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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2016;6(2): 251-256. doi: 10.15171/apb.2016.034
PMID: 27478788        PMCID: PMC4961984

Research Article

A Simple, Fast, Low Cost, HPLC/UV Validated Method for Determination of Flutamide: Application to Protein Binding Studies

Sara Esmaeilzadeh 1,2, Hadi Valizadeh 3, Parvin Zakeri-Milani 4 *

Cited by CrossRef: 16

1- Borse S, Murthy Z, Park T, Kailasa S. Pepsin mediated synthesis of blue fluorescent copper nanoclusters for sensing of flutamide and chloramphenicol drugs. Microchemical Journal. 2021;164:105947 [Crossref]
2- Li Y, Li C, Gao X, Wan Y, Lv H. Equilibrium solubility, inter- and intra-molecular interactions and solvation performance of flutamide in some aqueous blended co-solvents. The Journal of Chemical Thermodynamics. 2021;163:106611 [Crossref]
3- Bagherzadeh Z, Hosseini S, Esrafili dizaji M. A DFT study of pure and M-encapsulated (M=Na and K) B40 fullerenes as potential sensors for the flutamide drug. Journal of Molecular Graphics and Modelling. 2025;140:109084 [Crossref]
4- Sun W, Shen W, Xu H, Hu G, Deng Z, Zhao G, Li F, Hu Y, Yang W. Determination and analysis of flutamide solubility in different solvent systems at different temperatures (T = 278.15–323.15 K). Journal of Molecular Liquids. 2021;325:114762 [Crossref]
5- Siddaraju C, Pallavi B, Pooja T, Rajendraprasad N. Use of smartphone for determination of flutamide in pharmaceuticals: capture on paper approach. Chem Pap. 2023;77(4):2171 [Crossref]
6- Jiang L, Niu X, Pei W, Ma J. Electrochemical Detection of Flutamide by the Composite of Complex Based on Thiacalix[4]arene Derivatives and Reduced Graphene Oxide. Inorg Chem. 2023;62(32):12803 [Crossref]
7- Kesavan G, Pichumani M, Chen S, Ko C. Surfactant-assisted (CTAB, PVA, PVP) thermal decomposition synthesis of strontium spinel ferrite nanocrystals for electrochemical sensing of cytostatic drug flutamide. Materials Today Chemistry. 2022;26:101045 [Crossref]
8- Abd-AlGhafar W, Abo Shabana R, El-Shaheny R, Tolba M. A fluorescence switch-off nanosensor for sensitive determination of the antiandrogen drug flutamide in pharmaceutical and environmental samples. Analytical method greenness, blueness, and whiteness assessment. Microchemical Journal. 2024;204:111078 [Crossref]
9- Ashraf A, ElDin N, Rostom Y, El-Zeany B, Sedik G. Novel RP-HPLC–DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances. BMC Chemistry. 2024;18(1) [Crossref]
10- Shanbhag M, Kalanur S, Alodhayb A, Shetti N. Porous Nanostructured Chromium-Doped Tungsten Oxide Electrocatalysts for Flutamide and Nilutamide Detection. ACS Appl Nano Mater. 2024;7(8):9635 [Crossref]
11- Hossain M, Khatun A, Rahman M, Akter M, Chowdhury S, Alam S. Characterization of the Effect of Drug-Drug Interaction on Protein Binding in Concurrent Administration of Sulfamethoxazol and Diclofenac Sodium Using Bovine Serum Albumin. Adv Pharm Bull. 2016;6(4):589 [Crossref]
12- Subbareddy S, Santhosh A, Metry S, Venkatesan K, Selvaraj M, Ravikumar S, Shadakshari S. Synergistic innovation: MOF@GCN hybrid for electrochemical detection of flutamide—bridging experimental, computational, and real-world applications. Microchim Acta. 2025;192(5) [Crossref]
13- Ensafi A, Khoddami E, Nabiyan A, Rezaei B. Study the role of poly(diethyl aminoethyl methacrylate) as a modified and grafted shell for TiO2 and ZnO nanoparticles, application in flutamide delivery. Reactive and Functional Polymers. 2017;116:1 [Crossref]
14- Saka C. Chromatographic Methods for Determination of Drugs Used in Prostate Cancer in Biological and Pharmacological Samples. Critical Reviews in Analytical Chemistry. 2019;49(1):78 [Crossref]
15- Kesavan G, Pichumani M, Chen S. Influence of Crystalline, Structural, and Electrochemical Properties of Iron Vanadate Nanostructures on Flutamide Detection. ACS Appl Nano Mater. 2021;4(6):5883 [Crossref]
16- Abdelwahab N, Elshemy H, Farid N. Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methods. Chemistry Central Journal. 2018;12(1) [Crossref]
17- Okaru A, Brunner T, Ackermann S, Kuballa T, Walch S, Kohl-Himmelseher M, Lachenmeier D. Application of 19F NMR Spectroscopy for Content Determination of Fluorinated Pharmaceuticals. Journal of Analytical Methods in Chemistry. 2017;2017:1 [Crossref]
18- Musuvadhi Babulal S, Anupriya J, Chen S. Self assembled three dimensional β-Cu2V2O7 hierarchical flower decorated porous carbon: An efficient electrocatalyst for flutamide detection in biological and environmental samples. Chemosphere. 2022;303:135203 [Crossref]