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Adv Pharm Bull. 2015;5(4): 447-454. doi: 10.15171/apb.2015.061
PMID: 26819915        PMCID: PMC4729339

Review Article

A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles

Javad Khalili Fard 1,2,3,4, Samira Jafari 4,5, Mohammad Ali Eghbal 2,3 *

Cited by CrossRef: 201


1- Yazdimamaghani M, Moos P, Ghandehari H. Time- and dose-dependent gene expression analysis of macrophage response as a function of porosity of silica nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine. 2019;21:102041 [Crossref]
2- Tódor I, Marişca O, Rugină D, Diaconeasa Z, Leopold L, Coman C, Antonescu E, Szabó L, Iancu S, Bálint Z, Leopold N. Photothermal property assessment of gold nanoparticle assemblies obtained by hydroxylamine reduction. Colloid Polym Sci. 2020;298(10):1369 [Crossref]
3- Caloudova H, Blahova J, Mares J, Richtera L, Franc A, Garajova M, Tichy F, Lenz J, Caloudova J, Enevova V, Kopel P, Havelkova B, Lakdawala P, Svobodova Z. The effects of dietary exposure to Magnéli phase titanium suboxide and titanium dioxide on rainbow trout (Oncorhynchus mykiss). Chemosphere. 2022;293:133689 [Crossref]
4- Khan M, Ikram M, Haider A, Ul-Hamid A, Ullah H, Shahzadi I, Khan S, Kanoun M, Goumri-Said S, Medina F, Nabgan W. Experimental and DFT study of GO-decorated CaO quantum dots for catalytic dye degradation and bactericidal potential. Front Environ Sci. 2023;11 [Crossref]
5- Tian B, Chen W, Yu D, Lei Y, Ke Q, Guo Y, Zhu Z. Fabrication of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays for enhancing bactericidal effect and osteoinductivity. Journal of the Mechanical Behavior of Biomedical Materials. 2016;61:345 [Crossref]
6- Cánovas R, Padrell Sánchez S, Parrilla M, Cuartero M, Crespo G. Cytotoxicity Study of Ionophore-Based Membranes: Toward On-Body and in Vivo Ion Sensing. ACS Sens. 2019;4(9):2524 [Crossref]
7- Johnson K, Koshy P, Yang J, Sorrell C. Preclinical Cancer Theranostics—From Nanomaterials to Clinic: The Missing Link. Adv Funct Materials. 2021;31(43) [Crossref]
8- Tsymbalyuk O, Davydovska T, Naumenko A, Liashevych A, Lupaina I, Voiteshenko I, Nuryshchenko N, Skryshevsky V. Functional state of the myometrium of rats under chronic in vivo effect of nanostructured ZnO and ТіО2 materials. Regul Mech Biosyst. 2021;12(4):581 [Crossref]
9- Sierra M, Rubio L, Bayón G, Cobo I, Menendez P, Morales P, Mangas C, Urdinguio R, Lopez V, Valdes A, Vales G, Marcos R, Torrecillas R, Fernández A, Fraga M. DNA methylation changes in human lung epithelia cells exposed to multi-walled carbon nanotubes. Nanotoxicology. 2017;11(7):857 [Crossref]
10- Oyar P, Ulusoy M, Durkan R, Ulusoy N. Flexural strength of a polymethylmethacrylate resin produced by computer‐aided design and computer‐aided manufacturing system after repeated usage of tungsten carbide burs and thermocycling. Materialwissenschaft Werkst. 2023;54(12):1636 [Crossref]
11- Khalili Fard J, Hamzeiy H, Sattari M, Eghbal M. Protective Roles of N-acetyl Cysteine and/or Taurine against Sumatriptan-Induced Hepatotoxicity. Adv Pharm Bull. 2016;6(4):627 [Crossref]
12- Jabeen N, Maqbool Q, Bibi T, Nazar M, Hussain S, Hussain T, Jan T, Ahmad I, Maaza M, Anwaar S. Optimised synthesis of ZnO‐nano‐fertiliser through green chemistry: boosted growth dynamics of economically important L. esculentum . IET nanobiotechnol. 2018;12(4):405 [Crossref]
13- Baazeem R, Maheshwary P, Binjawhar D, Gulati K, Joshi S, Ojo S, Pareek P, Shukla P, Khan M, Dhiman G, VE S. Digital image processing for evaluating the impact of designated nanoparticles in biomedical applications. IDA. 2023;27:83 [Crossref]
14- Manukumar H, Umesha S, Kumar H. Promising biocidal activity of thymol loaded chitosan silver nanoparticles (T-C@AgNPs) as anti-infective agents against perilous pathogens. International Journal of Biological Macromolecules. 2017;102:1257 [Crossref]
15- Klekotka U, Rogacz D, Szymanek I, Malejko J, Rychter P, Kalska-Szostko B. Ecotoxicological assessment of magnetite and magnetite/Ag nanoparticles on terrestrial and aquatic biota from different trophic levels. Chemosphere. 2022;308:136207 [Crossref]
16- Rozhina E, Batasheva S, Miftakhova R, Yan X, Vikulina A, Volodkin D, Fakhrullin R. Comparative cytotoxicity of kaolinite, halloysite, multiwalled carbon nanotubes and graphene oxide. Applied Clay Science. 2021;205:106041 [Crossref]
17- Siafaka P, Özcan Bülbül E, Miliotou A, Karantas I, Okur M, Üstündağ Okur N. Nano-based carriers for pulmonary drug delivery: A review on the available drug delivery applications and toxicity issues. Journal of Drug Delivery Science and Technology. 2024;92:105381 [Crossref]
18- Yao C, Martins P. Nanotechnology Applications in Transplantation Medicine. 2020;104(4):682 [Crossref]
