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Adv Pharm Bull. 2018;8(1): 39-47. doi: 10.15171/apb.2018.005
PMID: 29670837        PMCID: PMC5896394

Research Article

Assessing the Effect of High Performance Inulin Supplementation via KLF5 mRNA Expression in Adults with Type 2 Diabetes: A Randomized Placebo Controlled Clinical Trail

Abed Ghavami 1, Neda Roshanravan 2, Shahriar Alipour 3, Meisam Barati 4, Behzad Mansoori 5, Faezeh Ghalichi 1, Elyas Nattagh- Eshtivan 1, Alireza Ostadrahimi 6 *

Cited by CrossRef: 24


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7- Faghihimani Z, Namazi N, Ghaffari S, Rezaei Kelishadi M, Sharifi S, Nattagh-Eshtivani E, Akbarzadeh M, Moravejolahkami A, Khorvash F, Roshanravan N, Alamdari N. Effects of Inulin Type-Carbohydrates on blood pressure: a systematic review and meta-analysis. International Journal of Food Properties. 2021;24(1):129 [Crossref]
8- Chakraborty P, Gamage H, Laird A. Butyrate as a potential therapeutic agent for neurodegenerative disorders. Neurochemistry International. 2024;176:105745 [Crossref]
9- Ghaffari S, Roshanravan N. The role of nutraceuticals in prevention and treatment of hypertension: An updated review of the literature. Food Research International. 2020;128:108749 [Crossref]
10- Wang L, Yang H, Huang H, Zhang C, Zuo H, Xu P, Niu Y, Wu S. Inulin-type fructans supplementation improves glycemic control for the prediabetes and type 2 diabetes populations: results from a GRADE-assessed systematic review and dose–response meta-analysis of 33 randomized controlled trials. J Transl Med. 2019;17(1) [Crossref]
11- Jayedi A, Aletaha A, Zeraattalab-Motlagh S, Shahinfar H, Mohammadpour S, Mirrafiei A, Jibril A, Soltani A, Shab-Bidar S. Comparative efficacy and safety of probiotics, prebiotics, and synbiotics for type 2 diabetes management: A systematic review and network meta-analysis. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2024;18(1):102923 [Crossref]
12- Mitchell C, Davy B, Ponder M, McMillan R, Hughes M, Hulver M, Neilson A, Davy K. Prebiotic Inulin Supplementation and Peripheral Insulin Sensitivity in adults at Elevated Risk for Type 2 Diabetes: A Pilot Randomized Controlled Trial. Nutrients. 2021;13(9):3235 [Crossref]
13- Juhász A, Greff D, Teutsch B, Gede N, Hegyi P, Horváth E, Deák P, Nyirády P, Ács N, Juhász R. Galactomannans are the most effective soluble dietary fibers in type 2 diabetes: a systematic review and network meta-analysis. The American Journal of Clinical Nutrition. 2023;117(2):266 [Crossref]
14- Thibonnier M, Ghosh S, Blanchard A. Effects of a short‐term cold exposure on circulating microRNAs and metabolic parameters in healthy adult subjects. J Cellular Molecular Medi. 2022;26(2):548 [Crossref]
15- Farrim M, Gomes A, Milenkovic D, Menezes R. Gene expression analysis reveals diabetes-related gene signatures. Hum Genomics. 2024;18(1) [Crossref]
16- Wang X, Yan C, Liu J. Hyperinsulinemia-induced KLF5 mediates endothelial angiogenic dysfunction in diabetic endothelial cells. J Mol Hist. 2019;50(3):239 [Crossref]
17- Manning P, Munasinghe P, Bellae Papannarao J, Gray A, Sutherland W, Katare R. Acute Weight Loss Restores Dysregulated Circulating MicroRNAs in Individuals Who Are Obese. 2019;104(4):1239 [Crossref]
18- Xie Y, Gou L, Peng M, Zheng J, Chen L. Effects of soluble fiber supplementation on glycemic control in adults with type 2 diabetes mellitus: A systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition. 2021;40(4):1800 [Crossref]
19- Li J, Liu L, Zhou W, Cai L, Xu Z, Rane M. Roles of Krüppel‐like factor 5 in kidney disease. J Cellular Molecular Medi. 2021;25(5):2342 [Crossref]
20- Tawfick M, Xie H, Zhao C, Shao P, Farag M. Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics. International Journal of Biological Macromolecules. 2022;208:948 [Crossref]
21- Musazadeh V, Roshanravan N, Dehghan P, Ahrabi S. Effect of Probiotics on Liver Enzymes in Patients With Non-alcoholic Fatty Liver Disease: An Umbrella of Systematic Review and Meta-Analysis. Front Nutr. 2022;9 [Crossref]
22- Javanshir E, Ebrahimi Z, Mirzohreh S, Ghaffari S, Banisefid E, Alamdari N, Roshanravan N. Disparity of gene expression in coronary artery disease: insights from MEIS1, HIRA, and Myocardin. Mol Biol Rep. 2024;51(1) [Crossref]
23- Roshanravan N, Askari S, Fazelian S, Ayati M, Namazi N. The roles of quercetin in diabetes mellitus and related metabolic disorders; special focus on the modulation of gut microbiota: A comprehensive review. Critical Reviews in Food Science and Nutrition. 2023;63(17):2990 [Crossref]
24- Chen S, Peng D, Shan Y, Liu F, Du R, Bao Y, Yu H, Tu Y. Black Tea drinks with inulin and dextrin reduced postprandial plasma glucose fluctuations in patients with type 2 diabetes: an acute, randomized, placebo-controlled, single-blind crossover study. Nutr Diabetes. 2024;14(1) [Crossref]