Logo-apb
Adv Pharm Bull. 2019;9(2): 205-218. doi: 10.15171/apb.2019.024
PMID: 31380246        PMCID: PMC6664112

Review Article

Understanding Apoptosis and Apoptotic Pathways Targeted Cancer Therapeutics

Rehmat Jan 1 ORCID, Gul-e-Saba Chaudhry 1 * ORCID

Cited by CrossRef: 494


1- Mohd Noor N, Elgharbawy A, Moniruzzaman M, Goto M. Unlocking the Anticancer Potential of Ionic Liquids. ChemBioEng Reviews. 2024;11(2):231 [Crossref]
2- Mu Q, Najafi M. Modulation of the tumor microenvironment (TME) by melatonin. European Journal of Pharmacology. 2021;907:174365 [Crossref]
3- Lopes I, Meireles I, Rocha R, Medeiros R, Cerqueira F. An Overview of the Therapeutic Potential of Dimeric Flavonoids for Targeting Cancer Hallmarks. BioChem. 2025;5(1):2 [Crossref]
4- Alkhammash A, Alotaibi G. Decoding ferroptosis and apoptosis crosstalk in glioblastoma: molecular mechanisms, microenvironmental regulation, and therapeutic advances. Mol Biol Rep. 2026;53(1) [Crossref]
5- Kumari S. Briefing on Nitric Oxide a Signal Molecule in Cancer Metastasis and Therapeutic Target. Cell Biochemistry & Function. 2026;44(3) [Crossref]
6- Liu Y, Fang C, Hsu L, Hsu F, Hu M. Imipramine Inhibits Osteosarcoma Invasion via Src Inactivation and Caspase‐Dependent Apoptosis. J Cellular Molecular Medi. 2025;29(17) [Crossref]
7- Mlyczyńska E, Pich K, Dupont J, Rak A. Effect of phoenixin-14 on angiogenesis, cell proliferation, and apoptosis in porcine corpus luteum: Role of GPR173 and ERK1/2, AKT, and AMPK signal pathway. Theriogenology. 2025;238:117366 [Crossref]
8- Kaewthawee N, Sharma A, Brimson J, Brimson S. Synergistic Induction of Caspase-8-Mediated Leukaemic Cell Death by Fisetin and Pinocembrin. IJMS. 2026;27(12):5622 [Crossref]
9- Pereira L, Valado A. From the ocean to the brain: harnessing the power of marine algae for neuroprotection and therapeutic advances. Explor Neuroprot Ther. 2023;:409 [Crossref]
10- Devaraji M, Thanikachalam P. Phytoconstituents as emerging therapeutics for breast cancer: Mechanistic insights and clinical implications. Cancer Pathogenesis and Therapy. 2025;3(5):364 [Crossref]
11- Andrysik Z, Espinosa J. Harnessing p53 for targeted cancer therapy: new advances and future directions. Transcription. 2025;16(1):3 [Crossref]
12- Hamidi Nokhostin K, Kasaei Kivi S, Safari Ezmare Sofla M. The Effect of Hypertonic Osmotic Stress and Its Duration on the Level and Activity of Executioner Caspase Enzymes in Blood Anuclear Cells (Platelets). Jentashapir J Cell Mol Biol. 2024;15(2) [Crossref]
13- Miao J, Chen J, Fan A, Luo J, Ma Q, Zhou N. Costunolide suppresses breast cancer progression in SK-BR-3 cells through CDK2/Cyclin E-mediated G1/S arrest, mitochondrial apoptosis, and PI3K/Akt-dependent inhibition of epithelial-mesenchymal transition. All Life. 2026;19(1) [Crossref]
14- Kanavos T, Birbas E. Cell-specific role of apoptosis in the process of atherosclerosis. 2025;2(1):21 [Crossref]
15- Sinha T, Adhikari P, Bhandari V. Sustainable Fabrication of Copper Nanoparticles: A Potent and Affordable Candidate for Water Treatment, Water Disinfection, Antioxidant Activity and Theranostic Agent. ChemistrySelect. 2022;7(15) [Crossref]
16- Živanović M, Selaković M, Pavić A, Selaković Ž, Šolaja B, Santibanez J, Srdić-Rajić T. Unveiling the 4-aminoquinoline derivatives as potent agents against pancreatic ductal adenocarcinoma (PDAC) cell lines. Chemico-Biological Interactions. 2024;404:111281 [Crossref]
17- Atmaca H, Ilhan S, Yilmaz E, Zora M. 4‐Propargyl‐substituted 1H‐pyrroles induce apoptosis and autophagy via extracellular signal‐regulated signaling pathway in breast cancer. Archiv der Pharmazie. 2021;354(10) [Crossref]
18- Zhong L, Deng J, Gu C, Shen L, Ren Z, Ma X, Yan Q, Deng J, Zuo Z, Wang Y, Cao S, Yu S. Protective effect of MitoQ on oxidative stress-mediated senescence of canine bone marrow mesenchymal stem cells via activation of the Nrf2/ARE pathway. In Vitro CellDevBiol-Animal. 2021;57(7):685 [Crossref]
19- Hamdi A, Elhusseiny W, Othman D, Haikal A, Bakheit A, El-Azab A, Al-Agamy M, Abdel-Aziz A. Synthesis, antitumor, and apoptosis-inducing activities of novel 5-arylidenethiazolidine-2,4-dione derivatives: Histone deacetylases inhibitory activity and molecular docking study. European Journal of Medicinal Chemistry. 2022;244:114827 [Crossref]
20- Khan F, Khan H, Awan U, Nurahmat M, Nabijan M, Abduwaki M, Dong J. c-Jun in neurodegeneration: A key transcriptional regulator with therapeutic implications. Molecular Therapy Nucleic Acids. 2026;37(2):102874 [Crossref]
21- Wang X, Wang B, Zhou L, Wang X, Veeraraghavan V, Mohan S, Xin F. Ganoderma lucidum put forth anti-tumor activity against PC-3 prostate cancer cells via inhibition of Jak-1/STAT-3 activity. Saudi Journal of Biological Sciences. 2020;27(10):2632 [Crossref]
22- Chota A, George B, Abrahamse H. Apoptotic efficiency of Dicoma anomala biosynthesized silver nanoparticles against A549 lung cancer cells. Biomedicine & Pharmacotherapy. 2024;176:116845 [Crossref]
23- Poyraz F, Colpan R, Derman S, Mansuroglu B, Erdemir A. Investigation of cellular and molecular mechanisms of caffeic acid phenethyl ester loaded nanoparticle systems in breast cancer cell lines. Process Biochemistry. 2023;134:32 [Crossref]
24- Choi N, Park S, Kim I. Tivozanib-induced activation of the mitochondrial apoptotic pathway and suppression of epithelial-to-mesenchymal transition in oral squamous cell carcinoma. Korean J Physiol Pharmacol. 2024;28(3):197 [Crossref]
25- Yan B, Chen X, Liu J, Liu S, Zhang J, Zeng Q, Duan J. Asiatic Acid Induces Mitochondrial Apoptosis via Inhibition of JAK2/STAT3 Signalling Pathway in Human Osteosarcoma. Fol Biol. 2021;67(3):108 [Crossref]
26- Rana G, Dhiman V, Ali S, Chauhan A, Jabir M, Ghotekar S. Emerging developments in plant-based metal nanomaterials for diverse versatile applications - A review. Results in Chemistry. 2025;15:102231 [Crossref]
27- El-Sawy W, Khalaf M, El-Bahrawy A, Messiha B, Hemeida R. Oxyresveratrol and/or Dapagliflozin Attenuate Doxorubicin-Induced Nephrotoxicity via Modulation of PPAR-γ/Nrf-2/HO-1, NF-κB/TNF-α/Keap-1, and Bcl-2/Caspase-3/ATG-5 signaling pathways in rats. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(5):5955 [Crossref]
28- Kasana S, Kumar S, Patel P, Kurmi B, Jain S, Sahu S, Vaidya A. Caspase inhibitors: a review on recently patented compounds (2016–2023). Expert Opinion on Therapeutic Patents. 2024;34(10):1047 [Crossref]
29- Vujović T, Paradžik T, Babić Brčić S, Piva R. Unlocking the Therapeutic Potential of Algae-Derived Compounds in Hematological Malignancies. Cancers. 2025;17(2):318 [Crossref]
30- Iyer P, Jasdanwala S, Bhatia K, Bhatt S. Mitochondria and Acute Leukemia: A Clinician’s Perspective. IJMS. 2024;25(17):9704 [Crossref]
31- Świątek P, Glomb T, Wiatrak B, Nowotarska P, Gębarowski T, Wojtkowiak K, Jezierska A, Strzelecka M. New 1,2,4-Triazole Derivatives with a N-Mannich Base Structure Based on a 4,6-Dimethylpyridine Scaffold as Anticancer Agents: Design, Synthesis, Biological Evaluation, and Molecular Modeling. IJMS. 2025;26(14):6572 [Crossref]
32- Dolgikh O, Dianova D, Krivtsov A. CELL DEATH UNDER CONDITIONS OF HAPTIC CONTAMINATION OF BIOLOGICAL MEDIA BY STABLE STRONTIUM. Ekologiya cheloveka (Human Ecology). 2021;28(10):21 [Crossref]
33- Li Z, Zhang R, Xu F, Yang J, Zhou L, Mao H. A Cell State Monitoring System with Integrated In Situ Imaging and pH Detection. Sensors. 2023;23(23):9340 [Crossref]
34- Popazova O, Belenichev I, Bukhtiyarova N, Ryzhenko V, Gorchakova N, Oksenych V, Kamyshnyi O. Molecular and Biochemical Mechanisms of Cardiomyopathy Development Following Prenatal Hypoxia—Focus on the NO System. Antioxidants. 2025;14(6):743 [Crossref]
35- Zaiki Y, Chee C, Ageitos L, Naharudin I, Zainudin B, Leong L, Jaime R, Jimenez C, Gan C, Traini D, Wong T. Multi-mechanistic mitochondria-mediated N-methylated YKWYYRGAA-decorated nano-chitosan conjugate carrier for treatment of NRAS-mutant-harbouring lung carcinoma. Carbohydrate Polymers. 2026;386:125423 [Crossref]
36- Nkune N, Abrahamse H. The Efficacy of Zinc Phthalocyanine Nanoconjugate on Melanoma Cells Grown as Three-Dimensional Multicellular Tumour Spheroids. Pharmaceutics. 2023;15(9):2264 [Crossref]
37- Simic D, Zaric M, Jakovljevic S, Pantic K, Petrovic D, Milic S, Canovic P. Antitumor Activity of Palladium(II) Complexes on DU-145 Cell Line In vitro . 2025;26(2):145 [Crossref]
38- Sun D, Li Y, Cao H, Guo H, Alahmadi T, Alharbi S, Yu J. Hepatoprotective potential of kirenol on ethanol‐induced liver toxicity in albino rats and acetaminophen‐induced oxidative stress‐mediated apoptosis in hepatic HepG2 cells. J Biochem & Molecular Tox. 2021;35(7) [Crossref]
39- Françon A, Torriglia A. Cell death mechanisms in retinal phototoxicity. Journal of Photochemistry and Photobiology. 2023;15:100185 [Crossref]
40- Golounina O, Minniakhmetov I, Salakhov R, Khusainova R, Zakharova E, Bychkov I, Mokrysheva N. Pathogenetic therapeutic approaches for endocrine diseases based on antisense oligonucleotides and RNA-interference. Front Endocrinol. 2025;16 [Crossref]
41- Ferreira-Silva G, Candido C, Garavelli G, Girotto Pressete C, Caixeta E, Graminha A, Barbosa M, Doriguetto A, Ionta M, Ferro Aissa A. Ruthenium(II) Complex with 3,4-Methylenedioxy Cinnamic Acid Induces Cell Cycle Arrest at G0/G1 and Apoptosis via ROS Generation and Bioenergetics Disruption in Non-Small Cell Lung Cancer Cells. 2025;10(27):28956 [Crossref]
42- Alrumaihi F, Rahmani A, Prabhu S, Kumar V, Anwar S. The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer. CIMB. 2025;47(7):498 [Crossref]
43- Kazmi Z, Safdar N, Chaudhry G, Ain N, Husnain S, Yasmin A. Radical Scavenging Capability Influences the Multifarious Therapeutic Tendencies of Phyto-Engineered CuO Nanostructures. J Inorg Organomet Polym. 2021;31(7):3125 [Crossref]
44- Dolkar R, Paudwal G, Singh D, Behera C, Malik S, Ali S, Kaur H, Nargotra A, Shankar R, Singh S, Gupta P. Mechanistic Approach into 1,2,3-triazoles-based IIIM(S)-RS98 Mediated Apoptosis in Lung Cancer Cells. AAPS J. 2025;27(1) [Crossref]
45- Lakshmikanthan M, Muthu S, Krishnan K, Altemimi A, Haider N, Govindan L, Selvakumari J, Alkanan Z, Cacciola F, Francis Y. A comprehensive review on anthocyanin-rich foods: Insights into extraction, medicinal potential, and sustainable applications. Journal of Agriculture and Food Research. 2024;17:101245 [Crossref]
46- Scuderi S, Casili G, Basilotta R, Lanza M, Filippone A, Raciti G, Puliafito I, Colarossi L, Esposito E, Paterniti I. NLRP3 Inflammasome Inhibitor BAY-117082 Reduces Oral Squamous Cell Carcinoma Progression. IJMS. 2021;22(20):11108 [Crossref]
47- Yulak F, Filiz A, Joha Z, Ergul M. Mechanism of anticancer effect of ETP-45658, a PI3K/AKT/mTOR pathway inhibitor on HT-29 Cells. Med Oncol. 2023;40(12) [Crossref]
48- Liu A, Chen S, Zhou Q, Yu F, Li G, Niu Z. Exploring a novel asymmetric tris-heteroleptic iridium(III) complex as mitochondria-targeted anticancer agents. Journal of Inorganic Biochemistry. 2026;274:113102 [Crossref]
49- Çiftçi B, Gülenç Z, Korkut Çelikateş B, Osmaniye D. Synthesis, Structural Characterization, and Investigation of Biological Effects of Novel Benzothiazole‐Triazole Derivatives Designed as AKT Kinase Inhibitors. Chem Biol Drug Des. 2026;108(3) [Crossref]
