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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2018;8(2): 341-346. doi: 10.15171/apb.2018.039
PMID: 30023336        PMCID: PMC6046424

Short Communication

Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive

Yousef Sohrabi 1,2,3, Hossein Mohammadzadeh-Aghdash 1,2,3, Elham Baghbani 1, Parvin Dehghan 2 * , Jafar Ezzati Nazhad Dolatabadi 4 *

Cited by CrossRef: 20

1- Mohammadzadeh-Aghdash H, Akbari N, Esazadeh K, Ezzati Nazhad Dolatabadi J. Molecular and technical aspects on the interaction of serum albumin with multifunctional food preservatives. Food Chemistry. 2019;293:491 [Crossref]
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3- Avuloglu-Yilmaz E, Yuzbasioglu D, Unal F. In vitro genotoxicity assessment of monopotassium glutamate and magnesium diglutamate. Toxicology in Vitro. 2020;65:104780 [Crossref]
4- Imran M, Titilayo B, Adil M, Adil L, Mehmood Q, Mustafa S, Shen Q. Ascorbyl palmitate: A comprehensive review on its characteristics, synthesis, encapsulation and applications. Process Biochemistry. 2024;142:68 [Crossref]
5- Khezerlou A, Akhlaghi A, Alizadeh A, Dehghan P, Maleki P. Alarming impact of the excessive use of tert-butylhydroquinone in food products: A narrative review. Toxicology Reports. 2022;9:1066 [Crossref]
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7- Zhao Y, Li B, Li C, Xu Y, Luo Y, Liang D, Huang C. Comprehensive Review of Polysaccharide-Based Materials in Edible Packaging: A Sustainable Approach. Foods. 2021;10(8):1845 [Crossref]
8- Favarin F, Forrati É, Bassoto V, da Silva Gündel S, Velho M, Ledur C, Verdi C, Lemos J, Sagrillo M, Fagan S, Gündel A, Copetti M, Santos R, de Oliveira Fogaça A, Ourique A. Ascorbic acid and ascorbyl palmitate-loaded liposomes: Development, characterization, stability evaluation, in vitro security profile, antimicrobial and antioxidant activities. Food Chemistry. 2024;460:140569 [Crossref]
9- Barreto M, Aleixo N, Silvestre R, Fregonezi N, Barud H, Dias D, Ribeiro C, Resende F. Genotoxicological safety assessment of puree‐only edible films from onion bulb (Allium cepa L.) for use in food packaging‐related applications. Journal of Food Science. 2020;85(1):201 [Crossref]
10- Sharawi Z. Therapeutic effect of Arthrocnemum machrostachyum methanolic extract on Ehrlich solid tumor in mice. BMC Complement Med Ther. 2020;20(1) [Crossref]
11- El-Far M, Essam A, El-Senduny F, El-Azim A, Yahia S, El-Sherbiny I. Novel highly effective combination of naturally-derived quercetin and ascorbyl palmitate and their nanoformulations as an advancement therapy of cancer. Journal of Drug Delivery Science and Technology. 2023;83:104405 [Crossref]
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14- Nazarparvar-Noshadi M, Ezzati Nazhad Dolatabadi J, Rasoulzadeh Y, Mohammadian Y, Shanehbandi D. Apoptosis and DNA damage induced by silica nanoparticles and formaldehyde in human lung epithelial cells. Environ Sci Pollut Res. 2020;27(15):18592 [Crossref]
15- El-Far M, Essam A, El-Senduny F, Abd El-Azim A, Yahia S, El-Sherbiny I. Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms. Journal of Drug Delivery Science and Technology. 2022;78:103920 [Crossref]
16- Younes M, Aquilina G, Castle L, Engel K, Fowler P, Frutos Fernandez M, Fürst P, Gürtler R, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens‐Berendsen I, Wölfle D, Wright M, Dusemund B, Mortensen A, Turck D, Barmaz S, Smeraldi C, Tard A, Vianello G, Rincon A, Gundert‐Remy U. Opinion on the re‐evaluation of ascorbyl palmitate (E 304i) as a food additive in foods for infants below 16 weeks of age and the follow‐up of its re‐evaluation as a food additive for uses in foods for all population groups. EFS2. 2020;18(6) [Crossref]
17- Karimi Z, Ghaffari M, Ezzati Nazhad Dolatabadi J, Dehghan P. The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells. 2019;8(6):1050 [Crossref]
18- Bohr A, Nascimento T, Harmankaya N, Antonino R, Beck-Broichsitter M. Antioxidant-mediated control of degradation and drug release from surface-eroding poly(ethylene carbonate). Acta Biomaterialia. 2020;113:210 [Crossref]
19- Behera S, Khan G, Singh S, Jena B, Sashank K, Patnaik S, Kumar R, Jeon B, Chakrabortty S, Tripathy S, Mishra A. Antibacterial Efficacy of ZnO/Bentonite (Clay) Nanocomposites against Multidrug-Resistant Escherichia coli. ACS Omega. 2024;9(2):2783 [Crossref]
20- You H, Ryu S, Lee H, Baek J. Enhanced antibacterial activity of multi-walled carbon nanotubes loaded with hot-melt extruded Mulberry leaf silver nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2024;699:134522 [Crossref]