Osteogenic/Odontogenic Bioengineering with co-Administration of Simvastatin and Hydroxyapatite on Poly Caprolactone Based Nanofibrous Scaffold

Mohammad Samiei ^1,2, Marziyeh Agazadeh ^2,3, Effat Alizadeh ^2,4, Naser Aslaminabadi ⁵, Soodabeh Davaran ^4,6, Sajjad Shirazi ⁷, Farhad Ashrafi ¹ * , Roya Salehi ^4,6,2 *

Cited by CrossRef: 29

1- Roshangar Zineh B, Shabgard M, Roshangar L. An Experimental Study on the Mechanical and Biological Properties of Bio-Printed Alginate/Halloysite Nanotube/Methylcellulose/Russian Olive-Based Scaffolds. Adv Pharm Bull. 2018;8(4):643 [Crossref]

2- Lee H, Lee H, Na C, Park J. Effects of Simvastatin on the Viability and Secretion of Vascular Endothelial Growth Factor of Cell Spheroids Cultured in Growth Media. 2018;27(4):480 [Crossref]

3- Hokmabad V, Davaran S, Aghazadeh M, Alizadeh E, Salehi R, Ramazani A. A Comparison of the Effects of Silica and Hydroxyapatite Nanoparticles on Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone)/Chitosan Nanofibrous Scaffolds for Bone Tissue Engineering. Tissue Eng Regen Med. 2018;15(6):735 [Crossref]

4- Aaminabadi N, Parto M, Emamverdizadeh P, Jamali Z, Shirazi S. Pulp bleeding color is an indicator of clinical and histohematologic status of primary teeth. Clin Oral Invest. 2017;21(5):1831 [Crossref]

5- Same S, Kadkhoda J, Navidi G, Abedi F, Aghazadeh M, Milani M, Akbarzadeh A, Davaran S. The fabrication of halloysite nanotube-based multicomponent hydrogel scaffolds for bone healing. Journal of Applied Biomaterials & Functional Materials. 2022;20 [Crossref]

6- Sabandal M, Schäfer E, Imper J, Jung S, Kleinheinz J, Sielker S. Simvastatin Induces In Vitro Mineralization Effects of Primary Human Odontoblast-Like Cells. Materials. 2020;13(20):4679 [Crossref]

7- Sabandal M, Schäfer E, Petsching S, Jung S, Kleinheinz J, Sielker S. Pleiotropic effects on proliferation and mineralization of primary human adipose tissue-derived stromal cells induced by simvastatin. Open Biol. 2022;12(6) [Crossref]

8- Guo Y, Li P, Wang Z, Zhang P, Wu X. Sustained Delivery of Methylsulfonylmethane from Biodegradable Scaffolds Enhances Efficient Bone Regeneration. IJN. 2022;Volume 17:4829 [Crossref]

9- Sharifi S, Zununi Vahed S, Ahmadian E, Maleki Dizaj S, Abedi A, Hosseiniyan Khatibi S, Samiei M. Stem Cell Therapy: Curcumin Does the Trick. Phytotherapy Research. 2019;33(11):2927 [Crossref]

10- Samiei M, Abdolahinia E, Fathi M, Barar J, Omidi Y. Chitosan-based bioactive hydrogels for osteogenic differentiation of dental pulp stem cells. Journal of Drug Delivery Science and Technology. 2022;73:103478 [Crossref]

11- Abdelaziz A, Nageh H, Abdo S, Abdalla M, Amer A, Abdal-hay A, Barhoum A. A Review of 3D Polymeric Scaffolds for Bone Tissue Engineering: Principles, Fabrication Techniques, Immunomodulatory Roles, and Challenges. Bioengineering. 2023;10(2):204 [Crossref]

12- Sarvari R, Keyhanvar P, Agbolaghi S, Gholami Farashah M, Sadrhaghighi A, Nouri M, Roshangar L. Shape-memory materials and their clinical applications. International Journal of Polymeric Materials and Polymeric Biomaterials. 2022;71(5):315 [Crossref]

13- Hokmabad V, Davaran S, Aghazadeh M, Alizadeh E, Salehi R, Ramazani A. Effect of incorporating Elaeagnus angustifolia extract in PCL-PEG-PCL nanofibers for bone tissue engineering. Front Chem Sci Eng. 2019;13(1):108 [Crossref]

14- El-hadi A, Abd Elbary A, Alluqmani S. The role of polyaniline and plasticizer on the development of the electrical conductivity of PHB composites. Journal of Composite Materials. 2019;53(16):2305 [Crossref]