50- Bruno P, Arshad A, Gogu M, Waterman N, Flack R, Dunn K, Darie C, Neagu A. Post-Translational Modifications of Proteins Orchestrate All Hallmarks of Cancer. Life. 2025;15(1):126 [Crossref]
51- Ekren Asici G, Kiral F, Bildik A, Ulutas P. Cytotoxic and apoptotic effects of etoposide and ellagic acid alone or with possible synergistic/additive combinations on a canine D-17 osteosarcoma cell line. Vet Med. 2025;70(8):279 [Crossref]
52- Raeisi H, Azimirad M, Abdemohamadi E, Pezzani R, Zali M, Yadegar A. Pleiotropic effects of Mentha longifolia L. extract on the regulation of genes involved in inflammation and apoptosis induced by Clostridioides difficile ribotype 001. Front Microbiol. 2023;14 [Crossref]
53- Turky A, Bayoumi A, Ghiaty A, El-Azab A, A.-M. Abdel-Aziz A, Abulkhair H. Design, synthesis, and antitumor activity of novel compounds based on 1,2,4-triazolophthalazine scaffold: Apoptosis-inductive and PCAF-inhibitory effects. Bioorganic Chemistry. 2020;101:104019 [Crossref]
54- Pedarpour S, Zarei S, Ghafouri H. Apoptosis enhancement in MCF-7 cells: Synergistic effects of doxorubicin and the novel sulfonamide Zm-093. Int J Immunopathol Pharmacol. 2026;40 [Crossref]
55- Jongcharoen O, Reabroi S, Sanvarinda P, Tungmunnithum D, Parichatikanond W, Pinthong D. Damnacanthal Suppresses Breast Cancer Cells by Inducing Apoptosis and Cell Cycle Arrest via NF‐ĸB Signaling. Pharmacology Res & Perspec. 2026;14(2) [Crossref]
56- Virchea L, Frum A, Georgescu C, Pecsenye B, Máthé E, Mironescu M, Crăciunaș M, Totan M, Tănăsescu C, Gligor F. An Overview of the Bioactivity of Spontaneous Medicinal Plants Suitable for the Improvement of Lung Cancer Therapies. Pharmaceutics. 2025;17(3):336 [Crossref]
57- Muzio L, Ferrati D, Colombo E, Molinaro C. The Regnase pathway: a core axis in immune regulation and inflammatory disease. Front Immunol. 2026;17 [Crossref]
58- Li J, Hu X, Zhang H, Peng Y, Li S, Xiong Y, Jiang W, Wang Z. N-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression. J Med Chem. 2022;65(15):10481 [Crossref]
59- Wang L, Li R, Zang Z, Song Y, Zhang Y, Zhang T, Wang F, Hao G, Cao L. 6-Methoxydihydrosanguinarine exhibits cytotoxicity and sensitizes TRAIL-induced apoptosis of hepatocellular carcinoma cells through ROS-mediated upregulation of DR5. Med Oncol. 2023;40(9) [Crossref]
60- Wu Y, Liu J, Shao M, Zhang P, Song S, Yang G, Liu X, Liu Z. Cyclometalated Iridium(Iii) Dithioformic Acid Complexes as Mitochondria-Targeted Imaging and Anticancer Agents. SSRN Journal. 2022; [Crossref]
61- Boonyanugomol W, Rukseree K, Prapatpong P, Reamtong O, Baik S, Jung M, Shin M, Kang H, Lee W. An In Vitro Anti-Cancer Activity of Ocimum tenuiflorum Essential Oil by Inducing Apoptosis in Human Gastric Cancer Cell Line. Medicina. 2021;57(8):784 [Crossref]
62- Addy B, Firempong C, Komlaga G, Addo-Fordjour P, Domfeh S, Afolayan O, Yaw Nyarko E, Emikpe B. A bioactive fraction from the leaves of Ceiba pentandra (L.) Gaertn. exhibits antiproliferative activity via cell cycle arrest at the G1/S checkpoint and initiation of apoptosis via poly [ADP-ribose] polymerase 1 (PARP1) cleavage in HeLa cells.. Journal of Ethnopharmacology. 2025;341:119363 [Crossref]
63- Wegrzyn M, Adamiec-Organisciok M, Dawicka A, Fochtman D, Galecki S, Magate N, Bartel K, Gendosz de Carrillo D, Witek-Zelazny E, Skonieczna M. Understanding variability in cell death modes and sensitivity: Potential implications for targeted cancer therapies. Experimental Cell Research. 2025;451(1):114688 [Crossref]
64- Timothy F, Zininga T. Small heat shock proteins as modulators of cell death in Plasmodium falciparum parasites and its human host. Front Cell Death. 2023;2 [Crossref]
65- Martel-Estrada S, Vargas-Requena C, Sifuentes-Chavarría J, Yepes-Mendoza M, Palacio-Castillo D, Jimenez-Vega F, Olivas-Armendáriz I, Villarreal-Gómez L. Cell Death Mechanisms Produced by Carbon‐Based Nanoparticles. Journal of Nanotechnology. 2025;2025(1) [Crossref]
66- Mitea G, Schröder V, Iancu I, Mireșan H, Iancu V, Bucur L, Badea F. Molecular Targets of Plant-Derived Bioactive Compounds in Oral Squamous Cell Carcinoma. Cancers. 2024;16(21):3612 [Crossref]
67- Khursheed N, Ashraf S, Ashraf Q, Khursheed A, Asiaf A, Ganie S. DNA methylation-mediated regulation of TRAIL pathway components (DR5, DcR2, and CASP3) in breast cancer: molecular mechanisms and therapeutic implications. Mol Biol Rep. 2026;53(1) [Crossref]
68- Batarfi W, Yunus M, Hamid A, Lee Y, Maarof M. Hydroxytyrosol: A Promising Therapeutic Agent for Mitigating Inflammation and Apoptosis. Pharmaceutics. 2024;16(12):1504 [Crossref]
69- Okyay T, Güler E, Kale E, Gultekin F, Koldas M. Impact of calcium propionate on cellular behavior in A549 and DMS114 lung cancer cell lines. 2024;49(5):666 [Crossref]
70- Kim S, Lee D. Orostachys japonicus induce caspase-dependent apoptosis in HeLa human cervical cancer cells. Nutr Res Pract. 2025;19(1):131 [Crossref]
71- Kafi S, Najafi S, Mahnam K, Farivar S, Ranjbari J. Virtual screening and experimental analysis of caspase-7 inhibitors as candidates for extending the lifespan of CHO cells. Electronic Journal of Biotechnology. 2024;71:28 [Crossref]
72- Noureldeen A, Aziz S, Shouman S, Mohamed M, Attia Y, Ramadan R, Elhady M. Molecular Design, Spectroscopic, DFT, Pharmacological, and Molecular Docking Studies of Novel Ruthenium(III)–Schiff Base Complex: An Inhibitor of Progression in HepG2 Cells. IJERPH. 2022;19(20):13624 [Crossref]
73- Chou S, Ramesh S, Kuo C, Ali A, Ho T, Chang K, Hsieh D, Kumar V, Weng Y, Kuo W, Huang C. Tanshinone IIA inhibits Leu27IGF‐II‐induced insulin‐like growth factor receptor II signaling and myocardial apoptosis via estrogen receptor‐mediated Akt activation. Environmental Toxicology. 2022;37(1):142 [Crossref]
74- Iqbal M, Waqas M, Mo Q, Shahzad M, Zeng Z, Qamar H, Mehmood K, Kulyar M, Nawaz S, Li J. Baicalin inhibits apoptosis and enhances chondrocyte proliferation in thiram-induced tibial dyschondroplasia in chickens by regulating Bcl-2/Caspase-9 and Sox-9/Collagen-II expressions. Ecotoxicology and Environmental Safety. 2023;268:115689 [Crossref]
75- Rok J, Rzepka Z, Banach K, Kowalska J, Wrześniok D. The Assessment of the Phototoxic Action of Chlortetracycline and Doxycycline as a Potential Treatment of Melanotic Melanoma—Biochemical and Molecular Studies on COLO 829 and G-361 Cell Lines. IJMS. 2023;24(3):2353 [Crossref]
76- Ruzic D, Ellinger B, Djokovic N, Santibanez J, Gul S, Beljkas M, Djuric A, Ganesan A, Pavic A, Srdic-Rajic T, Petkovic M, Nikolic K. Discovery of 1-Benzhydryl-Piperazine-Based HDAC Inhibitors with Anti-Breast Cancer Activity: Synthesis, Molecular Modeling, In Vitro and In Vivo Biological Evaluation. Pharmaceutics. 2022;14(12):2600 [Crossref]
77- Moremane M, Abrahams B, Tiloke C. Moringa oleifera: A Review on the Antiproliferative Potential in Breast Cancer Cells. CIMB. 2023;45(8):6880 [Crossref]
78- Gohal G. The Analogy between the Immune System and Human Life. OJI. 2024;14(03):47 [Crossref]
79- Unterberger C, McIlwain S, Tsourkas P, Maklakova V, Prince J, Onesti A, Hu R, Kopchick J, Swanson S, Marker P. Conditional gene regulation models demonstrate a pro‐proliferative role for growth hormone receptor in prostate cancer. The Prostate. 2023;83(5):416 [Crossref]
80- Kharisma V, Listiyani P, Ali Murtadlo A, Putra Pradana R, Ansori A, Patera Nugraha A, Rollando R, Kuncoroningrat Susilo R, Hayaza S, Olegovna Budagova S, Vadimovich Nadvodnyk G, Gennadievich Lebedev I, Nadirovna Khalibekova Z, Vladimirovich Rzhepakovsky I, Rebezov M, Jakhmola V, Purnobasuki H, Kusuma Wahyuni D. Molecular Network Simulation of Bawang Ada’ (Eleutherine americana Merr.) from Dayak Lundayeh in North Kalimantan Tackle various Viral Infection Targeting Key Protein. RJPT. 2024;:1961 [Crossref]
81- Jin S, Park J, Yun H, Oh Y, Oh S, Choi Y, Kim B, Kwon H. Cedrol, a Sesquiterpene Isolated from Juniperus chinensis, Inhibits Human Colorectal Tumor Growth associated through Downregulation of Minichromosome Maintenance Proteins. J Cancer Prev. 2022;27(4):221 [Crossref]
82- Chaudhary M, Chaudhary S, Sharma Y, Singh T, Mishra A, Sharma S, Mehdi M. Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies. Biogerontology. 2023;24(5):609 [Crossref]
83- Seetharaman A, Owens C, Gangaraju R. Cysteinyl Leukotriene Receptor Antagonism by Montelukast to Treat Visual Deficits. Journal of Ocular Pharmacology and Therapeutics. 2024;40(10):617 [Crossref]
84- Park C, Hwangbo H, Hong S, Jeong H, Yun S, Noh J, Moon S, Kim W, Kim G, Choi Y. 5-Aminoimidazole-4-carboxamide riboside, an AMPK activator, enhances TRAIL-mediated apoptosis in human bladder cancer cells in a p38 MAPK-dependent manner. Genes Genom. 2026;48(7):963 [Crossref]
85- Jurcau A, Ardelean I. Molecular pathophysiological mechanisms of ischemia/reperfusion injuries after recanalization therapy for acute ischemic stroke. J Integr Neurosci. 2021;20(3) [Crossref]
86- Choi J, Boo M, Boo Y. Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets. Molecules. 2024;29(10):2288 [Crossref]
87- Pasahan R, Demirci O, Taskin I, Pasahan A, Sever M, Gok Y, Aktas A. Design, Synthesis, Characterization, and Antitumor Activities of Benzimidazole-functionalized Organoruthenium Complexes Bearing Fluorine Group. MC. 2025;21(6):546 [Crossref]
88- Firouzi M, Akomea A, Jamei M, Harris G, Kim D. Immune cell-derived exosomes in cancer: double-edged mechanisms of antitumor immunity and tumor progression. Front Immunol. 2026;17 [Crossref]
89- Saxena K, Hung S, Ryu E, Singh S, Zhang Tatarata Q, Zeng Z, Wang Z, Konopleva M, Yee C. BH3 mimetics augment cytotoxic T cell killing of acute myeloid leukemia via mitochondrial apoptotic mechanism. Cell Death Discov. 2025;11(1) [Crossref]
90- Smirnova I, Drăghici G, Kazakova O, Vlaia L, Avram S, Mioc A, Mioc M, Macaşoi I, Dehelean C, Voicu A, Şoica C. Hollongdione arylidene derivatives induce antiproliferative activity against melanoma and breast cancer through pro-apoptotic and antiangiogenic mechanisms. Bioorganic Chemistry. 2022;119:105535 [Crossref]
91- Ghorbani Alvanegh A, Mirzaei Nodooshan M, Dorostkar R, Ranjbar R, Jalali Kondori B, Shahriary A, Parastouei K, Vazifedust S, Afrasiab E, Esmaeili Gouvarchinghaleh H. Antiproliferative effects of mesenchymal stem cells carrying Newcastle disease virus and Lactobacillus Casei extract on CT26 Cell line: synergistic effects in cancer therapy. Infect Agents Cancer. 2023;18(1) [Crossref]
92- Malekpoor Z, Taghian F, Jalali Dehkordi K. The effect of endurance training and consumption of gallic acid and kaempferol on the expression of ARC, VEGFα, HIF1α and CREB1 genes in mice with breast cancer treated with paclitaxel. ijbd. 2024;17(1):22 [Crossref]
93- Hołota M, Posmyk M. Nature-Inspired Strategies in Cancer Management: The Potential of Plant Extracts in Modulating Tumour Biology. IJMS. 2025;26(14):6894 [Crossref]
94- Zhang J, Li F, Lu K, Zhang W, Ma J. Recent advances in cold atmospheric plasma for tumor therapy. Process Biochemistry. 2023;131:77 [Crossref]
95- Pereyra-Vergara F, Olivares-Corichi I, Perez-Ruiz A, Luna-Arias J, García-Sánchez J. Apoptosis Induced by (−)-Epicatechin in Human Breast Cancer Cells is Mediated by Reactive Oxygen Species. Molecules. 2020;25(5):1020 [Crossref]
96- Li J, Zhang G, Yu C, Hu Z, Feng L, Yang P. Magnesium-based nanomaterials for cancer therapy: Unraveling mechanisms and current developments. Coordination Chemistry Reviews. 2026;547:217119 [Crossref]
