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Adv Pharm Bull. 2018;8(2): 341-346. doi: 10.15171/apb.2018.039
PMID: 30023336        PMCID: PMC6046424

Short Communication

Cytotoxicity and Genotoxicity Assessment of Ascorbyl Palmitate (AP) Food Additive

Yousef Sohrabi 1,2,3, Hossein Mohammadzadeh-Aghdash 1,2,3, Elham Baghbani 1, Parvin Dehghan 2 * , Jafar Ezzati Nazhad Dolatabadi 4 *

Cited by CrossRef: 15


1- Mohammadzadeh-Aghdash H, Akbari N, Esazadeh K, Ezzati Nazhad Dolatabadi J. Molecular and technical aspects on the interaction of serum albumin with multifunctional food preservatives. Food Chemistry. 2019;293:491 [Crossref]
2- Avuloglu-Yilmaz E, Yuzbasioglu D, Unal F. In vitro genotoxicity assessment of monopotassium glutamate and magnesium diglutamate. Toxicology in Vitro. 2020;65:104780 [Crossref]
3- Khezerlou A, Akhlaghi A, Alizadeh A, Dehghan P, Maleki P. Alarming impact of the excessive use of tert-butylhydroquinone in food products: A narrative review. Toxicology Reports. 2022;9:1066 [Crossref]
4- Eskandani M, Derakhshankhah H, Jahanban-Esfahlan R, Jaymand M. Folate-conjugated pH- and redox-responsive magnetic hydrogel based on tragacanth gum for “smart” chemo/hyperthermia treatment of cancerous cells. Journal of Drug Delivery Science and Technology. 2023;84:104449 [Crossref]
5- Zhao Y, Li B, Li C, Xu Y, Luo Y, Liang D, Huang C. Comprehensive Review of Polysaccharide-Based Materials in Edible Packaging: A Sustainable Approach. Foods. 2021;10(8):1845 [Crossref]
6- Barreto M, Aleixo N, Silvestre R, Fregonezi N, Barud H, Dias D, Ribeiro C, Resende F. Genotoxicological safety assessment of puree‐only edible films from onion bulb (Allium cepa L.) for use in food packaging‐related applications. Journal of Food Science. 2020;85(1):201 [Crossref]
7- Sharawi Z. Therapeutic effect of Arthrocnemum machrostachyum methanolic extract on Ehrlich solid tumor in mice. BMC Complement Med Ther. 2020;20(1) [Crossref]
8- El-Far M, Essam A, El-Senduny F, El-Azim A, Yahia S, El-Sherbiny I. Novel highly effective combination of naturally-derived quercetin and ascorbyl palmitate and their nanoformulations as an advancement therapy of cancer. Journal of Drug Delivery Science and Technology. 2023;83:104405 [Crossref]
9- Kim H, Ryu S, Baek J. The Effect of Hot-Melt Extrusion of Mulberry Leaf on the Number of Active Compounds and Antioxidant Activity. Plants. 2022;11(22):3019 [Crossref]
10- Javaheri-Ghezeldizaj F, Ghaffari M, Nazhad Dolatabadi J, Dehghan P. In vitro safety assessment of alkyl lactate esters in human umbilical vein endothelial cells (HUVECs). Toxicology Reports. 2023;10:11 [Crossref]
11- Nazarparvar-Noshadi M, Ezzati Nazhad Dolatabadi J, Rasoulzadeh Y, Mohammadian Y, Shanehbandi D. Apoptosis and DNA damage induced by silica nanoparticles and formaldehyde in human lung epithelial cells. Environ Sci Pollut Res. 2020;27(15):18592 [Crossref]
12- El-Far M, Essam A, El-Senduny F, Abd El-Azim A, Yahia S, El-Sherbiny I. Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms. Journal of Drug Delivery Science and Technology. 2022;78:103920 [Crossref]
13- Younes M, Aquilina G, Castle L, Engel K, Fowler P, Frutos Fernandez M, Fürst P, Gürtler R, Husøy T, Manco M, Mennes W, Moldeus P, Passamonti S, Shah R, Waalkens‐Berendsen I, Wölfle D, Wright M, Dusemund B, Mortensen A, Turck D, Barmaz S, Smeraldi C, Tard A, Vianello G, Rincon A, Gundert‐Remy U. Opinion on the re‐evaluation of ascorbyl palmitate (E 304i) as a food additive in foods for infants below 16 weeks of age and the follow‐up of its re‐evaluation as a food additive for uses in foods for all population groups. EFS2. 2020;18(6) [Crossref]
14- Karimi Z, Ghaffari M, Ezzati Nazhad Dolatabadi J, Dehghan P. The protective effect of thymoquinone on tert-butylhydroquinone induced cytotoxicity in human umbilical vein endothelial cells. 2019;8(6):1050 [Crossref]
15- Bohr A, Nascimento T, Harmankaya N, Antonino R, Beck-Broichsitter M. Antioxidant-mediated control of degradation and drug release from surface-eroding poly(ethylene carbonate). Acta Biomaterialia. 2020;113:210 [Crossref]
16- Behera S, Khan G, Singh S, Jena B, Sashank K, Patnaik S, Kumar R, Jeon B, Chakrabortty S, Tripathy S, Mishra A. Antibacterial Efficacy of ZnO/Bentonite (Clay) Nanocomposites against Multidrug-Resistant Escherichia coli. ACS Omega. 2024;9(2):2783 [Crossref]