Effects of Pharmacologic Dose of Resveratrol Supplementation on Oxidative/Antioxidative Status Biomarkers in Nonalcoholic Fatty Liver Disease Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

Somayyeh Asghari ¹, Maryam Rafraf ² * , Laleh Farzin ¹, Mohammad Asghari-Jafarabadi ^3,4, Seyed-Mostafa Ghavami ⁵, Mohammad-Hossein Somi ⁶

Cited by CrossRef: 29

1- Kasprzak-Drozd K, Niziński P, Kasprzak P, Kondracka A, Oniszczuk T, Rusinek A, Oniszczuk A. Does Resveratrol Improve Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)?. IJMS. 2024;25(7):3746 [Crossref]

2- Ezhilarasan D, Lakshmi T, Kosuru R. A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases. Oxidative Medicine and Cellular Longevity. 2022;2022:1 [Crossref]

3- Rafiee S, Mohammadi H, Ghavami A, Sadeghi E, Safari Z, Askari G. Efficacy of resveratrol supplementation in patients with nonalcoholic fatty liver disease: A systematic review and meta-analysis of clinical trials. Complementary Therapies in Clinical Practice. 2021;42:101281 [Crossref]

4- Zhou J, Chen Y, Yu J, Li T, Lu Z, Chen Y, Zhang X, Ye F. The efficacy of novel metabolic targeted agents and natural plant drugs for nonalcoholic fatty liver disease treatment. 2021;100(12):e24884 [Crossref]

5- Khattar S, Khan S, Zaidi S, Darvishikolour M, Farooq U, Naseef P, Kurunian M, Khan M, Shamim A, Khan M, Iqbal Z, Mirza M. Resveratrol from Dietary Supplement to a Drug Candidate: An Assessment of Potential. Pharmaceuticals. 2022;15(8):957 [Crossref]

6- Bahramrezaie M, Amidi F, Aleyasin A, Saremi A, Aghahoseini M, Brenjian S, Khodarahmian M, Pooladi A. Effects of resveratrol on VEGF & HIF1 genes expression in granulosa cells in the angiogenesis pathway and laboratory parameters of polycystic ovary syndrome: a triple-blind randomized clinical trial. J Assist Reprod Genet. 2019;36(8):1701 [Crossref]

7- Quetglas-Llabrés M, Monserrat-Mesquida M, Bouzas C, García S, Argelich E, Casares M, Ugarriza L, Llompart I, Tur J, Sureda A. Impact of Adherence to the Mediterranean Diet on Antioxidant Status and Metabolic Parameters in NAFLD Patients: A 24-Month Lifestyle Intervention Study. Antioxidants. 2024;13(4):480 [Crossref]

8- Hu D, Yang W, Mao P, Cheng M. Combined Amelioration of Prebiotic Resveratrol and Probiotic Bifidobacteria on Obesity and Nonalcoholic Fatty Liver Disease. Nutrition and Cancer. 2021;73(4):652 [Crossref]

9- Wang J, Zhang Y, Hu S, Ge S, Jia M, Wang N. Resveratrol inhibits MRGPRX2-mediated mast cell activation via Nrf2 pathway. International Immunopharmacology. 2021;93:107426 [Crossref]

10- Ahmadi A, Jamialahmadi T, Sahebkar A. Polyphenols and atherosclerosis: A critical review of clinical effects on LDL oxidation. Pharmacological Research. 2022;184:106414 [Crossref]

11- Hosseinabadi S, Rafraf M, Asghari S, Asghari-Jafarabadi M, Vojouhi S. Effect of green coffee extract supplementation on serum adiponectin concentration and lipid profile in patients with non-alcoholic fatty liver disease: A randomized, controlled trial. Complementary Therapies in Medicine. 2020;49:102290 [Crossref]

12- Jakubczyk K, Skonieczna-Żydecka K, Kałduńska J, Stachowska E, Gutowska I, Janda K. Effects of Resveratrol Supplementation in Patients with Non-Alcoholic Fatty Liver Disease—A Meta-Analysis. Nutrients. 2020;12(8):2435 [Crossref]

13- Karimi-Sales E, Jeddi S, Alipour M. trans-Chalcone inhibits transforming growth factor-β1 and connective tissue growth factor-dependent collagen expression in the heart of high-fat diet-fed rats. Archives of Physiology and Biochemistry. 2022;128(5):1221 [Crossref]

14- Seen S. Chronic liver disease and oxidative stress – a narrative review. Expert Review of Gastroenterology & Hepatology. 2021;15(9):1021 [Crossref]

15- Bouyahya A, Bakrim S, Aboulaghras S, El Kadri K, Aanniz T, Khalid A, Abdalla A, Abdallah A, Ardianto C, Ming L, El Omari N. Bioactive compounds from nature: Antioxidants targeting cellular transformation in response to epigenetic perturbations induced by oxidative stress. Biomedicine & Pharmacotherapy. 2024;174:116432 [Crossref]