97- Zhang Y, Zhu M, Krishna Mohan S, Hao Z. Crocin treatment promotes the oxidative stress and apoptosis in human thyroid cancer cells FTC‐133 through the inhibition of STAT/JAK signaling pathway. J Biochem & Molecular Tox. 2021;35(1) [Crossref]
98- YANG X, QU J, LI J. Nicotinic acid induces apoptosis of glioma cells via the calcium-dependent endoplasmic reticulum stress pathway. 2022;46(4):1041 [Crossref]
99- Kao S, Chang Y, Lin F, Huang T, Chen T, Lin S, Lin K, Kuo W, Ho T, Huang C. Jing‐Si Herbal Tea Suppresses H2O2‐Instigated Inflammation and Apoptosis by Inhibiting Bax and Mitochondrial Cytochrome C Release in HIG‐82 Synoviocytes. Environmental Toxicology. 2024;39(12):5347 [Crossref]
100- Jang W, Kim D, Park S, Yoon J, Shin C, Huang L, Nang K, Kry M, Byun H, Lee B, Lee S, Lee J, Cho J. Connarus semidecandrus Jack Exerts Anti-Alopecia Effects by Targeting 5α-Reductase Activity and an Intrinsic Apoptotic Pathway. Molecules. 2022;27(13):4086 [Crossref]
101- Maistry L, Gerrano A, Mellem J. Antiproliferative Effect of Okra Seed Protein Isolate against HepG2 and A549 Cell Lines. Chemistry & Biodiversity. 2026;23(1) [Crossref]
102- Loh T, Lee M, Agouni A, Fuloria N, Fuloria S, Sekar M, Saleem S, Gopinath S, Khan A, Wu Y. Cytotoxicity and potential cell death mechanisms of three new benzamidine derivatives in esophageal squamous cell carcinoma cells using in vitro and in silico approaches. Cytotechnology. 2026;78(3) [Crossref]
103- Liu Y, Meng Y, Bian J, Liu B, Li X, Guan Q, Li Z, Zhang W, Wu Y, Zuo D. 2‐Methoxy‐5((3,4,5‐trimethosyphenyl) seleninyl) phenol causes G2/M cell cycle arrest and apoptosis in NSCLC cells through mitochondrial apoptotic pathway and MDM2 inhibition. J Biochem & Molecular Tox. 2022;36(7) [Crossref]
104- Gorman L, Tivey T, Raymond E, Ashley I, Oakley C, Grossman A, Weis V, Davy S. Stability of the cnidarian–dinoflagellate symbiosis is primarily determined by symbiont cell-cycle arrest. Proc Natl Acad Sci USA. 2025;122(14) [Crossref]
105- Yu Y, Cao X. miR-190-5p in human diseases. Cancer Cell Int. 2019;19(1) [Crossref]
106- Kim H, Kim J, Park B, Park H. Chitosan Nanoparticle-Encapsulated Cordyceps militaris Grown on Germinated Rhynchosia nulubilis Reduces Type II Alveolar Epithelial Cell Apoptosis in PM2.5-Induced Lung Injury. IJMS. 2025;26(3):1105 [Crossref]
107- Bhuyan P, Nayak R, Patra S, Abdulabbas H, Jena M, Pradhan B. Seaweed-Derived Sulfated Polysaccharides; The New Age Chemopreventives: A Comprehensive Review. Cancers. 2023;15(3):715 [Crossref]
108- M. Ezzat S, M. Merghany R, M. Abdel Baki P, Ali Abdelrahim N, M. Osman S, A. Salem M, Peña‐Corona S, Cortés H, Kiyekbayeva L, Leyva‐Gómez G, Sharifi‐Rad J, Calina D. Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights. Molecular Nutrition Food Res. 2024;68(8) [Crossref]
109- AL-Ishaq R, Koklesova L, Kubatka P, Büsselberg D. Immunomodulation by Gut Microbiome on Gastrointestinal Cancers: Focusing on Colorectal Cancer. Cancers. 2022;14(9):2140 [Crossref]
110- Liu J, Zhu T, Liu J, Cui Y, Yang S, Zhao R. Synergistic antitumor effects of circularly permuted TRAIL with doxorubicin in triple-negative breast cancer. ABBS. 2023;55(8):1247 [Crossref]
111- Khedr M, Abu-Zied K, Zaghary W, Aly A, Shouman D, Haffez H. Novel thienopyrimidine analogues as potential metabotropic glutamate receptors inhibitors and anticancer activity: Synthesis, In-vitro, In-silico, and SAR approaches. Bioorganic Chemistry. 2021;109:104729 [Crossref]
112- Gul I, Yunus U, Ajmal M, Bhatti M, Chaudhry G. Development of biodegradable thin films for efficient, specific and controlled delivery of capecitabine. Biomed Mater. 2021;16(5):055019 [Crossref]
113- Di Paola R, De A, Capasso A, Giuliana S, Ranieri R, Ruosi C, Sciarra A, Vitagliano C, Perna A, Capasso G, Simeoni M. Impact of Thyroid Cancer Treatment on Renal Function: A Relevant Issue to Be Addressed. JPM. 2023;13(5):813 [Crossref]
114- Cseh K, Geisler H, Stanojkovska K, Westermayr J, Brunmayr P, Wenisch D, Gajic N, Hejl M, Schaier M, Koellensperger G, Jakupec M, Marquetand P, Kandioller W. Arene Variation of Highly Cytotoxic Tridentate Naphthoquinone-Based Ruthenium(II) Complexes and In-Depth In Vitro Studies. Pharmaceutics. 2022;14(11):2466 [Crossref]
115- Shams El Dine R, Youseef H, Awaad A, Hammoury S, Mohamed E. The potentially therapeutic effects of ascorbic acid in different cell line in attempt to reduce the risk of radiation therapy. Sci Rep. 2025;15(1) [Crossref]
116- Lozano-Gil J, Pedoto A, Conesa-Hernández A, Ocaña-Esparza M, Mulero V, Tyrkalska S. Programmed cell death pathways coordinate neutrophil and macrophage clearance in zebrafish and are differentially exploited by Salmonella Typhimurium. Cell Death Dis. 2025;17(1) [Crossref]
117- Tavakolpour V, Safari-Kharkeshi M, Soleimanpour-Lichaei H, Gardaneh M, Kouhkan F. MicroRNA-34a enhances immune response and suppresses PI3K/AKT signaling through targeting PD-L1 in triple-negative breast cancer. Gene Reports. 2025;40:102211 [Crossref]
118- Farzaneh Z, Vosough M, Agarwal T, Farzaneh M. Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches. Cancer Cell Int. 2021;21(1) [Crossref]
119- Colpan R, Erdemir A. Co-delivery of quercetin and caffeic-acid phenethyl ester by polymeric nanoparticles for improved antitumor efficacy in colon cancer cells. Journal of Microencapsulation. 2021;38(6):381 [Crossref]
120- Sun Y, Fang W, Peng J, Liu X, Wang C, Song L, Deng Z. Potential role of CFLAR in enhancing 5-FU sensitivity and modulating immune cell infiltration in breast cancer. Eur J Med Res. 2025;30(1) [Crossref]
121- Bowolaksono A, Fauzi M, Sundari A, Pustimbara A, Lestari R, Lestari A, Dwiranti A, Dwiranti F. The effects of luteinizing hormone as a suppression factor for apoptosis in bovine luteal cells in vitro. Reprod Domestic Animals. 2021;56(5):744 [Crossref]
122- Mara B, Mioc A, Deveseleanu-Corici L, Șoica C, Cseh L. Novel Compounds Featuring a Thiophene Carboxamide Scaffold: Synthesis, Characterization and Antiproliferative Evaluation. IJMS. 2025;26(14):6823 [Crossref]
123- Hao X, Qu C, Zhou Y, Wang X, Qian X, Chen X, Han F, Zhang X, Ji Y, Li H, Ju C, Xia P, Tang W, Zhuang H, Zhou J. Engineered CAR‐NKT Extracellular Vesicles Suppress Tumor Progression and Enhance Antitumor Immunity. Advanced Science. 2026;13(13) [Crossref]
124- Nashtahosseini Z, Nejatollahi M, Fazilat A, Zarif Fakoor E, Emamvirdizadeh A, Bahadori K, Hadian N, Valilo M. The crosstalk between exosomal miRNA and ferroptosis: A narrative review. Biology of the Cell. 2025;117(1) [Crossref]
125- Alkhathami A, Pallathadka H, Shah S, Ganesan S, Sharma A, Devi S, Mustafa Y, Alasheqi M, Kadhim A, Zwamel A. Mechanisms behind the LncRNAs-mediated regulation of paclitaxel (PTX) resistance in human malignancies. Experimental Cell Research. 2025;445(2):114434 [Crossref]
126- Zahra M, Abrahamse H, George B. Flavonoids: Antioxidant Powerhouses and Their Role in Nanomedicine. Antioxidants. 2024;13(8):922 [Crossref]
127- Fang Y, Ou S, Wu T, Zhou L, Tang H, Jiang M, Xu J, Guo K. Lycopene alleviates oxidative stress via the PI3K/Akt/Nrf2pathway in a cell model of Alzheimer’s disease. 2020;8:e9308 [Crossref]
128- Mohamed H, Mohamed B, Hakeem G, Elnawasani S, Nagy M, Essam R, Diab A, Safwat G. Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells. Sci Rep. 2025;15(1) [Crossref]
129- Rolando J, Singla D. BMP-7 Treatment Ameliorates PTEN-Akt Mediated Apoptosis and Adverse Cardiac Remodeling in Ponatinib-Induced Cardiotoxicity. Pharmaceuticals. 2025;18(12):1776 [Crossref]
130- Orysyk V, Zborovskii Y, Orysyk S, Filip-Psurska B, Wietrzyk J, Witek J, Schneider K, Shishkina S, Dyakonenko V, Yanko O, Vovk M. Novel n,π-chelate complexes of Pd(II) and Pt(II) with heterocycle-substituted thioureas: Synthesis, spectral properties, and cytotoxic activity. Journal of Molecular Structure. 2026;1353:144685 [Crossref]
131- Zhang L, Wang H. FTY720 in CNS injuries: Molecular mechanisms and therapeutic potential. Brain Research Bulletin. 2020;164:75 [Crossref]
132- Koklesova L, Liskova A, Samec M, Buhrmann C, Samuel S, Varghese E, Ashrafizadeh M, Najafi M, Shakibaei M, Büsselberg D, Giordano F, Golubnitschaja O, Kubatka P. Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back. Cancers. 2020;12(9):2425 [Crossref]
133- PAZARCI P. Alfa-Linolenik Asitin Apoptotik Etkileri. 2024;2(1):46 [Crossref]
134- Alhazza A, Oyegbesan A, Bousoik E, Montazeri Aliabadi H. Multidrug Resistance: Are We Still Afraid of the Big Bad Wolf. Pharmaceuticals. 2025;18(6):895 [Crossref]
135- Munir N, Gürbüz N, Chaudhry G, Özdemir İ, Sarfraz M, Şen B, Aygün M, Zafar M. Synergistic Antiproliferative Activity of Newly Synthesized Benzimidazole-Based Silver(I) Complexes on MCF-7 and T47D Cell Lines, CT-DNA Interactions Supported by Computational Studies. ACS Omega. 2025;10(13):13278 [Crossref]
136- Sekhoacha M, Riet K, Motloung P, Gumenku L, Adegoke A, Mashele S. Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches. Molecules. 2022;27(17):5730 [Crossref]
137- Bui I, Baritaki S, Libra M, Zaravinos A, Bonavida B. Cancer Resistance Is Mediated by the Upregulation of Several Anti-Apoptotic Gene Products via the Inducible Nitric Oxide Synthase/Nitric Oxide Pathway: Therapeutic Implications . Antioxidants & Redox Signaling. 2023;39(13-15):853 [Crossref]
138- YAZGAN B, MESCİ S, AKSAHIN M, AYAR A, GÜL M, YILDIRIM T. PhTAD-Substituted Dihydropyrrole Compounds Regulate Apoptotic Cell Death in MCF-7 Cells. 2021;14(2):737 [Crossref]
139- Hussar P. Apoptosis Regulators Bcl-2 and Caspase-3. Encyclopedia. 2022;2(4):1624 [Crossref]
140- Pierce M, Huang Y, Lin A, Franco Nitta C, Kuksin D, Lin B, Chan L. A Multiplex Assay to Simultaneously Monitor Apoptosis and Necrosis Using the Cellaca® PLX Image Cytometer. J Fluoresc. 2024;35(2):1111 [Crossref]
141- Koyuncu I, Temiz E, Seker F, Balos M, Akkafa F, Yuksekdag O, Yılmaz M, Zengin G. A mixed‐apoptotic effect of Jurinea mesopotamica extract on prostate cancer cells: a promising source for natural chemotherapeutics. Chemistry & Biodiversity. 2024;21(2) [Crossref]
142- Kaçaroğlu D, Yaylacı S, Gurbuz N. Anti‐tumorigenic effects of naive and TLR4‐primed adipose‐derived mesenchymal stem cells on pancreatic ductal adenocarcinoma cells. Cancer Medicine. 2024;13(2) [Crossref]
143- Saxena R, Welsh C, He Y. Targeting regulated cell death pathways in cancers for effective treatment: a comprehensive review. Front Cell Dev Biol. 2024;12 [Crossref]
144- Aljabali A, Bashatwah R, El-Tanani M, Tambuwala M. Natural Anticancer Drugs: Efficacy, Safety, and Future Challenges. CMC. 2025;32(31):6764 [Crossref]
145- Xing F, Ai N, Huang S, Jiang C, Mughal M, Ge W, Wang G, Deng C. An In Vivo Fluorescence Resonance Energy Transfer-Based Imaging Platform for Targeted Drug Discovery and Cancer Therapy. Front Bioeng Biotechnol. 2022;10 [Crossref]
146- El Tabaa M, Faheem H, Elballal M, Rashad E, Mohsen M, El Tabaa M. The PPAR-α agonist oleoyethanolamide (OEA) ameliorates valproic acid-induced steatohepatitis in rats via suppressing Wnt3a/β-catenin and activating PGC-1α: Involvement of network pharmacology and molecular docking. European Journal of Pharmacology. 2025;991:177306 [Crossref]
147- Fujimoto S, Endo M, Tonomura S, Tsuji F, Haraguchi H, Hasegawa K, Numao T, Izumi A, Tourtas T, Schlötzer-Schrehardt U, Kruse F, Oyama Y, Ikawa M, Jun A, Koizumi N, Okumura N. Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy. Cells. 2025;14(7):498 [Crossref]
