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Adv Pharm Bull. 2016;6(3): 391-398. doi: 10.15171/apb.2016.051
PMID: 27766223        PMCID: PMC5071802

Research Article

Design, Formulation and Evaluation of an Oral Gel from Punica Granatum Flower Extract for the Treatment of Recurrent Aphthous Stomatitis

Abolfazl Aslani 1 * , Behzad Zolfaghari 2, Fatemeh Davoodvandi 3

Cited by CrossRef: 24


1- Surboyo M, Mahdani F, Ernawati D, Sarasati A, Rezkita F. The Macrophage Responses during Diabetic Oral Ulcer Healing by Liquid Coconut Shell Smoke: An Immunohistochemical Analysis. Eur J Dent. 2020;14(03):410 [Crossref]
2- Wahyuni I, Sufiawati I, Shafuria A, Nittayananta W, Levita J. Formulation and Evaluation of Mucoadhesive Oral Care Gel Containing Kaempferia galanga Extract. Pharmaceutics. 2024;16(3):421 [Crossref]
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6- Lavaee F, Parhizkar E, Tavakoli F, Zarshenas M, Asmarian N. Evaluation of the Effects of Punica granatum Flower Tablets on Pain and Healing of Minor Recurrent Aphthous Stomatitis: A Randomized Clinical Trial. Clinical & Exp Dental Res. 2024;10(4) [Crossref]
7- Venugopal D, Senthilnathan R, Maanvizhi S, Madhavan Y, Sankarapandian S, Ramshankar V, Kalachaveedu M. Preparation and Characterization of Silymarin Gel: A Novel Topical Mucoadhesive Formulation for Potential Applicability in Oral Pathologies. Gels. 2023;9(2):139 [Crossref]
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13- Zamora C, Michaluk A, Torres C, Mouriño V, Chiappetta D, Nuñez M. Influence of herbal extracts in physicochemical properties and stability of antibacterial gels. J Adv Pharm Educ Res. 2023;13(4):16 [Crossref]
14- Vuletic M, Jakovljevic V, Zivanovic S, Papic M, Papic M, Mladenovic R, Zivkovic V, Srejovic I, Jeremic J, Andjic M, Kocovic A, Sretenovic J, Mitrovic S, Božin B, Kladar N, Bolevich S, Bradic J. The Evaluation of Healing Properties of Galium verum-Based Oral Gel in Aphthous Stomatitis in Rats. Molecules. 2022;27(15):4680 [Crossref]
15- Jahanbani Mazraeh E, Sadighi S, Manifar S, Bakhshandeh H, Rajabi M. Assessment of thyme honey oral gel for the prevention of adriamycin and cyclophosphamide chemotherapy-induced oral mucositis in patients with breast cancer. Support Care Cancer. 2023;31(8) [Crossref]
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19- Hosny K, Khallaf R, Asfour H, Rizg W, Alhakamy N, Sindi A, Alkhalidi H, Abualsunun W, Bakhaidar R, Almehmady A, Abdulaal W, Bakhrebah M, Alsuabeyl M, K. Kammoun A, Alghaith A, Alshehri S. Development and Optimization of Cinnamon Oil Nanoemulgel for Enhancement of Solubility and Evaluation of Antibacterial, Antifungal and Analgesic Effects against Oral Microbiota. Pharmaceutics. 2021;13(7):1008 [Crossref]
20- Suharyani I, Fouad Abdelwahab Mohammed A, Muchtaridi M, Wathoni N, Abdassah M. Evolution of Drug Delivery Systems for Recurrent Aphthous Stomatitis. DDDT. 2021;Volume 15:4071 [Crossref]
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22- Sindi A, Alharbi W, Alkhalidi H, Alghaith A, Hosny K. Development and optimization of Clotrimazole‒Rosehip oil nanoethosomal-gel for oral thrush and gingivitis. Journal of Drug Delivery Science and Technology. 2021;63:102482 [Crossref]
23- Ferreira D, da Silva T, de Melo R, Bastos K, Ucella-Filho J, Severi J, Villanova J, Resende J. Development of a gel formulation with pomegranate peel extract (Punica granatum L.) for antimicrobial and wound healing action. South African Journal of Botany. 2024;173:284 [Crossref]
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25- Alissa M, Hjazi A, Abusalim G, Aloraini G, Alghamdi S, Alharthi N, Rizg W, Hosny K, Binmadi N. Utilization of nanotechnology and experimental design in the development and optimization of a posaconazole‒calendula oil nanoemulgel for the treatment of mouth disorders. Front Pharmacol. 2024;15 [Crossref]