19- Almeida L, Magno L, Pereira A, Guidelli É, Filho O, Kinoshita A, Gonçalves P. Toxicity of silver nanoparticles released by Hancornia speciosa (Mangabeira) biomembrane. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 2019;210:329 [Crossref]
20- Herrera-Rodríguez M, del Pilar Ramos-Godinez M, Cano-Martínez A, Segura F, Ruiz-Ramírez A, Pavón N, Lira-Silva E, Bautista-Pérez R, Thomas R, Delgado-Buenrostro N, Chirino Y, López-Marure R. Food-grade titanium dioxide and zinc oxide nanoparticles induce toxicity and cardiac damage after oral exposure in rats. Part Fibre Toxicol. 2023;20(1) [Crossref]
21- Egbuna C, Parmar V, Jeevanandam J, Ezzat S, Patrick-Iwuanyanwu K, Adetunji C, Khan J, Onyeike E, Uche C, Akram M, Ibrahim M, El Mahdy N, Awuchi C, Saravanan K, Tijjani H, Odoh U, Messaoudi M, Ifemeje J, Olisah M, Ezeofor N, Chikwendu C, Ibeabuchi C, Hseu Y. Toxicity of Nanoparticles in Biomedical Application: Nanotoxicology. Journal of Toxicology. 2021;2021:1 [Crossref]
22- Zou Y, Li Q, Jiang L, Guo C, Li Y, Yu Y, Li Y, Duan J, Sun Z, Hsieh Y. DNA Hypermethylation of CREB3L1 and Bcl-2 Associated with the Mitochondrial-Mediated Apoptosis via PI3K/Akt Pathway in Human BEAS-2B Cells Exposure to Silica Nanoparticles. PLoS ONE. 2016;11(6):e0158475 [Crossref]
23- Samiei F, Shirazi F, Naserzadeh P, Dousti F, Seydi E, Pourahmad J. Toxicity of multi-wall carbon nanotubes inhalation on the brain of rats. Environ Sci Pollut Res. 2020;27(11):12096 [Crossref]
24- Tkachenko A, Onishchenko A, Butov D, Tkachenko M. FLOW CYTOMETRY IN NANOTOXICOLOGY: brief overview. IC. 2022;8(4):278 [Crossref]
25- Shishatskaya E, Nikitovic D, Vasilievich A, Tzanakakis G, Tsatsakis A, Menzianova N. Short-term culture of monocytes as an in vitro evaluation system for bionanomaterials designated for medical use. Food and Chemical Toxicology. 2016;96:302 [Crossref]
26- Monowar T, Rahman M, Bhore S, Raju G, Sathasivam K. Silver Nanoparticles Synthesized by Using the Endophytic Bacterium Pantoea ananatis are Promising Antimicrobial Agents against Multidrug Resistant Bacteria. Molecules. 2018;23(12):3220 [Crossref]
27- A, B, P, S, A. Review on Nanoparticle Toxicity and their Methods of Assessment in Humans. IJARSCT. 2023;:504 [Crossref]
28- Chen X, Argandona S, Melle F, Rampal N, Fairen-Jimenez D. Advances in surface functionalization of next-generation metal-organic frameworks for biomedical applications: Design, strategies, and prospects. Chem. 2024;10(2):504 [Crossref]
29- Chaudhary S, Sharma P, Chauhan P, Kumar R, Umar A. Functionalized nanomaterials: a new avenue for mitigating environmental problems. Int J Environ Sci Technol. 2019;16(9):5331 [Crossref]
30- Nikzamir M, Akbarzadeh A, Panahi Y. An overview on nanoparticles used in biomedicine and their cytotoxicity. Journal of Drug Delivery Science and Technology. 2021;61:102316 [Crossref]
31- Chousidis I, Stalikas C, Leonardos I. Induced toxicity in early-life stage zebrafish (Danio rerio) and its behavioral analysis after exposure to non-doped, nitrogen-doped and nitrogen, sulfur-co doped carbon quantum dots. Environmental Toxicology and Pharmacology. 2020;79:103426 [Crossref]
32- Lagos K, Buzzá H, Bagnato V, Romero M. Carbon-Based Materials in Photodynamic and Photothermal Therapies Applied to Tumor Destruction. IJMS. 2021;23(1):22 [Crossref]
33- Jain S, Saxena N, Sharma M, Chatterjee S. Metal nanoparticles and medicinal plants: Present status and future prospects in cancer therapy. Materials Today: Proceedings. 2020;31:662 [Crossref]
34- Karabatak A, Danışman-Kalındemirtaş F, Tan E, Erdem-Kuruca S, Karakuş S. Kappa carrageenan/PEG-CuO nanoparticles as a multifunctional nanoplatform: digital colorimetric biosensor and anticancer drug nanocarrier. Appl Phys A. 2022;128(8) [Crossref]
35- Alves M, Paschoal A, Klimeck T, Kuligovski C, Marcon B, de Aguiar A, Murray P. Biological Synthesis of Low Cytotoxicity Silver Nanoparticles (AgNPs) by the Fungus Chaetomium thermophilum—Sustainable Nanotechnology. JoF. 2022;8(6):605 [Crossref]
36- de Alteriis E, Falanga A, Galdiero S, Guida M, Maselli V, Galdiero E. Genotoxicity of gold nanoparticles functionalized with indolicidin towards Saccharomyces cerevisiae. Journal of Environmental Sciences. 2018;66:138 [Crossref]
37- Min Y, Suminda G, Heo Y, Kim M, Ghosh M, Son Y. Metal-Based Nanoparticles and Their Relevant Consequences on Cytotoxicity Cascade and Induced Oxidative Stress. Antioxidants. 2023;12(3):703 [Crossref]
38- Thakur N, Manna P, Das J. Synthesis and biomedical applications of nanoceria, a redox active nanoparticle. J Nanobiotechnol. 2019;17(1) [Crossref]
39- Zare E, Jamaledin R, Naserzadeh P, Afjeh-Dana E, Ashtari B, Hosseinzadeh M, Vecchione R, Wu A, Tay F, Borzacchiello A, Makvandi P. Metal-Based Nanostructures/PLGA Nanocomposites: Antimicrobial Activity, Cytotoxicity, and Their Biomedical Applications. ACS Appl Mater Interfaces. 2020;12(3):3279 [Crossref]
