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Adv Pharm Bull. 2015;5(3): 411-417. doi: 10.15171/apb.2015.056
PMID: 26504764        PMCID: PMC4616899

Original Research

The Relationship between Solubility and Transdermal Absorption of Tadalafil

Hamed Hamishehkar 1 * , Mehdi Khoshbakht 2,3, Abolghasem Jouyban 1, Saeed Ghanbarzadeh 4

Cited by CrossRef: 19


1- Shaker D, Ishak R, Elhuoni M, Ghoneim A. Boosting transdermal delivery of atorvastatin calcium via o/w nanoemulsifying system: Two-step optimization, ex vivo and in vivo evaluation. International Journal of Pharmaceutics. 2020;578:119073 [Crossref]
2- Ashara K, Shah K. Emulsion of Chloramphenicol: an Overwhelming Approach for Ocular Delivery. 2017;59(1):23 [Crossref]
3- KIM T, KIM M, HWANG Y, ROSA V, DEL FABBRO M, MIN K. Effect of a calcium hydroxide-based intracanal medicament containing N-2-methyl pyrrolidone as a vehicle against Enterococcus faecalis biofilm. J Appl Oral Sci. 2020;28 [Crossref]
4- Wojcik-Pastuszka D, Lisik A, Twarda M, Berkowski R, Musial W. The influence of hydrophylic polymers on the release rate of calcium dobesilate in hydrogel formulation assessed in vitro using porcine ear skin. 2015;28(4):225 [Crossref]
5- Zakharova A, Efimova S, Ostroumova O. Phosphodiesterase Type 5 Inhibitors Greatly Affect Physicochemical Properties of Model Lipid Membranes. Membranes. 2021;11(11):893 [Crossref]
6- KIM M, NEELAKANTAN P, MIN K. Effect of N-2-methyl-pyrrolidone on Enterococcus faecalis biofilms. Dent Mater J. 2022;41(5):774 [Crossref]
7- Su M, Xia Y, Shen Y, Heng W, Wei Y, Zhang L, Gao Y, Zhang J, Qian S. A novel drug–drug coamorphous system without molecular interactions: improve the physicochemical properties of tadalafil and repaglinide. RSC Adv. 2020;10(1):565 [Crossref]
8- Kobryń J, Sowa S, Gasztych M, Dryś A, Musiał W. Influence of Hydrophilic Polymers on theβFactor in Weibull Equation Applied to the Release Kinetics of a Biologically Active Complex ofAesculus hippocastanum. International Journal of Polymer Science. 2017;2017:1 [Crossref]
9- Rahbari R, Ichim I, Bamsey R, Burridge J, Guy O, Bolodeoku J, Graz M. Characterisation of Drug Delivery Efficacy Using Microstructure-Assisted Application of a Range of APIs. Pharmaceutics. 2020;12(12):1213 [Crossref]
10- Georgescu M, Meltzer V, Stănculescu I, Pincu E. Thermal Behavior of the Nimesulide-Salicylic Acid Eutectic Mixtures Prepared by Mechanosynthesis and Recrystallization. Materials. 2021;14(24):7715 [Crossref]
11- Lim M, Jang H, Yu M, Lee K, Min K. Removal efficacy and cytotoxicity of a calcium hydroxide paste using N-2-methyl-pyrrolidone as a vehicle. Restor Dent Endod. 2017;42(4):290 [Crossref]
12- Moshikur R, Chowdhury M, Wakabayashi R, Tahara Y, Kamiya N, Moniruzzaman M, Goto M. Ionic liquids with N-methyl-2-pyrrolidonium cation as an enhancer for topical drug delivery: Synthesis, characterization, and skin-penetration evaluation. Journal of Molecular Liquids. 2020;299:112166 [Crossref]
13- Hamzehnejadi M, Ranjbar Tavakoli M, Abiri A, Ghasempour A, Langarizadeh M, Forootanfar H. A Review on Phosphodiesterase-5 Inhibitors as a Topical Therapy for Erectile Dysfunction. Sexual Medicine Reviews. 2022;10(3):376 [Crossref]
14- de França B, Ghasemishahrestani Z, de Souza G, da Silva R, Queiroz D, Pierre M, Pereira M, Forero J, Corrêa R. In vitro Studies of Antitumor Effect, Toxicity/Cytotoxicity and Skin Permeation/Retention of a Green Fluorescence Pyrene‐based Dye for PDT Application. Photochem & Photobiology. 2021;97(2):408 [Crossref]
15- Kobryń J, Zięba T, Sowa S, Musiał W. Influence of Acetylated Annealed Starch on the Release of β-Escin from the Anionic and Non-Ionic Hydrophilic Gels. Pharmaceutics. 2020;12(1):84 [Crossref]
16- Sohn J, Choi J. Development of a tadalafil transdermal formulation and evaluation of its ability to in vitro transdermal permeate using Strat-M® membrane. European Journal of Pharmaceutical Sciences. 2024;192:106615 [Crossref]
17- Duarah S, Sharma M, Chen S, Proft T, Loh J, Wen J. Design, optimization and evaluation of dexamethasone-loaded microneedles for inflammatory disorders. International Journal of Pharmaceutics. 2023;635:122690 [Crossref]
18- Ashara K, Shah K. Association of Permeability and Lipid Content of Membrane. 2017;59(2):203 [Crossref]
19- Tuntiyasawasdikul S, Limpongsa E, Jaipakdee N, Sripanidkulchai B. Effects of Vehicles and Enhancers on the Skin Permeation of Phytoestrogenic Diarylheptanoids from Curcuma comosa. AAPS PharmSciTech. 2017;18(3):895 [Crossref]