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Adv Pharm Bull. 2016;6(1): 111-118. doi: 10.15171/apb.2016.017
PMID: 27123426        PMCID: PMC4845543

Original Research

The Effects of Cetirizine on P-glycoprotein Expression and Function In vitro and In situ

Mehran Mesgari Abbasi 1,2, Hadi Valizadeh 1, Hamed Hamishekar 1, Leila Mohammadnejad 3, Parvin Zakeri-Milani 4 *

Cited by CrossRef: 9


1- Li L, Fu Q, Xia M, Xin L, Shen H, Li G, Ji G, Meng Q, Xie Y. Inhibition of P-Glycoprotein Mediated Efflux in Caco-2 Cells by Phytic Acid. J Agric Food Chem. 2018;66(4):988 [Crossref]
2- Weng H, Tsai T. ABCB1 in dermatology: roles in skin diseases and their treatment. J Mol Med. 2021;99(11):1527 [Crossref]
3- Rehman F, Khan I, Khalid S, Asghar S, Irfan M, Khalid I, Rasul A, Mahmood H, Yousaf A, Shahzad Y, Mudassar M, Mohsin N. Optimization, in vitro release and toxicity evaluation of novel pH sensitive itaconic acid-g-poly(acrylamide)/sterculia gum semi-interpenetrating networks. DARU J Pharm Sci. 2021;29(1):171 [Crossref]
4- Rajesh G, Vishwakarma R, Koshy A, Henna F, Raju R, Somayaji K, Revikumar A, Vaswani R, Kumar P, Rehman N. The search for the holy grail: In silico design and analysis of a non-sedative third generation, cetirizine-derived H1R anti-histamine with reduced hERG toxicity. Letters in Drug Design & Discovery. 2025;22(2):100010 [Crossref]
5- Ghaemian P, Shayanfar A. Image-based QSAR Model for the Prediction of P-gp Inhibitory Activity of Epigallocatechin and Gallocatechin Derivatives. CAD. 2019;15(3):212 [Crossref]
6- Allahyari S, Trotta F, Valizadeh H, Jelvehgari M, Zakeri-Milani P. Cyclodextrin-based nanosponges as promising carriers for active agents. Expert Opinion on Drug Delivery. 2019;16(5):467 [Crossref]
7- Wu C, Hsiao S, Wu Y. Perspectives on drug repurposing to overcome cancer multidrug resistance mediated by ABCB1 and ABCG2. Drug Resistance Updates. 2023;71:101011 [Crossref]
8- Sawkar R, Shanbhag M, Tuwar S, Mondal K, Shetti N. Zinc Oxide–Graphene Nanocomposite-Based Sensor for the Electrochemical Determination of Cetirizine. Catalysts. 2022;12(10):1166 [Crossref]
9- Zhou Y, Peng Y, Huang Z, Zhou D, Jin F, Zhou Z. Quantitative analysis of five components of Sargentodoxae caulis-Radix alangii drug pair using UPLC-MS/MS in rat plasma and RAW264.7 cells for comparative pharmacokinetics in normal and diseased states. Journal of Pharmaceutical and Biomedical Analysis. 2026;280:117631 [Crossref]
10- Eteraf-Oskouei T, Mahmoudi Gharehbaba A, Asnaashari S, Fazli Z, Habibi Asl B. Reversing Morphine Induced Tolerance: Insights Into Cetirizine and Green Tea Extract Efficacy. Current Therapeutic Research. 2025;102:100783 [Crossref]
11- Dai Y, Ma B, Zheng M, Shi R, Li Y, Wang T, Ma Y. Identification of drug transporters involved in the uptake and efflux of rhein in hepatocytes. RSC Adv. 2017;7(25):15236 [Crossref]
12- Bender D. New Radiopharmaceutical Tools in Imaging. Seminars in Nuclear Medicine. 2025;55(5):789 [Crossref]
13- Dubbelboer I, Dahlgren D, Sjögren E, Lennernäs H. Rat intestinal drug permeability: A status report and summary of repeated determinations. European Journal of Pharmaceutics and Biopharmaceutics. 2019;142:364 [Crossref]