40- Herdiana Y, Wathoni N, Gozali D, Shamsuddin S, Muchtaridi M. Chitosan-Based Nano-Smart Drug Delivery System in Breast Cancer Therapy. Pharmaceutics. 2023;15(3):879 [Crossref]
41- Nabi S, Ali S, Rather M, Sheikh W, Altaf M, Singh H, Mumtaz P, Mishra N, Nazir S, Bashir S. Organoids: A new approach in toxicity testing of nanotherapeutics. J of Applied Toxicology. 2022;42(1):52 [Crossref]
42- Iavicoli I, Fontana L, Nordberg G. The effects of nanoparticles on the renal system. Critical Reviews in Toxicology. 2016;46(6):490 [Crossref]
43- BiBi T, Khan T. Assessment of engineered nanosilver as an alternative nano-antibiotic in marine water pollution using biomarker of fish cell line. Toxicology Research and Application. 2021;5:239784732199828 [Crossref]
44- Garcés M, Cáceres L, Chiappetta D, Magnani N, Evelson P. Current understanding of nanoparticle toxicity mechanisms and interactions with biological systems. New J Chem. 2021;45(32):14328 [Crossref]
45- Medici S, Peana M, Pelucelli A, Zoroddu M. An updated overview on metal nanoparticles toxicity. Seminars in Cancer Biology. 2021;76:17 [Crossref]
46- Manturova N, Stupin V, Silina E. Cerium oxide nanoparticles for surgery, plastic surgery and aesthetic medicine. Plast khir. 2023;(3):120 [Crossref]
47- Tayemeh M, Kalbassi M, Paknejad H, Joo H. Dietary nanoencapsulated quercetin homeostated transcription of redox-status orchestrating genes in zebrafish (Danio rerio) exposed to silver nanoparticles. Environmental Research. 2020;185:109477 [Crossref]
48- Bakand S, Hayes A. Toxicological Considerations, Toxicity Assessment, and Risk Management of Inhaled Nanoparticles. IJMS. 2016;17(6):929 [Crossref]
49- Hlongwane G, Sekoai P, Meyyappan M, Moothi K. Simultaneous removal of pollutants from water using nanoparticles: A shift from single pollutant control to multiple pollutant control. Science of The Total Environment. 2019;656:808 [Crossref]
50- Azria D, Blanquer S, Verdier J, Belamie E. Nanoparticles as contrast agents for brain nuclear magnetic resonance imaging in Alzheimer's disease diagnosis. J Mater Chem B. 2017;5(35):7216 [Crossref]
51- Maselli V, Siciliano A, Giorgio A, Falanga A, Galdiero S, Guida M, Fulgione D, Galdiero E. Multigenerational effects and DNA alterations of QDs-Indolicidin on Daphnia magna. Environmental Pollution. 2017;224:597 [Crossref]
52- Thakur N, Thakur S, Chatterjee S, Das J, Sil P. Nanoparticles as Smart Carriers for Enhanced Cancer Immunotherapy. Front Chem. 2020;8 [Crossref]
53- Gomez-Villalba L, Salcines C, Fort R. Application of Inorganic Nanomaterials in Cultural Heritage Conservation, Risk of Toxicity, and Preventive Measures. Nanomaterials. 2023;13(9):1454 [Crossref]
54- Rosa S, Connolly C, Schettino G, Butterworth K, Prise K. Biological mechanisms of gold nanoparticle radiosensitization. Cancer Nano. 2017;8(1) [Crossref]
55- Xin X, Judy J, Sumerlin B, He Z. Nano-enabled agriculture: from nanoparticles to smart nanodelivery systems. Environ Chem. 2020;17(6):413 [Crossref]
56- Yücel Y, Cardinell K, Khattak S, Zhou X, Lapinski M, Cheng F, Gupta N. Active Lymphatic Drainage From the Eye Measured by Noninvasive Photoacoustic Imaging of Near-Infrared Nanoparticles. Invest Ophthalmol Vis Sci. 2018;59(7):2699 [Crossref]
57- Gao L, Li J, Song T. Poly lactic-co-glycolic acid-based nanoparticles as delivery systems for enhanced cancer immunotherapy. Front Chem. 2022;10 [Crossref]
58- Xin X, Zhao F, Zhao H, Goodrich S, Hill M, Sumerlin B, Stoffella P, Wright A, He Z. Comparative assessment of polymeric and other nanoparticles impacts on soil microbial and biochemical properties. Geoderma. 2020;367:114278 [Crossref]
59- Barreto A, Luis L, Pinto E, Almeida A, Paíga P, Santos L, Delerue-Matos C, Trindade T, Soares A, Hylland K, Loureiro S, Oliveira M. Effects and bioaccumulation of gold nanoparticles in the gilthead seabream (Sparus aurata) – Single and combined exposures with gemfibrozil. Chemosphere. 2019;215:248 [Crossref]
60- Naji R, Bashandy M, Fathy A, Chandra Sekar C. Ameliorative Effects of some Natural Antioxidants against Blood and Cardiovascular Toxicity of Oral Subchronic Exposure to Silicon Dioxide, Aluminum Oxide, or Zinc Oxide Nanoparticles in Wistar Rats. International Journal of Food Science. 2023;2023:1 [Crossref]
61- Chaturvedi V, Yadav N, Rai N, Ellah N, Bohara R, Rehan I, Marraiki N, Batiha G, Hetta H, Singh M. Pleurotus sajor-caju-Mediated Synthesis of Silver and Gold Nanoparticles Active against Colon Cancer Cell Lines: A New Era of Herbonanoceutics. Molecules. 2020;25(13):3091 [Crossref]
62- Wang J, Li Y, Duan J, Yang M, Yu Y, Feng L, Yang X, Zhou X, Zhao Z, Sun Z. Silica nanoparticles induce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPR pathways in hepatocytes. Autophagy. 2018;14(7):1185 [Crossref]
