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Adv Pharm Bull. 2019;9(1): 12-21. doi: 10.15171/apb.2019.003
PMID: 31011554        PMCID: PMC6468223

Review Article

Crosstalk between Peroxisome Proliferator-Activated Receptors andToll-Like Receptors: A Systematic Review

Nasim Dana 1 ORCID, Golnaz Vaseghi 2,1 ORCID, Shaghayegh Haghjooy-Javanmard 1 * ORCID

Cited by CrossRef: 28


1- Huet A, Dvorshchenko K, Taburets O, Grebinyk D, Beregova T, Ostapchenko L. Tlr2 and Tjp1 Genes’ Expression during Restoration of Skin Integrity. Cytol Genet. 2020;54(6):539 [Crossref]
2- Yoon D, Kim J, Keon H, Lee H, Seo K, Shim J, Lee J, Kim H. Effects of plant-based heat killed lactic acid bacteria and its lithium chloride-extracted cellular protein on high-fat-induced obesity. Journal of Agriculture and Food Research. 2024;15:100965 [Crossref]
3- Shepard C. TLR9 in MAFLD and NASH: At the Intersection of Inflammation and Metabolism. Front Endocrinol. 2021;11 [Crossref]
4- Eroglu A, Al’Abri I, Kopec R, Crook N, Bohn T. Carotenoids and Their Health Benefits as Derived via Their Interactions with Gut Microbiota. Advances in Nutrition. 2023;14(2):238 [Crossref]
5- Li W, Huang R, Gong X, Zhao Z, Zhang L, Zhou Q, Jiang X, Tie H, Wan J, Wang B. Allicin attenuated hepatic ischemia/reperfusion injury in mice by regulating PPARγ-IRAK-M-TLR4 signal pathway. Food Funct. 2022;13(13):7361 [Crossref]
6- Demir E, Tutuk O, Dogan-Gocmen H, Ozyilmaz D, Karagul M, Kara M, Temiz M, Tumer C. CREB1 and PPAR-α/γ Pathways in Hepatic Ischemia/Reperfusion: Route for Curcumin to Hepatoprotection. Iran J Pharm Res. 2023;21(1) [Crossref]
7- Kytikovа O, Novgorodtseva T, Denisenko Y, Antonyuk M, Gvozdenko T. The role of lipids in the signaling mechanisms of toll-like receptors. Annals RAMS. 2020;75(6):585 [Crossref]
8- Palenca I, Seguella L, Del Re A, Franzin S, Corpetti C, Pesce M, Rurgo S, Steardo L, Sarnelli G, Esposito G. N-Palmitoyl-D-Glucosamine Inhibits TLR-4/NLRP3 and Improves DNBS-Induced Colon Inflammation through a PPAR-α-Dependent Mechanism. Biomolecules. 2022;12(8):1163 [Crossref]
9- Vaseghi G, Rashidi N, Zare N, Ghasemi F, Pourhadi M, Rafiee L, Javanmard S. Effects of methadone on the toll-like receptor 4 expression in human non-small cell lung carcinoma A549 cell line using in-silico and in vitro techniques. Adv Biomed Res. 2022;11(1):122 [Crossref]
10- Mierzejewski K, Kurzyńska A, Kunicka Z, Klepacka A, Golubska M, Bogacka I. Peroxisome proliferator-activated receptor gamma ligands regulate the expression of inflammatory mediators in porcine endometrium during LPS-induced inflammation. Theriogenology. 2022;187:195 [Crossref]
11- Dana N, Vaseghi G, Haghjooy Javanmard S. Activation of PPARγ Inhibits TLR4 Signal Transduction Pathway in Melanoma Cancer In Vitro. Adv Pharm Bull. 2020;10(3):458 [Crossref]
12- Easwaran M, Martinez J, Kim J, Erickson-DiRenzo E. Modulation of mouse laryngeal inflammatory and immune cell responses by low and high doses of mainstream cigarette smoke. Sci Rep. 2022;12(1) [Crossref]
13- Fernández-Quintela A, Milton-Laskibar I, Trepiana J, Gómez-Zorita S, Kajarabille N, Léniz A, González M, Portillo M. Key Aspects in Nutritional Management of COVID-19 Patients. JCM. 2020;9(8):2589 [Crossref]
14- Wang D, Wang T, Zhang Z, Li Z, Guo Y, Zhao G, Wu L. Recent advances in the effects of dietary polyphenols on inflammation in vivo: potential molecular mechanisms, receptor targets, safety issues, and uses of nanodelivery system and polyphenol polymers. Current Opinion in Food Science. 2022;48:100921 [Crossref]
