Metformin Protects against Radiation-Induced Pneumonitis and Fibrosis and Attenuates Upregulation of Dual Oxidase Genes Expression

Rasoul Azmoonfar ¹, Peyman Amini ², Hana Saffar ³, Saeed Rezapoor ², Elahe Motevaseli ⁴, Mohsen Cheki ⁵, Rasoul Yahyapour ⁶, Bagher farhood ⁷, Farzad Nouruzi ⁸, Ehsan Khodamoradi ¹, Dheyauldeen Shabeeb ^9,10, Ahmed Eleojo Musa ¹¹, Masoud Najafi ¹ *

Cited by CrossRef: 33

1- Wang B, Wang H, Zhang M, Ji R, Wei J, Xin Y, Jiang X. Radiation‐induced myocardial fibrosis: Mechanisms underlying its pathogenesis and therapeutic strategies. J Cellular Molecular Medi. 2020;24(14):7717 [Crossref]

2- Tseng C. Metformin and Risk of Malignant Brain Tumors in Patients with Type 2 Diabetes Mellitus. Biomolecules. 2021;11(8):1226 [Crossref]

3- Ahmadvand M, Nikzad S, Hashemi S, khoshghadam A, Kalhori F, Mirzaei F. Evaluating the Mitigation Effect of Spirulina Against Radiation-Induced Heart Injury. CRP. 2023;16(1):78 [Crossref]

4- Najafi M, Cheki M, Hassanzadeh G, Amini P, Shabeeb D, Musa A. The Radioprotective Effect of Combination of Melatonin and Metformin on Rat Duodenum Damage Induced by Ionizing Radiation: A Histological Study. Adv Biomed Res. 2019;8(1):51 [Crossref]

5- Jin H, Yoo Y, Kim Y, Kim Y, Cho J, Lee Y. Radiation-Induced Lung Fibrosis: Preclinical Animal Models and Therapeutic Strategies. Cancers. 2020;12(6):1561 [Crossref]

6- Hansel C, Barr S, Schemann A, Lauber K, Hess J, Unger K, Zitzelsberger H, Jendrossek V, Klein D. Metformin Protects against Radiation-Induced Acute Effects by Limiting Senescence of Bronchial-Epithelial Cells. IJMS. 2021;22(13):7064 [Crossref]

7- Chen Q, Wang Y, Sheng L, Huang Y. Metformin suppresses proliferation and differentiation induced by BMP9 via AMPK signaling in human fetal lung fibroblast-1. Front Pharmacol. 2022;13 [Crossref]

8- Najafi M, Cheki M, Hassanzadeh G, Amini P, Shabeeb D, Musa A. Protection from Radiation-induced Damage in Rat’s Ileum and Colon by Combined Regimens of Melatonin and Metformin: A Histopathological Study. AIAAMC. 2020;19(2):180 [Crossref]

9- Lai X, Najafi M. Redox Interactions in Chemo/Radiation Therapy-induced Lung Toxicity; Mechanisms and Therapy Perspectives. CDT. 2022;23(13):1261 [Crossref]

10- Azmoonfar R, Moslehi M, Shahbazi-Gahrouei D, Purohit S. Radioprotective Effect of Selenium Nanoparticles: A Mini Review. IET Nanobiotechnology. 2024;2024:1 [Crossref]

11- Wen L, Zhong W, Chai Y, Zhong Q, Gao J, Guan L, Guan Z, Huaiquan L, Haiyang Y, Qingxue W, Changfu Y, Yunzhi C. Association of Metformin Use with Asthma Exacerbation in Patients with Concurrent Asthma and Diabetes: A Systematic Review and Meta-Analysis of Observational Studies. Canadian Respiratory Journal. 2020;2020:1 [Crossref]

12- Ahmadvand M, Nikzad S, Changizi V, Pashaki A, Najafi M, Mirzaei F. Evaluation of the Mitigation Effect of Spirulina Against Lung Injury Induced by Radiation in Rats. CRP. 2023;16(1):71 [Crossref]

13- Hariyanti T, Margiana R, Al-Gazally M, Patra I, Lateef Al-Awsi G, Hameed N, Kayumova D, Ansari M, Torres-Criollo L, Mustafa Y, Abedi-Firouzjah R, Farhood B. The Protective Effects of Silymarin on the Reproductive Toxicity: A Comprehensive Review. CMC. 2023;30(39):4421 [Crossref]

14- Kolivand S, Amini P, Saffar H, Rezapoor S, Najafi M, Motevaseli E, Nouruzi F, Shabeeb D, Eleojo Musa A. Selenium-L-methionine modulates radiation injury and Duox1 and Duox2 upregulation in rat’s heart tissues. J Cardiovasc Thorac Res. 2019;11(2):121 [Crossref]

