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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2015;5(4): 569-581. doi: 10.15171/apb.2015.077
PMID: 26819931        PMCID: PMC4729349

Original Research

Enhancement of the Oral Bioavailability of Fexofenadine Hydrochloride via Cremophor® El-Based Liquisolid Tablets

Soad Ali Yehia 1, Mohamed Shafik El-Ridi 2, Mina Ibrahim Tadros 1 * , Nolwa Gamal El-Sherif 3

Cited by CrossRef: 12

1- Jadhav S, Bryant G, Mata J, Eldridge D, Palombo E, Harding I, Shah R. Structural aspects of a self-emulsifying multifunctional amphiphilic excipient: Part II. The case of Cremophor EL. Journal of Molecular Liquids. 2021;344:117881 [Crossref]
2- Effiong D, Onunkwo G. Principles, Applications and Limitations of the Liquisolid System of Drug Delivery: A Review. Trends Med Res. 2024;19(1):178 [Crossref]
3- El-Shahed S, Hassan D, El-Nabarawi M, El-Setouhy D, Abdellatif M. Polymeric Mixed Micelle-Loaded Hydrogel for the Ocular Delivery of Fexofenadine for Treating Allergic Conjunctivitis. Polymers. 2024;16(16):2240 [Crossref]
4- Singh S, Singh J, Arora D. Liquisolid Technique: A Novel Technique with Remarkable Applications in Pharmaceutics. CDDT. 2024;21(1) [Crossref]
5- KORNI R, GONUGUNTA C. Olanzapine Liquisolid Tablets Using Kolliphor EL with Improved Flowability and Bioavailability: In vitro and In vivo Characterization. tjps. 2024;21(1):52 [Crossref]
6- Helmy S, El-Bedaiwy H, El-Masry S. Applying Biopharmaceutical Classification System Criteria to Predict the Potential Effect of Cremophor ® RH 40 on Fexofenadine Bioavailability at Higher Doses . Ther Deliv. 2020;11(7):447 [Crossref]
7- Vasiljević I, Turković E, Parojčić J. Data-driven insights into the properties of liquisolid systems based on machine learning algorithms. European Journal of Pharmaceutical Sciences. 2024;203:106927 [Crossref]
8- Hussain Y, Cui J, Dormocara A, Khan H. The most recent advances in liquisolid technology: Perspectives in the pharmaceutical industry. Pharmaceutical Science Advances. 2024;2:100038 [Crossref]
9- Mirzaei S, Taghe S, Pirhayati F, Mohammadi G, Rahimpour E, Martinez F, Jouyban A. Measurement and correlation of fexofenadine hydrochloride solubility in ethanol + water mixtures at T = (293.2 to 313.2) K. Journal of Molecular Liquids. 2021;329:115554 [Crossref]
10- Tabboon P, Limpongsa E, Tuntiyasawasdikul S, Jarungsirawat R, Pongjanyakul T, Jaipakdee N. Screening the potential of pharmaceutical liquids on enhancing dissolution, intestinal permeation, and stability of Mitragyna speciosa bioactive for peroral delivery systems. Industrial Crops and Products. 2025;225:120525 [Crossref]
11- Islambulchilar Z, Barfar A, Mirzaeei S. Development of fexofenadine self-microemulsifying delivery systems: an efficient way to improve intestinal permeability. Therapeutic Delivery. 2024;15(8):593 [Crossref]
12- Vraníková B, Pavloková S, Gajdziok J. Experimental Design for Determination of Effects of Superdisintegrant Combinations on Liquisolid System Properties. Journal of Pharmaceutical Sciences. 2017;106(3):817 [Crossref]
13- Essa E, Amin M, Sultan A, Arafa M, El Maghraby G, McConville C. Hot melt extrusion for enhanced dissolution and intestinal absorption of hydrochlorothiazide. Journal of Drug Delivery Science and Technology. 2023;88:104895 [Crossref]
14- Zhang X, Xing H, Zhao Y, Ma Z. Pharmaceutical Dispersion Techniques for Dissolution and Bioavailability Enhancement of Poorly Water-Soluble Drugs. Pharmaceutics. 2018;10(3):74 [Crossref]