63- Gomes dos Reis L, Lee W, Svolos M, Moir L, Jaber R, Windhab N, Young P, Traini D. Nanotoxicologic Effects of PLGA Nanoparticles Formulated with a Cell-Penetrating Peptide: Searching for a Safe pDNA Delivery System for the Lungs. Pharmaceutics. 2019;11(1):12 [Crossref]
64- N, Sharma M, Thakur P, Gaur P, Rani G, Rustagi S, Talreja R, Chaudhary V. Cancer treatment and toxicity outlook of nanoparticles. Environmental Research. 2023;237:116870 [Crossref]
65- Aljabali A, Obeid M, Bashatwah R, Serrano-Aroca Á, Mishra V, Mishra Y, El-Tanani M, Hromić-Jahjefendić A, Kapoor D, Goyal R, Naikoo G, Tambuwala M. Nanomaterials and Their Impact on the Immune System. IJMS. 2023;24(3):2008 [Crossref]
66- Valeriano A, Bondaug F, Ebardo I, Almonte P, Sabugaa M, Bagnol J, Latayada M, Macalalag J, Paradero B, Mayes M, Balanay M, Alguno A, Capangpangan R. Predicting cytotoxicity of engineered nanoparticles using regularized regression models: an in silico approach. SAR and QSAR in Environmental Research. 2023;34(7):591 [Crossref]
67- Kim H, Choi J, Lee H, Park J, Yoon B, Jin S, Park K. Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM. ToxicolRes. 2016;32(4):311 [Crossref]
68- Martínez-Rodríguez M, Madla-Cruz E, Urrutia-Baca V, de la Garza-Ramos M, González-González V, Garza-Navarro M. Influence of Polysaccharides’ Molecular Structure on the Antibacterial Activity and Cytotoxicity of Green Synthesized Composites Based on Silver Nanoparticles and Carboxymethyl-Cellulose. Nanomaterials. 2020;10(6):1164 [Crossref]
69- Salau A, Osineye S, Lateef A. Nanotoxicological investigations of cocoa pod husk extract-mediated silver nanoparticles in selected tissues of albino rats. Toxicol Environ Health Sci. 2022;14(2):193 [Crossref]
70- Navyatha B, Nara S. Comparative in vitro toxicity assessment of spiked anisotropic gold nanostructures. J Nanopart Res. 2020;22(5) [Crossref]
71- Sengul A, Asmatulu E. Toxicity of metal and metal oxide nanoparticles: a review. Environ Chem Lett. 2020;18(5):1659 [Crossref]
72- Balci-Ozyurt A, Yirün A, Cakır D, Zeybek N, Oral D, Sabuncuoğlu S, Erkekoğlu P. Evaluation of possible cytotoxic, genotoxic and epigenotoxic effects of titanium dioxide nanoparticles and possible protective effect of melatonin. Toxicology Mechanisms and Methods. 2024;34(2):109 [Crossref]
73- Yaqoob S, Adnan R, Rameez Khan R, Rashid M. Gold, Silver, and Palladium Nanoparticles: A Chemical Tool for Biomedical Applications. Front Chem. 2020;8 [Crossref]
74- El Damaty H, Yousef S, Mahmmod Y, El-Balkemy F, Mweu M. Sensitivity and specificity of piroplasm indirect fluorescent antibody test and PCR for Theileria annulata infection in clinically asymptomatic large ruminants using Bayesian latent class analysis. Veterinary Parasitology: Regional Studies and Reports. 2021;24:100563 [Crossref]
75- Abbasi-Oshaghi E, Mirzaei F, Mirzaei A. Effects of ZnO nanoparticles on intestinal function and structure in normal/high fat diet-fed rats and Caco-2 cells. Nanomedicine. 2018;13(21):2791 [Crossref]
76- Yedgar S, Barshtein G, Gural A. Hemolytic Activity of Nanoparticles as a Marker of Their Hemocompatibility. Micromachines. 2022;13(12):2091 [Crossref]
77- Reus T, Machado T, Bezerra A, Marcon B, Paschoal A, Kuligovski C, de Aguiar A, Dallagiovanna B. Dose-dependent cytotoxicity of bismuth nanoparticles produced by LASiS in a reference mammalian cell line BALB/c 3T3. Toxicology in Vitro. 2018;53:99 [Crossref]
78- Yamini V, Shanmugam V, Rameshpathy M, Venkatraman G, Ramanathan G, AL Garalleh H, Hashmi A, Brindhadevi K, Devi Rajeswari V. Environmental effects and interaction of nanoparticles on beneficial soil and aquatic microorganisms. Environmental Research. 2023;236:116776 [Crossref]
79- Brassolatti P, de Almeida Rodolpho J, Franco de Godoy K, de Castro C, Flores Luna G, Dias de Lima Fragelli B, Pedrino M, Assis M, Nani Leite M, Cancino-Bernardi J, Speglich C, Frade M, de Freitas Anibal F. Functionalized Titanium Nanoparticles Induce Oxidative Stress and Cell Death in Human Skin Cells. IJN. 2022;Volume 17:1495 [Crossref]
80- Elarabi N, Abdel-Rahman A, Abdel-Haleem H, Abdel-Hakeem M. Silver and zinc oxide nanoparticles disrupt essential parasitism, neuropeptidergic, and expansion-like proteins genes in Meloidogyne incognita. Experimental Parasitology. 2022;243:108402 [Crossref]
81- Das S, Panicker N, Rather M, Mandal M, Sahu P. Green synthesis of cerium oxide nanoparticles using Dillenia indica aqueous extract and its anti-oxidant activity. Bull Mater Sci. 2022;46(1) [Crossref]
82- Cai Y, Chang S, Gan S, Ma S, Lu W, Yen C. Cell-Laden Nanocomposite Bioinks for 3D Bioprinting. SSRN Journal. 2022; [Crossref]
83- Čaloudová H, Čaloudová J, Svobodová Z. A review of the effects of metallic nanoparticles on fish. Acta Vet Brno. 2021;90(3):331 [Crossref]
