ISSN: 2228-5881 eISSN: 2251-7308

Adv Pharm Bull. 2018;8(4): 565-574. doi: 10.15171/apb.2018.065

PMID: 30607329 PMCID: PMC6311648

Review Article

Effects of Prebiotic and Synbiotic Supplementation on Glycaemia and Lipid Profile in Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials

Sepideh Mahboobi ¹ , Fatemeh Rahimi ², Sadegh Jafarnejad ³ *

Cited by CrossRef: 53

1- Mirmiranpour H, Huseini H, Derakhshanian H, Khodaii Z, Tavakoli-Far B. Effects of probiotic, cinnamon, and synbiotic supplementation on glycemic control and antioxidant status in people with type 2 diabetes; a randomized, double-blind, placebo-controlled study. J Diabetes Metab Disord. 2020;19(1):53 [Crossref]

2- Li S, Guo Y. Gut microbiome: New perspectives for type 2 diabetes prevention and treatment. World J Clin Cases. 2023;11(31):7508 [Crossref]

3- Chugunova E, Darenskaya M. Modern Understanding of the Gut Microbiotа in Patients with Diabetes Mellitus. Acta biomedica scientifica. 2021;5(6):51 [Crossref]

4- Bhandarkar N, Mouatt P, Goncalves P, Thomas T, Brown L, Panchal S. Modulation of gut microbiota by spent coffee grounds attenuates diet‐induced metabolic syndrome in rats. FASEB j. 2020;34(3):4783 [Crossref]

5- Paul P, Kaul R, Harfouche M, Arabi M, Al-Najjar Y, Sarkar A, Saliba R, Chaari A. The effect of microbiome-modulating probiotics, prebiotics and synbiotics on glucose homeostasis in type 2 diabetes: A systematic review, meta-analysis, and meta-regression of clinical trials. Pharmacological Research. 2022;185:106520 [Crossref]

6- Baghel K, Khan A, Kango N. Role of Synbiotics (Prebiotics and Probiotics) as Dietary Supplements in Type 2 Diabetes Mellitus Induced Health Complications. Journal of Dietary Supplements. 2024;:1 [Crossref]

7- Matias L, Costa R, Passos T, Queiroz J, Serquiz A, Maciel B, Santos P, Camillo C, Gonçalves C, Amado I, Pastrana L, Morais A. Tamarind Trypsin Inhibitor in Chitosan–Whey Protein Nanoparticles Reduces Fasting Blood Glucose Levels without Compromising Insulinemia: A Preclinical Study. Nutrients. 2019;11(11):2770 [Crossref]

8- S, K, C. A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics. Sci Pharm. 2019;87(4):26 [Crossref]

9- Gil-Cardoso K, Saldaña G, Luengo E, Pastor J, Virto R, Alcaide-Hidalgo J, del Bas J, Arola L, Caimari A. Consumption of Sourdough Breads Improves Postprandial Glucose Response and Produces Sourdough-Specific Effects on Biochemical and Inflammatory Parameters and Mineral Absorption. J Agric Food Chem. 2021;69(10):3044 [Crossref]

10- Velayati A, Kareem I, Sedaghat M, Sohrab G, Nikpayam O, Hedayati M, Abhari K, Hejazi E. Does symbiotic supplementation which contains Bacillus Coagulans Lactobacillus rhamnosus, Lactobacillus acidophilus and fructooligosaccharide has favourite effects in patients with type-2 diabetes? A randomised, double-blind, placebo-controlled trial . Archives of Physiology and Biochemistry. 2023;129(6):1211 [Crossref]

11- Bielka W, Przezak A, Pawlik A. The Role of the Gut Microbiota in the Pathogenesis of Diabetes. IJMS. 2022;23(1):480 [Crossref]

12- Antony M, Patel S, Verma V, Kant R. The Role of Gut Microbiome Supplementation in COVID-19 Management. 2023; [Crossref]

