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Adv Pharm Bull. 2016;6(2): 143-151. doi: 10.15171/apb.2016.021
PMID: 27478775        PMCID: PMC4961971

Mini Review

The Impact of Variables on Particle Size of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers; A Comparative Literature Review

Leila Azhar Shekoufeh Bahari 1,2, Hamed Hamishehkar 2 *

Cited by CrossRef: 30


1- Játiva P, Ceña V. Use of nanoparticles for glioblastoma treatment: a new approach. Nanomedicine. 2017;12(20):2533 [Crossref]
2- Houacine C, Adams D, Singh K. Impact of liquid lipid on development and stability of trimyristin nanostructured lipid carriers for oral delivery of resveratrol. Journal of Molecular Liquids. 2020;316:113734 [Crossref]
3- Bicak B, Budama-Kilinc Y, Kecel-Gunduz S, Zorlud T, Akman G. Peptide based nano-drug candidate for cancer treatment: Preparation, characterization, in vitro and in silico evaluation. Journal of Molecular Structure. 2021;1240:130573 [Crossref]
4- Hossain S, Zainal Abidin S, Chowdhury E. Krebs Cycle Intermediate-Modified Carbonate Apatite Nanoparticles Drastically Reduce Mouse Tumor Burden and Toxicity by Restricting Broad Tissue Distribution of Anticancer Drugs. Cancers. 2020;12(1):161 [Crossref]
5- Czerwińska M, Fracasso G, Pruszyński M, Bilewicz A, Kruszewski M, Majkowska-Pilip A, Lankoff A. Design and Evaluation of 223Ra-Labeled and Anti-PSMA Targeted NaA Nanozeolites for Prostate Cancer Therapy–Part I. Materials. 2020;13(17):3875 [Crossref]
6- Khan A, ud Din F, Ali Z, Bibi M, Zahid F, Zeb A, Zeb M, Khan G. Development, in vitro and in vivo evaluation of miltefosine loaded nanostructured lipid carriers for the treatment of Cutaneous Leishmaniasis. International Journal of Pharmaceutics. 2021;593:120109 [Crossref]
7- Wang S, Liu Z, Wang W, You H. Fate and transformation of nanoparticles (NPs) in municipal wastewater treatment systems and effects of NPs on the biological treatment of wastewater: a review. RSC Adv. 2017;7(59):37065 [Crossref]
8- Rouco H, Diaz-Rodriguez P, Rama-Molinos S, Remuñán-López C, Landin M. Delimiting the knowledge space and the design space of nanostructured lipid carriers through Artificial Intelligence tools. International Journal of Pharmaceutics. 2018;553(1-2):522 [Crossref]
9- El-Gizawy S, El-Maghraby G, Hedaya A. Formulation of acyclovir-loaded solid lipid nanoparticles: design, optimization, and in-vitro characterization. Pharmaceutical Development and Technology. 2019;24(10):1287 [Crossref]
10- Barroso L, Viegas C, Vieira J, Ferreira-Pêgo C, Costa J, Fonte P. Lipid-based carriers for food ingredients delivery. Journal of Food Engineering. 2021;295:110451 [Crossref]
11- Lin H, Cheng W, Chen L, Ho H, Lin S, Hsieh C. Honokiol/Magnolol-Loaded Self-Assembling Lecithin-Based Mixed Polymeric Micelles (lbMPMs) for Improving Solubility to Enhance Oral Bioavailability. IJN. 2021;Volume 16:651 [Crossref]
12- Ammar H, Ghorab M, Mostafa D, Abd El-Alim S, Kassem A, Salah S, Shalaby E. Development of folic acid–loaded nanostructured lipid carriers for topical delivery: preparation, characterisation and ex vivo investigation. Journal of Microencapsulation. 2020;37(5):366 [Crossref]
13- Danaei M, Dehghankhold M, Ataei S, Hasanzadeh Davarani F, Javanmard R, Dokhani A, Khorasani S, Mozafari M. Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems. Pharmaceutics. 2018;10(2):57 [Crossref]
14- Operti M, Dölen Y, Keulen J, van Dinther E, Figdor C, Tagit O. Microfluidics-Assisted Size Tuning and Biological Evaluation of PLGA Particles. Pharmaceutics. 2019;11(11):590 [Crossref]
15- Lakhani P, Patil A, Wu K, Sweeney C, Tripathi S, Avula B, Taskar P, Khan S, Majumdar S. Optimization, stabilization, and characterization of amphotericin B loaded nanostructured lipid carriers for ocular drug delivery. International Journal of Pharmaceutics. 2019;572:118771 [Crossref]
16- Niamprem P, Srinivas S, Tiyaboonchai W. Penetration of Nile red-loaded nanostructured lipid carriers (NLCs) across the porcine cornea. Colloids and Surfaces B: Biointerfaces. 2019;176:371 [Crossref]
