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Adv Pharm Bull. 2015;5(2): 151-159. doi: 10.15171/apb.2015.022
PMID: 26236652        PMCID: PMC4517084

Original Research

Solid Lipid Nanoparticles as Efficient Drug and Gene Delivery Systems: Recent Breakthroughs

Jafar Ezzati Nazhad Dolatabadi 1,2, Hadi Valizadeh 3,4 * , Hamed Hamishehkar 3

Cited by CrossRef: 106


1- Salah E, Abouelfetouh M, Pan Y, Chen D, Xie S. Solid lipid nanoparticles for enhanced oral absorption: A review. Colloids and Surfaces B: Biointerfaces. 2020;196:111305 [Crossref]
2- Wang H, Qin L, Zhang X, Guan J, Mao S. Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery. Journal of Controlled Release. 2022;352:970 [Crossref]
3- Senthil Kumar C, Thangam R, Mary S, Kannan P, Arun G, Madhan B. Targeted delivery and apoptosis induction of trans-resveratrol-ferulic acid loaded chitosan coated folic acid conjugate solid lipid nanoparticles in colon cancer cells. Carbohydrate Polymers. 2020;231:115682 [Crossref]
4- Lalan M, Shah P, Barve K, Parekh K, Mehta T, Patel P. Skin cancer therapeutics: nano-drug delivery vectors—present and beyond. Futur J Pharm Sci. 2021;7(1) [Crossref]
5- Tupal A, Sabzichi M, Ramezani F, Kouhsoltani M, Hamishehkar H. Dermal delivery of doxorubicin-loaded solid lipid nanoparticles for the treatment of skin cancer. Journal of Microencapsulation. 2016;33(4):372 [Crossref]
6- Escalona-Rayo O, Fuentes-Vázquez P, Leyva-Gómez G, Cisneros B, Villalobos R, Magaña J, Quintanar-Guerrero D. Nanoparticulate strategies for the treatment of polyglutamine diseases by halting the protein aggregation process. Drug Development and Industrial Pharmacy. 2017;43(6):871 [Crossref]
7- Faustino C, Rijo P, Reis C. Nanotechnological strategies for nerve growth factor delivery: Therapeutic implications in Alzheimer’s disease. Pharmacological Research. 2017;120:68 [Crossref]
8- Zeeshan F, Tabbassum M, Kesharwani P. Investigation on Secondary Structure Alterations of Protein Drugs as an Indicator of Their Biological Activity Upon Thermal Exposure. Protein J. 2019;38(5):551 [Crossref]
9- Khotimah H, Aulanni'am A, Nandar Kurniawan S, Eka Puspita O, Rahayu Adianingsih O, Mardhiyah M, Setiawan A. Development and optimization of orally disintegrating tablets containing Centella asiatica solid lipid nanoparticles for supportive therapies of Parkinson's disease. F1000Res. 2022;11:517 [Crossref]
10- Prasanna P, Upadhyay A. Flavonoid-Based Nanomedicines in Alzheimer’s Disease Therapeutics: Promises Made, a Long Way To Go. ACS Pharmacol Transl Sci. 2021;4(1):74 [Crossref]
11- Stefanov S, Gugleva V, Andonova V. Technological strategies for the preparation of lipid nanoparticles: an updated review. PHAR. 2023;70(3):449 [Crossref]
12- Madni A, Batool A, Noreen S, Maqbool I, Rehman F, Kashif P, Tahir N, Raza A. Novel nanoparticulate systems for lung cancer therapy: an updated review. Journal of Drug Targeting. 2017;25(6):499 [Crossref]
13- Zeeshan F, Tabbassum M, Jorgensen L, Medlicott N. Investigation on Secondary Structure Perturbations of Proteins Embedded in Solid Lipid Matrices as a Novel Indicator of their Biological Activity upon In Vitro Release. AAPS PharmSciTech. 2018;19(2):769 [Crossref]