13- Naseri K, Saadati S, Ghaemi F, Ashtary-Larky D, Asbaghi O, Sadeghi A, Afrisham R, de Courten B. The effects of probiotic and synbiotic supplementation on inflammation, oxidative stress, and circulating adiponectin and leptin concentration in subjects with prediabetes and type 2 diabetes mellitus: a GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Eur J Nutr. 2022; [Crossref]

14- Liu W, Luo Z, Zhou J, Sun B. Gut Microbiota and Antidiabetic Drugs: Perspectives of Personalized Treatment in Type 2 Diabetes Mellitus. Front Cell Infect Microbiol. 2022;12 [Crossref]

15- Bai F, Niu X, Wang X, Ye J. Growth performance, biochemical composition and expression of lipid metabolism related genes in groupers ( Epinephelus coioides ) are altered by dietary taurine . Aquacult Nutr. 2021;27(6):2690 [Crossref]

16- Robertson M. Prebiotics and type 2 diabetes: targeting the gut microbiota for improved glycaemic control?. Practical Diabetes. 2020;37(4):133 [Crossref]

17- Naseri K, Saadati S, Yari Z, Asbaghi O, Hezaveh Z, Mafi D, Hoseinian P, Ashtary-Larky D, Hekmatdoost A, de Courten B. Beneficial effects of probiotic and synbiotic supplementation on some cardiovascular risk factors among individuals with prediabetes and type 2 diabetes mellitus: A grade-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Pharmacological Research. 2022;182:106288 [Crossref]

18- Wang X, Bai F, Niu X, Sun Y, Ye J. The Lipid-Lowering Effect of Dietary Taurine in Orange-Spotted Groupers (Epinephelus coioides) Involves Both Bile Acids and Lipid Metabolism. Front Mar Sci. 2022;9 [Crossref]

19- Talib N, Mohamad N, Yeap S, Ho C, Masarudin M, Abd-Aziz S, Izham M, Kumar M, Hussin Y, Alitheen N. Anti-Diabetic Effect of Lactobacillus Paracasei Isolated from Malaysian Water Kefir Grains. Probiotics & Antimicro Prot. 2023; [Crossref]

20- Jian Z, Zeng L, Xu T, Sun S, Yan S, Zhao S, Su Z, Ge C, Zhang Y, Jia J, Dou T. The intestinal microbiome associated with lipid metabolism and obesity in humans and animals. 2022;133(5):2915 [Crossref]

21- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Nussbaumer H, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus. Diabetologie und Stoffwechsel. 2022;17(S 02):S256 [Crossref]

22- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Nussbaumer H, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus. Diabetologie. 2023;19(4):482 [Crossref]

23- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Nussbaumer H, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus. Diabetologie. 2024; [Crossref]

24- Huda M, Kim M, Bennett B. Modulating the Microbiota as a Therapeutic Intervention for Type 2 Diabetes. Front Endocrinol. 2021;12 [Crossref]

25- Al-Shaheeb S, Kamil Hashim H, Kadhim Mohammed A, Abdulkareem Almashhadani H, Al Fandi A. Assessment of lipid profile with HbA1c in type 2 diabetic Iraqi patients. RB. 2022;7(3):1 [Crossref]

26- Naseri K, Saadati S, Ashtary-Larky D, Asbaghi O, Ghaemi F, Pashayee-Khamene F, Yari Z, de Courten B. Probiotics and synbiotics supplementation improve glycemic control parameters in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Pharmacological Research. 2022;184:106399 [Crossref]

27- Ojo O, Wang X, Ojo O, Brooke J, Jiang Y, Dong Q, Thompson T. The Effect of Prebiotics and Oral Anti-Diabetic Agents on Gut Microbiome in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials. Nutrients. 2022;14(23):5139 [Crossref]

28- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Nussbaumer H, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Dietary Recommendations for Persons with Type 2 Diabetes Mellitus. Exp Clin Endocrinol Diabetes. 2024;132(04):182 [Crossref]

