Cardioprotective Effect of Grape Seed Extract on Chronic Doxorubicin-Induced Cardiac Toxicity in Wistar Rats

Nasser Razmaraii ^1,2, Hossein Babaei ^1,3 * , Alireza Mohajjel Nayebi ³, Gholamreza Assadnassab ⁴, Javad Ashrafi Helan ⁵, Yadollah Azarmi ³

Cited by CrossRef: 22

1- Abdulkareem Aljumaily S, Demir M, Elbe H, Yigitturk G, Bicer Y, Altinoz E. Antioxidant, anti-inflammatory, and anti-apoptotic effects of crocin against doxorubicin-induced myocardial toxicity in rats. Environ Sci Pollut Res. 2021;28(46):65802 [Crossref]

2- Santos S, Amaral R, Graça A, Gomes S, Santana F, de Oliveira I, Andrade L, Severino P, de Albuquerque-Júnior R, Santos S, Souto E, Carvalho A. Antitumor Profile of Combined Matricaria recutita Flower Extract and 5-Fluorouracil Chemotherapy in Sarcoma 180 In Vivo Model. Toxics. 2023;11(4):375 [Crossref]

3- Eisvand F, Imenshahidi M, Ghasemzadeh Rahbardar M, Tabatabaei Yazdi S, Rameshrad M, Razavi B, Hosseinzadeh H. Cardioprotective effects of alpha‐mangostin on doxorubicin‐induced cardiotoxicity in rats. Phytotherapy Research. 2022;36(1):506 [Crossref]

4- Abdul-Rahman T, Dunham A, Huang H, Bukhari S, Mehta A, Awuah W, Ede-Imafidon D, Cantu-Herrera E, Talukder S, Joshi A, Sundlof D, Gupta R. Chemotherapy Induced Cardiotoxicity: A State of the Art Review on General Mechanisms, Prevention, Treatment and Recent Advances in Novel Therapeutics. Current Problems in Cardiology. 2023;48(4):101591 [Crossref]

5- Rahbardar M, Eisvand F, Rameshrad M, Razavi B, Hosseinzadeh H. In Vivo and In Vitro Protective Effects of Rosmarinic Acid against Doxorubicin-Induced Cardiotoxicity. Nutrition and Cancer. 2022;74(2):747 [Crossref]

6- El‐Sheikh S, Youssef F, Mohamed H, El‐Saber Batiha G, Albrakati A, Galal A. Efficacy of grape seed hydro‐alcoholic extract in the treatment of experimentally Pasteurella multocida infected rabbits. Veterinary Medicine & Sci. 2021;7(3):923 [Crossref]

7- Nour M, Sarhan N, Mazroa S, Gawish S. Histological and immunohistochemical study of cardiac telocytes in a rat model of isoproterenol-induced myocardial infarction with a reference to the effect of grape seed extract. Acta Histochemica. 2017;119(7):747 [Crossref]

8- Abu‐Khudir R, Ibrahim W, Shams M, Salama A. Trehalose alleviates doxorubicin‐induced cardiotoxicity in female Swiss albino mice by suppression of oxidative stress and autophagy. J Biochem & Molecular Tox. 2021;35(9) [Crossref]

9- Mezni A, Aoua H, Khazri O, Limam F, Aouani E. Lithium induced oxidative damage and inflammation in the rat’s heart: Protective effect of grape seed and skin extract. Biomedicine & Pharmacotherapy. 2017;95:1103 [Crossref]

10- Tabeshpour J, Mehri S, Shaebani Behbahani F, Hosseinzadeh H. Protective effects of Vitis vinifera (grapes) and one of its biologically active constituents, resveratrol, against natural and chemical toxicities: A comprehensive review. Phytotherapy Research. 2018;32(11):2164 [Crossref]

11- JAKOVLJEVIC V, Milic P, Bradic J, Jeremic J, Zivkovic V, Srejovic I, Nikolic Turnic T, Milosavljevic I, Jeremic N, Bolevich S, Labudovic Borovic M, Mitrovic M, Vucic V. Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model. IJMS. 2018;20(1):6 [Crossref]

12- Khairnar S, Kulkarni Y, Singh K. Cardiotoxicity linked to anticancer agents and cardioprotective strategy. Arch Pharm Res. 2022;45(10):704 [Crossref]

13- Tousson E, Elgharabawy R, Elmasry T, Maraldi T. Grape Seed Proanthocyanidin Ameliorates Cardiac Toxicity Induced by Boldenone Undecylenate through Inhibition of NADPH Oxidase and Reduction in the Expression of NOX2 and NOX4. Oxidative Medicine and Cellular Longevity. 2018;2018(1) [Crossref]

14- Mottaghi S, Abbaszadeh H. Grape seed extract in combination with deferasirox ameliorates iron overload, oxidative stress, inflammation, and liver dysfunction in beta thalassemia children. Complementary Therapies in Clinical Practice. 2023;53:101804 [Crossref]

15- Khan R, Ali S, Mumtaz S, Kanwal L, Mumtaz S, Nauroze T. Ameliorating and pharmacological intervention potential of grape seed extract against lead- and cadmium-induced toxicity. Int J Environ Sci Technol. 2022;19(10):10441 [Crossref]

16- Makarova N, Valiulina D, Eremeeva N. Comparative studies of extraction methods of biologically-active substances with antioxidant properties from grape seed (Vitis vinifera L.). Izvestiâ vuzov Prikladnaâ himiâ i biotehnologiâ. 2020;10(1):140 [Crossref]

17- Parandoosh M, Yousefi R, Khorsandi H, Nikpayam O, Saidpour A, Babaei H. The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial. Phytotherapy Research. 2020;34(2):379 [Crossref]

18- Yousefi R, Parandoosh M, Khorsandi H, Hosseinzadeh N, Madani Tonekaboni M, Saidpour A, Babaei H, Ghorbani A. Grape seed extract supplementation along with a restricted‐calorie diet improves cardiovascular risk factors in obese or overweight adult individuals: A randomized, placebo‐controlled trial. Phytotherapy Research. 2021;35(2):987 [Crossref]

19- Hanan E, Hasan N, Zahiruddin S, Ahmad S, Sharma V, Ahmad F. Metabolite profiling and Ameliorative effect of quince (Cydonia oblonga) leaves against doxorubicin induced cardiotoxicity in Wistar rats. Food Bioscience. 2023;53:102691 [Crossref]

20- Naddafi M, Eghbal M, Ghazi Khansari M, Sattari M, Azarmi Y, Samadi M, Mehrizi A. Sensing of oxidative stress biomarkers: The cardioprotective effect of taurine & grape seed extract against the poisoning induced by an agricultural pesticide aluminum phosphide. Chemosphere. 2022;287:132245 [Crossref]

21- Рахимжанова А, Сағдатқызы Б. Determination of antioxidant and antimicrobial properties. 2024;(1(60)):60 [Crossref]

22- Gutierrez-Docio A, Almodóvar P, Moreno-Fernandez S, Silvan J, Martinez-Rodriguez A, Alonso G, Prodanov M. Evaluation of an Integrated Ultrafiltration/Solid Phase Extraction Process for Purification of Oligomeric Grape Seed Procyanidins. Membranes. 2020;10(7):147 [Crossref]