Logo-apb

Journal Info:

Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

Permission: CC By

Platinum Open Access

(no submission or publication fees)

Powered by
Adv Pharm Bull. 2018;8(3): 507-516. doi: 10.15171/apb.2018.059
PMID: 30276148        PMCID: PMC6156471

Research Article

The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubicin on MCF-7/HER2 Cells

Riris Istighfari Jenie 1,2 ORCID, Sri Handayani 2,3 ORCID, Ratna Asmah Susidarti 1,2, Linar Zalinar Udin 3, Edy Meiyanto 1,2 * ORCID

Cited by CrossRef: 24

1- Xu Z, Zheng X, Xia X, Wang X, Luo N, Huang B, Pan X. 17β-estradiol at low concentrations attenuates the efficacy of tamoxifen in breast cancer therapy. Environmental Pollution. 2019;255:113228 [Crossref]
2- Raptania C, Zakia S, Fahira A, Amalia R. Article review: Brazilin as potential anticancer agent. Front Pharmacol. 2024;15 [Crossref]
3- Fahimian G, Zahiri J, Arab S, Sajedi R. RepCOOL: computational drug repositioning via integrating heterogeneous biological networks. J Transl Med. 2020;18(1) [Crossref]
4- Yunita E, Muflikhasari H, Ilmawati G, Meiyanto E, Hermawan A. Hesperetin alleviates doxorubicin-induced migration in 4T1 breast cancer cells. Futur J Pharm Sci. 2020;6(1) [Crossref]
5- Rajput M, Nirmal N, Nirmal S, Santivarangkna C. Bio-actives from Caesalpinia sappan L.: Recent advancements in phytochemistry and pharmacology. South African Journal of Botany. 2022;151:60 [Crossref]
6- Hernández-Moreno A, Nava-Tapia D, Zuñiga-Eulogio M, Bello-Martínez J, Olea-Flores M, Hernández-Moreno T, Ordoñez M, Zacapala-Gómez A, Mendoza-Catalán M, Navarro-Tito N. Anti-Migratory Activity of Brazilin Chemodiversification on Breast Cancer Cells. Sci Pharm. 2025;93(1):4 [Crossref]
7- Amalina N, Salsabila I, Zulfin U, Jenie R, Meiyanto E. In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells. J Egypt Natl Canc Inst. 2023;35(1) [Crossref]
8- Xu Z, Zhao D, Zheng X, Huang B, Xia X, Pan X. Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor‐positive breast cancer therapy: An in vitro study. Environmental Toxicology. 2020;35(11):1179 [Crossref]
9- Jamaddar S, Sarkar C, Akter S, Mubarak M, El-Nashar H, El-Shazly M, Islam M. Brazilin: An updated literature-based review on its promising therapeutic approaches and toxicological studies. South African Journal of Botany. 2023;158:118 [Crossref]
10- Hermansyah D, Paramita D, Muhar A, Amalina N. Curcuma longa extract inhibits migration by reducing MMP-9 and Rac-1 expression in highly metastatic breast cancer cells. 2024;19(2):157 [Crossref]
11- Chatterjee B, Ghosh K, Swain A, Nalla K, Ravula H, Pan A, Kanade S. The phytochemical brazilin suppress DNMT1 expression by recruiting p53 to its promoter resulting in the epigenetic restoration of p21 in MCF7cells. Phytomedicine. 2022;95:153885 [Crossref]
12- Mollaeva М, Yabbarov N, Sokol М, Chirkina М, Nikolskaya E. Evaluation of the Synergistic Effect of the Combination of Doxorubicin and Vorinostat on Breast Tumor Cells Using the Loewe Model. A&Ch. 2023;68(7-8):53 [Crossref]
13- Zheng X, Shi Z, Qiu C, Hong Z, Wang C, Zhuang H, Chen Z, Pan J. Protosappanin B Exerts Anti-tumor Effects on Colon Cancer Cells via Inhibiting GOLPH3 Expression. Integr Cancer Ther. 2020;19 [Crossref]
14- Alsufyani T, Al-Otaibi N, Alotaibi N, M’sakni N, Alghamdi E. GC Analysis, Anticancer, and Antibacterial Activities of Secondary Bioactive Compounds from Endosymbiotic Bacteria of Pomegranate Aphid and Its Predator and Protector. Molecules. 2023;28(10):4255 [Crossref]
15- Abbass E, Khalil A, Mohamed M, Eissa I, El-Naggar A. Design, efficient synthesis, docking studies, and anticancer evaluation of new quinoxalines as potential intercalative Topo II inhibitors and apoptosis inducers. Bioorganic Chemistry. 2020;104:104255 [Crossref]
16- Cayetano‐Salazar L, Olea‐Flores M, Zuñiga‐Eulogio M, Weinstein‐Oppenheimer C, Fernández‐Tilapa G, Mendoza‐Catalán M, Zacapala‐Gómez A, Ortiz‐Ortiz J, Ortuño‐Pineda C, Navarro‐Tito N. Natural isoflavonoids in invasive cancer therapy: From bench to bedside. Phytotherapy Research. 2021;35(8):4092 [Crossref]
17- Correia Soeiro M, Vergoten G, Bailly C. Molecular docking of brazilin and its analogs to barrier‐to‐autointegration factor 1 (BAF1). Annals of the New York Academy of Sciences. 2022;1511(1):154 [Crossref]
18- Shaikh S, Tambe P, Mujahid Y, Santra M, Biersack B, Ahmed K. Targeting growth of breast cancer cell line (MCF-7) with curcumin-pyrimidine analogs. J Chem Sci. 2022;134(4) [Crossref]
19- Sun Q, Wang Q, Zhu Y, Mao M, Liao R, Yan X, Zhu B, Qin L. Traditional Uses and Phytochemical and Pharmacological Analyses of Caesalpinia sappan Linn.. Chemistry & Biodiversity. 2025;22(8) [Crossref]
20- Yang X, Wu Q, Zhao L, Chen L, Yang Y, Wang J, Yan L, Zhang S, Zhang H. A novel thin-layer chromatography-based method for Brazilin quantification. JPC-J Planar Chromat. 2021;34(5):419 [Crossref]
21- Asevedo E, Ramos Santiago L, Kim H, Syahputra R, Park M, Ribeiro R, Kim B. Unlocking the therapeutic mechanism of Caesalpinia sappan: a comprehensive review of its antioxidant and anti-cancer properties, ethnopharmacology, and phytochemistry. Front Pharmacol. 2025;15 [Crossref]
22- Nava-Tapia D, Cayetano-Salazar L, Herrera-Zúñiga L, Bello-Martínez J, Mendoza-Catalán M, Navarro-Tito N. Brazilin: Biological activities and therapeutic potential in chronic degenerative diseases and cancer. Pharmacological Research. 2022;175:106023 [Crossref]