzadeh M. The promising future of nano-antioxidant therapy against environmental pollutants induced-toxicities. Biomedicine & Pharmacotherapy. 2018;103:1018 [Crossref]

22- Allen J, Caruncho H, Kalynchuk L. Severe life stress, mitochondrial dysfunction, and depressive behavior: A pathophysiological and therapeutic perspective. Mitochondrion. 2021;56:111 [Crossref]

23- Tao L, Qing Y, Cui Y, Shi D, Liu W, Chen L, Cao Y, Dai Z, Ge X, Zhang L. Lysosomal membrane permeabilization mediated apoptosis involve in perphenazine-induced hepatotoxicity in vitro and in vivo. Toxicology Letters. 2022;367:76 [Crossref]

24- Ommati M, Niknahad H, Farshad O, Azarpira N, Heidari R. In Vitro and In Vivo Evidence on the Role of Mitochondrial Impairment as a Mechanism of Lithium-Induced Nephrotoxicity. Biol Trace Elem Res. 2021;199(5):1908 [Crossref]

25- Ribeiro O, Félix L, Ribeiro C, Castro B, Tiritan M, Monteiro S, Carrola J. Enantioselective Ecotoxicity of Venlafaxine in Aquatic Organisms: Daphnia and Zebrafish. Enviro Toxic and Chemistry. 2022;41(8):1851 [Crossref]

26- Ahmadian E, Dizaj S, Rahimpour E, Hasanzadeh A, Eftekhari A, Hosain zadegan H, Halajzadeh J, Ahmadian H. Effect of silver nanoparticles in the induction of apoptosis on human hepatocellular carcinoma (HepG2) cell line. Materials Science and Engineering: C. 2018;93:465 [Crossref]

27- Dong M, Ding Y, Liu Y, Xu Z, Hong H, Sun H, Huang X, Yu X, Chen Q. Molecular insights of 2,6‐dichlorobenzoquinone‐induced cytotoxicity in zebrafish embryo: Activation of ROS‐mediated cell cycle arrest and apoptosis. Environmental Toxicology. 2023;38(3):694 [Crossref]

28- Alves C, Tamagno W, Pompermaier A, Vanin A, Barcellos L. Neurotoxicological effects of venlafaxine on Caenorhabditis elegans and Danio rerio. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology. 2023;271:109658 [Crossref]

29- Shaban N, Mohammed A, Abu-Serie M, Maher A, Habashy N. Inhibition of oxidative stress, IL-13, and WNT/β-catenin in ovalbumin-sensitized rats by a novel organogel of Punica granatum seed oil saponifiable fraction. Biomedicine & Pharmacotherapy. 2022;154:113667 [Crossref]

30- Yazdani J, Ahmadian E, Sharifi S, Shahi S, Maleki Dizaj S. A short view on nanohydroxyapatite as coating of dental implants. Biomedicine & Pharmacotherapy. 2018;105:553 [Crossref]

31- Ahmadian E, Khosroushahi A, Eftekhari A, Farajnia S, Babaei H, Eghbal M. Novel angiotensin receptor blocker, azilsartan induces oxidative stress and NFkB-mediated apoptosis in hepatocellular carcinoma cell line HepG2. Biomedicine & Pharmacotherapy. 2018;99:939 [Crossref]

32- Ghanbarinejad V, Ahmadi A, Niknahad H, Ommati M, Heidari R. Carnosine Mitigates Manganese Mitotoxicity in an In Vitro Model of Isolated Brain Mitochondria. Adv Pharm Bull. 2019;9(2):294 [Crossref]

33- Geilen J, Kainz M, Zapletal B, Geleff S, Wisser W, Bohle B, Schweiger T, Schultz M, Tschernko E. Unilateral acute lung injury in pig: a promising animal model. J Transl Med. 2022;20(1) [Crossref]

34- Robichaud K, Bragg L, Servos M, Craig P. Venlafaxine exposure alters mitochondrial respiration and mitomiR abundance in zebrafish brains. Enviro Toxic and Chemistry. 2024;43(7):1569 [Crossref]

35- Ahmadian E, Khosroushahi A, Eghbal M, Eftekhari A. Betanin reduces organophosphate induced cytotoxicity in primary hepatocyte via an anti-oxidative and mitochondrial dependent pathway. Pesticide Biochemistry and Physiology. 2018;144:71 [Crossref]

36- Fang L, Wang S, Cao L, Yao K. Early intervention of acute liver injury related to venlafaxine. 2021;100(49):e28140 [Crossref]

37- Todorović Vukotić N, Đorđević J, Pejić S, Đorđević N, Pajović S. Antidepressants- and antipsychotics-induced hepatotoxicity. Arch Toxicol. 2021;95(3):767 [Crossref]

38- Ommati M, Farshad O, Jamshidzadeh A, Heidari R. Taurine enhances skeletal muscle mitochondrial function in a rat model of resistance training. PharmaNutrition. 2019;9:100161 [Crossref]

39- Chang J, Wu H, Wu J, Liu M, Zhang W, Hu Y, Zhang X, Xu J, Li L, Yu P, Zhu J. Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma. J Transl Med. 2023;21(1) [Crossref]

40- Migheli R, Lostia G, Galleri G, Rocchitta G, Serra P, Campesi I, Bassareo V, Acquas E, Peana A. New perspective for an old drug: Can naloxone be considered an antioxidant agent?. Biochemistry and Biophysics Reports. 2023;34:101441 [Crossref]

41- Tiefensee Ribeiro C, Gasparotto J, Teixeira A, Portela L, Flores V, Moreira J, Gelain D. Immune neutralization of the receptor for advanced glycation end products reduce liver oxidative damage induced by an acute systemic injection of lipopolysaccharide. 2018;163(6):515 [Crossref]

42- Heidari R, Arabnezhad M, Ommati M, Azarpira N, Ghodsimanesh E, Niknahad H. Boldine Supplementation Regulates Mitochondrial Function and Oxidative Stress in a Rat Model of Hepatotoxicity. Pharm Sci. 2019;25(1):1 [Crossref]