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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2015;5(3): 315-320. doi: 10.15171/apb.2015.044
PMID: 26504752        PMCID: PMC4616885

Original Research

Ghrelin Decreases Angiogenesis, HIF-1α and VEGF Protein Levels in Chronic Hypoxia in Lung Tissue of Male Rats

Fariba Mirzaei Bavil 1, Mohammad Reza Alipour 1, Rana Keyhanmanesh 1, Alireza Alihemmati 2, Rafigheh Ghiyasi 2, Gisou Mohaddes 2 *

Cited by CrossRef: 15

1- Matuszyk A, Ceranowicz P, Warzecha Z, Cieszkowski J, Ceranowicz D, Gałązka K, Bonior J, Jaworek J, Bartuś K, Gil K, Olszanecki R, Dembiński A. Exogenous Ghrelin Accelerates the Healing of Acetic Acid-Induced Colitis in Rats. IJMS. 2016;17(9):1455 [Crossref]
2- Yadav A, Yadav B, Yadav P, Pandey S, Sarvottam K. Exposure to Various Degrees and Durations of Hypobaric Hypoxia Causes a Reduction in Body Weight of Female Adult Rats. 2024;14(3):151 [Crossref]
3- Mohaddes G, Abdolalizadeh J, Babri S, Abedini N, Hossienzadeh F. The Anti-Edematous Effect of Ghrelin in Brain Hypoxia is Associated with Decreasing Expression of Vascular Endothelial Growth Factor. J Mol Neurosci. 2015;56(2):273 [Crossref]
4- Colldén G, Tschöp M, Müller T. Therapeutic Potential of Targeting the Ghrelin Pathway. IJMS. 2017;18(4):798 [Crossref]
5- Wang T, Chen H, Lv K, Ji G, Liang F, Zhang Y, Wang Y, Liu X, Cao H, Kan G, Xiong J, Li Y, Qu L. Activation of HIF-1α and its downstream targets in rat hippocampus after long-term simulated microgravity exposure. Biochemical and Biophysical Research Communications. 2017;485(3):591 [Crossref]
6- Zhang Z, Sun Y, Yuan Z, Wang L, Dong Q, Zhou Y, Zheng G, Aschner M, Zou Y, Luo W, Sita G. Insight into the Effects of High‐Altitude Hypoxic Exposure on Learning and Memory. Oxidative Medicine and Cellular Longevity. 2022;2022(1) [Crossref]
7- Eroğlu E, Tomruk C, Tomruk C, Hortu I, Kose T, Uyanikgil Y. The Impact of Ghrelin on Intrauterine Adhesions: Insights from Experimental Models. Bratisl Med J. 2025; [Crossref]
8- Hazrati A, Salimnejad R, Alipour M, Mirzaei Bavil F, Alihemmati A. Protective effect of ghrelin on testicular damages caused by chronic hypoxia in rats: A histopathological study. Andrologia. 2018;50(4):e12989 [Crossref]
9- Kim H, Lee W, Kim Y, Lee S, Choi W, Lee G, Park S, Ju S, Kim S, Lee C, Han J. Proteogenomic characterization identifies clinical subgroups in EGFR and ALK wild-type never-smoker lung adenocarcinoma. Exp Mol Med. 2024;56(9):2082 [Crossref]
10- Wang R, Wang Y, Qin Y, Wei H. Antioxidative effects of ghrelin on human trabecular meshwork cells. Journal Français d'Ophtalmologie. 2024;47(1):103746 [Crossref]
11- Ortega M, Saez M, Asúnsolo Á, Romero B, Bravo C, Coca S, Sainz F, Álvarez-Mon M, Buján J, García-Honduvilla N. Upregulation of VEGF and PEDF in Placentas of Women with Lower Extremity Venous Insufficiency during Pregnancy and Its Implication in Villous Calcification. BioMed Research International. 2019;2019:1 [Crossref]
12- Ahmadian S, Sheshpari S, Pazhang M, Bedate A, Beheshti R, Abbasi M, Nouri M, Rahbarghazi R, Mahdipour M. Intra-ovarian injection of platelet-rich plasma into ovarian tissue promoted rejuvenation in the rat model of premature ovarian insufficiency and restored ovulation rate via angiogenesis modulation. Reprod Biol Endocrinol. 2020;18(1) [Crossref]
13- Mirzaei Bavil F, Karimi-Sales E, Alihemmati A, Alipour M. Effect of ghrelin on hypoxia-related cardiac angiogenesis: involvement of miR-210 signalling pathway. Archives of Physiology and Biochemistry. 2022;128(1):270 [Crossref]
14- Ghiasi R, Naderi R, Sheervalilou R, Alipour M. Swimming training by affecting the pancreatic Sirtuin1 (SIRT1) and oxidative stress, improves insulin sensitivity in diabetic male rats. 2019;40(3) [Crossref]
15- Hussein N, Rashad M, Abdou A, Hussein A, Mohamed H. Gene profiling of SEC13, SMAD7, GHRL, long non-coding RNA GHRLOS, HIF-1α in gastric cancer patients. Sci Rep. 2022;12(1) [Crossref]
16- Zwierzchowska A, Iwan A, Hyc A, Suchońska B, Malejczyk J, Barcz E. Recurrent miscarriage is associated with increased ghrelin mRNA expression in the endometrium- a case-control study. Reproductive Biology. 2018;18(1):12 [Crossref]