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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2018;8(4): 591-597. doi: 10.15171/apb.2018.067
PMID: 30607331        PMCID: PMC6311650

Mini Review

The Impact of CRISPR-Cas System on Antiviral Therapy

Hadi Bayat 1,2 ORCID, Fatemeh Naderi 3 ORCID, Amjad Hayat Khan 4 ORCID, Arash Memarnejadian 5 ORCID, Azam Rahimpour 1 * ORCID

Cited by CrossRef: 25

1- Vilela J, Rohaim M, Munir M. Application of CRISPR/Cas9 in Understanding Avian Viruses and Developing Poultry Vaccines. Front Cell Infect Microbiol. 2020;10 [Crossref]
2- Mohanty B, Ahmad Mir R, Priyadarshini A, Ahmad Bhat K, Barati S, Roshani Asl E, Choi J, Rasmi Y. Potential use of CRISPR/Cas13 system for vaccine development against various RNA-viral infections . Future Virology. 2024;19(10-11):401 [Crossref]
3- Bhattacharjee G, Gohil N, Khambhati K, Murjani K, Chu D, Le Bui N, Thi H, Mani I, Bansal A, Shamili S, Satish L, Ramakrishna S, Alzahrani K, Singh V. Advancements in CRISPR–Cas Systems for Genome Editing towards Eradication of Human Microbial Pathogens. Mol Biotechnol. 2025; [Crossref]
4- Karimian A, Gorjizadeh N, Alemi F, Asemi Z, Azizian K, Soleimanpour J, Malakouti F, Targhazeh N, Majidinia M, Yousefi B. CRISPR/Cas9 novel therapeutic road for the treatment of neurodegenerative diseases. Life Sciences. 2020;259:118165 [Crossref]
5- Siegrist C, Kinahan S, Settecerri T, Greene A, Santarpia J. CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector. Sci Rep. 2020;10(1) [Crossref]
6- DEMİREL S, USTA M, DEMİREL F. Fitopatojenlere Karşı Dayanıklılıkta CRISPR/Cas Teknolojisi. 2020; [Crossref]
7- Şeflek Z, Hasöksüz M. CRISPR-cas technology and use in antiviral development. J Ist Vet Sci. 2024;8(2):195 [Crossref]
8- Najafi S, Tan S, Aghamiri S, Raee P, Ebrahimi Z, Jahromi Z, Rahmati Y, Sadri Nahand J, Piroozmand A, Jajarmi V, Mirzaei H. Therapeutic potentials of CRISPR-Cas genome editing technology in human viral infections. Biomedicine & Pharmacotherapy. 2022;148:112743 [Crossref]
9- Xu Y, Li Z. CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy. Computational and Structural Biotechnology Journal. 2020;18:2401 [Crossref]
10- Nouri F, Alibabaei F, Forouzanmehr B, Tahmasebi H, Oksenych V, Eslami M. Progress in CRISPR Technology for Antiviral Treatments: Genome Editing as a Potential Cure for Chronic Viral Infections. Microbiology Research. 2025;16(5):104 [Crossref]
11- Zahedipour F, Zahedipour F, Zamani P, Jaafari M, Sahebkar A. Harnessing CRISPR technology for viral therapeutics and vaccines: from preclinical studies to clinical applications. Virus Research. 2024;341:199314 [Crossref]
12- Gupta R, Kazi T, Dey D, Ghosh A, Ravichandiran V, Swarnakar S, Roy S, Biswas S, Ghosh D. CRISPR detectives against SARS-CoV-2: a major setback against COVID-19 blowout. Appl Microbiol Biotechnol. 2021;105(20):7593 [Crossref]
13- Bellizzi A, Ahye N, Jalagadugula G, Wollebo H. A Broad Application of CRISPR Cas9 in Infectious Diseases of Central Nervous System. J Neuroimmune Pharmacol. 2019;14(4):578 [Crossref]