15- Fallah A, Alipour M, Jamali Z, Farjadfar A, Roshangar L, Partovi Nasr M, Hashemi P, Aghazadeh M, Abdollahifar M. Overexpression Effects of miR-424 and BMP2 on the Osteogenesis of Wharton’s Jelly-Derived Stem Cells. BioMed Research International. 2021;2021:1 [Crossref]

16- Taghipour Y, Hokmabad V, Del Bakhshayesh A, Asadi N, Salehi R, Nasrabadi H. The Application of Hydrogels Based on Natural Polymers for Tissue Engineering. CMC. 2020;27(16):2658 [Crossref]

17- Castro A, Löwik D, van Steenbergen M, Jansen J, van den Beucken J, Yang F. Incorporation of simvastatin in PLLA membranes for guided bone regeneration: effect of thermal treatment on simvastatin release. RSC Adv. 2018;8(50):28546 [Crossref]

18- Sarvari R, Keyhanvar P, Agbolaghi S, Roshangar L, Bahremani E, Keyhanvar N, Haghdoost M, Keshel S, Taghikhani A, Firouzi N, Valizadeh A, Hamedi E, Nouri M. A comprehensive review on methods for promotion of mechanical features and biodegradation rate in amniotic membrane scaffolds. J Mater Sci: Mater Med. 2022;33(3) [Crossref]

19- Alipour M, Firouzi N, Aghazadeh Z, Samiei M, Montazersaheb S, Khoshfetrat A, Aghazadeh M. The osteogenic differentiation of human dental pulp stem cells in alginate-gelatin/Nano-hydroxyapatite microcapsules. BMC Biotechnol. 2021;21(1) [Crossref]

20- Wongsupa N, Nuntanaranont T, Kamolmattayakul S, Thuaksuban N. Assessment of bone regeneration of a tissue-engineered bone complex using human dental pulp stem cells/poly(ε-caprolactone)-biphasic calcium phosphate scaffold constructs in rabbit calvarial defects. J Mater Sci: Mater Med. 2017;28(5) [Crossref]

21- Akbari E, Mousazadeh H, Sabet Z, Fattahi T, Dehnad A, Akbarzadeh A, Alizadeh E. Dual drug delivery of trapoxin A and methotrexate from biocompatible PLGA-PEG polymeric nanoparticles enhanced antitumor activity in breast cancer cell line. Journal of Drug Delivery Science and Technology. 2021;61:102294 [Crossref]

22- Alipour M, Aghazadeh M, Akbarzadeh A, Vafajoo Z, Aghazadeh Z, Raeisdasteh Hokmabad V. Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds. Artificial Cells, Nanomedicine, and Biotechnology. 2019;47(1):3431 [Crossref]

23- Fu K, Yang L, Gao N, Liu P, Xue B, He W, Qiu W, Wen X. Modified five times simulated body fluid for efficient biomimetic mineralization. Heliyon. 2024;10(12):e32850 [Crossref]

24- Jamali Z, Alavi V, Najafpour E, Aminabadi N, Shirazi S. Randomized Controlled Trial of Pulpotomy in Primary Molars using MTA and Formocresol Compared to 3Mixtatin: A Novel Biomaterial. 2018;42(5):361 [Crossref]

25- Ahmadi A, Mazloomnejad R, Kasravi M, Gholamine B, Bahrami S, Sarzaeem M, Niknejad H. Recent advances on small molecules in osteogenic differentiation of stem cells and the underlying signaling pathways. Stem Cell Res Ther. 2022;13(1) [Crossref]

26- Sadeghi Ghadi Z, Asadi A, Pilehvar Y, Abasi M, Ebrahimnejad P. Enhancing osteogenic differentiation of dental pulp stem cells through rosuvastatin loaded niosomes optimized by Box-Behnken design and modified by hyaluronan: a novel strategy for improved efficiency. J Biol Eng. 2024;18(1) [Crossref]

27- Azaryan E, Emadian Razavi F, Hanafi‐Bojd M, Alemzadeh E, Naseri M. Dentin regeneration based on tooth tissue engineering: A review. Biotechnology Progress. 2023;39(2) [Crossref]

28- Rakhshaei R, Namazi H, Hamishehkar H, Kafil H, Salehi R. In situsynthesized chitosan–gelatin/ZnO nanocomposite scaffold with drug delivery properties: Higher antibacterial and lower cytotoxicity effects. J of Applied Polymer Sci. 2019;136(22) [Crossref]