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Adv Pharm Bull. 2015;5(2): 283-288. doi: 10.15171/apb.2015.039
PMID: 26236669        PMCID: PMC4517091

Original Research

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Hasan Omrani 1, Mohammad Reza Alipour 2, Gisou Mohaddes 1 *

Cited by CrossRef: 16


1- Cui G, Wang L, Huang W. Circular RNA HIPK3 regulates human lens epithelial cell dysfunction by targeting the miR-221–3p/PI3K/AKT pathway in age-related cataract. Experimental Eye Research. 2020;198:108128 [Crossref]
2- Hosseinzadeh M, Shamshirian A, Ebrahimzadeh M. Dexamethasone vs COVID‐19: An experimental study in line with the preliminary findings of a large trial. Int J Clinical Practice. 2021;75(6) [Crossref]
3- Hazrati A, Salimnejad R, Alipour M, Mirzaei Bavil F, Alihemmati A. Protective effect of ghrelin on testicular damages caused by chronic hypoxia in rats: A histopathological study. Andrologia. 2018;50(4):e12989 [Crossref]
4- Omrani H, Alipour M, Farajdokht F, Ebrahimi H, Mesgari Abbasi M, Mohaddes G. Effects of Chronic Ghrelin Treatment on Hypoxia-Induced Brain Oxidative Stress and Inflammation in a Rat Normobaric Chronic Hypoxia Model. High Altitude Medicine & Biology. 2017;18(2):145 [Crossref]
5- Bai J, Yang F, Dong L, Zheng Y, Bartosz G. Ghrelin Protects Human Lens Epithelial Cells against Oxidative Stress‐Induced Damage. Oxidative Medicine and Cellular Longevity. 2017;2017(1) [Crossref]
6- Budzyński J, Ziółkowski M, Kłopocka M, Czarnecki D. Oxidoreductive homeostasis in alcohol-dependent male patients and the risk of alcohol drinking relapse in a 6-month follow-up. Alcohol. 2016;50:57 [Crossref]
7- Salimnejad R, Soleimani Rad J, Mohammad Nejad D, Roshangar L. Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide. Andrologia. 2018;50(2):e12883 [Crossref]
8- Tabari S, Babri S, Mirzaie F, Farajdokht F, Mohaddes G. Enduring amnesia induced by ICV scopolamine is reversed by sesame oil in male rats. Acta Cir Bras. 2016;31(8):520 [Crossref]
9- Gortan Cappellari G, Barazzoni R. Ghrelin forms in the modulation of energy balance and metabolism. Eat Weight Disord. 2019;24(6):997 [Crossref]
10- Ramírez N, Luque E, Jones X, Torres P, Moreira Espinoza M, Cantarelli V, Ponzio M, Arja A, Rabaglino M, Martini A. Modulatory effects of ghrelin on sperm quality alterations induced by a fructose-enriched diet. Heliyon. 2019;5(11):e02886 [Crossref]
11- Mingardi J, Meanti R, Paoli C, Cifani C, Torsello A, Popoli M, Musazzi L. Ghrelin, Neuroinflammation, Oxidative Stress, and Mood Disorders: What Are the Connections?. CN. 2025;23(2):172 [Crossref]
12- Akki R, Raghay K, Errami M. Potentiality of ghrelin as antioxidant and protective agent. Redox Report. 2021;26(1):71 [Crossref]
13- Razzaghy-Azar M, Nourbakhsh M, Pourmoteabed A, Nourbakhsh M, Ilbeigi D, Khosravi M. An Evaluation of Acylated Ghrelin and Obestatin Levels in Childhood Obesity and Their Association with Insulin Resistance, Metabolic Syndrome, and Oxidative Stress. JCM. 2016;5(7):61 [Crossref]
14- Xu X, Lv H, Xia Z, Fan R, Zhang C, Wang Y, Wang D. Rhein exhibits antioxidative effects similar to Rhubarb in a rat model of traumatic brain injury. BMC Complement Altern Med. 2017;17(1) [Crossref]
15- Khaksari M, Shahryari M, Raji-Amirhasani A, Soltani Z, Bibak B, Keshavarzi Z, Shakeri F, Arcanjo D. Aloe vera Leaf Extract Reduced BBB Permeability and Improved Neurological Results after Traumatic Brain Injury: The Role of Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2024;2024(1) [Crossref]
16- Abdanipour A, Dadkhah M, Alipour M, Feizi H. Effect of Ghrelin on Caspase 3 and Bcl2 Gene Expression in H2O2 Treated Rat’s Bone Marrow Stromal Cells. Adv Pharm Bull. 2018;8(3):429 [Crossref]
17- Boshra V, Abbas A. Effects of peripherally and centrally applied ghrelin on the oxidative stress induced by renin angiotensin system in a rat model of renovascular hypertension. 2017;28(4):347 [Crossref]