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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2018;8(4): 705-713. doi: 10.15171/apb.2018.079
PMID: 30607343        PMCID: PMC6311646

Research Article

Physiological and Biochemical Effects of Echium Amoenum Extract on Mn2+-Imposed Parkinson Like Disorder in Rats

Leila Sadeghi 1 * ORCID, Farzeen Tanwir 2 ORCID, Vahid Yousefi Babadi 3 ORCID

Cited by CrossRef: 16

1- Zannou O, Pashazadeh H, Ghellam M, Koca I, Kaddour A, Leriche F. Appraisal of phenolic compounds, antioxidant activity and in vitro gastrointestinal digestion of borage (Echium amoenum) flowers using natural deep eutectic solvent (NADES). Biomass Conv Bioref. 2024;14(7):8523 [Crossref]
2- Fan H, Guo Z. Tumor microenvironment-responsive manganese-based nanomaterials for cancer treatment. Coordination Chemistry Reviews. 2023;480:215027 [Crossref]
3- He T, Lin X, Su A, Zhang Y, Xing Z, Mi L, Wei T, Li Z, Wu W. Mitochondrial dysfunction-targeting therapeutics of natural products in Parkinson’s disease. Front Pharmacol. 2023;14 [Crossref]
4- Chen L, Shen Q, Liu Y, Zhang Y, Sun L, Ma X, Song N, Xie J. Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases. Sig Transduct Target Ther. 2025;10(1) [Crossref]
5- Sivagurunathan N, Gnanasekaran P, Calivarathan L. Mitochondrial Toxicant-Induced Neuronal Apoptosis in Parkinson’s Disease: What We Know so Far. DNND. 2023;Volume 13:1 [Crossref]
6- Zannou O, Pashazadeh H, Ghellam M, Ibrahim S, Koca I. Extraction of Anthocyanins from Borage (Echium amoenum) Flowers Using Choline Chloride and a Glycerol-Based, Deep Eutectic Solvent: Optimization, Antioxidant Activity, and In Vitro Bioavailability. Molecules. 2021;27(1):134 [Crossref]
7- Wang Y, Tang Y, Li Z, Hua Q, Wang L, Song X, Zou B, Ding M, Zhao J, Tang C. Joint Toxicity of a Multi-Heavy Metal Mixture and Chemoprevention in Sprague Dawley Rats. IJERPH. 2020;17(4):1451 [Crossref]
8- Taghizadeh S, Rezaee R, Badibostan H, Karimi G. Probabilistic carcinogenic and non-carcinogenic risk assessment of heavy metal ingestion through consumption of different walnut cultivars: An Iranian study. Environ Monit Assess. 2020;192(9) [Crossref]
9- Urbanska N, Ashaolu T, Mattova S, Simko P, Kiskova T. The Potential of Selected Plants and Their Biologically Active Molecules in the Treatment of Depression and Anxiety Disorders. IJMS. 2025;26(5):2368 [Crossref]
10- Obón C, Rivera D, Fonollá E, Alcaraz F, Attieh L. A Comparison Study on Traditional Mixtures of Herbal Teas Used in Eastern Mediterranean Area. Front Pharmacol. 2021;12 [Crossref]
11- Brahadeeswaran S, Lateef M, Calivarathan L. An Insight into the Molecular Mechanism of Mitochondrial Toxicant-induced Neuronal Apoptosis in Parkinson’s Disease. CMM. 2023;23(1):63 [Crossref]
12- Ibrahim F, Nomier M, Sabik L, Shaheen M. Manganese-induced neurotoxicity and the potential protective effects of lipoic acid andSpirulina platensis. Toxicology Mechanisms and Methods. 2020;30(7):497 [Crossref]
13- Mishra A, Dahia A, Jaiswal A. Protective Effect of Monoisoamyl-2, 3-Dimercaptosuccinic Acid against Manganese-induced Neurotoxicity in Rats. CNSAMC. 2021;21(3):165 [Crossref]
14- He F, Yu H, Shi H, Li X, Chu S, Huo C, Liu R. Behavioral, histopathological, genetic, and organism-wide responses to phenanthrene-induced oxidative stress in Eisenia fetida earthworms in natural soil microcosms. Environ Sci Pollut Res. 2022;29(26):40012 [Crossref]
15- Peng S, Zhou Y, Lu M, Wang Q. Review of Herbal Medicines for the Treatment of Depression. Natural Product Communications. 2022;17(11) [Crossref]
16- Khindri N, Maj M. Manganese-Induced Parkinsonism: A Review of Etiologies and Treatments. DNND. 2025;Volume 15:65 [Crossref]
17- Martins A, Gubert P, Villas Boas G, Meirelles Paes M, Santamaría A, Lee E, Tinkov A, Bowman A, Aschner M. Manganese-induced neurodegenerative diseases and possible therapeutic approaches. Expert Review of Neurotherapeutics. 2020;20(11):1109 [Crossref]
18- Abu‐Elfotuh K, Abbas A, Najm M, Qasim Q, Hamdan A, Abdelrehim A, Gowifel A, Al‐Najjar A, Atwa A, Kozman M, Khalil A, Negm A, Mousa S, Hamdan A, Abd El‐Rhman R, Abdelmohsen S, Tolba A, Aboelsoud H, Salahuddin A, Darwish A. Neuroprotective effects of punicalagin and/or micronized zeolite clinoptilolite on manganese‐induced Parkinson's disease in a rat model: Involvement of multiple pathways. CNS Neurosci Ther. 2024;30(10) [Crossref]
19- Nouri M, Farajdokht F, Torbati M, Ranjbar F, Hamedyazdan S, Sadigh-Eteghad S, Araj-Khodaei M. Antidepressant and Anxiolytic Effect of Echium amoenum in Restraint Stress Model: The Role of Neuroinflammation in the Prefrontal Cortex and Hippocampus. Iran Red Crescent Med J. 2019;21(10) [Crossref]