84- Yousefvand P, Mohammadi E, Zhuang Y, Bloukh S, Edis Z, Gamasaee N, Zanganeh H, Mansour F, Heidarzadeh M, Attar F, Babadaei M, Keshtali A, Shahpasand K, Sharifi M, Falahati M, Cai Y. Biothermodynamic, antiproliferative and antimicrobial properties of synthesized copper oxide nanoparticles. Journal of Molecular Liquids. 2021;324:114693 [Crossref]
85- Flores‐López L, Espinoza‐Gómez H, Somanathan R. Silver nanoparticles: Electron transfer, reactive oxygen species, oxidative stress, beneficial and toxicological effects. Mini review. J of Applied Toxicology. 2019;39(1):16 [Crossref]
86- Zhang H, Li Z, Dai C, Wang P, Fan S, Yu B, Qu Y. Antibacterial properties and mechanism of selenium nanoparticles synthesized by Providencia sp. DCX. Environmental Research. 2021;194:110630 [Crossref]
87- Baghdadchi Y, Khoshkam M, Fathi M, Jalilvand A, Fooladsaz K, Ramazani A. The assessment of metabolite alteration induced by –OH functionalized multi-walled carbon nanotubes in mice using NMR-based metabonomics. BI. 2017;8(2):107 [Crossref]
88- Abbasi R, Shineh G, Mobaraki M, Doughty S, Tayebi L. Structural parameters of nanoparticles affecting their toxicity for biomedical applications: a review. J Nanopart Res. 2023;25(3) [Crossref]
89- Stuparu-Cretu M, Braniste G, Necula G, Stanciu S, Stoica D, Stoica M. Metal Oxide Nanoparticles in Food Packaging and Their Influence on Human Health. Foods. 2023;12(9):1882 [Crossref]
90- Lebepe T, Parani S, Oluwafemi O. Graphene Oxide-Coated Gold Nanorods: Synthesis and Applications. Nanomaterials. 2020;10(11):2149 [Crossref]
91- Safwat S, Hathout R, Ishak R, Mortada N. Elaborated survey in the scope of nanocarriers engineering for boosting chemotherapy cytotoxicity: A meta-analysis study. International Journal of Pharmaceutics. 2021;610:121268 [Crossref]
92- Hante N, Medina C, Santos-Martinez M. Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications. Front Cardiovasc Med. 2019;6 [Crossref]
93- Singh K, Nayak V, Sarkar T, Singh R. Cerium oxide nanoparticles: properties, biosynthesis and biomedical application. RSC Adv. 2020;10(45):27194 [Crossref]
94- González-Palomo A, Saldaña-Villanueva K, Cortés-García J, Fernández-Macias J, Méndez-Rodríguez K, Pérez Maldonado I. Effect of silver nanoparticles (AgNPs) exposure on microRNA expression and global DNA methylation in endothelial cells EA.hy926. Environmental Toxicology and Pharmacology. 2021;81:103543 [Crossref]
95- Mani R, Balasubramanian S, Raghunath A, Perumal E. Chronic exposure to copper oxide nanoparticles causes muscle toxicity in adult zebrafish. Environ Sci Pollut Res. 2020;27(22):27358 [Crossref]
96- Okeke E, Ezeorba T, Mao G, Chen Y, Feng W, Wu X. Nano-enabled agrochemicals/materials: Potential human health impact, risk assessment, management strategies and future prospects. Environmental Pollution. 2022;295:118722 [Crossref]
97- Dubey A, Chauhan A, Kaur A, Alam M, Yadav S, Rao G. CUBOSOME-A Novel Drug Delivery for Anticancer Drugs. CNANO. 2024;20(2):206 [Crossref]
98- Ramalho M, Andrade S, Loureiro J, do Carmo Pereira M. Nanotechnology to improve the Alzheimer’s disease therapy with natural compounds. Drug Deliv and Transl Res. 2020;10(2):380 [Crossref]
99- Weber J, Beard P, Bohndiek S. Contrast agents for molecular photoacoustic imaging. Nat Methods. 2016;13(8):639 [Crossref]
100- Bhandari V, Jose S, Badanayak P, Sankaran A, Anandan V. Antimicrobial Finishing of Metals, Metal Oxides, and Metal Composites on Textiles: A Systematic Review. Ind Eng Chem Res. 2022;61(1):86 [Crossref]
101- Miyani V, Hughes M. Assessment of the in vitro dermal irritation potential of cerium, silver, and titanium nanoparticles in a human skin equivalent model. Cutaneous and Ocular Toxicology. 2017;36(2):145 [Crossref]
102- Madannejad R, Shoaie N, Jahanpeyma F, Darvishi M, Azimzadeh M, Javadi H. Toxicity of carbon-based nanomaterials: Reviewing recent reports in medical and biological systems. Chemico-Biological Interactions. 2019;307:206 [Crossref]
103- Mohammadalipour Z, Rahmati M, Khataee A, Moosavi M. Different Concentrations of Titanium Dioxide Nanoparticles Induce Autophagy Followed by Growth Inhibition or Cell Death in A375 Melanoma Cells. J Skin Stem Cell. 2017;In Press(In Press) [Crossref]
104- Esmaeilpour T, Fereydouni E, Dehghani F, Bókkon I, Panjehshahin M, Császár-Nagy N, Ranjbar M, Salari V. An Experimental Investigation of Ultraweak Photon Emission from Adult Murine Neural Stem Cells. Sci Rep. 2020;10(1) [Crossref]
105- Santacruz-Márquez R, González-De los Santos M, Hernández-Ochoa I. Ovarian toxicity of nanoparticles. Reproductive Toxicology. 2021;103:79 [Crossref]
106- Banaye Yazdipour A, Masoorian H, Ahmadi M, Mohammadzadeh N, Ayyoubzadeh S. Predicting the toxicity of nanoparticles using artificial intelligence tools: a systematic review. Nanotoxicology. 2023;17(1):62 [Crossref]
