Logo-apb
Adv Pharm Bull. 2016;6(3): 391-398. doi: 10.15171/apb.2016.051
PMID: 27766223        PMCID: PMC5071802

Research Article

Design, Formulation and Evaluation of an Oral Gel from Punica Granatum Flower Extract for the Treatment of Recurrent Aphthous Stomatitis

Abolfazl Aslani 1 * , Behzad Zolfaghari 2, Fatemeh Davoodvandi 3

Cited by CrossRef: 15


1- Amparo T, Seibert J, Vieira P, Teixeira L, Santos O, de Souza G. Herbal medicines to the treatment of skin and soft tissue infections: advantages of the multi‐targets action. Phytotherapy Research. 2020;34(1):94 [Crossref]
2- Yisimayili Z, Abdulla R, Tian Q, Wang Y, Chen M, Sun Z, Li Z, Liu F, Aisa H, Huang C. A comprehensive study of pomegranate flowers polyphenols and metabolites in rat biological samples by high-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Journal of Chromatography A. 2019;1604:460472 [Crossref]
3- Zamora C, Michaluk A, Torres C, Mouriño V, Chiappetta D, Nuñez M. Influence of herbal extracts in physicochemical properties and stability of antibacterial gels. J Adv Pharm Educ Res. 2023;13(4):16 [Crossref]
4- Surboyo M, Mahdani F, Ernawati D, Sarasati A, Rezkita F. The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis. Eur J Dent. 2020;14(03):410 [Crossref]
5- Wahyuni I, Sufiawati I, Shafuria A, Nittayananta W, Levita J. Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract. Pharmaceutics. 2024;16(3):421 [Crossref]
6- Vuletic M, Jakovljevic V, Zivanovic S, Papic M, Papic M, Mladenovic R, Zivkovic V, Srejovic I, Jeremic J, Andjic M, Kocovic A, Sretenovic J, Mitrovic S, Božin B, Kladar N, Bolevich S, Bradic J. The Evaluation of Healing Properties of Galium verum-Based Oral Gel in Aphthous Stomatitis in Rats. Molecules. 2022;27(15):4680 [Crossref]
7- Jahanbani Mazraeh E, Sadighi S, Manifar S, Bakhshandeh H, Rajabi M. Assessment of thyme honey oral gel for the prevention of adriamycin and cyclophosphamide chemotherapy-induced oral mucositis in patients with breast cancer. Support Care Cancer. 2023;31(8) [Crossref]
8- Khalid F, Ijaz M, Mahmood A, Waqas M, Hussain T, Asim M, Ahmad N, Arshad S, Rehman M, Nazir I. Mucoadhesive, Fluconazole-Loaded Nanogels Complexed with Sulfhydryl-β-cyclodextrin for Oral Thrush Treatment. AAPS PharmSciTech. 2023;24(7) [Crossref]
9- Sunita P, Sumati P. Control of Oral Thrush causing Candida albicans by Novel Synergistic Formulation. AJPS. 2023;:1 [Crossref]
10- Chaiwaree S, Srilai K, Kheawfu K, Thammasit P. Antibacterial Activities of Oral Care Products Containing Natural Plant Extracts from the Thai Highlands against Staphylococcus aureus: Evaluation and Satisfaction Studies. Processes. 2023;11(9):2768 [Crossref]
11- Hosny K, Sindi A, Alkhalidi H, Kurakula M, Alruwaili N, Alhakamy N, Abualsunun W, Bakhaidar R, Bahmdan R, Rizg W, Ali S, Abdulaal W, Nassar M, Alsuabeyl M, Alghaith A, Alshehri S. Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis. Drug Delivery. 2021;28(1):1043 [Crossref]
12- Hosny K, Khallaf R, Asfour H, Rizg W, Alhakamy N, Sindi A, Alkhalidi H, Abualsunun W, Bakhaidar R, Almehmady A, Abdulaal W, Bakhrebah M, Alsuabeyl M, K. Kammoun A, Alghaith A, Alshehri S. Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota. Pharmaceutics. 2021;13(7):1008 [Crossref]
13- Suharyani I, Fouad Abdelwahab Mohammed A, Muchtaridi M, Wathoni N, Abdassah M. Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis. DDDT. 2021;Volume 15:4071 [Crossref]
14- Giammarinaro E, Cosola S, Oldoini G, Gulia F, Peñarrocha-Oltra D, Marconcini S, Genovesi A. Local Formula with Mucoadhesive Property: A Randomized Clinical Trial of a Therapeutic Agent for the Treatment of Oral Aphthous Ulcers. 2019;20(11):1249 [Crossref]
15- Sindi A, Alharbi W, Alkhalidi H, Alghaith A, Hosny K. Development and optimization of Clotrimazole‒Rosehip oil nanoethosomal-gel for oral thrush and gingivitis. Journal of Drug Delivery Science and Technology. 2021;63:102482 [Crossref]
16- Venugopal D, Senthilnathan R, Maanvizhi S, Madhavan Y, Sankarapandian S, Ramshankar V, Kalachaveedu M. Preparation and Characterization of Silymarin Gel: A Novel Topical Mucoadhesive Formulation for Potential Applicability in Oral Pathologies. Gels. 2023;9(2):139 [Crossref]
17- Gan C, Cheng R, Xu K, Zhang J, Wang H, Xu T, Li H, Yang L. Preparation and physicochemical properties of coenzyme Q10 loaded niosomal hydrogels based on carbomer and scleroglucan. Polymer Engineering & Sci. 2023;63(9):2999 [Crossref]
18- Ullah N, Amin A, Farid A, Selim S, Rashid S, Aziz M, Kamran S, Khan M, Rahim Khan N, Mashal S, Mohtasheemul Hasan M. Development and Evaluation of Essential Oil-Based Nanoemulgel Formulation for the Treatment of Oral Bacterial Infections. Gels. 2023;9(3):252 [Crossref]
19- Alissa M, Hjazi A, Abusalim G, Aloraini G, Alghamdi S, Alharthi N, Rizg W, Hosny K, Binmadi N. Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders. Front Pharmacol. 2024;15 [Crossref]
20- Aly N, Elnaker Y, Salama Z, Diab M, Saber E, Sotohy S, Elfeil W, Khodeir M. Preparation and the assessed efficacy of oral baits for the vaccination of free-roaming dogs against rabies. Vet World. 2022;:1383 [Crossref]