14- Bayat H, Mirahmadi M, Azarshin Z, Ohadi H, Delbari A, Ohadi M. CRISPR/Cas9-mediated deletion of a GA-repeat in human GPM6B leads to disruption of neural cell differentiation from NT2 cells. Sci Rep. 2024;14(1) [Crossref]
15- Hasanzadeh A, Alamdaran M, Ahmadi S, Nourizadeh H, Bagherzadeh M, Mofazzal Jahromi M, Simon P, Karimi M, Hamblin M. Nanotechnology against COVID-19: Immunization, diagnostic and therapeutic studies. Journal of Controlled Release. 2021;336:354 [Crossref]
16- Shams F, Bayat H, Mohammadian O, Mahboudi S, Vahidnezhad H, Soosanabadi M, Rahimpour A. Advance trends in targeting homology-directed repair for accurate gene editing: An inclusive review of small molecules and modified CRISPR-Cas9 systems. Bioimpacts. 2022;12(4):371 [Crossref]
17- Panda K, Alagarasu K, Parashar D. Oligonucleotide-Based Approaches to Inhibit Dengue Virus Replication. Molecules. 2021;26(4):956 [Crossref]
18- Souri M, Chiani M, Farhangi A, Mehrabi M, Nourouzian D, Raahemifar K, Soltani M. Anti-COVID-19 Nanomaterials: Directions to Improve Prevention, Diagnosis, and Treatment. Nanomaterials. 2022;12(5):783 [Crossref]
19- Khurana A, Sayed N, Singh V, Khurana I, Allawadhi P, Rawat P, Navik U, Pasumarthi S, Bharani K, Weiskirchen R. A comprehensive overview of CRISPR/Cas 9 technology and application thereof in drug discovery. J of Cellular Biochemistry. 2022;123(10):1674 [Crossref]
20- Ullah A, Khan M, Akram M, Abdullah M, Abdullah S, Iqbal I, Siddique F, Arain M, Hassan F, Shafi M. CRISPR Cas-9 for treatment and control of Avian viral diseases: challenges and opportunities. World's Poultry Science Journal. 2024;80(3):745 [Crossref]
21- Kumar P, Malik Y, Ganesh B, Rahangdale S, Saurabh S, Natesan S, Srivastava A, Sharun K, Yatoo M, Tiwari R, Singh R, Dhama K. CRISPR-Cas System: An Approach With Potentials for COVID-19 Diagnosis and Therapeutics. Front Cell Infect Microbiol. 2020;10 [Crossref]
22- Le T, Paris C, Khan K, Robson F, Ng W, Rocchi P. Nucleic Acid-Based Technologies Targeting Coronaviruses. Trends in Biochemical Sciences. 2021;46(5):351 [Crossref]
23- Lou J, Wang B, Li J, Ni P, Jin Y, Chen S, Xi Y, Zhang R, Duan G. The CRISPR-Cas system as a tool for diagnosing and treating infectious diseases. Mol Biol Rep. 2022;49(12):11301 [Crossref]
24- Abdeldayem O, Dabbish A, Habashy M, Mostafa M, Elhefnawy M, Amin L, Al-Sakkari E, Ragab A, Rene E. Viral outbreaks detection and surveillance using wastewater-based epidemiology, viral air sampling, and machine learning techniques: A comprehensive review and outlook. Science of The Total Environment. 2022;803:149834 [Crossref]
25- Dehshahri A, Biagioni A, Bayat H, Lee E, Hashemabadi M, Fekri H, Zarrabi A, Mohammadinejad R, Kumar A. Editing SOX Genes by CRISPR-Cas: Current Insights and Future Perspectives. IJMS. 2021;22(21):11321 [Crossref]
26- Kim J, Koo B, Yoon K. Modeling Host-Virus Interactions in Viral Infectious Diseases Using Stem-Cell-Derived Systems and CRISPR/Cas9 Technology. Viruses. 2019;11(2):124 [Crossref]