148- Amirchaghmaghi M, Pakfetrat A, Mohtasham N, Mohajertehran F, shakeri M, Vazavandi E. Comparative Study of the Expressions of Nuclear (∆EX3) and Cytoplasmic (2B) Survivins in Oral Squamous Cell Carcinoma and Oral Lichen Planus Using Real‐Time PCR. Clinical & Exp Dental Res. 2025;11(1) [Crossref]
149- Bensam M, Rechreche H, Abdelwahab A, Abu-Serie M, Ali S. The role of Algerian Ephedra alata ethanolic extract in inhibiting the growth of breast cancer cells by inducing apoptosis in a p53- dependent pathway. Saudi Journal of Biological Sciences. 2023;30(6):103650 [Crossref]
150- Hajimirza Shafiesoltani P, Forouzesh F, Shabani M, Aghaei M. Synergistic Anti-proliferative Effects of Lenalidomide and Dexamethasone on the HT-29 Cell Line Through Apoptotic Genes. Int J Cancer Manag. 2021;14(8) [Crossref]
151- Wang Y, Li Y, Chen J, Liu H, Zhou Y, Huang C, Liang L, Liu Y, Wang X. Anticancer effect evaluation of iridium(III) complexes targeting mitochondria and endoplasmic reticulum. Journal of Inorganic Biochemistry. 2023;238:112054 [Crossref]
152- AL-Noshokaty T, Abdelhamid R, Reda T, Alaaeldien A, Abdellatif N, Mansour A, Gendi D, Abdelmaksoud N, Elshaer S, Doghish A, Sobhy M, Mohammed O, Abulsoud A. Exploring the clinical potential of circulating LncRNAs in breast cancer: insights into primary signaling pathways and therapeutic interventions. Funct Integr Genomics. 2024;24(6) [Crossref]
153- Modi J, Roy A, Pradhan A, Kumar A, Talukdar S, Bhoopathi P, Maji S, Mannangatti P, Sanchez De La Rosa D, Li J, Guo C, Subler M, Windle J, Cavenee W, Sarkar D, Wang X, Das S, Emdad L, Fisher P. Insights into the Mechanisms of Action of MDA-7/IL-24: A Ubiquitous Cancer-Suppressing Protein. IJMS. 2021;23(1):72 [Crossref]
154- Li X, Han M, Fan H, Li S, Peng F. Leonurus japonicus: A promising anticancer Chinese medicine modulating regulated cell death. 2025;138(3):373 [Crossref]
155- de Menezes A, Aguiar R, Santos J, Sarkar C, Islam M, Braga A, Hasan M, da Silva F, Sharifi-Rad J, Dey A, Calina D, Melo-Cavalcante A, Sousa J. Citrinin as a potential anti-cancer therapy: A comprehensive review. Chemico-Biological Interactions. 2023;381:110561 [Crossref]
156- Patel N, Gupta A, Mishra R, Pandey S, Goyal K, Ali H, Maji C, Rekha A, Hussain M, Singh S, Gupta G. Withaferin A in breast cancer therapy: multi-targeted modulation of redox homeostasis, autophagy, and apoptosis. Journal of Asian Natural Products Research. 2026;:1 [Crossref]
157- Zafar M, Butt A, Chaudhry G, Perveen F, Nazar M, Masood S, Dalebrook A, Mughal E, Sumrra S, Sung Y, Muhammad T, Wright L. Pd(II) complexes with chelating N-(1-alkylpyridin-4(1H)-ylidene)amide (PYA) ligands: Synthesis, characterization and evaluation of anticancer activity. Journal of Inorganic Biochemistry. 2021;224:111590 [Crossref]
158- Agrawal S, Podber A, Gillespie M, Dietz N, Hansen L, Nandipati K. Regulation of pro-apoptotic and anti-apoptotic factors in obesity-related esophageal adenocarcinoma. Mol Biol Rep. 2024;51(1) [Crossref]
159- Zomorodimanesh S, Razavi S, Zomorodimanesh P. Exploring the Role of Probiotics in the Prevention and Treatment of Gastrointestinal Cancer. Probiotics & Antimicro Prot. 2026; [Crossref]
160- Permatasari H, Fatiha R, Ngabdi C, Azizah J, Lestari B, To S, Malek N. Modulation of apoptotic pathways and epithelial–mesenchymal transition in HeLa cervical cancer cells by Ficus deltoidea-silver nanoparticles (FD-AgNPs). Phytomedicine Plus. 2026;6(1):100923 [Crossref]
161- Paliwal K, Swain A, Mishra D, Kumar M. Targeting Triple Negative Breast Cancer with a Dinuclear Copper(II) Thiocarbohydrazone Complex: Efficacy Evaluation and Cellular Response. ACS Omega. 2025;10(36):41342 [Crossref]
162- Yunus U, Zulfiqar M, Ajmal M, Bhatti M, Chaudhry G, Muhammad T, Sung Y. Targeted drug delivery systems: synthesis and in vitro bioactivity and apoptosis studies of gemcitabine-carbon dot conjugates. Biomed Mater. 2020;15(6):065004 [Crossref]
163- Dastmalchi N, Hosseinpourfeizi M, Khojasteh S, Baradaran B, Safaralizadeh R. Tumor suppressive activity of miR-424-5p in breast cancer cells through targeting PD-L1 and modulating PTEN/PI3K/AKT/mTOR signaling pathway. Life Sciences. 2020;259:118239 [Crossref]
164- Park Y, Kang S, Lee J, Jang B. The Growth Inhibitory Effect on B16F10 Melanoma Cells by 4-BPCA, an Amide Derivative of Caffeic Acid. Keimyung Med J. 2022;41(1):17 [Crossref]
165- Lu Y, Chiang C, Hsu Y, Chen C, Chen W, Tseng C, Deng L, Chen S, Kuan Y. Cyclizine induces cytotoxicity and apoptosis in macrophages through the extrinsic and intrinsic apoptotic pathways. Environmental Toxicology. 2024;39(5):2970 [Crossref]
166- Rezaei A, Moqadami A, Khalaj-Kondori M, Feizi M. Minocycline induced apoptosis and suppressed expression of matrix metalloproteinases 2 and 9 in the breast cancer MCF-7 cells. Mol Biol Rep. 2024;51(1) [Crossref]
167- Phull A, Ali A, Dhong K, Zia M, Mahajan P, Park H. Synthesis, characterization, anticancer activity assessment and apoptosis signaling of fucoidan mediated copper oxide nanoparticles. Arabian Journal of Chemistry. 2021;14(8):103250 [Crossref]
168- Arumugam P, Sampathkumar B, Perumalsamy H, Balusamy S, Ramesh V, Sundaravadevel S. Synergistic effect of anethole and doxorubicin alleviates cell proliferation, cell cycle arrest, and ER stress and promotes ROS‐mediated apoptosis in triple‐negative breast cancer cells. J Biochem & Molecular Tox. 2021;35(12) [Crossref]
169- DANDOTI S. Mechanisms adopted by cancer cells to escape apoptosis–A review. 2021;45(4):863 [Crossref]
170- Ding Z, Li Y, Zhang G, Yang Y. Programmed cell death in osteosarcoma: apoptosis, ferroptosis and pyroptosis. Journal of Radiation Research and Applied Sciences. 2025;18(4):101936 [Crossref]
171- Kumar A, Lunawat A, Narang R, Kumar M. Recent Advances in Nanomaterial-Based Immunotherapy for Prostate Cancer: A Comprehensive Review. CNM. 2025;10(2):138 [Crossref]
172- Bradic M, Taleb S, Thomas B, Chidiac O, Robay A, Hassan N, Malek J, Ait Hssain A, Abi Khalil C. DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome. J Transl Med. 2022;20(1) [Crossref]
173- Abdelaal M, Soror S, Elnagar M, Haffez H. Revealing the Potential Application of EC-Synthetic Retinoid Analogues in Anticancer Therapy. Molecules. 2021;26(2):506 [Crossref]
174- Dai W, Dai Y, Ren D, Zhu D. Dieckol, a natural polyphenolic drug, inhibits the proliferation and migration of colon cancer cells by inhibiting PI3K, AKT, and mTOR phosphorylation. J Biochem & Molecular Tox. 2023;37(5) [Crossref]
175- Chaudhry G, Rahman N, Sevakumaran V, Ahmad A, Mohamad H, Zafar M, Sung Y, Tengku Muhammad T. Induction of cytotoxicity by Bruguiera gymnorrhiza in human breast carcinoma (MCF-7) cell line via activation of the intrinsic pathway. J Adv Pharm Technol Res. 2020;11(4):233 [Crossref]
176- Alode Vodo C. Peripheral Blood Leukocyte Cells Variation and their Involvement in the Immune-Inflammatory Response of Patients with Bronchial Asthma. Asian J of Cell Biology. 2022;17(1):1 [Crossref]
177- lihui X, Jinming G, Yalin G, Hemeng W, Hao W, Ying C. Albicanol inhibits the toxicity of profenofos to grass carp hepatocytes cells through the ROS/PTEN/PI3K/AKT axis. Fish & Shellfish Immunology. 2022;120:325 [Crossref]
178- Atmaca H, Çamlı Pulat Ç, Ilhan S, Yilmaz E, Zora M. Novel Enyne-Modified 1,4-Thiazepines as Epidermal Growth Factor Receptor Inhibitors: Anticancer and Computational Studies. ACS Omega. 2025;10(1):821 [Crossref]
179- Alshehade S, Almoustafa H, Alshawsh M, Chik Z. Flow cytometry-based quantitative analysis of cellular protein expression in apoptosis subpopulations: A protocol. Heliyon. 2024;10(13):e33665 [Crossref]
180- Eissa I, Yousef R, Elkaeed E, Alsfouk A, Husein D, Ibrahim I, El-Mahdy H, Elkady H, Metwaly A. Computer-Assisted Drug Discovery of a Novel Theobromine Derivative as an EGFR Protein-Targeted Apoptosis Inducer. Evol Bioinform Online. 2023;19 [Crossref]
181- Gökşen Tosun N, Kaplan Ö, Imamoğlu R, Türkekul İ, Gökçe İ, Özgür A. Green synthesized silver nanoparticles with mushroom extracts of Paxina leucomelas and Rhizopogon luteolus induce ROS-Induced intrinsic apoptotic pathway in cancer cells . Inorganic and Nano-Metal Chemistry. 2024;54(11):1057 [Crossref]
182- Liu K, Li Z, Li L, Heyward S, Wang S, He L, Wang H. Mechanistic Understanding of Dexamethasone-Mediated Protection against Remdesivir-Induced Hepatotoxicity. Molecular Pharmacology. 2024;106(1):71 [Crossref]
183- Salem H, Gouda A, Essam N, El-Bahnasy H. Silymarin attenuates oxidative, inflammatory and apoptotic damage induced by a fungicide mixture in rat liver, kidney and brain. Toxicology Reports. 2026;16:102287 [Crossref]
184- Jin X, Ma Y, Liu D, Huang Y. Role of pyroptosis in the pathogenesis and treatment of diseases. MedComm. 2023;4(3) [Crossref]
185- Amin T, Sharma R, Mir K, Slathia N, Chhabra S, Tsering D, Kotwal P, Bhagat M, Nandi U, Parkesh R, Kapoor K, Goswami A. Quinoxalinone substituted pyrrolizine (4h)-induced dual inhibition of AKT and ERK instigates apoptosis in breast and colorectal cancer by modulating mitochondrial membrane potential. European Journal of Pharmacology. 2023;957:175945 [Crossref]
186- Alanazi N, Alrafiah M. Advances in Prostate Cancer Immunotherapy: Current Options and Emerging Novel Approaches. ann urol oncol. 2024; [Crossref]
187- Ferdous U, Khan S, Shakoor A, Uddin S, Nazarudin M, Zia A. Chlorella spp. as an Emerging Source for Anticancer Remedy and Nutraceuticals: An Advance Study . Food Reviews International. 2026;42(2):665 [Crossref]
188- Alkandahri M, Pamungkas B, Oktoba Z, Shafirany M, Sulastri L, Arfania M, Anggraeny E, Pratiwi A, Astuti F, Astuti I, Dewi S, Hamidah S, Mutalik S. Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety. Advances in Pharmacological and Pharmaceutical Sciences. 2023;2023:1 [Crossref]
189- Kopiasz Ł, Dziendzikowska K, Oczkowski M, Harasym J, Gromadzka-Ostrowska J. Low-molar-mass oat beta-glucan impacts autophagy and apoptosis in early stages of induced colorectal carcinogenesis in rats. International Journal of Biological Macromolecules. 2024;254:127832 [Crossref]
190- Ayoup M, Yousry K, Abdel-Hamid H, Nafie M, Ghareeb D, Masoud A, Harras M, Al Nawah J, Ismail M, Tageldin G. Dual targeted Ugi-bisamides induce caspase-mediated apoptosis and inhibit PI3K/mTOR signaling in NSCLC. New J Chem. 2025;49(24):10102 [Crossref]
191- Ahluwalia P, Ahluwalia M, Mondal A, Sahajpal N, Kota V, Rojiani M, Rojiani A, Kolhe R. Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer. Cancers. 2021;13(1):155 [Crossref]
192- Abi Sleiman M, Younes M, Hajj R, Salameh T, Abi Rached S, Abi Younes R, Daoud L, Doumiati J, Frem F, Ishak R, Medawar C, Naim H, Rizk S. Urtica dioica: Anticancer Properties and Other Systemic Health Benefits from In Vitro to Clinical Trials. IJMS. 2024;25(13):7501 [Crossref]
193- Akhavan R, Jabari Harsini S, Shafiee S, Eftekhari M, Tahmasvand R, Taghipour F, Kooshafar Z, Mohammadmirzaeizarandi H, Salimi M, Almasirad A, Salimi M. Discovery of a new hydrazone-oxamide hybrid capable of inducing necroptotic cell death in triple negative breast cancer cells. Bioorganic Chemistry. 2025;157:108267 [Crossref]
194- Luo Y, Peng B, Chen Z, Xiong X, Huang J, Chen M, Wang F, Li X, Wang J. The Combination of Chrysin and Cisplatin Induces Apoptosis in HepG2 through Down-regulation of cFLIP and Activity of Caspase. ACAMC. 2023;23(4):432 [Crossref]