107- Clement P, Kuether J, Borgatta J, Buchman J, Cahill M, Qiu T, Hamers R, Feng Z, Haynes C. Cobalt Release from a Nanoscale Multiphase Lithiated Cobalt Phosphate Dominates Interaction with Shewanella oneidensis MR-1 and Bacillus subtilis SB491. Chem Res Toxicol. 2020;33(3):806 [Crossref]
108- Tsymbalyuk O, Veselsky S, Naumenko A. ТiО(2) hepatotoxicity under long-term administration to rats. UkrBiochemJ. 2020;92(4):45 [Crossref]
109- Qi S, Wang X, Chang K, Shen W, Yu G, Du J. The bright future of nanotechnology in lymphatic system imaging and imaging-guided surgery. J Nanobiotechnol. 2022;20(1) [Crossref]
110- Fasoli E. Protein corona: Dr. Jekyll and Mr. Hyde of nanomedicine. Biotechnology and Applied Biochemistry. 2020; [Crossref]
111- Ortega V, Boyle D, Hodgkinson J, Simmons D, Belosevic M, Stafford J, Goss G. Polymer-coated TiO2 nanoparticles bioaccumulate, immunoactivate and suppress pathogenic Mycobacterium chelonae clearance when intravenously injected into goldfish (Carassius auratus L.). Environ Sci: Nano. 2021;8(7):1910 [Crossref]
112- Ayoubi M, Naserzadeh P, Hashemi M, Reza Rostami M, Tamjid E, Tavakoli M, Simchi A. Biochemical mechanisms of dose-dependent cytotoxicity and ROS-mediated apoptosis induced by lead sulfide/graphene oxide quantum dots for potential bioimaging applications. Sci Rep. 2017;7(1) [Crossref]
113- Yazdanbakhsh A, Rafiee M, Daraei H, Amoozegar M. Responses of flocculated activated sludge to bimetallic Ag-Fe nanoparticles toxicity: Performance, activity enzymatic, and bacterial community shift. Journal of Hazardous Materials. 2019;366:114 [Crossref]
114- Shabbir H, Muhammad A. A Review on Gold Nanoparticles (GNPs) and their Advancement in Cancer Therapy. Int J Nanomater Nanotechnol Nanomed. 2021;:019 [Crossref]
115- Prakash A, Yadav S, Tiwari P, Saxena P, Srivastava A, Tilak R. Facile synthesis of highly fluorescent nitrogen-doped carbon quantum dots and their role in bioimaging of some pathogenic microorganisms. J Nanopart Res. 2023;25(12) [Crossref]
116- Garnica-Gutiérrez R, Lara-Martínez L, Palacios E, Masso F, Contreras A, Hernández-Gutiérrez S, Cervantes-Sodi F. Effect of Functionalized Carbon Nanotubes and their Citric Acid Polymerization on Mesenchymal Stem Cells In Vitro. Journal of Nanomaterials. 2018;2018:1 [Crossref]
117- Ajdary M, Moosavi M, Rahmati M, Falahati M, Mahboubi M, Mandegary A, Jangjoo S, Mohammadinejad R, Varma R. Health Concerns of Various Nanoparticles: A Review of Their in Vitro and in Vivo Toxicity. Nanomaterials. 2018;8(9):634 [Crossref]
118- Visalli G, Currò M, Iannazzo D, Pistone A, Pruiti Ciarello M, Acri G, Testagrossa B, Bertuccio M, Squeri R, Di Pietro A. In vitro assessment of neurotoxicity and neuroinflammation of homemade MWCNTs. Environmental Toxicology and Pharmacology. 2017;56:121 [Crossref]
119- Hao X, Zhang L, Zheng X, Zong W, Liu C. Molecular mechanism of composite nanoparticles TiO 2 /WO 3 /GO-induced activity changes of catalase and superoxide dismutase. Chemico-Biological Interactions. 2018;292:30 [Crossref]
120- Espinosa C, Hoyos-Palacio L, López-López L, Gallego-González D, Aranzazu-Ceballos A, Marín-Cárdenas J, Quintero-Moreno D, Ortiz-Trujillo I. Evaluación del efecto genotóxico y mutagénico en linfocitos humanos expuestos a nanotubos de carbono modificados. DYNA. 2018;85(205):348 [Crossref]
121- Chaudhari V, Vairagade V, Thakkar A, Shende H, Vora A. Nanotechnology-based fungal detection and treatment: current status and future perspective. Naunyn-Schmiedeberg's Arch Pharmacol. 2024;397(1):77 [Crossref]
122- Ng P, Ling L, Chellian J, Madheswaran T, Panneerselvam J, Kunnath A, Gupta G, Satija S, Mehta M, Hansbro P, Collet T, Dua K, Chellappan D. Applications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents. CPD. 2020;26(36):4580 [Crossref]
123- El Yamani N, Rubio L, García-Rodríguez A, Kažimírová A, Rundén-Pran E, Magdalena B, Marcos R, Dusinska M. Lack of mutagenicity of TiO2 nanoparticles in vitro despite cellular and nuclear uptake. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2022;882:503545 [Crossref]
124- Kwak D, Lee S, Pan Z, Liang Y, Lee H, Pui D. Semi-empirical equation for determining the pressure drop of nanofibers. Separation and Purification Technology. 2023;324:124585 [Crossref]
125- Patoo T, Khanday F, Qurashi A. Prospectus of advanced nanomaterials for antiviral properties. Mater Adv. 2022;3(7):2960 [Crossref]
126- Fathy A, Naji R, Bashandy M, Kang W. Antioxidant and Hepatoprotective Effects of Fig Fruit Extract with Olive Oil and Date-Palm Fruit Extract on Hepatic Toxicity of Oral Subchronic Exposure to Some Nanoparticles in Wistar Rats. Journal of Food Quality. 2023;2023:1 [Crossref]
127- Velusamy P, Su C, Venkat Kumar G, Adhikary S, Pandian K, Gopinath S, Chen Y, Anbu P, Mishra Y. Biopolymers Regulate Silver Nanoparticle under Microwave Irradiation for Effective Antibacterial and Antibiofilm Activities. PLoS ONE. 2016;11(6):e0157612 [Crossref]