16- Trepiana J, Krisa S, Renouf E, Portillo M. Resveratrol Metabolites Are Able to Reduce Steatosis in Cultured Hepatocytes. Pharmaceuticals. 2020;13(10):285 [Crossref]

17- Nemati A, Nikniaz Z, Mota A. Effects of Resveratrol Supplementation on Nonalcoholic Fatty Liver Disease Management. 2023;38(2):144 [Crossref]

18- Izzo C, Annunziata M, Melara G, Sciorio R, Dallio M, Masarone M, Federico A, Persico M. The Role of Resveratrol in Liver Disease: A Comprehensive Review from In Vitro to Clinical Trials. Nutrients. 2021;13(3):933 [Crossref]

19- Pedroza-Diaz J, Arroyave-Ospina J, Serna Salas S, Moshage H. Modulation of Oxidative Stress-Induced Senescence during Non-Alcoholic Fatty Liver Disease. Antioxidants. 2022;11(5):975 [Crossref]

20- Brown K, Theofanous D, Britton R, Aburido G, Pepper C, Sri Undru S, Howells L. Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities. IJMS. 2024;25(2):747 [Crossref]

21- Öztürk Y, Günaydın C, Yalçın F, Nazıroğlu M, Braidy N. Resveratrol Enhances Apoptotic and Oxidant Effects of Paclitaxel through TRPM2 Channel Activation in DBTRG Glioblastoma Cells. Oxidative Medicine and Cellular Longevity. 2019;2019:1 [Crossref]

22- Soltani S, Sharifi‐Zahabi E, Sangsefidi Z, Ahmadi Vasmehjani A, Meshkini F, Clayton Z, Abdollahi S. The effect of resveratrol supplementation on biomarkers of liver health: A systematic review and meta‐analysis of randomized controlled trials. Phytotherapy Research. 2023;37(3):1153 [Crossref]

23- Omidian M, Abdolahi M, Daneshzad E, Sedighiyan M, Aghasi M, Abdollahi H, Omidian P, Dabiri S, Mahmoudi M. The Effects of Resveratrol on Oxidative Stress Markers: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. EMIDDT. 2020;20(5):718 [Crossref]

24- Zhang S, Xu M, Zhang W, Liu C, Chen S. Natural Polyphenols in Metabolic Syndrome: Protective Mechanisms and Clinical Applications. IJMS. 2021;22(11):6110 [Crossref]

25- Li Q, Yang G, Xu H, Tang S, Lee W. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther. 2021;21(1) [Crossref]

26- Komolafe O, Buzzetti E, Linden A, Best L, Madden A, Roberts D, Chase T, Fritche D, Freeman S, Cooper N, Sutton A, Milne E, Wright K, Pavlov C, Davidson B, Tsochatzis E, Gurusamy K. Nutritional supplementation for nonalcohol-related fatty liver disease: a network meta-analysis. 2021;2021(7) [Crossref]

27- Asghari S, Rezaei M, Rafraf M, Taghizadeh M, Asghari-Jafarabadi M, Ebadi M. Effects of Calorie Restricted Diet on Oxidative/Antioxidative Status Biomarkers and Serum Fibroblast Growth Factor 21 Levels in Nonalcoholic Fatty Liver Disease Patients: A Randomized, Controlled Clinical Trial. Nutrients. 2022;14(12):2509 [Crossref]

28- Akbari M, Tamtaji O, Lankarani K, Tabrizi R, Dadgostar E, Haghighat N, Kolahdooz F, Ghaderi A, Mansournia M, Asemi Z. The effects of resveratrol on lipid profiles and liver enzymes in patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Lipids Health Dis. 2020;19(1) [Crossref]

29- Saavedra-Leos M, Jordan-Alejandre E, López-Camarillo C, Pozos-Guillen A, Leyva-Porras C, Silva-Cázares M. Nanomaterial Complexes Enriched With Natural Compounds Used in Cancer Therapies: A Perspective for Clinical Application. Front Oncol. 2021;11 [Crossref]

30- Hoseini A, Namazi G, Farrokhian A, Reiner Ž, Aghadavod E, Bahmani F, Asemi Z. The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. Food Funct. 2019;10(9):6042 [Crossref]

31- Vargas-Pozada E, Muriel P. Herbal medicines for the liver: from bench to bedside. 2020;32(2):148 [Crossref]

32- Tang R, Li R, Li H, Ma X, Du P, Yu X, Ren L, Wang L, Zheng W. Design of Hepatic Targeted Drug Delivery Systems for Natural Products: Insights into Nomenclature Revision of Nonalcoholic Fatty Liver Disease. ACS Nano. 2021;15(11):17016 [Crossref]