195- Chrobak E, Świtalska M, Wietrzyk J, Bębenek E. New Difunctional Derivatives of Betulin: Preparation, Characterization and Antiproliferative Potential. Molecules. 2025;30(3):611 [Crossref]
196- Svandova E, Vesela B, Janeckova E, Chai Y, Matalova E. Exploring caspase functions in mouse models. Apoptosis. 2024;29(7-8):938 [Crossref]
197- Kassem A, Sediek A, Omran M, Foda D, Al-Ashmawy A. Design, synthesis and in vitro anti-proliferative evaluation of new pyridine-2,3-dihydrothiazole/thiazolidin-4-one hybrids as dual CDK2/GSK3β kinase inhibitors. RSC Adv. 2024;14(43):31607 [Crossref]
198- Sekar R, Prasad M, Alagumuthu M. Friedelin induces apoptosis in oral cancer: Insights from in vitro and in silico studies. Journal of Oral Biology and Craniofacial Research. 2025;15(6):1354 [Crossref]
199- Yong M, Tani A, Mohamed Salih F, Pare R, Norgainathai R, Fong S. Aqueous leaf extract ofClinacanthus nutansinhibits growth and induces apoptosis via the intrinsic and extrinsic pathways in MDA-MB-231 human breast cancer cells. Phcog Mag. 2020;16(72):689 [Crossref]
200- Luković D, Franich A, Živković M, Rajković S, Stojanović B, Gajović N, Jurišević M, Pavlović S, Simović Marković B, Jovanović M, Stojanović B, Pavlović R, Jovanović I. Biological Evaluation of Dinuclear Platinum(II) Complexes with Aromatic N-Heterocycles as Bridging Ligands. IJMS. 2024;25(15):8525 [Crossref]
201- Sim S, Jang J, Choi J, Chun K. Domperidone, a Dopamine Receptor D2 Antagonist, Induces Apoptosis by Inhibiting the ERK/STAT3-Mediated Pathway in Human Colon Cancer HCT116 Cells. Biomol Ther (Seoul). 2024;32(5):568 [Crossref]
202- Won Y, Kim H, Jeong S, Bhosale P, Abusaliya A, Heo J, Seong J, Ahn M, Kim H, Kim G. The Effects of Iridin and Irigenin on Cancer: Comparison with Well-Known Isoflavones in Breast, Prostate, and Gastric Cancers. IJMS. 2025;26(6):2390 [Crossref]
203- Coussens N, Dexheimer T, Silvers T, Sanchez P, Chen L, Hollingshead M, Takebe N, Doroshow J, Teicher B. Combinatorial screen with apoptosis pathway targeted agents alrizomadlin, pelcitoclax, and dasminapant in multi-cell type tumor spheroids. SLAS Discovery. 2025;33:100230 [Crossref]
204- Chen Q, Li K, Li J, Liu X, Li J, Xu L, Han Y, Zou T, Wang X, Yao Y, Mao Y. Targeting Metal Ion Homeostasis for Regulated Cell Death-Amplified Tumor Nanomedicine. IJN. 2025;Volume 20:15627 [Crossref]
205- De Silva F, Alcorn J. A Tale of Two Cancers: A Current Concise Overview of Breast and Prostate Cancer. Cancers. 2022;14(12):2954 [Crossref]
206- Shi X, Ding H, Tao J, Zhu Y, Zhang X, He G, Yang J, Wu X, Liu X, Yu X. Comprehensive evaluation of cell death-related genes as novel diagnostic biomarkers for breast cancer. Heliyon. 2023;9(11):e21341 [Crossref]
207- Rajabi S, Maresca M, Yumashev A, Choopani R, Hajimehdipoor H. The Most Competent Plant-Derived Natural Products for Targeting Apoptosis in Cancer Therapy. Biomolecules. 2021;11(4):534 [Crossref]
208- Tonon C, Monte M, Balin P, Fujimori A, Ribeiro A, Ferreira N, Vieira N, Cabral R, Okoshi M, Okoshi K, Zornoff L, Minicucci M, Paiva S, Gomes M, Polegato B. Liraglutide Pretreatment Does Not Improve Acute Doxorubicin-Induced Cardiotoxicity in Rats. IJMS. 2024;25(11):5833 [Crossref]
209- Lama R, Wu W, Mavis C, Ruiz F, Querol-García J, Martin D, Chemler S, Chandra D, Goodrich D, Hernandez-Ilizaliturri F, Muñoz I, Wang X. Small-molecule MMRi36 induces apoptosis in p53-mutant lymphomas by targeting MDM2/MDM4/XIAP for degradation. Front Oncol. 2024;14 [Crossref]
210- Noh-Burgos M, García-Sánchez S, Tun-Rosado F, Chávez-González A, Moo-Puc R, Peraza-Sánchez S, Quintal-Novelo C. Semi-Synthetic Derivatives from a Lupane-Type Triterpene Isolated from Phoradendron wattii with Anti-Leukemia Activity . Natural Product Communications. 2025;20(3) [Crossref]
211- Shaernejad S, Nosrat A, Baeeri M, Hashemi Goradel N, SeyedSadeghi M, Akbariani M, Arabzadeh A, Rahimifard M, Haghi-Aminjan H. Role of hesperidin/hesperetin against chemotherapy-induced cardiotoxicity: a systematic review of non-clinical studies. Cancer Cell Int. 2025;25(1) [Crossref]
212- Mansour N, Ghaly M, El-Gohary N. Dual topoisomerase IIα/EGFR-TK inhibitors: Synthesis, biological evaluation, and in silico studies of new thiadiazolo[3,2-a]pyrimidinone derivatives as potential anticancer agents. Bioorganic Chemistry. 2026;169:109366 [Crossref]
213- Chen Y, Zhang Y, Lu J, Liu Z, Zhao S, Zhang M, Lu M, Xu W, Sun F, Wu Q, Zhong Q, Cui Z. Characteristics of Prognostic Programmed Cell Death–Related Long Noncoding RNAs Associated With Immune Infiltration and Therapeutic Responses to Colon Cancer. Front Immunol. 2022;13 [Crossref]
214- Yazicioglu Y, Mitchell R, Clarke A. Mitochondrial control of lymphocyte homeostasis. Seminars in Cell & Developmental Biology. 2024;161-162:42 [Crossref]
215- Pal P, Thummuri D, Lv D, Liu X, Zhang P, Hu W, Poddar S, Hua N, Khan S, Yuan Y, Zhang X, Zhou D, Zheng G. Discovery of a Novel BCL-XL PROTAC Degrader with Enhanced BCL-2 Inhibition. J Med Chem. 2021;64(19):14230 [Crossref]
216- Zhou X, Zeng Y, Zheng R, Wang Y, Li T, Song S, Zhang S, Huang J, Ren Y. Natural products modulate cell apoptosis: a promising way for treating endometrial cancer. Front Pharmacol. 2023;14 [Crossref]
217- Razi S, Mozdarani H, Behzadi Andouhjerdi R. Evaluation of the Potential Diagnostic Role of the Lnc-MIAT, miR-29a-3p, and FOXO3a ceRNA Networks as Noninvasive Circulatory Bioindicator in Ductal Carcinoma Breast Cancer. Breast Cancer�(Auckl). 2023;17 [Crossref]
218- Ahmad S, Garg C, Kaur S. Metabolite profiling and cytotoxicity of Tragopogon dubius fractions against MCF-7 cells. Biochemical Systematics and Ecology. 2025;123:105065 [Crossref]
219- Yazdiniapour Z, Mirian M, Zolfaghari B, Mehdifar P, Ghanadian M, Lanzotti V. Myrsinane-type diterpenes from Euphorbia gedrosiaca with cell growth inhibitory activity and apoptotic effects on melanoma cancer cells. Fitoterapia. 2022;157:105138 [Crossref]
220- Caruso G, Laera R, Ferrarotto R, Garcia Moreira C, Kumar R, Ius T, Lombardi G, Caffo M. Mitochondrial Dysfunction: Effects and Therapeutic Implications in Cerebral Gliomas. Medicina. 2024;60(11):1888 [Crossref]
221- Limboonreung T, Suansilpong T, Jumjitvi P, Lohawittayanan D, Krobthong S, Charoensutthivarakul S. Quinazolinedione Derivatives as Potential Anticancer Agents Through Apoptosis Induction in MCF-7. IJMS. 2025;26(13):6038 [Crossref]
222- Kołodziejska R, Tafelska-Kaczmarek A, Pawluk M, Sergot K, Pisarska L, Woźniak A, Pawluk H. Ashwagandha-Induced Programmed Cell Death in the Treatment of Breast Cancer. CIMB. 2024;46(7):7668 [Crossref]
223- Gonzalez Quesada Y, Bonnet-Magnaval F, DesGroseillers L. Phosphomimicry on STAU1 Serine 20 Impairs STAU1 Posttranscriptional Functions and Induces Apoptosis in Human Transformed Cells. IJMS. 2022;23(13):7344 [Crossref]
224- Tosun N, Kaplan Ö, Özgür A. Apoptosis Induced by Tarantula cubensis Crude Venom (Theranekron® D6) in Cancer Cells. Rev Bras Farmacogn. 2021;31(6):824 [Crossref]
225- Girigoswami A, Girigoswami K. Cell Death Mechanisms Elicited by Multifactorial Stress Inducers- A Minireview. COVID. 2023;4(3) [Crossref]
226- Kuo Y, Rajesh R. Functionalized drug-gene delivery materials to transport inhibitor of apoptosis protein antagonists for tumor malignancy management. Journal of the Taiwan Institute of Chemical Engineers. 2022;133:104283 [Crossref]
227- Zangooie A, Piroozkhah M, Mazloomnejad R, Ahmadi A, Ghazizadeh Ahsaei H, Alitotonchi Z, Shahmoradi A, Qaderi K, Halimi A, Eghbali Z, Aliabadi L, Forouzesh F, Nazemalhosseini‐Mojarad E, Salehi Z. Comprehensive analysis of the BID gene to uncover the role of novel alternative splicing isoforms in colon adenocarcinoma: a systematic review of literature and bioinformatics analysis. Cancer Cell Int. 2025;25(1) [Crossref]
228- Sumneang N, Kobroob A, Phungphong S, Boonhoh W, Punsawad C, Kangwan N. Fermented Houttuynia cordata Juice Exerts Cardioprotective Effects by Alleviating Cardiac Inflammation and Apoptosis in Rats with Lipopolysaccharide-Induced Sepsis. Nutrients. 2025;17(3):501 [Crossref]
229- Subashree K, Harithpriya K, Ganesh G, Ramkumar K. Decoding PANoptosis: Crosstalk of cell death pathways in immunity and inflammation. Immunol Res. 2026;74(1) [Crossref]
230- Jia P, Li Y, Duan L, Zhang J, Xu Y, Zhang H, Wang C, Gong Y, Zhang Y, Zhao L, Huang Y, Zhang S. PLK1 inhibition impairs erythroid differentiation. Front Cell Dev Biol. 2024;12 [Crossref]
231- Bharathi D, Preethi S, Abarna K, Nithyasri M, Kishore P, Deepika K. Bio-inspired synthesis of flower shaped iron oxide nanoparticles (FeONPs) using phytochemicals of Solanum lycopersicum leaf extract for biomedical applications. Biocatalysis and Agricultural Biotechnology. 2020;27:101698 [Crossref]
232- Xu R, Wu Y, Liu Z, Liu J, Liu X. Lysosomal Targeted Cyclometallic Iridium(Ⅲ) Salicylaldehyde-Coumarin Schiff Base Complexes and Anticancer Application. Front Chem. 2022;10 [Crossref]
233- Saraceni P, Miccoli A, Bada A, Taddei A, Mazzonna M, Fausto A, Scapigliati G, Picchietti S. Polystyrene nanoplastics as an ecotoxicological hazard: cellular and transcriptomic evidences on marine and freshwater in vitro teleost models. Science of The Total Environment. 2024;934:173159 [Crossref]
234- Huang W, Zheng J, Wang M, Du L, Bai L, Tang H. The potential therapeutic role of melatonin in organ fibrosis: a comprehensive review. Front Med. 2024;11 [Crossref]
235- Torres K, Landeros N, Wichmann I, Polakovicova I, Aguayo F, Corvalan A. EBV miR-BARTs and human lncRNAs: Shifting the balance in competing endogenous RNA networks in EBV-associated gastric cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2021;1867(4):166049 [Crossref]
236- Egorova A, Shtykalova S, Maretina M, Selutin A, Shved N, Deviatkin D, Selkov S, Baranov V, Kiselev A. Polycondensed Peptide Carriers Modified with Cyclic RGD Ligand for Targeted Suicide Gene Delivery to Uterine Fibroid Cells. IJMS. 2022;23(3):1164 [Crossref]
237- Gallegos-Saucedo R, Barrios-García T, Valdez-Morales E, Cabañas-García E, Barajas-Espinosa A, Gómez-Aguirre Y, Guerrero-Alba R. Cytotoxic Activity of Lepidium virginicum L. Methanolic Extract on Human Colorectal Cancer Cells, Caco-2, through p53-Mediated Apoptosis. Molecules. 2024;29(16):3920 [Crossref]
238- Yoo J, Lee J, Ahn B, Han J, Lim M. Multi-target-directed therapeutic strategies for Alzheimer's disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition. Chem Sci. 2025;16(5):2105 [Crossref]
239- Alamery S, AlAjmi A, Wani T, Zargar S. In Silico and In Vitro Exploration of Poziotinib and Olmutinib Synergy in Lung Cancer: Role of hsa-miR-7-5p in Regulating Apoptotic Pathway Marker Genes. Medicina. 2023;59(11):1923 [Crossref]
240- Güçlü E, Çınar Ayan İ, Dursun H, Vural H. Tomentosin induces apoptosis in pancreatic cancer cells through increasing reactive oxygen species and decreasing mitochondrial membrane potential. Toxicology in Vitro. 2022;84:105458 [Crossref]
241- Tkachenko A, Havranek O. Cell death signaling in human erythron: erythrocytes lose the complexity of cell death machinery upon maturation. Apoptosis. 2025;30(3-4):652 [Crossref]
242- Jassem A, Saeed B. Microwave‐Promoted Multicomponent Synthesis Catalyzed by DABCO, Anti‐Esophageal Cancer, Apoptotic Morphology, Kinetic Mechanism, and Computational Studies of New Pyrrole Derivatives. ChemistrySelect. 2026;11(11) [Crossref]
