Astaxanthin-Rich Haematococcus pluvialis Algal Hepatic Modulation in D-Galactose-Induced Aging in Rats: Role of Nrf2

Farouk Kamel El-Baz ¹ , Rehab Ali Hussein ² , Gehad Abdel Raheem Abdel Jaleel ³ , Dalia Osama Saleh ³ *

Cited by CrossRef: 15

1- El-Baz F, Saleh D, Abdel Jaleel G, Hussein R. Attenuation of Age-Related Hepatic Steatosis by Dunaliella salina Microalgae in Senescence Rats through the Regulation of Redox Status, Inflammatory Indices, and Apoptotic Biomarkers. Advances in Pharmacological and Pharmaceutical Sciences. 2020;2020:1 [Crossref]

2- Chen Z, Xiao J, Liu H, Yao K, Hou X, Cao Y, Liu X. Astaxanthin attenuates oxidative stress and immune impairment in d-galactose-induced aging in rats by activating the Nrf2/Keap1 pathway and suppressing the NF-κB pathway. Food Funct. 2020;11(9):8099 [Crossref]

3- Kanwugu O, Glukhareva T. Activation of Nrf2 pathway as a protective mechanism against oxidative stress-induced diseases: Potential of astaxanthin. Archives of Biochemistry and Biophysics. 2023;741:109601 [Crossref]

4- Saleh D, Mansour D, Hashad I, Bakeer R. Effects of sulforaphane on D-galactose-induced liver aging in rats: Role of keap-1/nrf-2 pathway.. European Journal of Pharmacology. 2019;855:40 [Crossref]

5- Ross K, Smith C. d-galactose: a model of accelerated ageing sufficiently sensitive to reflect preventative efficacy of an antioxidant treatment. Biogerontology. 2020;21(6):745 [Crossref]

6- El-Baz F, Saleh D, Abdel Jaleel G, Hussein R, Hassan A. Heamatococcus pluvialis ameliorates bone loss in experimentally-induced osteoporosis in rats via the regulation of OPG/RANKL pathway. Biomedicine & Pharmacotherapy. 2019;116:109017 [Crossref]

7- Lykov A, Uvarov I, Gevorgiz R, Zheleznova S. Effect of extracts from microalgae on cytokine levels in female C57Bl6 mice. Med immunol. 2023;25(1):81 [Crossref]

8- Kahroba H, Shirmohamadi M, Hejazi M, Samadi N. The Role of Nrf2 signaling in cancer stem cells: From stemness and self-renewal to tumorigenesis and chemoresistance. Life Sciences. 2019;239:116986 [Crossref]

9- El-Maadawy W, Hafiz E, Okasha H, Osman N, Ali G, Hussein R. Phycocyanin stimulates ulcerative colitis healing via selective activation of cannabinoid receptor-2, intestinal mucosal healing, Treg accumulation, and p38MAPK/MK2 signaling inhibition. Life Sciences. 2022;305:120741 [Crossref]

10- Priddy C, Li J. The role of the Nrf2/Keap1 signaling cascade in mechanobiology and bone health. Bone Reports. 2021;15:101149 [Crossref]

11- El-Baz F, Salama A, Ali S, Elgohary R, Al Attar A. Haematococcus pluvialis Carotenoids Enrich Fractions Ameliorate Liver Fibrosis Induced by Thioacetamide in Rats: Modulation of Metalloproteinase and Its Inhibitor. BioMed Research International. 2021;2021:1 [Crossref]

12- Ashrafizadeh M, Ahmadi Z, Yaribeygi H, Sathyapalan T, Sahebkar A. Astaxanthin and Nrf2 Signaling Pathway: A Novel Target for New Therapeutic Approaches. MRMC. 2022;22(2):312 [Crossref]

13- Liu X, Xie J, Zhou L, Zhang J, Chen Z, Xiao J, Cao Y, Xiao H. Recent advances in health benefits and bioavailability of dietary astaxanthin and its isomers. Food Chemistry. 2023;404:134605 [Crossref]

14- Alugoju P, Krishna Swamy V, Anthikapalli N, Tencomnao T. Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review. Critical Reviews in Food Science and Nutrition. 2023;63(31):10709 [Crossref]

15- Culletta G, Buttari B, Arese M, Brogi S, Almerico A, Saso L, Tutone M. Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects. European Journal of Medicinal Chemistry. 2024;270:116355 [Crossref]