14- Soltani S, Rafiei A, Ramezani Z, Abbaspour M, Jelowdar A, Sagha Kahvaz M. Evaluation of the Hydatid Cyst Membrane Permeability of Albendazole and Albendazole Sulfoxide-Loaded Solid Lipid Nanoparticles. Jundishapur J Nat Pharm Prod. 2016;12(2) [Crossref]
15- Firdaus S, Hassan N, Mirza M, Ara T, El-Serehy H, Al-Misned F, Iqbal Z. FbD directed fabrication and investigation of luliconazole based SLN gel for the amelioration of candidal vulvovaginitis: a 2 T (thermosensitive & transvaginal) approach. Saudi Journal of Biological Sciences. 2021;28(1):317 [Crossref]
16- Oliveira M, Aryasomayajula B, Pattni B, Mussi S, Ferreira L, Torchilin V. Solid lipid nanoparticles co-loaded with doxorubicin and α-tocopherol succinate are effective against drug-resistant cancer cells in monolayer and 3-D spheroid cancer cell models. International Journal of Pharmaceutics. 2016;512(1):292 [Crossref]
17- Mo K, Kim A, Choe S, Shin M, Yoon H. Overview of Solid Lipid Nanoparticles in Breast Cancer Therapy. Pharmaceutics. 2023;15(8):2065 [Crossref]
18- Vollrath M, Engert J, Winter G. Long-term release and stability of pharmaceutical proteins delivered from solid lipid implants. European Journal of Pharmaceutics and Biopharmaceutics. 2017;117:244 [Crossref]
19- Garg J, Pathania K, Sah S, Pawar S. Nanostructured lipid carriers: a promising drug carrier for targeting brain tumours. Futur J Pharm Sci. 2022;8(1) [Crossref]
20- Hawryłkiewicz A, Ptaszyńska N. Gemcitabine Peptide-Based Conjugates and Their Application in Targeted Tumor Therapy. Molecules. 2021;26(2):364 [Crossref]
21- Bibi M, Din F, Anwar Y, Alkenani N, Zari A, Mukhtiar M, Abu Zeid I, Althubaiti E, Nazish H, Zeb A, Ullah I, Khan G, Choi H. Cilostazol-loaded solid lipid nanoparticles: Bioavailability and safety evaluation in an animal model. Journal of Drug Delivery Science and Technology. 2022;74:103581 [Crossref]
22- Agrawal Y, Husain M, Patil K, Sodgir V, Patil T, Agnihotri V, Mahajan H, Sharma C, Ojha S, Goyal S. Verapamil hydrochloride loaded solid lipid nanoparticles: Preparation, optimization, characterisation, and assessment of cardioprotective effect in experimental model of myocardial infarcted rats. Biomedicine & Pharmacotherapy. 2022;154:113429 [Crossref]
23- Feng H, Zhu Y, Fu Z, Li D. Preparation, characterization, and in vivo study of rhein solid lipid nanoparticles for oral delivery. Chem Biol Drug Des. 2017;90(5):867 [Crossref]
24- Kesharwani P, Chadar R, Shukla R, Jain G, Aggarwal G, Abourehab M, Sahebkar A. Recent advances in multifunctional dendrimer-based nanoprobes for breast cancer theranostics. Journal of Biomaterials Science, Polymer Edition. 2022;33(18):2433 [Crossref]
25- Patel P, Agrawal Y. Targeting nanocarriers containing antisense oligonucleotides to cancer cell. Journal of Drug Delivery Science and Technology. 2017;37:97 [Crossref]
26- Bharti S, Anant P, Kumar A. Nanotechnology in stem cell research and therapy. J Nanopart Res. 2023;25(1) [Crossref]
27- Awasthi R, Singh A, Mishra G, Maurya A, Dhiman N, Kharkwal H, Sharma B, Jha N, Dureja H, Dua K, de Jesus Andreoli Pinto T, Kulkarni G. Diagnosis and Clinical Aspects of Lung Cancer: A Special Emphasis on Drug Targeting to Cancer Cells through Nanoparticles. LDDD. 2023;20(5):499 [Crossref]