243- Taheri M, Seirafianpour F, Fallahian A, Hosseinzadeh A, Reiter R, Mehrzadi S. Exploring melatonin's signalling pathways in the protection against age-related skin deterioration. Pharmacol Rep. 2025;77(2):375 [Crossref]
244- Fu B, Lin H, Tang Z, Chen N, Zhao P. ATP aptamer/i-motif-grafted multi-functional SPION nanocarrier for chemotherapeutic/phototherapeutic synergistic research. Journal of Materials Research. 2022;37(12):2021 [Crossref]
245- Narasimhan B, Sapra A. Benzimidazole derivatives as anticancer agents: A review of recent literature and structure-activity relationships. Letters in Drug Design & Discovery. 2025;22(11):100237 [Crossref]
246- Liu Y, Li H, Zheng Z, Niu A, Liu S, Li W, Ren P, Liu Y, Inam M, Guan L, Ma H. Rosa rugosa polysaccharide induces autophagy-mediated apoptosis in human cervical cancer cells via the PI3K/AKT/mTOR pathway. International Journal of Biological Macromolecules. 2022;212:257 [Crossref]
247- Wu Y, Zhang F, Xu P, Li P. Brucine Inhibits Proliferation of Pancreatic Ductal Adenocarcinoma through PI3K/AKT Pathway-induced Mitochondrial Apoptosis. CCDT. 2024;24(7):749 [Crossref]
248- Papadakos S, Chatzikalil E, Vakadaris G, Reppas L, Arvanitakis K, Koufakis T, Siakavellas S, Manolakopoulos S, Germanidis G, Theocharis S. Exploring the Role of GITR/GITRL Signaling: From Liver Disease to Hepatocellular Carcinoma. Cancers. 2024;16(14):2609 [Crossref]
249- Martins F, Iglesias B, Chaves O, Gutknecht da Silva J, Leal D, Back D. Vanadium(v) complexes derived from triphenylphosphonium and hydrazides: cytotoxicity evaluation and interaction with biomolecules. Dalton Trans. 2024;53(19):8315 [Crossref]
250- Wang Y, Yuan A, Wu Y, Wu L, Zhang L. Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations. Journal of Functional Foods. 2023;100:105384 [Crossref]
251- Wang D, Wang S, Liu W, Li M, Zheng Q, Li D. Hydroxysafflor yellow B induces apoptosis via mitochondrial pathway in human gastric cancer cells. 2022;74(9):1320 [Crossref]
252- Angel-Lerma L, Carrillo-Campos J, Siañez-Estrada L, Siqueiros-Cendón T, León-Flores D, Espinoza-Sánchez E, Arévalo-Gallegos S, Iglesias-Figueroa B, Rascón-Cruz Q. Molecular Docking of Lactoferrin with Apoptosis-Related Proteins Insights into Its Anticancer Mechanism. IJMS. 2025;26(5):2023 [Crossref]
253- Wang X, Zhang F, Cao Z, Ren L, Wang N, Wang W, Hu F, Liu N, Gao H, Zhou J, Bai X. Cholangiocarcinoma derived exosomes attenuate the anti-tumor functions of NK cells. Sci Rep. 2026;16(1) [Crossref]
254- Kumar A, Kaur S, Pandit K, Kaur V, Thakur S, Kaur S. Onosma bracteata Wall. induces G0/G1 arrest and apoptosis in MG-63 human osteosarcoma cells via ROS generation and AKT/GSK3β/cyclin E pathway. Environ Sci Pollut Res. 2021;28(12):14983 [Crossref]
255- Sabran A, Kumolosasi E, Jantan I, Jamal J, Azmi N, Jasamai M. Induction of cell death and modulation of Annexin A1 by phytoestrogens in human leukemic cell lines. Saudi Pharmaceutical Journal. 2021;29(1):73 [Crossref]
256- Mangrum D, Finley S. Modeling the heterogeneous apoptotic response of caspase-mediated signaling in tumor cells. Journal of Theoretical Biology. 2024;590:111857 [Crossref]
257- Yunus U, Khan M, Sadiq S, Aamir M, Ullah Z, Bhatti M, Sher M, Chaudhry G. Methotrexate-loaded Fe-metal organic frameworks: Synthesis, characterizations, and drug release investigations. Journal of Drug Delivery Science and Technology. 2024;97:105790 [Crossref]
258- Icsel C, Aydinlik S, Aygun M, Yilmaz V. A highly cytotoxic Pd(II) saccharinate complex with tris(2-pyridylmethyl)amine acting through mitochondrial and ROS-induced DNA damage. Inorganica Chimica Acta. 2025;580:122590 [Crossref]
259- Yulak F, Ergul M. Tannic acid protects neuroblastoma cells against hydrogen peroxide – triggered oxidative stress by suppressing oxidative stress and apoptosis. Brain Research. 2024;1844:149175 [Crossref]
260- Jang J, Lee T, Sung E, Song I, Kim J. Dapagliflozin induces apoptosis by downregulating cFILPL and increasing cFILPS instability in Caki‑1 cells. Oncol Lett. 2022;24(5) [Crossref]
261- Ghosh S, Chakrabarty R, Paira P. Harnessing photodynamic therapy for programmed cell death: the central role and contributions of metal complexes as next generation photosensitizers. RSC Med Chem. 2025;16(12):5886 [Crossref]
262- Bakar-Ates F, Sengel-Turk C. Preferential enhancement of mitochondria-mediated apoptosis and modulation of metastasis-related markers by etoposide-loaded nanoparticles in breast cancer cell lines. Naunyn-Schmiedeberg's Arch Pharmacol. 2026; [Crossref]
263- Xu Y, Wang X, Yang X, Liu X, Wang M, An S, Na R, Hao Y. The toxicity of insecticide broflanilide on human SH-SY5Y cells. 2025;44(12):3603 [Crossref]
264- Shad P, Karizi S, Javan R, Mirzaie A, Noorbazargan H, Akbarzadeh I, Rezaie H. Folate conjugated hyaluronic acid coated alginate nanogels encapsulated oxaliplatin enhance antitumor and apoptosis efficacy on colorectal cancer cells (HT29 cell line). Toxicology in Vitro. 2020;65:104756 [Crossref]
265- Jiang M, Qi L, Li L, Li Y. The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer. Cell Death Discov. 2020;6(1) [Crossref]
266- An N, Zhao Y, Lan H, Zhang M, Yin Y, Yi C. SEZ6L2 knockdown impairs tumour growth by promoting caspase‐dependent apoptosis in colorectal cancer. J Cellular Molecular Medi. 2020;24(7):4223 [Crossref]
267- Sun G, Song X, Zou Y, Teng T, Jiang L, Shi B. Dietary Glucose Ameliorates Impaired Intestinal Development and Immune Homeostasis Disorders Induced by Chronic Cold Stress in Pig Model. IJMS. 2022;23(14):7730 [Crossref]
268- 서 아, 홍 다, 윤 정. 수국(Hydrangea serrata)에서 분리된 Hygrangenol의 HCT116 세포 증식 억제에 대한 기전 연구. Korean J Food Cook Sci. 2025;41(6):405 [Crossref]
269- Kayser J, Rodrigues G, Thomazi C, Hansen A, Moreira M, Pitta M, Pitta I, Ziulkoski A, Betti A. Cytotoxicity evaluation of haloperidol, clozapine and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells. Braz J Pharm Sci. 2023;59 [Crossref]
270- Lazovic A, Markovic B, Corovic I, Markovic T, Andjelkovic M, Stojanovic B, Jovanovic I, Mitrovic M. Unlocking the molecular mechanisms of anticancer and immunomodulatory potentials of cariprazine in triple negative breast cancer. Biomedicine & Pharmacotherapy. 2025;184:117931 [Crossref]
271- Lem F, Cheong B, Teoh P. Ruellia tuberosa Ethyl Acetate Leaf Extract Induces Apoptosis and Cell Cycle Arrest in Human Breast Cancer Cell Line, MCF-7. Sci Pharm. 2022;90(3):44 [Crossref]
272- Lee J, Lee H, Ryu K, Kim M, Ko D, Chung K, Hassan A, Lee S, Lee J, Lee K. KCP10043F Represses the Proliferation of Human Non-Small Cell Lung Cancer Cells by Caspase-Mediated Apoptosis via STAT3 Inactivation. JCM. 2020;9(3):704 [Crossref]
273- Majirská M, Kudličková Z, Kello M, Michalková R, Bago Pilátová M, Vojtek M, Diniz C. A novel Indole–Dihydroisoxazole compound activates apoptotic, mitochondrial and autophagy-related responses in lymphoid and myeloid leukemia cells. European Journal of Pharmacology. 2026;1035:179373 [Crossref]
274- Zhou H, Li F, Li Y. Anti-Cancer Activity of Gedunin by Induction of Apoptosis in Human Gastric Cancer AGS Cells. Appl Biochem Biotechnol. 2022;194(11):5322 [Crossref]
275- Ruse G, Avram Ș, Munteanu A, Iftode O, Vlase L, Vlase A, Muntean D, Mioc A, Pop R, Jojic A, Șoica C, Tchiakpe-Antal D. Solvent-Guided Fractionation of Green Coffea arabica Seeds Uncovers Divergent Antioxidant and Mitochondria-Targeted Activities. Plants. 2026;15(10):1494 [Crossref]
276- Keser M, Atmaca H. Let-7a microRNA modulates caspase-3-dependent apoptosis in melanoma cells treated with dabrafenib and trametinib combination. Ir J Med Sci. 2025;194(3):797 [Crossref]
277- Mousavi S, Hashemi A, Ebrahimpoorghalehjoghi S, Izadian A, Ghorbani H. Prodigiosin, a biocolorant produced by Serratia marcescens, interferes with apoptosis and MAPK-ERK1/2 signaling in the A-431 skin cancer cell line. 2026;55(6):946 [Crossref]
278- Baghrsad S, Moghaddam A, Pruidze P, Hainfellner A, Geyer S, Weninger J, Bauer S, Mallik A, Weninger W. Post-mortem RNA fragmentation and apoptosis marker gene expression in clinically relevant organs of the human body. Sci Rep. 2026;16(1) [Crossref]
279- Rahimmanesh I, Davoodi A, Chen Y, Tay F, Bhol C, Sethi G, Makvandi P, Xu Y. Resensitizing drug-resistant cancers by co-targeting apoptosis and mitochondrial stress pathway. Drug Resistance Updates. 2026;88:101443 [Crossref]
280- Chimento A, De Luca A, D’Amico M, De Amicis F, Pezzi V. The Involvement of Natural Polyphenols in Molecular Mechanisms Inducing Apoptosis in Tumor Cells: A Promising Adjuvant in Cancer Therapy. IJMS. 2023;24(2):1680 [Crossref]
281- Khanjari Z, Chamani E, Heydaryan K, Mizwari Z, Salmani F, Rezaei Farimani A, Siami-Aliabad M, Kiani Z, Mohammadparast-Tabas P, Mortazavi-Derazkola S. Unlocking the therapeutic potential: Green synthesized zinc oxide/silver nanoparticles from Sophora pachycarpa for anticancer activity, gene expression analysis, and antibacterial applications. Materials Today Communications. 2024;39:109214 [Crossref]
282- Alves C, Silva J, Afonso M, Guedes R, Guedes R, Alvariño R, Pinteus S, Gaspar H, Goettert M, Alfonso A, Rodrigues C, Alpoím M, Botana L, Pedrosa R. Disclosing the antitumour potential of the marine bromoditerpene sphaerococcenol A on distinct cancer cellular models. Biomedicine & Pharmacotherapy. 2022;149:112886 [Crossref]
283- Boonyanugomol W, Rukseree K, Prapatpong P, Reamtong O, Baik S, Jung M, Shin M, Kang H, Lee W. Endoplasmic Reticulum Stress and Impairment of Ribosome Biogenesis Mediate the Apoptosis Induced by Ocimum x africanum Essential Oil in a Human Gastric Cancer Cell Line. Medicina. 2022;58(6):799 [Crossref]
284- Alsulays B, Aodah A, Ahmed M, Anwer M. Preparation and Evaluation of Chitosan Coated PLGA Nanoparticles Encapsulating Ivosidenib with Enhanced Cytotoxicity Against Human Liver Cancer Cells. IJN. 2024;Volume 19:3461 [Crossref]
285- Zheng Z, Yang P, Li R, Liu L, Xu X, Liao L, Li X, Chu M, Peng L, Huang Q, Heng J, Wang S, Wu Z, Chang Z, Li E, Xu L. STAT3β disrupted mitochondrial electron transport chain enhances chemosensitivity by inducing pyroptosis in esophageal squamous cell carcinoma. Cancer Letters. 2021;522:171 [Crossref]
286- He Z, Qiao H, Yang F, Zhou W, Gong Y, Zhang X, Wang H, Zhao B, Ma L, Liu H, Zhao W. Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent. European Journal of Medicinal Chemistry. 2019;184:111764 [Crossref]
287- Li L, Du W, Wang H, Zhao Y, Huang Z, Peng Y, Zeng S, Zhang G. Small-molecule MX-C2/3 suppresses non-small cell lung cancer progression via p53 activation. Chemico-Biological Interactions. 2022;366:110142 [Crossref]
288- Ojo O, Nwafor-Ezeh P, Rotimi D, Iyobhebhe M, Ogunlakin A, Ojo A. Apoptosis, inflammation, and oxidative stress in infertility: A mini review. Toxicology Reports. 2023;10:448 [Crossref]
289- Situmorang P, Wibowo S, Ilyas S, Sari R, Nugraha A, Ibrahim A, Fitrianita A, Abiyyu N, Syahputra R. Rhodomyrtus tomentosa attenuates HER2 expression and modulates apoptotic pathways in DMBA-induced breast carcinogenesis: In vivo and in silico insights. Journal of Agriculture and Food Research. 2025;24:102360 [Crossref]
290- Nwachuya C, Eche O, Ngige A, Isah A, Nworu C. Therapeutic potential of anti-cancer compounds from African medicinal plants: From in vitro studies to clinical applications. JPP. 2025;4(1):20 [Crossref]
