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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2018;8(2): 245-256. doi: 10.15171/apb.2018.029
PMID: 30023326        PMCID: PMC6046421

Research Article

Application of Response Surface Method for Preparation, Optimization, and Characterization of Nicotinamide Loaded Solid Lipid Nanoparticles

Molood Alsadat Vakilinezhad 1, Shima Tanha 1, Hashem Montaseri 2, Rassoul Dinarvand 3, Amir Azadi 4, Hamid Akbari Javar 1 *

Cited by CrossRef: 12

1- Lee J, Noh M, Jang J, Lee J, Hwang Y, Lee H. Skin Penetration Enhancer-Incorporated Lipid Nanovesicles (SPE-LNV) for Skin Brightening and Wrinkle Treatment. ACS Appl Mater Interfaces. 2022;14(32):36331 [Crossref]
2- Duangjit S, Sritananuwat P, Bumrungthai S, Ngawhirunpat T, Takayama K. Application of Electrochemically Reduced Water for New No-Rinse Shampoo: Design and Optimization Using Response Surface Methodology. Cosmetics. 2022;9(5):104 [Crossref]
3- Vakilinezhad M, Amini A, Akbari Javar H, Baha’addini Beigi Zarandi B, Montaseri H, Dinarvand R. Nicotinamide loaded functionalized solid lipid nanoparticles improves cognition in Alzheimer’s disease animal model by reducing Tau hyperphosphorylation. DARU J Pharm Sci. 2018;26(2):165 [Crossref]
4- Tan F, Cui H, Bai C, Qin C, Xu L, Han J. Preparation, optimization, and transcorneal permeability study of lutein-loaded solid lipid nanoparticles. Journal of Drug Delivery Science and Technology. 2021;62:102362 [Crossref]
5- M, S. PREPARATION AND EVALUATION OF VORICONAZOLE HYDROGEL USING CYCLODEXTRIN-BASED NANO SPONGES. Asian J Pharm Clin Res. 2025;:184 [Crossref]
6- PATEL H, LALAN M. QBD-GUIDED DESIGN OF NLC-BASED BUCCAL FILMS OF A PHYTOCONSTITUENT FOR ENHANCED CHEMOPREVENTION. Int J App Pharm. 2026;:242 [Crossref]
7- Akkın S, Varan G, Aksüt D, Malanga M, Ercan A, Şen M, Bilensoy E. A different approach to immunochemotherapy for colon Cancer: Development of nanoplexes of cyclodextrins and Interleukin-2 loaded with 5-FU. International Journal of Pharmaceutics. 2022;623:121940 [Crossref]
8- Ghate V, Kodoth A, Raja S, Vishalakshi B, Lewis S. Development of MART for the Rapid Production of Nanostructured Lipid Carriers Loaded with All-Trans Retinoic Acid for Dermal Delivery. AAPS PharmSciTech . 2019;20(4) [Crossref]
9- Vakilinezhad M, Amini A, Dara T, Alipour S. Methotrexate and Curcumin co-encapsulated PLGA nanoparticles as a potential breast cancer therapeutic system: In vitro and in vivo evaluation. Colloids and Surfaces B: Biointerfaces. 2019;184:110515 [Crossref]
10- Miles C, Gwin C, Zubris K, Gormley A, Kohn J. Tyrosol Derived Poly(ester-arylate)s for Sustained Drug Delivery from Microparticles. ACS Biomater Sci Eng. 2021;7(6):2580 [Crossref]
11- Li S, Xuan B, Wong S, Lee H, Low K, Chow S. Towards the discovery of unrevealed flufenamic acid cocrystals via structural resemblance for enhanced topical drug delivery. International Journal of Pharmaceutics. 2025;668:124959 [Crossref]
12- Dara T, Vatanara A, Nabi Meybodi M, Vakilinezhad M, Malvajerd S, Vakhshiteh F, Shamsian A, Sharifzadeh M, Kaghazian H, Mosaddegh M. Erythropoietin-loaded solid lipid nanoparticles: Preparation, optimization, and in vivo evaluation. Colloids and Surfaces B: Biointerfaces. 2019;178:307 [Crossref]
13- Fraga S, Duarte L, Contri R, Külkamp Guerreiro I. Sustainable vesicular nanosystems incorporated into film-forming gels for niacinamide cutaneous delivery. Drug Development and Industrial Pharmacy. 2025;51(12):1883 [Crossref]
14- Bashir D, Manzoor S, Siddiqui M, Bashir M, Bashir N, Rastogi S, Arora I, Samim M. Nanosized epiberberine-loaded chitosan-collagen nanocomposites: synthesis and evaluation of their cognitive and AChE inhibition enhancing potential in a scopolamine-induced amnesia rat model. New J Chem. 2024;48(7):3166 [Crossref]
15- Bashir D, Manzoor S, Khan I, Bashir M, Agarwal N, Rastogi S, Arora I, Samim M. Nanonization of Magnoflorine-Encapsulated Novel Chitosan–Collagen Nanocapsules for Neurodegenerative Diseases: In Vitro Evaluation. ACS Omega. 2022;7(8):6472 [Crossref]
16- BHAVANI C, BALAJI P. QUALITY BY DESIGN AND CHARACTERIZATION OF EDARAVONE SLN TO IMPROVE BRAIN DELIVERY BY NASAL ROUTE FOR THE TREATMENT OF ALZHEIMER’S DISEASE. Int J App Pharm. 2026;:292 [Crossref]