17- Mazonde P, Khamanga S, Walker R. Design, Optimization, Manufacture and Characterization of Efavirenz-Loaded Flaxseed Oil Nanoemulsions. Pharmaceutics. 2020;12(9):797 [Crossref]
18- Czajkowska-Kośnik A, Szekalska M, Winnicka K. Nanostructured lipid carriers: A potential use for skin drug delivery systems. Pharmacological Reports. 2019;71(1):156 [Crossref]
19- Mirahadi M, Ghanbarzadeh S, Ghorbani M, Gholizadeh A, Hamishehkar H. A review on the role of lipid-based nanoparticles in medical diagnosis and imaging. Therapeutic Delivery. 2018;9(8):557 [Crossref]
20- Hosny K, Bahmdan R, Alhakamy N, Alfaleh M, Ahmed O, Elkomy M. Physically Optimized Nano-Lipid Carriers Augment Raloxifene and Vitamin D Oral Bioavailability in Healthy Humans for Management of Osteoporosis. Journal of Pharmaceutical Sciences. 2020;109(7):2145 [Crossref]
21- Haider M, Elsherbeny A, Jagal J, Hubatová-Vacková A, Saad Ahmed I. Optimization and Evaluation of Poly(lactide-co-glycolide) Nanoparticles for Enhanced Cellular Uptake and Efficacy of Paclitaxel in the Treatment of Head and Neck Cancer. Pharmaceutics. 2020;12(9):828 [Crossref]
22- Montenegro L, Pasquinucci L, Zappalà A, Chiechio S, Turnaturi R, Parenti C. Rosemary Essential Oil-Loaded Lipid Nanoparticles: In Vivo Topical Activity from Gel Vehicles. Pharmaceutics. 2017;9(4):48 [Crossref]
23- de Souza I, Saez V, de Campos V, Mansur C. Size and Vitamin E Release of Nanostructured Lipid Carriers with Different Liquid Lipids, Surfactants and Preparation Methods. Macromol Symp. 2019;383(1):1800011 [Crossref]
24- Oner E, Kotmakci M, Kantarci A. A promising approach to develop nanostructured lipid carriers from solid lipid nanoparticles: preparation, characterization, cytotoxicity and nucleic acid binding ability. Pharmaceutical Development and Technology. 2020;25(8):936 [Crossref]
25- Sun Y, Zhang J, Bo R, Ou N, Gu P, Liu Z, Hu Y, Liu J, Wu Y, Wang D. Polysaccharides of Atractylodes macrocephala Koidz-loaded nanostructured lipid carriers: Optimization on conditions by RSM and immunological activity in vitro. Journal of Drug Delivery Science and Technology. 2018;44:305 [Crossref]
26- Masiiwa W, Gadaga L. Intestinal Permeability of Artesunate-Loaded Solid Lipid Nanoparticles Using the Everted Gut Method. Journal of Drug Delivery. 2018;2018:1 [Crossref]
27- Jeong S, Jang J, Cho H, Lee Y. Soft- and hard-lipid nanoparticles: a novel approach to lymphatic drug delivery. Arch Pharm Res. 2018;41(8):797 [Crossref]
28- Al-Maghrabi P, Khafagy E, Ghorab M, Gad S. Influence of formulation variables on miconazole nitrate–loaded lipid based nanocarrier for topical delivery. Colloids and Surfaces B: Biointerfaces. 2020;193:111046 [Crossref]
29- Abosabaa S, Arafa M, ElMeshad A. Drug delivery systems integrated with conventional and advanced treatment approaches toward cellulite reduction. Journal of Drug Delivery Science and Technology. 2020;60:102084 [Crossref]
30- Chaiyana W, Anuchapreeda S, Somwongin S, Marsup P, Lee K, Lin W, Lue S. Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers. Pharmaceutics. 2020;12(4):309 [Crossref]
31- Mohammadabadi M, Mozafari M. Enhanced efficacy and bioavailability of thymoquinone using nanoliposomal dosage form. Journal of Drug Delivery Science and Technology. 2018;47:445 [Crossref]
32- Bors L, Erdő F. Overcoming the Blood–Brain Barrier. Challenges and Tricks for CNS Drug Delivery. Sci Pharm. 2019;87(1):6 [Crossref]
33- Francis J, Skakic I, Dekiwadia C, Shukla R, Taki A, Walduck A, Smooker P. Solid Lipid Nanoparticle Carrier Platform Containing Synthetic TLR4 Agonist Mediates Non-Viral DNA Vaccine Delivery. Vaccines. 2020;8(3):551 [Crossref]
34- Xing J, Liu D, Zhou G, Li Y, Wang P, Hu K, Gu N, Ji M. Liposomally formulated phospholipid-conjugated novel near-infrared fluorescence probe for particle size effect on cellular uptake and biodistribution in vivo. Colloids and Surfaces B: Biointerfaces. 2018;161:588 [Crossref]
35- Ding S, Yu Q, Wang J, Zhu L, Li T, Guo X, Zhang X. Activation of ATF3/AP-1 signaling pathway is required for P2X3-induced endometriosis pain. 2020;35(5):1130 [Crossref]