291- Prabhu S, Nair A, Nirmala S. Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs. Arch Pharm Res. 2023;46(9-10):723 [Crossref]
292- Abd El-Lateef H, Elbastawesy M, Abdelghani Ibrahim T, Khalaf M, Gouda M, Wahba M, Zaki I, Morcoss M. Design, Synthesis, Docking Study, and Antiproliferative Evaluation of Novel Schiff Base–Benzimidazole Hybrids with VEGFR-2 Inhibitory Activity. Molecules. 2023;28(2):481 [Crossref]
293- Cabadak H, Kanlı Z, Aydın B. Effects of atropine on megakaryocytic differentiated K562 leukemia cells. 2025;38(3):265 [Crossref]
294- Alvarez-Arellano L, Salazar-García M, Corona J. Neuroprotective Effects of Quercetin in Pediatric Neurological Diseases. Molecules. 2020;25(23):5597 [Crossref]
295- Liu J, Jiang C, Xu C, Wang D, Shen Y, Liu Y, Gu L. Identification and development of a novel invasion-related gene signature for prognosis prediction in colon adenocarcinoma. Cancer Cell Int. 2021;21(1) [Crossref]
296- Krawiec K, Strzałka P, Czemerska M, Wiśnik A, Zawlik I, Wierzbowska A, Pluta A. Targeting Apoptosis in AML: Where Do We Stand?. Cancers. 2022;14(20):4995 [Crossref]
297- Dezhpour A, Ghafouri H, Jafari S, Nilkar M. Effects of cold atmospheric-pressure plasma in combination with doxorubicin drug against breast cancer cells in vitro and in vivo. Free Radical Biology and Medicine. 2023;209:202 [Crossref]
298- Bao Y, Zhu J, Yang Q, Wu L, Zhao W, Zhu T, Sun P, Zhou Q, Jin M. Dietary lutein mitigates high fat diet and lipopolysaccharide induced intestinal barrier dysfunction and immune inflammatory responses in juvenile black seabream (Acanthopagrus schlegelii). Fish & Shellfish Immunology. 2026;177:111609 [Crossref]
299- Rajasegaran Y, Azlan A, Rosli A, Yik M, Kang Zi K, Yusoff N, Moses E. Footprints of microRNAs in Cancer Biology. Biomedicines. 2021;9(10):1494 [Crossref]
300- Yarmohammadi F, Miraghaee S, Karimi G. Plants and Plant‐Derived Compounds Mediate Protection Across Diverse Pathological Conditions by Targeting the PANoptosis Pathways. Phytotherapy Research. 2026;40(8):5048 [Crossref]
301- Butt D, Harun M, Che Jalil N, Shamsuddin S, Jaafar S, Ahmad B. Protumorigenic Interferon-Stimulated Genes in Cancer: A Comprehensive Review. 2024; [Crossref]
302- Tavares-Carreón F, De la Torre-Zavala S, Arocha-Garza H, Souza V, Galán-Wong L, Avilés-Arnaut H. In vitro anticancer activity of methanolic extract of Granulocystopsis sp., a microalgae from an oligotrophic oasis in the Chihuahuan desert. 2020;8:e8686 [Crossref]
303- Yuan W, Xia H, Xu Y, Xu C, Chen N, Shao C, Dai Z, Chen R, Tao A. The role of ferroptosis in endothelial cell dysfunction. Cell Cycle. 2022;21(18):1897 [Crossref]
304- Ahsan N, Shariq M, Surolia A, Raj R, Khan M, Kumar P. Multipronged regulation of autophagy and apoptosis: emerging role of TRIM proteins. Cell Mol Biol Lett. 2024;29(1) [Crossref]
305- Li Y, Hu Q, Lu L, An N. Rhoifolin Inhibits Cell Growth and Induces Caspase-dependent Apoptosis in Oral Cancer KB Cells. Pharmacognosy Magazine. 2026; [Crossref]
306- Sharma V, Sinha E, Singh J. Ginger-derived nanovesicles inhibit breast cancer cell proliferation by induction of apoptosis. ADV TRADIT MED (ADTM). 2025;25(1):297 [Crossref]
307- Goyal S, Chaturvedi R. Mitochondrial Protein Import Dysfunction in Pathogenesis of Neurodegenerative Diseases. Mol Neurobiol. 2021;58(4):1418 [Crossref]
308- Murata K, Fujita N, Takahashi R. Ninjinyoeito ameliorated cigarette smoke extract-induced apoptosis and inflammation through JNK signaling inhibition in human lung fibroblasts. BMC Complement Med Ther. 2022;22(1) [Crossref]
309- Alajroush D, Smith C, Anderson B, Oyeyemi I, Beebe S, Holder A. A comparison of in vitro studies between cobalt(III) and copper(II) complexes with thiosemicarbazone ligands to treat triple negative breast cancer. Inorganica Chimica Acta. 2024;562:121898 [Crossref]
310- Permatasari H, Firdaus S, Susanto H, Malek N, Malek W, Malek H, Sulistomo H. Green synthesized Moringa oleifera Leaf Powder – Silver Nanoparticles (MOLP-AgNPs) promotes apoptosis by targeting Caspase-3 and Phosphorylated-AKT signaling in MCF-7 cells. Journal of Agriculture and Food Research. 2025;19:101640 [Crossref]
311- Lee Y, Mun J, Park S, Hong D, Kim H, Kim S, Lee S, Jang J, Han Y, Kee J. Saikosaponin D Inhibits Lung Metastasis of Colorectal Cancer Cells by Inducing Autophagy and Apoptosis. Nutrients. 2024;16(12):1844 [Crossref]
312- Yang J, Xiao B, Li Y, Liu X, Zhang M, Luo Y, Wang B, Liu H. A novel biflavone from Reineckia carnea induces apoptosis of human renal cancer 786-O cells. Front Pharmacol. 2022;13 [Crossref]
313- Hu X, Li J, Zhang H, Yu Q, Wang Y, Li X, Long L, Jiang W, Wang Z. Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy. European Journal of Medicinal Chemistry. 2022;240:114560 [Crossref]
314- Azeem M, Akhtar S, Siddiqui M, Ahmad Khan M. Elucidation of dibenzo[a,l]pyrene and its metabolites as a mammary carcinogen: A comprehensive review. NeuroPharmac J. 2021;:204 [Crossref]
315- Ergul M, Bakar-Ates F. A specific inhibitor of polo-like kinase 1, GSK461364A, suppresses proliferation of Raji Burkitt's lymphoma cells through mediating cell cycle arrest, DNA damage, and apoptosis. Chemico-Biological Interactions. 2020;332:109288 [Crossref]
316- Kowalewski A, Borowczak J, Maniewski M, Gostomczyk K, Grzanka D, Szylberg Ł. Targeting apoptosis in clear cell renal cell carcinoma. Biomedicine & Pharmacotherapy. 2024;175:116805 [Crossref]
317- Pérez-Ortega H, Córdova-Espíritu R, Cano-Serrano S, García-González E, Bravo-Sánchez M, Orozco-Mosqueda M, Jiménez-Islas H, Luna-Bárcenas G, Villaseñor-Ortega F. Camptothecin in Cancer Therapy: Current Challenges and Emerging Strategies with Nanoemulsions. Pharmaceutics. 2025;17(11):1414 [Crossref]
318- Zhou Y, Yu Y, Lv H, Zhang H, Liang T, Zhou G, Huang L, Tian Y, Liang W. Apigenin in cancer therapy: From mechanism of action to nano-therapeutic agent. Food and Chemical Toxicology. 2022;168:113385 [Crossref]
319- Saadh M, Pecho R, Jamal A, Alothaim A, Kamal M, Warsi M, Ahmad F, Obaid M, Moslem H, Zainab H, Amin A, Arias-Gonzáles J, Margiana R, Akhavan-Sigari R. Reduced expression of miR-221 is associated with the pro-apoptotic pathways in spermatozoa of oligospermia men. Journal of Reproductive Immunology. 2023;160:104159 [Crossref]
320- Ali M, Zein N, Abdo M, Adel G, Sitohy B. Synthesis, characterization of Mg doped CuFe2O4 nanoparticles for potential anticancer applications. Sci Rep. 2026;16(1) [Crossref]
321- Quiambao J, Fowler P, Tayo L. Potential Role of Tarantula Venom Peptides in Targeting Human Death Receptors: A Computational Study. Applied Sciences. 2024;14(19):8701 [Crossref]
322- Yin P, Xie S, Zhuang Z, Fang H, Tian L, Liu Y, Niu J. Chlorogenic acid improves health in juvenile largemouth bass (Micropterus salmoides) fed high-fat diets: Involvement of lipid metabolism, antioxidant ability, inflammatory response, and intestinal integrity. Aquaculture. 2021;545:737169 [Crossref]
323- Dhar R, Subramaniyan V. Decoding Molecular Mechanisms of Pongamia pinnata Phytochemicals in Cancer Therapy. Medicine Advances. 2026;4(3):342 [Crossref]
324- Sun Y, Aisha A, Qu Y, Zhu Y, Aosiman Y, Yu J. Study on the mechanism of TMZ resistance in brain glioma regulated by copper death. Neurological Research. 2026;:1 [Crossref]
325- Sandoval-Petris E, Ramos-Payan R, Santacruz-Ortega H, Plascencia-Jatomea M, Burboa-Zazueta M, Osuna-Ruíz I, Aguilar-Medina E, López-Saiz C. Structural Characterization and Cytotoxic Effects of Bioactive Compounds Isolated from Caulerpa sertularioides Against Human Cancer Cell Lines. Sci Pharm. 2026;94(3):79 [Crossref]
326- Pavlović S, Petrović B, Ćoćić D, Schreurer A, Sretenović S, Nešić M, Nišavić M, Maric Z, Stanisavljević I, Ćorović I, Simović Marković B, Maric V, Jovanović I, Radić G, Radisavljević S, Jovanović Stević S. New Pd(ii)-pincer type complexes as potential antitumor drugs: synthesis, nucleophilic substitution reactions, DNA/HSA interaction, molecular docking study and cytotoxic activity. Dalton Trans. 2024;53(46):18560 [Crossref]
327- Gómez‐Apo E, Silva‐Pereyra J, Soto‐Abraham V, Mondragón‐Maya A, Sanchez‐Lopez J. Immunohistochemical analysis of caspase expression in the brains of individuals with obesity or overweight. Obesity Science & Practice. 2023;9(2):137 [Crossref]
328- Si L, Zhang L, Xing S, Fang P, Tian X, Liu X, Xv X. Curcumin as a therapeutic agent in cancer therapy: Focusing on its modulatory effects on circularRNAs. Phytotherapy Research. 2023;37(7):3121 [Crossref]
329- Alrosan A, Heilat G, Al Subeh Z, Alrosan K, Alrousan A, Abu-Safieh A, Alabdallat N. The effects of statin therapy on brain tumors, particularly glioma: a review. 2023;34(9):985 [Crossref]
330- Ramushu P, Mangoakoane D, Makola R, Matsebatlela T. Lithium Induces Oxidative Stress, Apoptotic Cell Death, and G2/M Phase Cell Cycle Arrest in A549 Lung Cancer Cells. Molecules. 2025;30(8):1797 [Crossref]
331- Trinidad-Calderón P, Varela-Chinchilla C, García-Lara S. Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics. Molecules. 2021;26(24):7453 [Crossref]
332- Chiaino E, Micucci M, Durante M, Budriesi R, Gotti R, Marzetti C, Chiarini A, Frosini M. Apoptotic-Induced Effects of Acacia Catechu Willd. Extract in Human Colon Cancer Cells. IJMS. 2020;21(6):2102 [Crossref]
333- Alaee S, Moradi L, Marcu D, Shokri S, Talaei- Khozani T, Zal F. Culture of Immature Ovarian Follicles within Decellularized Ovary Enhances Oocyte Maturation and Improves In vitro Fertilization Results. WKMJ. 2024;66(3):267 [Crossref]
334- Kashyap S, Ahmed S, Borah J, Phukan P. Novel Thiazolyl‐2‐(N‐Sulfonyl)Guanidines as Potential Anticancer Leads Targeting Caspase‐9: Synthesis, Apoptosis Induction, and In Silico Profiling. ChemistrySelect. 2026;11(11) [Crossref]
335- Kopustinskiene D, Jakstas V, Savickas A, Bernatoniene J. Flavonoids as Anticancer Agents. Nutrients. 2020;12(2):457 [Crossref]
336- Jeong S, Kim H, Park M, Bhosale P, Abusaliya A, Hwang K, Moon Y, Heo J, Seong J, Ahn M, Park K, Won C, Kim G. Potential Anticancer Effects of Isoflavone Prunetin and Prunetin Glycoside on Apoptosis Mechanisms. IJMS. 2024;25(21):11713 [Crossref]
337- Kaplan Ö, Gök M, Pekmez M, Erden Tayhan S, Özgümüş S, Gökçe İ, Arda N. Development of recombinant protein-based nanoparticle systems for inducing tumor cell apoptosis: In vitro evaluation of their cytotoxic and apoptotic effects on cancer cells. Journal of Drug Delivery Science and Technology. 2024;95:105565 [Crossref]
338- Fatiha R, Ngabdi C, Azizah J, Lestari B, Malek N, Permatasari H. Metallic nanoparticles in cervical cancer therapy: A molecular perspective on modulating sensitivity to conventional treatments. Particuology. 2026;113:264 [Crossref]
339- Kumari S, Dhapola R, Reddy D. Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues. Apoptosis. 2023;28(7-8):943 [Crossref]
340- Nieto Marín V, Buccini D, Arboleda V J, Cardoso M, Franco O. Expanding therapeutic strategies for intracellular bacterial infections through conjugates of apoptotic body–antimicrobial peptides. Drug Discovery Today. 2023;28(2):103444 [Crossref]
341- Zavadinack M, de Lima Bellan D, Mazepa E, Cantu-Jungles T, Klassen G, Cordeiro L, Iacomini M. Structural and functional insights into β-D-glucans from mushrooms: A comprehensive review. Carbohydrate Polymers. 2026;391:125785 [Crossref]
