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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2018;8(2): 319-329. doi: 10.15171/apb.2018.037
PMID: 30023334        PMCID: PMC6046419

Research Article

Combination of Vildagliptin and Ischemic Postconditioning in Diabetic Hearts as a Working Strategy to Reduce Myocardial Reperfusion Injury by Restoring Mitochondrial Function and Autophagic Activity

Goltaj Bayrami 1, Alireza Alihemmati 1, Pouran Karimi 2, Aniseh Javadi 3,4, Rana Keyhanmanesh 1,5, Mustafa Mohammadi 1, Milad Zadi-Heydarabad 4, Reza Badalzadeh 1,5,6 *

Cited by CrossRef: 25

1- Mokhtari B, Abdoli-Shadbad M, Alihemmati A, Javadi A, Badalzadeh R. Alpha-lipoic acid preconditioning plus ischemic postconditioning provides additional protection against myocardial reperfusion injury of diabetic rats: modulation of autophagy and mitochondrial function. Mol Biol Rep. 2022;49(3):1773 [Crossref]
2- Awad M, El-Gohary R, Ibrahim S, Abdel Ghafar M, Farghal E, Aboalsoud A, El-Shaer R. Potential mitigating impact of a dipeptidyl peptidase-IV inhibitor, vildagliptin, on oxazolone-induced ulcerative colitis: Targeting the role of PI3K/AKT/mTOR and AMPK/Nrf2 signaling pathways. International Immunopharmacology. 2024;133:112110 [Crossref]
3- Yin Q, Ni Q, Wang Y, Zhang H, Li W, Nie A, Wang S, Gu Y, Wang Q, Ning G. Raptor determines β-cell identity and plasticity independent of hyperglycemia in mice. Nat Commun. 2020;11(1) [Crossref]
4- Lin J, Ren Q, Zhang F, Gui J, Xiang X, Wan Q. D-β-Hydroxybutyrate Dehydrogenase Mitigates Diabetes-Induced Atherosclerosis through the Activation of Nrf2. Thromb Haemost. 2023;123(10):1003 [Crossref]
5- Mokhtari B, Delkhah M, Badalzadeh R, Ghaffari S. Mitochondrial transplantation combined with mitoquinone and melatonin: A survival strategy against myocardial reperfusion injury in aged rats. Experimental Physiology. 2025; [Crossref]
6- Hosseini L, Vafaee M, Mahmoudi J, Badalzadeh R. Nicotinamide adenine dinucleotide emerges as a therapeutic target in aging and ischemic conditions. Biogerontology. 2019;20(4):381 [Crossref]
7- Yang L, Xie P, Wu J, Yu J, Li X, Ma H, Yu T, Wang H, Ye J, Wang J, Zheng H. Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats. Front Pharmacol. 2020;11 [Crossref]
8- Yaribeygi H, Maleki M, Santos R, Jamialahmadi T, Sahebkar A. Glp-1 Mimetics and Autophagy in Diabetic Milieu: State-of-the-Art. CDR. 2024;20(10) [Crossref]
9- Deng R, Zhou J. Targeting NF-κB in Hepatic Ischemia–Reperfusion Alleviation: from Signaling Networks to Therapeutic Targeting. Mol Neurobiol. 2024;61(6):3409 [Crossref]
10- Amin S, Sakr H, El Gazzar W, Shaltout S, Ghaith H, Elberry D. Combined saline and vildagliptin induced M2 macrophage polarization in hepatic injury induced by acute kidney injury. 2023;11:e14724 [Crossref]
11- Nagy-Grócz G, Spekker E, Vécsei L. Kynurenines, Neuronal Excitotoxicity, and Mitochondrial Oxidative Stress: Role of the Intestinal Flora. IJMS. 2024;25(3):1698 [Crossref]
12- FAN X, YANG Y, QI L. Vildagliptin protects hypoxia/reoxygenation-induced injury of cardiac microvascular endothelial cells. Minerva Med. 2023;114(2) [Crossref]
13- Anna Z, Joanna K, Sara Z, Jan M, Paula K, Izabela S, Robert Ł, Małgorzata Ż, Mateusz M. N-acetylcysteine supplementation did not reverse mitochondrial oxidative stress, apoptosis, and inflammation in the salivary glands of hyperglycemic rats. Nutr Diabetes. 2021;11(1) [Crossref]
14- Sherif I, Al-Shaalan N, Muriel P. Vildagliptin Attenuates Hepatic Ischemia/Reperfusion Injury via the TLR4/NF‐κB Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2018;2018(1) [Crossref]
15- Yang Q, Ai W, Nie L, Yan C, Wu S. Vildagliptin reduces myocardial ischemia-induced arrhythmogenesis via modulating inflammatory responses and promoting expression of genes regulating mitochondrial biogenesis in rats with type-II diabetes. J Interv Card Electrophysiol. 2020;59(3):517 [Crossref]
16- Zakaria E, Tawfeek W, Hassanin M, Hassaballah M. Cardiovascular protection by DPP-4 inhibitors in preclinical studies: an updated review of molecular mechanisms. Naunyn-Schmiedeberg's Arch Pharmacol. 2022;395(11):1357 [Crossref]
17- Bafadam S, Mokhtari B, Vafaee M, Oscuyi Z, Nemati S, Badalzadeh R. Mitochondrial transplantation combined with coenzyme Q10 induces cardioprotection and mitochondrial improvement in aged male rats with reperfusion injury. Experimental Physiology. 2024; [Crossref]
18- Li S, Wang M, Ke W, Wang M. Naringenin alleviates myocardial ischemia reperfusion injury by enhancing the myocardial miR-126-PI3K/AKT axis in streptozotocin-induced diabetic rats. Exp Ther Med. 2021;22(2) [Crossref]
19- Ashrafizadeh M, Yaribeygi H, Atkin S, Sahebkar A. Effects of newly introduced antidiabetic drugs on autophagy. Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 2019;13(4):2445 [Crossref]
20- Macho González A, Martínez Sesmero J, Sánchez-Muniz F. Autophagy, a relevant process for metabolic health and type-2 diabetes. Nutr Hosp. 2023; [Crossref]
21- Gholami S, Mokhtari B, Badalzadeh R. Alpha-lipoic acid potentiates the anti-arrhythmic effects of ischemic postconditioning in the setting of cardiac ischemia/reperfusion injury in diabetic rats. J Diabetes Metab Disord. 2022;21(1):707 [Crossref]
22- Yuan T, Yang T, Chen H, Fu D, Hu Y, Wang J, Yuan Q, Yu H, Xu W, Xie X. New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis. Redox Biology. 2019;20:247 [Crossref]
23- Mokhtari B, Badalzadeh R. Mitochondria-targeted combination treatment strategy counteracts myocardial reperfusion injury of aged rats by modulating autophagy and inflammatory response. Mol Biol Rep. 2023;50(5):3973 [Crossref]
24- Sherif I, Alshaalan A, Al-Shaalan N. Renoprotective effect of vildagliptin following hepatic ischemia/reperfusion injury. Renal Failure. 2020;42(1):208 [Crossref]
25- Sherif I, Al-Shaalan N. Alleviation of remote lung injury following liver ischemia/reperfusion: Possible protective role of vildagliptin. International Immunopharmacology. 2021;91:107305 [Crossref]
26- Yao E, Luo L, Lin C, Wen J, Li Y, Ren T, Chen Y, Huang J, Jin X. OEA alleviates apoptosis in diabetic rats with myocardial ischemia/reperfusion injury by regulating the PI3K/Akt signaling pathway through activation of TRPV1. Front Pharmacol. 2022;13 [Crossref]