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Adv Pharm Bull. 2019;9(2): 294-301. doi: 10.15171/apb.2019.034

PMID: 31380256 PMCID: PMC6664115

Research Article

Carnosine Mitigates Manganese Mitotoxicity in an In Vitro Model of Isolated Brain Mitochondria

Vahid Ghanbarinejad ^1,2, Asrin Ahmadi ¹, Hossein Niknahad ^1,2, Mohammad Mehdi Ommati ¹, Reza Heidari ¹ *

Cited by CrossRef: 9

1- Leng X, Liu B, An R, Chen S, Li K, Wang D, Pang Y. The Ameliorative Effects of Carnosine on the In Vitro Developmental Competence of Bovine Oocytes. Antioxidants. 2026;15(7):828 [Crossref]

2- Ommati M, Sabouri S, Niknahad H, Arjmand A, Alidaee S, Mazloomi S, Najibi A, Rezaei H, Ghiasvand A, Ahmadi P, Nikoozadeh A, Khodaei F, Abdoli N, Azarpira N, Heidari R. Pulmonary inflammation, oxidative stress, and fibrosis in a mouse model of cholestasis: the potential protective properties of the dipeptide carnosine. Naunyn-Schmiedeberg's Arch Pharmacol. 2023;396(6):1129 [Crossref]

3- Fu X, Chen S, Wang X, Shen Y, Zeng R, Wu Q, Lu Y, Shi J, Zhou S. Dendrobium nobile Lindl. alkaloids alleviate Mn-induced neurotoxicity via PINK1/Parkin-mediated mitophagy in PC12 cells. Biochemistry and Biophysics Reports. 2021;26:100877 [Crossref]

4- Mousavi K, Niknahad H, Li H, Jia Z, Manthari R, Zhao Y, Shi X, Chen Y, Ahmadi A, Azarpira N, Khalvati B, Ommati M, Heidari R. The activation of nuclear factor-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling blunts cholestasis-induced liver and kidney injury. 2021;10(4):911 [Crossref]

5- Parmeggiani B, Ferreira B, Schuck P, Ferreira G. Considerations for Carnosine Actions in Biology. Neurochem Res. 2026;51(2) [Crossref]

6- Wang C, Zhao H, Liu Y, Qu M, Lv S, He G, Liang H, Chen K, Yang L, He Y, Ou C. Neurotoxicity of manganese via ferroptosis induced by redox imbalance and iron overload. Ecotoxicology and Environmental Safety. 2024;278:116404 [Crossref]

7- Akbarpournikghalb L, Pourdehghan Shahrestani P, Gomi M, Hayes A, Gholami M, Motaghinejad M. Aprepitant’s neuroprotective effects on methylphenidate-induced biochemical/mitochondrial dysfunction, neuroinflammation, and mood-related behavior alterations. DARU J Pharm Sci. 2026;34(2) [Crossref]

8- Liu Y, Lv S, He G, Wang C, Ou C. Ferroptosis at the crossroads of manganese-induced neurotoxicity: A retrospective study. Toxicology. 2024;502:153727 [Crossref]

9- Ommati M, Arabnezhad M, Farshad O, Jamshidzadeh A, Niknahad H, Retana-Marquez S, Jia Z, Nateghahmadi M, Mousavi K, Arazi A, Azmoon M, Azarpira N, Heidari R. The Role of Mitochondrial Impairment and Oxidative Stress in the Pathogenesis of Lithium-Induced Reproductive Toxicity in Male Mice. Front Vet Sci. 2021;8 [Crossref]

10- Niknahad H, Mobasheri A, Arjmand A, Rafiei E, Alidaee S, Razavi H, Bagheri S, Rezaei H, Sabouri S, Najibi A, Khodaei F, Kashani S, Ommati M, Heidari R. Hepatic encephalopathy complications are diminished by piracetam via the interaction between mitochondrial function, oxidative stress, inflammatory response, and locomotor activity. Heliyon. 2023;9(10):e20557 [Crossref]

11- Ommati M, Jin Y, Zamiri M, Retana-Marquez S, Nategh Ahmadi H, Sabouri S, Song S, Heidari R, Wang H. Sex-Specific Mechanisms of Fluoride-Induced Gonadal Injury: A Multi-Omics Investigation into Reproductive Toxicity and Gut Microbiota Disruption. J Agric Food Chem. 2025;73(4):2527 [Crossref]

12- Farshad O, Ommati M, Yüzügülen J, Jamshidzadeh A, Mousavi K, Ahmadi Z, Azarpira N, Ghaffari H, Najibi A, Shafaghat M, Niknahad H, Heidari R. Carnosine Mitigates Biomarkers of Oxidative Stress, Improves Mitochondrial Function, and Alleviates Histopathological Alterations in the Renal Tissue of Cholestatic Rats . Pharm Sci. 2020;27(1):32 [Crossref]