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Adv Pharm Bull. 2017;7(1): 21-34. doi: 10.15171/apb.2017.004
PMID: 28507934        PMCID: PMC5426730

Review Article

The Challenges of Recombinant Endostatin in Clinical Application: Focus on the Different Expression Systems and Molecular Bioengineering

Abbas Mohajeri 1,2, Sarvin Sanaei 2, Farhad Kiafar 1, Amir Fattahi 3, Majid Khalili 4, Nosratollah Zarghami 2,3,5 *

Cited by CrossRef: 16


1- Cui J, Yue J. Current status and advances in arginine‐glycine‐aspartic acid peptide‐based molecular imaging to evaluate the effects of anti‐angiogenic therapies. Precision Radiation Oncology. 2019;3(1):29 [Crossref]
2- Bracke A, Hoogewijs D, Dewilde S. Exploring three different expression systems for recombinant expression of globins: Escherichia coli, Pichia pastoris and Spodoptera frugiperda. Analytical Biochemistry. 2018;543:62 [Crossref]
3- Zamani M, Nezafat N, Mokarram P, Kadkhodaei B. Application of Cell Penetrating Peptides for Intracellular Delivery of Endostatin: A Computational Approach. CAD. 2024;20(3):208 [Crossref]
4- Xu Y, Qiang X, Xing L, Wang H, Zhang J, Zhang F, Caliskan B, Wang M, Qiu Z. A fusion antitumor peptide regulates proliferation and apoptosis of endothelial cells. Amino Acids. 2018;50(8):1121 [Crossref]
5- Sun E, Han R, Lu B. Gene therapy of renal cancer using recombinant adeno‑associated virus encoding human endostatin. Oncol Lett. 2018; [Crossref]
6- Kaur G, Roy B. Decoding Tumor Angiogenesis for Therapeutic Advancements: Mechanistic Insights. Biomedicines. 2024;12(4):827 [Crossref]
7- Méndez-Valdés G, Gómez-Hevia F, Lillo-Moya J, González-Fernández T, Abelli J, Cereceda-Cornejo A, Bragato M, Saso L, Rodrigo R. Endostatin and Cancer Therapy: A Novel Potential Alternative to Anti-VEGF Monoclonal Antibodies. Biomedicines. 2023;11(3):718 [Crossref]
8- Wang H, Cai Q, Liang Y, Shui J, Tang S. A simple and high-throughput luciferase immunosorbent assay for both qualitative and semi-quantitative detection of anti-HIV-1 antibodies. Virus Research. 2019;263:9 [Crossref]
9- Guo L, Hua L, Hu B, Wang J. Pre-clinical Efficacy and Safety Pharmacology of PEGylated Recombinant Human Endostatin. CMM. 2024;24(3):389 [Crossref]
10- Wang X, Shi Y, Jia Y, Zhao W, Zhang L, Bai G, Ren Y, Chen Y, Tong Z. Tolerance and Pharmacokinetics of Recombinant Human Endostatin Administered as Single-Dose or Multiple-Dose Infusions in Patients With Advanced Solid Tumors: A Phase I Clinical Trial. Technol Cancer Res Treat. 2021;20 [Crossref]
11- Wallwitz J, Aigner P, Gadermaier E, Bauer E, Casanova E, Bauer A, Stoiber D, Shearer G. Validation of an enzyme-linked immunosorbent assay (ELISA) for quantification of endostatin levels in mice as a biomarker of developing glomerulonephritis. PLoS ONE. 2019;14(8):e0220935 [Crossref]
12- Saman H, Raza S, Uddin S, Rasul K. Inducing Angiogenesis, a Key Step in Cancer Vascularization, and Treatment Approaches. Cancers. 2020;12(5):1172 [Crossref]
13- Alday-Parejo B, Stupp R, Rüegg C. Are Integrins Still Practicable Targets for Anti-Cancer Therapy?. Cancers. 2019;11(7):978 [Crossref]
14- Chen Y, Mathy N, Lu H. The role of VEGF in the diagnosis and treatment of malignant pleural effusion in patients with non‑small cell lung cancer (Review). Mol Med Report. 2018; [Crossref]
15- Zhuo H, Zheng B, Liu J, Huang Y, Wang H, Zheng D, Mao N, Meng J, Zhou S, Zhong L, Zhao Y. Efficient targeted tumor imaging and secreted endostatin gene delivery by anti-CD105 immunoliposomes. J Exp Clin Cancer Res. 2018;37(1) [Crossref]