28- Zoń A, Bednarek I. Cisplatin in Ovarian Cancer Treatment—Known Limitations in Therapy Force New Solutions. IJMS. 2023;24(8):7585 [Crossref]
29- Jesus J, Sousa I, da Silva T, Ferreira A, Laurenti M, Antonangelo L, Faria C, da Costa P, de Carvalho Ferreira D, Passero L. Preclinical Assessment of Ursolic Acid Loaded into Nanostructured Lipid Carriers in Experimental Visceral Leishmaniasis. Pharmaceutics. 2021;13(6):908 [Crossref]
30- Yang C, Alpini G, Glaser S, Merlin D. Lipid nanoparticles for oral delivery of nucleic acids for treating inflammatory bowel disease. Nanomedicine. 2022;17(21):1501 [Crossref]
31- Adeyemi S, Az-Zamakhshariy Z, Choonara Y. In Vitro Prototyping of a Nano-Organogel for Thermo-Sonic Intra-Cervical Delivery of 5-Fluorouracil-Loaded Solid Lipid Nanoparticles for Cervical Cancer. AAPS PharmSciTech. 2023;24(5) [Crossref]
32- Koyyada A, Orsu P. Natural gum polysaccharides as efficient tissue engineering and drug delivery biopolymers. Journal of Drug Delivery Science and Technology. 2021;63:102431 [Crossref]
33- Lotfallah A, Andreu J, Hathout R, Kassem D, Ibrahim S, Altava B, García-Verdugo E, Luis S. Tripodal amphiphilic pseudopeptidic nanovesicles as p-coumaric acid delivery systems for brain cancer cells. Materials Today Chemistry. 2023;27:101266 [Crossref]
34- Eroğlu C, Sinani G, Ulker Z. Current State of Lipid Nanoparticles (SLN and NLC) for Skin Applications. CPD. 2023;29(21):1632 [Crossref]
35- Soltani S, Rafiei A, Ramezani Z, Abbaspour M, Jelowdar A, Sagha Kahvaz M. Evaluation of the Hydatid Cyst Membrane Permeability of Albendazole and Albendazole Sulfoxide-Loaded Solid Lipid Nanoparticles. Jundishapur J Nat Pharm Prod. 2016;Inpress(Inpress) [Crossref]
36- Rafiei A, Soltani S, Ramezani Z, Abbaspour M, Jelowdar A, Kahvaz M. Ultrastructural changes on fertile and infertile hydatid cysts induced by conventional and solid lipid nanoparticles of albendazole and albendazole sulfoxide. Comp Clin Pathol. 2019;28(4):1045 [Crossref]
37- Qi C, Mohd Nordin U, Mahmood S, Karusan N, Khalid R, Nordin N, Fornaguera C, Ahmad N. Gout Management Using Nanocarrier Systems: A Review. ACS Appl Nano Mater. 2024; [Crossref]
38- Singh C, Rai P, Kumar M, Tiwari V, Tiwari A, Sharma A, Sharma K. Emphasis on Nanostructured Lipid Carriers in the Ocular Delivery of Antibiotics. PNT. 2024;12(2):126 [Crossref]
39- Abdellatif A, Alsowinea A. Approved and marketed nanoparticles for disease targeting and applications in COVID-19. 2021;10(1):1941 [Crossref]
40- Kumar Singh P, Gorain B, Choudhury H, Kumar Singh S, Whadwa P, Whadwa S, Sahu S, Gulati M, Kesharwani P. Macrophage targeted amphotericin B nanodelivery systems against visceral leishmaniasis. Materials Science and Engineering: B. 2020;258:114571 [Crossref]
41- Abedi-Gaballu F, Dehghan G, Ghaffari M, Yekta R, Abbaspour-Ravasjani S, Baradaran B, Ezzati Nazhad Dolatabadi J, Hamblin M. PAMAM dendrimers as efficient drug and gene delivery nanosystems for cancer therapy. Applied Materials Today. 2018;12:177 [Crossref]
42- Ghidini M, Silva S, Evangelista J, do Vale M, Farooqi A, Pinheiro M. Nanomedicine for the Delivery of RNA in Cancer. Cancers. 2022;14(11):2677 [Crossref]
43- Lu H, Zhang S, Wang J, Chen Q. A Review on Polymer and Lipid-Based Nanocarriers and Its Application to Nano-Pharmaceutical and Food-Based Systems. Front Nutr. 2021;8 [Crossref]