29- Dewi L, Rosidi A, Noer E, Ayuningtyas A. The Prospect for Type 2 Diabetes Mellitus Combined with Exercise and Synbiotics: A Perspective. CDR. 2021;17(8) [Crossref]

30- Arora A, Behl T, Sehgal A, Singh S, Sharma N, Bhatia S, Sobarzo-Sanchez E, Bungau S. Unravelling the involvement of gut microbiota in type 2 diabetes mellitus. Life Sciences. 2021;273:119311 [Crossref]

31- Al-Najjar Y, Arabi M, Paul P, Chaari A. Can probiotic, prebiotic, and synbiotic supplementation modulate the gut-liver axis in type 2 diabetes? A narrative and systematic review of clinical trials. Front Nutr. 2022;9 [Crossref]

32- Mohamed EL Kafoury B, Ebrahim A, Abd-El Hamid Ali M, Shaker Mehanna N, Ibrahim Ramadan G, Ezzat Morsy W. Short chain fatty acids and GIT hormones mitigate gut barrier disruption in high fat diet fed rats supplemented by synbiotics. MNM. 2023;16(2):139 [Crossref]

33- Michels N, Zouiouich S, Vanderbauwhede B, Vanacker J, Indave Ruiz B, Huybrechts I. Human microbiome and metabolic health: An overview of systematic reviews. Obesity Reviews. 2022;23(4) [Crossref]

34- Shafie M, Homayouni Rad A, Mirghafourvand M. Effects of prebiotic-rich yogurt on menopausal symptoms and metabolic indices in menopausal women: a triple-blind randomised controlled trial. International Journal of Food Sciences and Nutrition. 2022;73(5):693 [Crossref]

35- Vega-Cárdenas M, Martínez-Gutierrez F, Lara-Ramírez E, Reynaga-Hernandez E, Yañez-Estrada L, Ratering S, Schnell S, Godínez-Hernández C, Vargas-Morales J, Portales-Pérez D. Agave fructans enhance the effects of fermented milk products on obesity biomarkers: a randomised trial. BM. 2023;14(2):153 [Crossref]

36- Ebrahimzadeh Leylabadlo H, Sanaie S, Sadeghpour Heravi F, Ahmadian Z, Ghotaslou R. From role of gut microbiota to microbial-based therapies in type 2-diabetes. Infection, Genetics and Evolution. 2020;81:104268 [Crossref]

37- Musazadeh V, Mohammadi Anilou M, Vajdi M, Karimi A, Sedgh Ahrabi S, Dehghan P. Effects of synbiotics supplementation on anthropometric and lipid profile parameters: Finding from an umbrella meta-analysis. Front Nutr. 2023;10 [Crossref]

38- Ojo O, Jiang Y, Ojo O, Wang X. The Association of Planetary Health Diet with the Risk of Type 2 Diabetes and Related Complications: A Systematic Review. Healthcare. 2023;11(8):1120 [Crossref]

39- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Nussbaumer H, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus. Diabetologie und Stoffwechsel. 2023;18(S 02):S270 [Crossref]

40- Doğan D, Çelik T. Research trends on the gut microbiota in endocrine metabolism: a thematic and bibliometric analysis. Front Cell Infect Microbiol. 2024;14 [Crossref]

41- Nauck M, Wefers J, Meier J. Treatment of type 2 diabetes: challenges, hopes, and anticipated successes. The Lancet Diabetes & Endocrinology. 2021;9(8):525 [Crossref]

42- Wang C, Zhang C, Li S, Yu L, Tian F, Zhao J, Zhang H, Chen W, Zhai Q. Effects of Probiotic Supplementation on Dyslipidemia in Type 2 Diabetes Mellitus: A Meta-Analysis of Randomized Controlled Trials. Foods. 2020;9(11):1540 [Crossref]

43- Jiang H, Cai M, Shen B, Wang Q, Zhang T, Zhou X. Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus. Foods. 2022;11(16):2438 [Crossref]

