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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2016;6(2): 195-200. doi: 10.15171/apb.2016.027
PMID: 27478781        PMCID: PMC4961977

Research Article

Development of Floating-Mucoadhesive Microsphere for Site Specific Release of Metronidazole

Md. Lutful Amin 1 * , Tajnin Ahmed 1, Md. Abdul Mannan 1

Cited by CrossRef: 15

1- BHISE M, SHUKLA K, JAIN S, BHAJIPALE N, SUDKE S, BURAKLE P. Development and Evaluation of Floating Microspheres of Anticonvulsant Drug by 32 Full Factorial Design. tjps. 2022;19(5):595 [Crossref]
2- Saha M, Gupta A, Shetty S, Mutalik S, Nandakumar K, Raghu Chandrashekar H, Dhas N, Moorkoth S. DoE-Aided Optimization of RP-HPLC Method for Simultaneous Estimation of Amoxicillin and Tinidazole Loaded Mucoadhesive GRDDS Formulation for the Treatment of H. pylori. Chromatographia. 2024;87(9):533 [Crossref]
3- Rajput K, Tawade S, Nangare S, Shirsath N, Bari S, Zawar L. Formulation, optimization, and in-vitro-ex-vivo evaluation of dual-crosslinked zinc pectinate-neem gum-interpenetrating polymer network mediated lansoprazole loaded floating microbeads. International Journal of Biological Macromolecules. 2022;222:915 [Crossref]
4- Komati S, Swain S, Rao M, Jena B, Dasi V. Mucoadhesive Multiparticulate Drug Delivery Systems: An ExtensiveReview of Patents. Adv Pharm Bull. 2019;9(4):521 [Crossref]
5- Mahmoud D, Schulz‐Siegmund M. Utilizing 4D Printing to Design Smart Gastroretentive, Esophageal, and Intravesical Drug Delivery Systems. Adv Healthcare Materials. 2023;12(10) [Crossref]
6- Patel A, Mishra M, Gupta J, Ghoshal S, Gupta R, Kushwaha K. Guar Gum-Based Floating Microspheres of Repaglinide Using 32 Factorial Design: Fabrication, Optimization, Characterization, and In Vivo Buoyancy Behavior in Albino Rats. ASSAY and Drug Development Technologies. 2021;19(2):63 [Crossref]
7- Kar A, Shil A, Kar B, Dey S. Formulation development and statistical optimization of zingiberol incorporated sodium alginate-methyl cellulose blend microspheres. International Journal of Biological Macromolecules. 2020;162:1578 [Crossref]
8- Srivastava A, Verma A, Saraf S, Jain A, Tiwari A, Panda P, Jain S. Mucoadhesive gastroretentive microparticulate system for programmed delivery of famotidine and clarithromycin. Journal of Microencapsulation. 2021;38(3):151 [Crossref]
9- Briones Nieva C, Real J, Campos S, Romero A, Villegas M, Gonzo E, Bermúdez J, Palma S, Cid A. Modeling and evaluation of ivermectin release kinetics from 3D-printed tablets. Therapeutic Delivery. 2024;15(11):845 [Crossref]
10- Barboza Duarte Rodrigues I, Pereira J, Lima L, Lins Silva K, Silva M, da Costa Silva V, Manso Costa S, Gomes do Nascimento T, de Oliveira A, Duarte de Freitas J, Mclaine Duarte de Freitas J, Benatti Justino A, Salmen Espindola F, Diniz Basílio Júnior I, Almeida Silva A. Development and evaluation of capsules loaded with red propolis extract and metallic nanoparticles using the ionic gelation method. Journal of Apicultural Research. 2025;:1 [Crossref]
11- Mwila C, Walker R. Improved Stability of Rifampicin in the Presence of Gastric-Resistant Isoniazid Microspheres in Acidic Media. Pharmaceutics. 2020;12(3):234 [Crossref]
12- Mora-Castaño G, Domínguez-Robles J, Himawan A, Millán-Jiménez M, Caraballo I. Current trends in 3D printed gastroretentive floating drug delivery systems: A comprehensive review. International Journal of Pharmaceutics. 2024;663:124543 [Crossref]
13- Grosso R, Benito E, Carbajo-Gordillo A, García-Martín M, Perez-Puyana V, Sánchez-Cid P, de-Paz M. Biodegradable Guar-Gum-Based Super-Porous Matrices for Gastroretentive Controlled Drug Release in the Treatment of Helicobacter pylori: A Proof of Concept. IJMS. 2023;24(3):2281 [Crossref]
14- Deshmukh R, Harwansh R, Rahman M. Sodium alginate-guar gum and carbopol based methotrexate loaded mucoadhesive microparticles for colon delivery: An in vitro evaluation. Braz J Pharm Sci. 2021;57 [Crossref]
15- Grosso R, Benito E, Carbajo-Gordillo A, Díaz M, García-Martín M, de-Paz M. Advanced interpenetrating polymer networks for innovative gastroretentive formulations targeting Helicobacter pylori gastric colonization. European Journal of Pharmaceutical Sciences. 2024;200:106840 [Crossref]
16- Reddy Dumpa N, Bandari S, A. Repka M. Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing. Pharmaceutics. 2020;12(1):52 [Crossref]
17- Grosso R, de-Paz M. Scope and Limitations of Current Antibiotic Therapies against Helicobacter pylori: Reviewing Amoxicillin Gastroretentive Formulations. Pharmaceutics. 2022;14(7):1340 [Crossref]
18- Aher S, Jain A, Solanki D, Yadav P, Redij S. Timolol Maleate Microspheres: An Ingenious Carrier for Sustained Release Antihypertensive Formulation. J Drug Delivery Ther. 2024;14(11):39 [Crossref]