44- Minakshi P, Ghosh M, Brar B, Kumar R, Lambe U, Ranjan K, Manoj J, Prasad G. Nano-antimicrobials: A New Paradigm for Combating Mycobacterial Resistance. CPD. 2019;25(13):1554 [Crossref]
45- Paliwal R, Paliwal S, Kenwat R, Kurmi B, Sahu M. Solid lipid nanoparticles: a review on recent perspectives and patents. Expert Opinion on Therapeutic Patents. 2020;30(3):179 [Crossref]
46- Nemati E, Mokhtarzadeh A, Panahi-Azar V, Mohammadi A, Hamishehkar H, Mesgari-Abbasi M, Ezzati Nazhad Dolatabadi J, de la Guardia M. Ethambutol-Loaded Solid Lipid Nanoparticles as Dry Powder Inhalable Formulation for Tuberculosis Therapy. AAPS PharmSciTech. 2019;20(3) [Crossref]
47- Gautam M, Verma M, Chauhan I, Yasir M, Singh A, Saraswat P. Solid Lipid Nanoparticles for Oral Drug Delivery: A Review. CNANOM. 2020;10(3):208 [Crossref]
48- Akbari J, Saeedi M, Ahmadi F, Hashemi S, Babaei A, Yaddollahi S, Rostamkalaei S, Asare-Addo K, Nokhodchi A. Solid lipid nanoparticles and nanostructured lipid carriers: a review of the methods of manufacture and routes of administration. Pharmaceutical Development and Technology. 2022;27(5):525 [Crossref]
49- Hsu C, Wang P, Alalaiwe A, Lin Z, Fang J. Use of Lipid Nanocarriers to Improve Oral Delivery of Vitamins. Nutrients. 2019;11(1):68 [Crossref]
50- Ghanbarzadeh S, Hariri R, Kouhsoltani M, Shokri J, Javadzadeh Y, Hamishehkar H. Enhanced stability and dermal delivery of hydroquinone using solid lipid nanoparticles. Colloids and Surfaces B: Biointerfaces. 2015;136:1004 [Crossref]
51- Rajasekar K, Raja B. An investigation on heat and mass transfer characteristics during spray drying of saline water. Sādhanā. 2022;47(2) [Crossref]
52- Kim J, Baek J, Park J, Lee B, Kim M, Hwang S, Lee J, Cho C. Development of Houttuynia cordata Extract-Loaded Solid Lipid Nanoparticles for Oral Delivery: High Drug Loading Efficiency and Controlled Release. Molecules. 2017;22(12):2215 [Crossref]
53- Abedi E, Akhavan H, Mohammadi H, Banasaz S. Structure-based modifications of nano lipid carriers: Comparative review on release properties and anti-microbial activities of bioactive compounds. Food Control. 2024;159:110237 [Crossref]
54- Jahanfar F, Hasani A, Shanebandi D, Rahmati M, Hamishehkar H. Enhanced in Vitro Anti-Tumor Activity of 5-Azacytidine by Entrapment into Solid Lipid Nanoparticles. Adv Pharm Bull. 2016;6(3):367 [Crossref]
55- Al-Sayadi G, Verma A, Choudhary Y, Sandal P, Patel P, Singh D, Gupta G, Kurmi B. Solid Lipid Nanoparticles (SLNs): Advancements in Modification Strategies Toward Drug Delivery Vehicle. PNT. 2023;11(2):138 [Crossref]
56- Mohammad Rahimi H, Hesari Z, Mirsamadi E, Nemati S, Mirjalali H. Anti‐Toxoplasma gondii activity of rose hip oil–solid lipid nanoparticles. Food Science & Nutrition. 2024; [Crossref]
57- Magalhães M, Alvarez-Lorenzo C, Concheiro A, Figueiras A, Santos A, Veiga F. RNAi-based therapeutics for lung cancer: biomarkers, microRNAs, and nanocarriers. Expert Opinion on Drug Delivery. 2018;15(10):965 [Crossref]
58- Subroto E, Andoyo R, Indiarto R. Solid Lipid Nanoparticles: Review of the Current Research on Encapsulation and Delivery Systems for Active and Antioxidant Compounds. Antioxidants. 2023;12(3):633 [Crossref]
