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Adv Pharm Bull. 2017;7(2): 269-274. doi: 10.15171/apb.2017.032
PMID: 28761829        PMCID: PMC5527241

Research Article

Effects of Pomegranate (Punica Granatum L.) Seed and Peel Methanolic Extracts on Oxidative Stress and Lipid Profile Changes Induced by Methotrexate in Rats

Farideh Doostan 1, Roxana Vafafar 2, Parvin Zakeri-Milani 3, Aliasghar Pouri 3, Rogayeh Amini Afshar 4, Mehran Mesgari Abbasi 5 *

Cited by CrossRef: 23


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3- Jalali A, Kiafar M, Seddigh M, Zarshenas M. Punica granatum as a Source of Natural Antioxidant and Antimicrobial Agent: A Comprehensive Review on Related Investigations. CDDT. 2021;18(2):207 [Crossref]
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6- Golmakani M, Keramat M, Zare Darniyani L. A Kinetic Approach to the Oxidation of Linseed Oil as Influenced by Fruit Peel and Seeds of Pomegranate. Euro J Lipid Sci & Tech. 2020;122(2) [Crossref]
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10- Taha R, Abdel-Latif G, Said R, Alhajj M. The Prospective Effect of Green Tea versus Pomegranate Peels Extracts on Submandibular Salivary Glands of Albino Rats after Methotrexate Administration (Histological and Immunohistochemical Study). International Journal of Dentistry. 2024;2024:1 [Crossref]
11- Mostafa H, Barakat L, Abdo W, Khalil R. Omega-3 offers better hypothalamus protection by decreasing POMC expression and elevating ghrelin hormone: a prospective trial to overcome methotrexate-induced anorexia. Endocrine. 2020;69(2):358 [Crossref]
12- Seyed Hashemi M, Namiranian N, Tavahen H, Dehghanpour A, Rad M, Jam-Ashkezari S, Emtiazy M, Hashempur M. Efficacy of Pomegranate Seed Powder on Glucose and Lipid Metabolism in Patients with Type 2 Diabetes: A Prospective Randomized Double-Blind Placebo-Controlled Clinical Trial. Complement Med Res. 2021;28(3):226 [Crossref]
13- Özgöçmen M, Aşcı H, Doğan H, İlhan İ, Pekgöz Ş, Mustafaoğlu A. A study on Wistar Albino rats: investigating protective role of ramelteon on liver damage caused by methotrexate. Drug and Chemical Toxicology. 2022;45(6):2678 [Crossref]
14- Sayed S, Alotaibi S, El-Shehawi A, Hassan M, Shukry M, Alkafafy M, Soliman M. The Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Effects of a Pomegranate-Peel Extract against Acrylamide-Induced Hepatotoxicity in Rats. Life. 2022;12(2):224 [Crossref]
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16- Grabež M, Škrbić R, Stojiljković M, Rudić-Grujić V, Paunović M, Arsić A, Petrović S, Vučić V, Mirjanić-Azarić B, Šavikin K, Menković N, Janković T, Vasiljević N. Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A randomized, double-blind, placebo-controlled study. Journal of Functional Foods. 2020;64:103692 [Crossref]
17- PEHLİVANOĞLU H, YARDIMCI M, YAĞCILAR Ç. Effects of Dietary Cold-Pressed Seed Oils on Growth, Coloration and Blood Parameters in Goldfish. EJOSAT. 2022; [Crossref]
18- Fathy S, El-Dash H, Said N. Neuroprotective effects of pomegranate (Punica granatum L.) juice and seed extract in paraquat-induced mouse model of Parkinson’s disease. BMC Complement Med Ther. 2021;21(1) [Crossref]
19- Arkoub F, Hamdi L, Kahalerras L, Hamoudi M, Khelili K. Evaluation of the in vitro and in vivo antioxidant potential of Punica granatum L. against toluene-induced liver injuries in rats. Vet World. 2022;:374 [Crossref]
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21- Talib W, AL-ataby I, Mahmod A, Jawarneh S, Al Kury L, AL-Yasari I. The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood. Molecules. 2020;25(18):4207 [Crossref]
22- KORKMAZ Y, GUNGOR H, DEMIRBAS A, DIK B. Pomegranate peel extract, N-Acetylcysteine and their combination with Ornipural alleviate Cadmium-induced toxicity in rats. J Vet Med Sci. 2023;85(9):990 [Crossref]
23- Smaoui S, Hlima H, Mtibaa A, Fourati M, Sellem I, Elhadef K, Ennouri K, Mellouli L. Pomegranate peel as phenolic compounds source: Advanced analytical strategies and practical use in meat products. Meat Science. 2019;158:107914 [Crossref]
24- Siddiqui S, Singh S, Nayik G. Bioactive compounds from pomegranate peels - Biological properties, structure–function relationships, health benefits and food applications – A comprehensive review. Journal of Functional Foods. 2024;116:106132 [Crossref]