128- Lin Q, Yang Y, Hu Q, Guo Z, Liu T, Xu J, Wu J, Kirk T, Ma D, Xue W. Injectable supramolecular hydrogel formed from α-cyclodextrin and PEGylated arginine-functionalized poly(l-lysine) dendron for sustained MMP-9 shRNA plasmid delivery. Acta Biomaterialia. 2017;49:456 [Crossref]
129- Abdulwahid F, Haider A, Al-Musawi S. Iron Oxide Nanoparticles (IONPs): Synthesis, Surface Functionalization, and Targeting Drug Delivery Strategies: Mini-Review. NANO. 2022;17(11) [Crossref]
130- Anastasiadis S, Chrissopoulou K, Stratakis E, Kavatzikidou P, Kaklamani G, Ranella A. How the Physicochemical Properties of Manufactured Nanomaterials Affect Their Performance in Dispersion and Their Applications in Biomedicine: A Review. Nanomaterials. 2022;12(3):552 [Crossref]
131- Barabadi H, Vahidi H, Damavandi Kamali K, Rashedi M, Hosseini O, Saravanan M. Emerging Theranostic Gold Nanomaterials to Combat Colorectal Cancer: A Systematic Review. J Clust Sci. 2020;31(4):651 [Crossref]
132- Naumenko A, Dmytrenko O, Shapoval L, Tsymbalyuk O, Sagach V, Davydovska T. Effects of Injections of Nanostructured Titanium Dioxide into the Rat Medullary Nuclei Involved in Cardiovascular Control. Neurophysiology. 2018;50(6):409 [Crossref]
133- Marzi M, Osanloo M, Vakil M, Mansoori Y, Ghasemian A, Dehghan A, Zarenezhad E, Wang H. Applications of Metallic Nanoparticles in the Skin Cancer Treatment. BioMed Research International. 2022;2022:1 [Crossref]
134- Sani A, Cao C, Cui D. Toxicity of gold nanoparticles (AuNPs): A review. Biochemistry and Biophysics Reports. 2021;26:100991 [Crossref]
135- Cucci L, Naletova I, Consiglio G, Satriano C. A Hybrid Nanoplatform of Graphene Oxide/Nanogold for Plasmonic Sensing and Cellular Applications at the Nanobiointerface. Applied Sciences. 2019;9(4):676 [Crossref]
136- McClements D, DeLoid G, Pyrgiotakis G, Shatkin J, Xiao H, Demokritou P. The role of the food matrix and gastrointestinal tract in the assessment of biological properties of ingested engineered nanomaterials (iENMs): State of the science and knowledge gaps. NanoImpact. 2016;3-4:47 [Crossref]
137- De Matteis V. Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation. Toxics. 2017;5(4):29 [Crossref]
138- Komedchikova E, Kolesnikova O, Syuy A, Volkov V, Deyev S, Nikitin M, Shipunova V. Targosomes: Anti-HER2 PLGA nanocarriers for bioimaging, chemotherapy and local photothermal treatment of tumors and remote metastases. Journal of Controlled Release. 2024;365:317 [Crossref]
139- Shearer L, Petersen N. Internalization of Phospholipid-Coated Gold Nanoparticles. Crystals. 2019;9(10):544 [Crossref]
140- Higashisaka K, Nagano K, Yoshioka Y, Tsutsumi Y. Nano-safety Research: Examining the Associations among the Biological Effects of Nanoparticles and Their Physicochemical Properties and Kinetics. Biological & Pharmaceutical Bulletin. 2017;40(3):243 [Crossref]
141- Temiz Ö, Kargın F. Toxicological Impacts on Antioxidant Responses, Stress Protein, and Genotoxicity Parameters of Aluminum Oxide Nanoparticles in the Liver of Oreochromis niloticus. Biol Trace Elem Res. 2022;200(3):1339 [Crossref]
142- Ciftci N, Sargin I, Arslan G, Karakurt S, Arslan U. Investigation of in vitro antimicrobial and cytotoxic effects of gold nanoparticles capped with meropenem and imipenem. Nanomedicine. 2023;18(24):1719 [Crossref]
143- Martin C, Nourian A, Babaie M, Nasr G. Environmental, health and safety assessment of nanoparticle application in drilling mud – Review. Geoenergy Science and Engineering. 2023;226:211767 [Crossref]
144- Forest V, Hochepied J, Pourchez J. Importance of Choosing Relevant Biological End Points To Predict Nanoparticle Toxicity with Computational Approaches for Human Health Risk Assessment. Chem Res Toxicol. 2019;32(7):1320 [Crossref]
145- Mohanty A, Parida A, Raut R, Behera R. Ferritin: A Promising Nanoreactor and Nanocarrier for Bionanotechnology. ACS Bio Med Chem Au. 2022;2(3):258 [Crossref]
146- Gandomani E, Mosaffa N, Zendehdel R, Kohneshahri M, Vahabi M, Sabour S. Release of Interleukin-1β evaluation among mineral oil mist‐exposed workers. Toxicol Ind Health. 2022;38(5):270 [Crossref]
147- Ochocinska M, Zlokovic B, Searson P, Crowder A, Kraig R, Ljubimova J, Mainprize T, Banks W, Warren R, Kindzelski A, Timmer W, Liu C. NIH workshop report on the trans-agency blood–brain interface workshop 2016: exploring key challenges and opportunities associated with the blood, brain and their interface. Fluids Barriers CNS. 2017;14(1) [Crossref]
148- Stock V, Böhmert L, Lisicki E, Block R, Cara-Carmona J, Pack L, Selb R, Lichtenstein D, Voss L, Henderson C, Zabinsky E, Sieg H, Braeuning A, Lampen A. Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo. Arch Toxicol. 2019;93(7):1817 [Crossref]
149- Zhang J, Guo W, Li Q, Wang Z, Liu S. The effects and the potential mechanism of environmental transformation of metal nanoparticles on their toxicity in organisms. Environ Sci: Nano. 2018;5(11):2482 [Crossref]