59- Goh W, Zou S, Ong W, Torta F, Alexandra A, Schiffelers R, Storm G, Wang J, Czarny B, Pastorin G. Bioinspired Cell-Derived Nanovesicles versus Exosomes as Drug Delivery Systems: a Cost-Effective Alternative. Sci Rep. 2017;7(1) [Crossref]
60- Mardhiah Adib Z, Ghanbarzadeh S, Kouhsoltani M, Yari Khosroshahi A, Hamishehkar H. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study. Adv Pharm Bull. 2016;6(1):31 [Crossref]
61- Ashkar A, Sosnik A, Davidovich-Pinhas M. Structured edible lipid-based particle systems for oral drug-delivery. Biotechnology Advances. 2022;54:107789 [Crossref]
62- Islan G, Durán M, Cacicedo M, Nakazato G, Kobayashi R, Martinez D, Castro G, Durán N. Nanopharmaceuticals as a solution to neglected diseases: Is it possible?. Acta Tropica. 2017;170:16 [Crossref]
63- Redruello P, Perazzoli G, Cepero A, Quiñonero F, Mesas C, Doello K, Láinez-Ramos-Bossini A, Rivera-Izquierdo M, Melguizo C, Prados J. Nanomedicine in Pancreatic Cancer: A New Hope for Treatment. CDT. 2020;21(15):1580 [Crossref]
64- Ortiz R, Cabeza L, Perazzoli G, Jimenez-Lopez J, García-Pinel B, Melguizo C, Prados J. Nanoformulations for glioblastoma multiforme: a new hope for treatment. Future Medicinal Chemistry. 2019;11(18):2461 [Crossref]
65- Yetisgin A, Cetinel S, Zuvin M, Kosar A, Kutlu O. Therapeutic Nanoparticles and Their Targeted Delivery Applications. Molecules. 2020;25(9):2193 [Crossref]
66- Mohammed H, Khan R, Singh V, Yusuf M, Akhtar N, Sulaiman G, Albukhaty S, Abdellatif A, Khan M, Mohammed S, Al-Subaiyel A. Solid lipid nanoparticles for targeted natural and synthetic drugs delivery in high-incidence cancers, and other diseases: Roles of preparation methods, lipid composition, transitional stability, and release profiles in nanocarriers’ development. 2023;12(1) [Crossref]
67- Edis Z, Wang J, Waqas M, Ijaz M, Ijaz M. Nanocarriers-Mediated Drug Delivery Systems for Anticancer Agents: An Overview and Perspectives. IJN. 2021;Volume 16:1313 [Crossref]
68- De K. Decapeptide Modified Doxorubicin Loaded Solid Lipid Nanoparticles as Targeted Drug Delivery System against Prostate Cancer. Langmuir. 2021;37(45):13194 [Crossref]
69- Wang K, Chi C, Hu Z, Liu M, Hui H, Shang W, Peng D, Zhang S, Ye J, Liu H, Tian J. Optical Molecular Imaging Frontiers in Oncology: The Pursuit of Accuracy and Sensitivity. Engineering. 2015;1(3):309 [Crossref]
70- Ezzati Nazhad Dolatabadi J, Omidi Y. Solid lipid-based nanocarriers as efficient targeted drug and gene delivery systems. TrAC Trends in Analytical Chemistry. 2016;77:100 [Crossref]
71- Ali A, Ali A, Warsi M, Ahmad W, Amir M, Abdi S. Formulation of lemongrass oil (Cymbopogon citratus)-loaded solid lipid nanoparticles: an in vitro assessment study. 3 Biotech. 2023;13(9) [Crossref]
72- Bakhtiary Z, Barar J, Aghanejad A, Saei A, Nemati E, Ezzati Nazhad Dolatabadi J, Omidi Y. Microparticles containing erlotinib-loaded solid lipid nanoparticles for treatment of non-small cell lung cancer. Drug Development and Industrial Pharmacy. 2017;43(8):1244 [Crossref]
73- Faria R, Boisguérin P, Sousa Â, Costa D. Delivery Systems for Mitochondrial Gene Therapy: A Review. Pharmaceutics. 2023;15(2):572 [Crossref]