44- Swanson K, Gibson G, Hutkins R, Reimer R, Reid G, Verbeke K, Scott K, Holscher H, Azad M, Delzenne N, Sanders M. The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of synbiotics. Nat Rev Gastroenterol Hepatol. 2020;17(11):687 [Crossref]

45- Birkeland E, Gharagozlian S, Gulseth H, Birkeland K, Hartmann B, Holst J, Holst R, Aas A. Effects of prebiotics on postprandial GLP‐1, GLP‐2 and glucose regulation in patients with type 2 diabetes: A randomised, double‐blind, placebo‐controlled crossover trial. Diabet Med. 2021;38(10) [Crossref]

46- Kushnarova N, Zinych O, Korpavchev V, Kovalchuk A, Prybyla O, Shyshkan-Shishova K. Decrease in the efficacy of glucagon-like peptide-1 receptor agonists: what is the reason?. Mìžnarodnij endokrinologìčnij žurnal. 2021;17(8):637 [Crossref]

47- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Dietary recommendations for persons with type 2 diabetes mellitus. Exp Clin Endocrinol Diabetes. 2022;130(S 01):S151 [Crossref]

48- Al-Shaheeb S, Kamil Hashim H, Kadhim Mohammed A, Abdulkareem Almashhadani H, Al Fandi A. Assessment of lipid profile with HbA1c in type 2 diabetic Iraqi patients. RB. 2022;7(4):1 [Crossref]

49- Birkeland E, Gharagozlian S, Birkeland K, Valeur J, Måge I, Rud I, Aas A. Prebiotic effect of inulin-type fructans on faecal microbiota and short-chain fatty acids in type 2 diabetes: a randomised controlled trial. Eur J Nutr. 2020;59(7):3325 [Crossref]

50- Shyshkan-Shyshova K, Zinych O, Kushnareva N, Кovalchuk A, Prybyla O. Effect of probiotics and incretine mimeticss on the levels of glucagon-like peptide-1 in blood serum of patients with type 2 diabetes mellitus. Mìžnarodnij endokrinologìčnij žurnal. 2021;17(8):604 [Crossref]

51- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Empfehlungen zur Ernährung von Personen mit Diabetes mellitus Typ 2. Diabetologie. 2022;18(4):449 [Crossref]

52- Zepeda-Hernández A, Garcia-Amezquita L, Requena T, García-Cayuela T. Probiotics, prebiotics, and synbiotics added to dairy products: Uses and applications to manage type 2 diabetes. Food Research International. 2021;142:110208 [Crossref]

53- Skurk T, Bosy-Westphal A, Grünerbel A, Kabisch S, Keuthage W, Kronsbein P, Müssig K, Pfeiffer A, Simon M, Tombek A, Weber K, Rubin D. Empfehlungen zur Ernährung von Personen mit Typ-2-Diabetes mellitus. Diabetologie und Stoffwechsel. 2021;16(S 02):S255 [Crossref]

54- Urrutia M, Ramos A, Menegusso R, Lenz R, Ramos M, Tarone A, Cazarin C, Cottica S, da Silva S, Bernardi D. Effects of supplementation with kombucha and green banana flour on Wistar rats fed with a cafeteria diet. Heliyon. 2021;7(5):e07081 [Crossref]

55- Birkeland E, Gharagozlian S, Valeur J, Aas A. Short-chain fatty acids as a link between diet and cardiometabolic risk: a narrative review. Lipids Health Dis. 2023;22(1) [Crossref]

56- Ghorbani Y, Schwenger K, Allard J. Manipulation of intestinal microbiome as potential treatment for insulin resistance and type 2 diabetes. Eur J Nutr. 2021;60(5):2361 [Crossref]

57- Vallianou N, Stratigou T, Christodoulatos G, Dalamaga M. Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives. Curr Obes Rep. 2019;8(3):317 [Crossref]