15- Messina A, Concerto C, Rodolico A, Petralia A, Caraci F, Signorelli M. Is It Time for a Paradigm Shift in the Treatment of Schizophrenia? The Use of Inflammation-Reducing and Neuroprotective Drugs—A Review. Brain Sciences. 2023;13(6):957 [Crossref]
16- Parksepp M, Haring L, Kilk K, Taalberg E, Kangro R, Zilmer M, Vasar E. A Marked Low-Grade Inflammation and a Significant Deterioration in Metabolic Status in First-Episode Schizophrenia: A Five-Year Follow-Up Study. Metabolites. 2022;12(10):983 [Crossref]
17- Subudhi B, Chattopadhyay S, Chattopadhyay S. Targeting host factors of virus-induced inflammation: a strategy for tackling future epidemics by RNA viruses. Future Virology. 2022;17(4):201 [Crossref]
18- Pagliari F, Marafioti M, Genard G, Candeloro P, Viglietto G, Seco J, Tirinato L. ssRNA Virus and Host Lipid Rearrangements: Is There a Role for Lipid Droplets in SARS-CoV-2 Infection?. Front Mol Biosci. 2020;7 [Crossref]
19- Heidarzadeh M, Roodbari F, Hassanpour M, Ahmadi M, Saberianpour S, Rahbarghazi R. Toll-like receptor bioactivity in endothelial progenitor cells. Cell Tissue Res. 2020;379(2):223 [Crossref]
20- Shirinsky I, Shirinsky V. Pleiotropic effects of PPAR-α – from benchside to bedside. Med immunol. 2021;23(3):439 [Crossref]
21- Abulaban A, Al-kuraishy H, Al-Gareeb A, Elekhnawy E, Alanazi A, Alexiou A, Papadakis M, Batiha G. Role of fenofibrate in multiple sclerosis. Eur J Med Res. 2024;29(1) [Crossref]
22- Salama Y, Hassan H, El-Gayar A, Abdel-Rahman N. Combined quercetin and simvastatin attenuate hepatic fibrosis in rats by modulating SphK1/NLRP3 pathways. Life Sciences. 2024;337:122349 [Crossref]
23- Santamarina A, Pisani L, Baker E, Marat A, Valenzuela C, Miles E, Calder P. Anti-inflammatory effects of oleic acid and the anthocyanin keracyanin alone and in combination: effects on monocyte and macrophage responses and the NF-κB pathway. Food Funct. 2021;12(17):7909 [Crossref]
24- Kim E, Lee H, Han S, Seo K, Kim H. Effect of Surface Layer Proteins Derived from Paraprobiotic Kefir Lactic Acid Bacteria on Inflammation and High-Fat Diet-Induced Obesity. J Agric Food Chem. 2021;69(50):15157 [Crossref]
25- Dana N, Ferns G, Nedaeinia R, Haghjooy Javanmard S. Leptin signaling in breast cancer and its crosstalk with peroxisome proliferator-activated receptors α and γ. Clin Transl Oncol. 2022;25(3):601 [Crossref]
26- Miao M, Wang X, Liu T, Li Y, Yu W, Yang T, Guo S. Targeting PPARs for therapy of atherosclerosis: A review. International Journal of Biological Macromolecules. 2023;242:125008 [Crossref]
27- Hossen I, Kaiqi Z, Hua W, Junsong X, Mingquan H, Yanping C. Epigallocatechin gallate (EGCG) inhibits lipopolysaccharide‐induced inflammation in RAW 264.7 macrophage cells via modulating nuclear factor kappa‐light‐chain enhancer of activated B cells (NF‐κB) signaling pathway. Food Science & Nutrition. 2023;11(8):4634 [Crossref]
28- Chistyakov D, Astakhova A, Goriainov S, Sergeeva M. Comparison of PPAR Ligands as Modulators of Resolution of Inflammation, via Their Influence on Cytokines and Oxylipins Release in Astrocytes. IJMS. 2020;21(24):9577 [Crossref]
29- Hou J, Tolbert E, Birkenbach M, Ghonem N. Treprostinil alleviates hepatic mitochondrial injury during rat renal ischemia-reperfusion injury. Biomedicine & Pharmacotherapy. 2021;143:112172 [Crossref]
30- Vaseghi G, Dana N, Ghasemi A, Abediny R, Laher I, Javanmard S. Morphine promotes migration and lung metastasis of mouse melanoma cells. Brazilian Journal of Anesthesiology (English Edition). 2023;73(4):441 [Crossref]
31- Kytikova O, Perelman J, Novgorodtseva T, Denisenko Y, Kolosov V, Antonyuk M, Gvozdenko T. Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma. PPAR Research. 2020;2020:1 [Crossref]