74- S, Saka Dwipayanti K, Azhar M, Rahman L, Pakki E, Himawan A, Permana A. Enhanced skin localization of metronidazole using solid lipid microparticles incorporated into polymeric hydrogels for potential improved of rosacea treatment: An ex vivo proof of concept investigation. International Journal of Pharmaceutics. 2022;628:122327 [Crossref]
75- Ashique S, Garg A, Mishra N, Raina N, Ming L, Tulli H, Behl T, Rani R, Gupta M. Nano-mediated strategy for targeting and treatment of non-small cell lung cancer (NSCLC). Naunyn-Schmiedeberg's Arch Pharmacol. 2023;396(11):2769 [Crossref]
76- Zeeshan F, Tabbassum M, Jorgensen L, Medlicott N. Attenuated Total Reflection Fourier Transform Infrared (ATR FT-IR) Spectroscopy as an Analytical Method to Investigate the Secondary Structure of a Model Protein Embedded in Solid Lipid Matrices. Appl Spectrosc. 2018;72(2):268 [Crossref]
77- Rahimpour Y, Javadzadeh Y, Hamishehkar H. Solid lipid microparticles for enhanced dermal delivery of tetracycline HCl. Colloids and Surfaces B: Biointerfaces. 2016;145:14 [Crossref]
78- Pei J, Yan Y, Palanisamy C, Jayaraman S, Natarajan P, Umapathy V, Gopathy S, Roy J, Sadagopan J, Thalamati D, Mironescu M. Materials-based drug delivery approaches: Recent advances and future perspectives. 2024;13(1) [Crossref]
79- Lin H, Zheng D, Li Y, Wang N, Chen S, Fu Y, Xu W, Wei C. Incorporation of VSV-G produces fusogenic plasma membrane vesicles capable of efficient transfer of bioactive macromolecules and mitochondria. Biomed Microdevices. 2016;18(3) [Crossref]
80- Motawea A, Borg T, Abd El-Gawad A. Topical phenytoin nanostructured lipid carriers: design and development. Drug Development and Industrial Pharmacy. 2018;44(1):144 [Crossref]
81- Shanta Taher S, Sadeq Z, Al-Kinani K, Alwan Z. SOLID LIPID NANOPARTICLES AS A PROMISING APPROACH FOR DELIVERY OF ANTICANCER AGENTS: REVIEW ARTICLE. MMSL. 2022;91(3):197 [Crossref]
82- Vasam M, Goulikar R. Approaches for designing and delivering solid lipid nanoparticles of distinct antitubercular drugs. Journal of Biomaterials Science, Polymer Edition. 2023;34(6):828 [Crossref]
83- Lin C, Chen C, Lin Z, Fang J. Recent advances in oral delivery of drugs and bioactive natural products using solid lipid nanoparticles as the carriers. Journal of Food and Drug Analysis. 2017;25(2):219 [Crossref]
84- Chang L, Hu J, Chen F, Chen Z, Shi J, Yang Z, Li Y, Lee L. Nanoscale bio-platforms for living cell interrogation: current status and future perspectives. Nanoscale. 2016;8(6):3181 [Crossref]
85- Tabbassum M, Zeeshan F. Effects of formulation development methods on the stability of model protein pharmaceuticals embedded in solid lipid matrices. Pharmaceutical Development and Technology. 2019;24(5):649 [Crossref]
86- Motawea A, Abd El-Gawad A, Borg T, Motawea M, Tarshoby M. The impact of topical phenytoin loaded nanostructured lipid carriers in diabetic foot ulceration. The Foot. 2019;40:14 [Crossref]
87- Akbari A, Akbarzadeh A, Rafiee Tehrani M, Ahangari Cohan R, Chiani M, Mehrabi M. Development and Characterization of Nanoliposomal Hydroxyurea Against BT-474 Breast Cancer Cells. Adv Pharm Bull. 2019;10(1):39 [Crossref]
88- Yang J, Ciftci O. Formation of hollow solid lipid micro- and nanoparticles using supercritical carbon dioxide. Food and Bioproducts Processing. 2016;98:151 [Crossref]