36- Al-otaibi W. Rosemary oil nano-emulsion potentiates the apoptotic effect of mitomycin C on cancer cells in vitro. PHAR. 2021;68(1):201 [Crossref]
37- Saghafi Z, Mohammadi M, Mahboobian M, Derakhshandeh K. Preparation, characterization, and in vivo evaluation of perphenazine-loaded nanostructured lipid carriers for oral bioavailability improvement. Drug Development and Industrial Pharmacy. 2021;47(3):509 [Crossref]
38- Din F, Zeb A, Shah K, Shah Z. Development, in-vitro and in-vivo evaluation of ezetimibe-loaded solid lipid nanoparticles and their comparison with marketed product. Journal of Drug Delivery Science and Technology. 2019;51:583 [Crossref]
39- Limayem A, Patil S, Mehta M, Cheng F, Nguyen M. A Streamlined Study on Chitosan-Zinc Oxide Nanomicelle Properties to Mitigate a Drug-Resistant Biofilm Protection Mechanism. Front Nanotechnol. 2020;2 [Crossref]
40- Patil A, Lakhani P, Taskar P, Wu K, Sweeney C, Avula B, Wang Y, Khan I, Majumdar S. Formulation Development, Optimization, and In Vitro–In Vivo Characterization of Natamycin-Loaded PEGylated Nano-Lipid Carriers for Ocular Applications. Journal of Pharmaceutical Sciences. 2018;107(8):2160 [Crossref]
41- Dobreva M, Stefanov S, Andonova V. Natural Lipids as Structural Components of Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Topical Delivery. CPD. 2020;26(36):4524 [Crossref]
42- Fonseca-Santos B, Silva P, Rigon R, Sato M, Chorilli M. Formulating SLN and NLC as Innovative Drug Delivery Systems for Non-Invasive Routes of Drug Administration. CMC. 2020;27(22):3623 [Crossref]
43- Montenegro L, Parenti C, Turnaturi R, Pasquinucci L. Resveratrol-Loaded Lipid Nanocarriers: Correlation between In Vitro Occlusion Factor and In Vivo Skin Hydrating Effect. Pharmaceutics. 2017;9(4):58 [Crossref]
44- El-Housiny S, Shams Eldeen M, El-Attar Y, Salem H, Attia D, Bendas E, El-Nabarawi M. Fluconazole-loaded solid lipid nanoparticles topical gel for treatment of pityriasis versicolor: formulation and clinical study. Drug Delivery. 2018;25(1):78 [Crossref]
45- Karimi M, Gheybi F, Zamani P, Mashreghi M, Golmohammadzadeh S, Darban S, Badiee A, Jaafari M. Preparation and characterization of stable nanoliposomal formulations of curcumin with high loading efficacy: In vitro and in vivo anti-tumor study. International Journal of Pharmaceutics. 2020;580:119211 [Crossref]
46- Chu C, Tan C, Nyam K. Development of Nanostructured Lipid Carriers (NLCs) Using Pumpkin and Kenaf Seed Oils with Potential Photoprotective and Antioxidative Properties. Eur J Lipid Sci Technol. 2019;121(10):1900082 [Crossref]
47- Lakhani P, Patil A, Majumdar S. Recent advances in topical nano drug-delivery systems for the anterior ocular segment. Therapeutic Delivery. 2018;9(2):137 [Crossref]
48- Yanar F, Mosayyebi A, Nastruzzi C, Carugo D, Zhang X. Continuous-Flow Production of Liposomes with a Millireactor under Varying Fluidic Conditions. Pharmaceutics. 2020;12(11):1001 [Crossref]
49- Ahmed O, Fahmy U, Bakhaidar R, El-Moselhy M, Alfaleh M, Ahmed A, Hammad A, Aldawsari H, Alhakamy N.

Pumpkin Oil–Based Nanostructured Lipid Carrier System for Antiulcer Effect in NSAID-Induced Gastric Ulcer Model in Rats

. IJN. 2020;Volume 15:2529 [Crossref]
50- Khater D, Nsairat H, Odeh F, Saleh M, Jaber A, Alshaer W, Al Bawab A, Mubarak M. Design, Preparation, and Characterization of Effective Dermal and Transdermal Lipid Nanoparticles: A Review. Cosmetics. 2021;8(2):39 [Crossref]
51- Dudhipala N, AY A. Amelioration of ketoconazole in lipid nanoparticles for enhanced antifungal activity and bioavailability through oral administration for management of fungal infections. Chemistry and Physics of Lipids. 2020;232:104953 [Crossref]
52- Publisher’s note. Colloids and Surfaces B: Biointerfaces. 2017;160:265 [Crossref]
53- Wanczinski Ferrari B, Pelegrini B, Bassi da Silva J, Neves Pereira O, Miriam de Souza Lima M, Bruschi M, Bazotte R. Formulation and in vivo study of the solid effervescent system as a new strategy for oral glutamine delivery. Journal of Drug Delivery Science and Technology. 2021;63:102516 [Crossref]