150- Maleki P, Nemati F, Gholoobi A, Hashemzadeh A, Sabouri Z, Darroudi M. Green facile synthesis of silver-doped cerium oxide nanoparticles and investigation of their cytotoxicity and antibacterial activity. Inorganic Chemistry Communications. 2021;131:108762 [Crossref]
151- Falahati M, Attar F, Sharifi M, Haertlé T, Berret J, Khan R, Saboury A. A health concern regarding the protein corona, aggregation and disaggregation. Biochimica et Biophysica Acta (BBA) - General Subjects. 2019;1863(5):971 [Crossref]
152- Tkachenko A, Pogozhykh D, Onishchenko A, Myasoedov V, Podrigalo L, Klochkov V, Chumachenko T, Prokopyuk V, Yefimova S, Gubina-Vakulyck G, Kavok N, Butov D, Andrieiev A, Polikarpova H, Nakonechna O. Gadolinium Orthovanadate GdVO4:Eu3+ Nanoparticles Ameliorate Carrageenan-Induced Intestinal Inflammation. J Pharm Nutr Sci. 2021;11:40 [Crossref]
153- Flores-Contreras E, González-González R, González-González E, Parra-Saldívar R, Iqbal H. Nano-vehicles modulated delivery of therapeutic epigenetic regulators to treat Triple-Negative Breast Cancer. Journal of Drug Delivery Science and Technology. 2022;77:103924 [Crossref]
154- Otero C, Carreño A, Polanco R, Llancalahuen F, Arratia-Pérez R, Gacitúa M, Fuentes J. Rhenium (I) Complexes as Probes for Prokaryotic and Fungal Cells by Fluorescence Microscopy: Do Ligands Matter?. Front Chem. 2019;7 [Crossref]
155- Kapoor D, Patel R, Gaur M, Parikh S, Prajapati B. Metallic and metal oxide nanoparticles in treating Pseudomonas aeruginosa infections. Journal of Drug Delivery Science and Technology. 2024;91:105290 [Crossref]
156- Karimi M, Sadeghi R, Kokini J. Human exposure to nanoparticles through trophic transfer and the biosafety concerns that nanoparticle-contaminated foods pose to consumers. Trends in Food Science & Technology. 2018;75:129 [Crossref]
157- Ghiasvand Mohammadkhani L, Khoshkam M, Kompany‐Zareh M, Amiri M, Ramazani A. Metabolomics approach to study in vivo toxicity of graphene oxide nanosheets. J of Applied Toxicology. 2022;42(3):506 [Crossref]
158- Zhao L, Wang S, Ilves M, Lehtonen S, Saikko L, El-Nezami H, Alenius H, Karisola P. Transcriptomic Profiling the Effects of Airway Exposure of Zinc Oxide and Silver Nanoparticles in Mouse Lungs. IJMS. 2023;24(6):5183 [Crossref]
159- Parhiz H, Khoshnejad M, Myerson J, Hood E, Patel P, Brenner J, Muzykantov V. Unintended effects of drug carriers: Big issues of small particles. Advanced Drug Delivery Reviews. 2018;130:90 [Crossref]
160- Albalawi F, Hussein M, Fakurazi S, Masarudin M. Engineered Nanomaterials: The Challenges and Opportunities for Nanomedicines. IJN. 2021;Volume 16:161 [Crossref]
161- Obaidat I, Narayanaswamy V, Alaabed S, Sambasivam S, Muralee Gopi C. Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles. Magnetochemistry. 2019;5(4):67 [Crossref]
162- Sanginario A, Miccoli B, Demarchi D. Carbon Nanotubes as an Effective Opportunity for Cancer Diagnosis and Treatment. Biosensors. 2017;7(4):9 [Crossref]
163- Uzair B, Liaqat A, Iqbal H, Menaa B, Razzaq A, Thiripuranathar G, Fatima Rana N, Menaa F. Green and Cost-Effective Synthesis of Metallic Nanoparticles by Algae: Safe Methods for Translational Medicine. Bioengineering. 2020;7(4):129 [Crossref]
164- Landh E, Wang R, Moir L, Traini D, Young P, Ong H. Prospective nanoparticle treatments for lymphangioleiomyomatosis. Expert Opinion on Drug Delivery. 2022;19(1):75 [Crossref]
165- Achtschin C, Sipahi A. The role of titanium dioxide in the gut. NFS. 2017;47(3):432 [Crossref]
166- Reus T, Marcon B, Paschoal A, Ribeiro I, Cardoso M, Dallagiovanna B, Aguiar A. Dose-dependent cell necrosis induced by silica nanoparticles. Toxicology in Vitro. 2020;63:104723 [Crossref]
167- Cai Y, Chang S, Gan S, Ma S, Lu W, Yen C. Nanocomposite bioinks for 3D bioprinting. Acta Biomaterialia. 2022;151:45 [Crossref]
168- Ning X, Li X, Ma K, Pang H, Tian T, Hao H, Hou Q, Li M, Liu T, Hou S, Du H, Song X, Sun Z, Zhao C, Jin M. VDAC1 Protein Regulation of Oxidative Damage and Mitochondrial Dysfunction-Mediated Cytotoxicity by Silica Nanoparticles in SH-SY5Y Cells. Mol Neurobiol. 2023;60(11):6542 [Crossref]
169- Fornasier M, Biffi S, Bortot B, Macor P, Manhart A, Wurm F, Murgia S. Cubosomes stabilized by a polyphosphoester-analog of Pluronic F127 with reduced cytotoxicity. Journal of Colloid and Interface Science. 2020;580:286 [Crossref]
170- Avila-Alejo J, González-Palomo A, Plascencia-Villa G, José-Yacamán M, Navarro-Contreras H, Pérez-Maldonado I. Low cytotoxicity of anisotropic gold nanoparticles coated with lysine on peripheral blood mononuclear cells “in vitro”. Environmental Toxicology and Pharmacology. 2017;56:210 [Crossref]
171- Won S, Song E, Reeder J, Rogers J. Emerging Modalities and Implantable Technologies for Neuromodulation. Cell. 2020;181(1):115 [Crossref]