15- Mortezaee K, Shabeeb D, Musa A, Najafi M, Farhood B. Metformin as a Radiation Modifier; Implications to Normal Tissue Protection and Tumor Sensitization. CCP. 2019;14(1):41 [Crossref]

16- Chen T, Zhuang B, Huang Y, Liu Y, Yuan B, Wang W, Yuan T, Du L, Jin Y. Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis. Acta Pharmaceutica Sinica B. 2022;12(5):2522 [Crossref]

17- Tang Y, Yang L, Qin W, Yi M, Liu B, Yuan X. Validation study of the association between genetic variant of IL4 and severe radiation pneumonitis in lung cancer patients treated with radiation therapy. Radiotherapy and Oncology. 2019;141:86 [Crossref]

18- Sadeghinezhad S, Khodamoradi E, Diojan L, Taeb S, Najafi M. Radioprotective Mechanisms of Arbutin: A Systematic Review. CDRR. 2022;14(2):132 [Crossref]

19- Wei J, Wang B, Wang H, Meng L, Zhao Q, Li X, Xin Y, Jiang X. Radiation-Induced Normal Tissue Damage: Oxidative Stress and Epigenetic Mechanisms. Oxidative Medicine and Cellular Longevity. 2019;2019:1 [Crossref]

20- Farhood B, Aliasgharzadeh A, Amini P, Rezaeyan A, Tavassoli A, Motevaseli E, Shabeeb D, Eleojo Musa A, Najafi M. Mitigation of Radiation-Induced Lung Pneumonitis and Fibrosis Using Metformin and Melatonin: A Histopathological Study. Medicina. 2019;55(8):417 [Crossref]

21- Yahyapour R, Amini P, Saffar H, Motevaseli E, Farhood B, Pooladvand V, Shabeeb D, Musa A, Najafi M. Protective Effect of Metformin, Resveratrol and Alpha-lipoic Acid on Radiation- Induced Pneumonitis and Fibrosis: A Histopathological Study. CDRR. 2019;11(2):111 [Crossref]

22- Nowak P, Bil-Lula I, Śliwińska-Mossoń M. A Cross-Talk about Radioresistance in Lung Cancer—How to Improve Radiosensitivity According to Chinese Medicine and Medicaments That Commonly Occur in Pharmacies. IJMS. 2023;24(13):11206 [Crossref]

23- Wu Z, Zhang C, Najafi M. Targeting of the tumor immune microenvironment by metformin. J Cell Commun Signal. 2022;16(3):333 [Crossref]

24- Amini P, Kolivand S, Saffar H, Rezapoor S, Motevaseli E, Najafi M, Nouruzi F, Shabeeb D, Musa A. Protective Effect of Selenium-L-methionine on Radiation-induced Acute Pneumonitis and Lung Fibrosis in Rat. CCP. 2019;14(2):157 [Crossref]

25- Da F, Guo J, Yao L, Gao Q, Jiao S, Miao X, Liu J. Pretreatment with metformin protects mice from whole-body irradiation. 2021;62(4):618 [Crossref]

26- Chevalier B, Pasquier D, Lartigau E, Chargari C, Schernberg A, Jannin A, Mirabel X, Vantyghem M, Escande A. Metformin: (future) best friend of the radiation oncologist?. Radiotherapy and Oncology. 2020;151:95 [Crossref]

27- Chen T, Zhuang B, Huang Y, Wang W, Jin Y. Inhaled amifostine for the prevention of radiation-induced lung injury. Radiation Medicine and Protection. 2022;3(2):72 [Crossref]

28- Farhood B, Ashrafizadeh M, khodamoradi E, Hoseini-Ghahfarokhi M, Afrashi S, Musa A, Najafi M. Targeting of cellular redox metabolism for mitigation of radiation injury. Life Sciences. 2020;250:117570 [Crossref]

29- Xu C, Shang Z, Najafi M. Lung Pneumonitis and Fibrosis in Cancer Therapy: A Review on Cellular and Molecular Mechanisms. CDT. 2022;23(16):1505 [Crossref]

30- Yu Z, Xu C, Song B, Zhang S, Chen C, Li C, Zhang S. Tissue fibrosis induced by radiotherapy: current understanding of the molecular mechanisms, diagnosis and therapeutic advances. J Transl Med. 2023;21(1) [Crossref]

31- Tanigami Y, Kawai Y, Kaba S, Uozumi R, Ohnishi H, Kita T, Omori K, Kishimoto Y. Establishment of a radiation-induced vocal fold fibrosis mouse model. Biochemical and Biophysical Research Communications. 2022;601:31 [Crossref]

32- Wu X, Xu W, Huan X, Wu G, Li G, Zhou Y, Najafi M. Mechanisms of cancer cell killing by metformin: a review on different cell death pathways. Mol Cell Biochem. 2023;478(1):197 [Crossref]

33- Brücher B, Jamall I, Bandapalli O. Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”. 4open. 2019;2:12 [Crossref]