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Adv Pharm Bull. 2017;7(3): 367-374. doi: 10.15171/apb.2017.044
PMID: 29071218        PMCID: PMC5651057

Research Article

Melatonin and N- Acetylcysteine as Remedies for Tramadol-Induced Hepatotoxicity in Albino Rats

Elias Adikwu 1 * , Bonsome Bokolo 2

Cited by CrossRef: 10


1- Gao Q, Guo X, Cao Y, Jia X, Xu S, Lu C, Zhu H. Melatonin Protects HT22 Hippocampal Cells from H2O2-induced Injury by Increasing Beclin1 and Atg Protein Levels to Activate Autophagy. CPD. 2021;27(3):446 [Crossref]
2- Sadek K, Lebda M, Abouzed T, Nasr S, EL-Sayed Y. The molecular and biochemical insight view of lycopene in ameliorating tramadol-induced liver toxicity in a rat model: implication of oxidative stress, apoptosis, and MAPK signaling pathways. Environ Sci Pollut Res. 2018;25(33):33119 [Crossref]
3- Helmy M, Abdalla H, Abd El Rahman H, Ahmed D. Hepatotoxic effect of tramadol and O-desmethyltramadol in HepG2 cells and potential role of PI3K/AKT/mTOR. Xenobiotica. 2021;51(9):1029 [Crossref]
4- Ölmeztürk Karakurt T, Eren N, Subaşı F, Kuyrukluyıldız U, Çoban T, Süleyman H, Mokhtare B. Effects of taxifolin on tramadol-induced oxidative and inflammatory liver injury in rats: an experimental study. Drug and Chemical Toxicology. 2023;:1 [Crossref]
5- Khatab L, Abdel-Raheem I, Ghoneim A. Protective effects of melatonin and l-carnitine against methotrexate-induced toxicity in isolated rat hepatocytes. Naunyn-Schmiedeberg's Arch Pharmacol. 2022;395(1):87 [Crossref]
6- Mogheiseh A, Koohi F, Nazifi S, Shojaee Tabrizi A, Taheri P, Salavati S. Oxidative-antioxidative status and hepatic and renal factors following melatonin administration in castrated and intact dogs. Basic Clin Androl. 2019;29(1) [Crossref]
7- Mohammadnejad L, Soltaninejad K, Seyedabadi M, Ghasem Pouri S, Shokrzadeh M, Mohammadi H. Evaluation of mitochondrial dysfunction due to oxidative stress in therapeutic, toxic and lethal concentrations of tramadol. 2021;10(6):1162 [Crossref]
8- Majidinia M, Reiter R, Shakouri S, Yousefi B. The role of melatonin, a multitasking molecule, in retarding the processes of ageing. Ageing Research Reviews. 2018;47:198 [Crossref]
9- Adikwu E. Alpha-lipoic acid attenuates cyclophosphamide-doxorubicin-induced hepatic perturbation in rats. J Mar Med Soc. 2020;22(1):62 [Crossref]