342- Meechem M, Jadli A, Patel V. Uncovering the link between diabetes and cardiovascular diseases: insights from adipose-derived stem cells. Can J Physiol Pharmacol. 2024;102(4):229 [Crossref]
343- Sirajunnisa A, Surendhiran D, Kozani P, Kozani P, Hamidi M, Cabrera-Barjas G, Delattre C. An overview on the role of microalgal metabolites and pigments in apoptosis induction against copious diseases. Algal Research. 2021;60:102556 [Crossref]
344- Agena R, Cortés-Sánchez A, Hernández-Sánchez H, Álvarez-Salas L, Martínez-Rodríguez O, García V, Jaramillo Flores M. Pro-Apoptotic Activity and Cell Cycle Arrest of Caulerpa sertularioides against SKLU-1 Cancer Cell in 2D and 3D Cultures. Molecules. 2023;28(11):4361 [Crossref]
345- Dasgupta S, Kar K, Barua A, Ghosh D, Kabi B, Dewan K, Chandra A. A significantly non-toxic novel Cobalt(III) Schiff base complex induces apoptosis via G2-M cell cycle arrest in human breast cancer cell line MCF-7. Life Sciences. 2022;308:120963 [Crossref]
346- Zhang Z, Zheng Q, Zhang D, Li S. Sophoricoside Inhibits Cell Growth and Induces Oxidative Stress-dependent Apoptosis in Colon Cancer HCT-116 Cells. Pharmacognosy Magazine. 2026;22(1):334 [Crossref]
347- Xu D, Du J, Liu S, Zhang H, Yang L, Zhu X, Liu Y. Upregulation of KLK8 contributes to CUMS-induced hippocampal neuronal apoptosis by cleaving NCAM1. Cell Death Dis. 2023;14(4) [Crossref]
348- Luo Y, Wang Z, Jiang J, Wu S, Zhai Y. Curzerene Suppresses Hepatocellular Carcinoma Progression Through the pi3k/akt/mtor pathway. Revista de Investigación Clínica. 2024;76(4):173 [Crossref]
349- González-Ballesteros N, Diego-González L, Lastra-Valdor M, Grimaldi M, Cavazza A, Bigi F, Rodríguez-Argüelles M, Simón-Vázquez R. Immunomodulatory and Antitumoral Activity of Gold Nanoparticles Synthesized by Red Algae Aqueous Extracts. Marine Drugs. 2022;20(3):182 [Crossref]
350- Yaşar K, Özçimen A, Oruç Demirbağ H. Anti-cancer effect of vitexin onto the CFPAC-1 and MIAPaCa-2 pancreatic cancer cells. Cytotechnology. 2026;78(6) [Crossref]
351- Imran M, Rehman Z, Hogarth G, Tocher D, Chaudhry G, Butler I, Bélanger-Gariepy F, Kondratyuk T. Two new monofunctional platinum(ii) dithiocarbamate complexes:phenanthriplatin-type axial protection, equatorial-axial conformational isomerism, and anticancer and DNA binding studies. Dalton Trans. 2020;49(43):15385 [Crossref]
352- Fu B, Lin H, Liu Y, Lin J, Xiong W, Deng S, Chen N, Liang R, Zhao P. VEGF aptamer/i-motif-grafted multi-functional SPION nanocarrier for chemotherapeutic/phototherapeutic synergistic research. J Biomater Appl. 2022;36(7):1277 [Crossref]
353- Tsirvouli E, Ashcroft F, Johansen B, Kuiper M. Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes. iScience. 2021;24(12):103451 [Crossref]
354- Abusaliya A, Jeong S, Bhosale P, Kim H, Park M, Kim E, Won C, Park K, Heo J, Kim H, Ahn M, Seong J, Kim G. Mechanistic Action of Cell Cycle Arrest and Intrinsic Apoptosis via Inhibiting Akt/mTOR and Activation of p38-MAPK Signaling Pathways in Hep3B Liver Cancer Cells by Prunetrin—A Flavonoid with Therapeutic Potential. Nutrients. 2023;15(15):3407 [Crossref]
355- Jeong H, Park S, Kim S, Cho S, Jeong M, Kim S, Seo J, Kim S, Kim K. 1-Cinnamoyltrichilinin from Melia azedarach Causes Apoptosis through the p38 MAPK Pathway in HL-60 Human Leukemia Cells. IJMS. 2020;21(20):7506 [Crossref]
356- Zhao J, Zhao X, Lu Y, Wang H, Zhang Y, Wang Y, Xing L, Guo Y, Peng P, Zhang W, Wu Q. Juglone induces GSDME axis pyroptosis in osteosarcoma cells via the JNK/P38 MAPK pathway. Sci Rep. 2026;16(1) [Crossref]
357- Yin S, Niu L, Zhang J, Liu Y. Gardenia yellow pigment: Extraction methods, biological activities, current trends, and future prospects. Food Research International. 2024;179:113981 [Crossref]
358- Kumar G, Pandey D, Ghosh M, Dall'Acqua S, Gupta R, Tiwari N, Mohd Siddique U, Vishwakrama L, Guleri S, Lal U, Dubey S. Karanjin, A Promising Bioactive Compound Possessing Anti-cancer Activity against Experimental Model of Non-small Cell Lung Cancer Cells. ACAMC. 2024;24(5):317 [Crossref]
359- de Oliveira Chagas M, Mendonca da Costa V, Montenegro C, de Lima M, da Rosa M, Pereira M, de Melo Rego M, da Rocha Pitta M. The Imidazacridine Derivative LPSF/AC-05 Induces Apoptosis, Cell Cycle Arrest, and Topoisomerase II Inhibition in Breast Cancer, Leukemia, and Lymphoma. CCDT. 2025;25(5):431 [Crossref]
360- Interdonato L, Impellizzeri D, D’Amico R, Cordaro M, Siracusa R, D’Agostino M, Genovese T, Gugliandolo E, Crupi R, Fusco R, Cuzzocrea S, Di Paola R. Modulation of TLR4/NFκB Pathways in Autoimmune Myocarditis. Antioxidants. 2023;12(8):1507 [Crossref]
361- Lotfi N, Alipour F, Mohasel-Roodi M, Idoon F, Sadeghi A. Maternal diabetes type I triggers apoptosis in the cerebellar cortex of rat offspring. Comp Clin Pathol. 2024;33(6):871 [Crossref]
362- Sharma A, Virmani T, Kumar G, Sharma A, Virmani R, Gugulothu D, Singh K, Misra S, Pathak K, Chitranshi N, Coutinho H, Jain D. Mitochondrial signaling pathways and their role in cancer drug resistance. Cellular Signalling. 2024;122:111329 [Crossref]
363- Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan C, Kubatka P, Büsselberg D, Golubnitschaja O. Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology. IJMS. 2020;21(21):7988 [Crossref]
364- Shi J, Meng X, Ye Y, Wang Y, Ding H, Qi W, Feng R, Zhang K, Lei M. Regulatory mechanisms of neuro inflammation from a gender perspective: interactions among astrocytes, sex hormones, and the gut-brain axis. Front Aging Neurosci. 2025;17 [Crossref]
365- Malla R, Marni R, Chakraborty A, Kamal M. Diallyl disulfide and diallyl trisulfide in garlic as novel therapeutic agents to overcome drug resistance in breast cancer. Journal of Pharmaceutical Analysis. 2022;12(2):221 [Crossref]
366- Kulyar M, Yao W, Mo Q, Ding Y, Zhang Y, Gao J, Li K, Pan H, Nawaz S, Shahzad M, Mehmood K, Iqbal M, Akhtar M, Bhutta Z, Waqas M, Li J, Qi D. Regulatory Role of Apoptotic and Inflammasome Related Proteins and Their Possible Functional Aspect in Thiram Associated Tibial Dyschondroplasia of Poultry. Animals. 2022;12(16):2028 [Crossref]
367- Elkotamy M, Elkelesh I, Giovannuzzi S, Ismail R, El-Refaie W, Almehizia A, Naglah A, Nocentini A, Supuran C, Fares M, Ghabbour H, Salem R, Eldehna W, Abdel-Aziz H. Rationally designed Pyrazolo[1,5-a]pyrimidines as dual inhibitors of CA IX/XII and CDK6: A novel approach for NSCLC treatment. European Journal of Medicinal Chemistry. 2025;293:117752 [Crossref]
368- Wijeweera W, Jeyakanesh J, Tharanga E, Jayasinghe J, Dissanayake D, Omeka W, Sohn H, Park C, Hwang S, Wan Q, Lee S, Lee J. Characterization of Fas-associated death domain protein (FADD) in chub mackerel (Scomber japonicus): Insights into its apoptotic regulation, antiviral activity, and role in macrophage polarization. Fish & Shellfish Immunology. 2026;168:110961 [Crossref]
369- van Eijck C, Mustafa D, Vadgama D, de Miranda N, Groot Koerkamp B, van Tienhoven G, van der Burg S, Malats N, van Eijck C. Enhanced antitumour immunity following neoadjuvant chemoradiotherapy mediates a favourable prognosis in women with resected pancreatic cancer. Gut. 2024;73(2):311 [Crossref]
370- Lim H, Jang J, Shin H, Jang J, Ahn J, Jung H. Cytotoxic Activities and Molecular Mechanisms of the Beauvericin and Beauvericin G1 Microbial Products against Melanoma Cells. Molecules. 2020;25(8):1974 [Crossref]
371- Siva M, Das K, Rana P, Saha A, Mandal D, Barik A, Stewart A, Maity B, Das P. Liposomal Encapsulation of Chlorambucil with a Terpyridine-Based, Glutathione-Targeted Optical Probe Facilitates Cell Entry and Cancer Cell Death. ACS Appl Bio Mater. 2025;8(1):570 [Crossref]
372- O’Sullivan E, O’Shea D, Devereux M, Howe O. Apoptotic cell death induced by copper (II), manganese (II) and silver (I) complexes containing bridging dicarboxylate and 1,10-phenanthroline ligands: one of the multi-modes of anticancer activity?. Biometals. 2025;38(3):785 [Crossref]
373- Boualli A, Fawzi M, Laamari Y, Tahtamouni L, Erkan S, Riahi A, Robert A, Ait Itto M, Auhmani A. Design, Hemisynthesis, Computational, and Biological Evaluation of Novel Totarol‐1,3‐Thiazol Derivatives as Anticancer Agents. Chem Biol Drug Des. 2026;107(4) [Crossref]
374- de Andrade C, de Oliveira Lopes A, Sousa Duarte S, Assunção Araújo de Azevedo F, Araújo Loureiro P, Wanderley Amorim G, de Abreu Junior A, Sobral da Silva M, Fechine Tavares J, Santos Golzio S, Ramos Gonçalves J, Vieira Sobral M. Potential In Vitro Antimelanoma Effect of the Essential Oil from Croton grewioides Baill. Chemistry & Biodiversity. 2025;22(2) [Crossref]
375- Chaudhry G, Chaudhry Z, Safdar N, Begum S, Akim A, Sung Y, Muhammad T. Cytotoxicity assays for cancer drug screening: methodological insights and considerations for reliable assessment in drug discovery. Braz J Biol. 2024;84 [Crossref]
376- Rahmani A, Almatroudi A, Allemailem K, Alharbi H, Alwanian W, Alhunayhani B, Algahtani M, Theyab A, Almansour N, Algefary A, Aldeghaim S, Khan A. Role of Mangiferin in Management of Cancers through Modulation of Signal Transduction Pathways. Biomedicines. 2023;11(12):3205 [Crossref]
377- Gerashchenko G, Zaharuk O, Kashuba V. The evidence of potential tumor suppressor properties of TAGLN in vitro. Biopolym Cell. 2023;39(1):14 [Crossref]
378- Kaimuangpak K, Rosalina R, Thumanu K, Weerapreeyakul N. Macromolecules with predominant β-pleated sheet proteins in extracellular vesicles released from Raphanus sativus L. var. caudatus Alef microgreens induce DNA damage-mediated apoptosis in HCT116 colon cancer cells. International Journal of Biological Macromolecules. 2024;269:132001 [Crossref]
379- Dabur R, Yadav A. Programmed Cell Death and its Implications for Skeletal Muscle Wasting. Ind J Clin Biochem. 2026;41(1):31 [Crossref]
380- Choi N, Choi W, Zhu A, Park J, Kim Y, Hong J, Kim B. Exploring the Therapeutic Effects of Atractylodes macrocephala Koidz against Human Gastric Cancer. Nutrients. 2024;16(7):965 [Crossref]
381- Leal A, Saikia S, Khan S, Tomatsu S. Three-dimensional human mucopolysaccharidosis IVA chondrocyte culture reveals significant impairments in the lysosomal-mitochondrial crosstalk. Sci Rep. 2025;15(1) [Crossref]
382- Aslantürk Ö, Aşkin Çelik T. Anticancer effect of umbelliferone on MKN-45 and MIA PaCa-2 cell lines. Toxicology in Vitro. 2023;93:105694 [Crossref]
383- Annapoorani A, Koodalingam A, Beulaja M, Saiprasad G, Chitra P, Stephen A, Palanisamy S, Prabhu N, You S, Janarthanan S, Manikandan R. Eco-friendly synthesis of zinc oxide nanoparticles using Rivina humilis leaf extract and their biomedical applications. Process Biochemistry. 2022;112:192 [Crossref]
384- Chitoh A, Yedjou C, Tchakoua I, Njiki S, Noubissi F, Komolafe T, Komolafe K, Odubanjo O, Tchounwou P. Mechanistic Insights into Vernonia calvoana-Induced Apoptosis in Ovarian Cancer Cells via the Intrinsic Pathway. Int J Mol Sci. 2026;27(17):7887 [Crossref]
385- Wang P, Hu X, Pu H, Bai J, Sun L, Ma T, Du Y, Fu W. Leonurine Attenuates Ischemia–Reperfusion Injury Through PI3K/AKT/mTOR Pathway in Mouse Liver. Phytotherapy Research. 2026;40(5):2230 [Crossref]
386- Patra S, Pradhan B, Nayak R, Behera C, Panda K, Das S, Jena M, Bhutia S. Apoptosis and autophagy modulating dietary phytochemicals in cancer therapeutics: Current evidences and future perspectives. Phytotherapy Research. 2021;35(8):4194 [Crossref]
387- Maghsoudi H, Sheikhnia F, Hajmalek N, Gholipour F, Alipour S, Ghorbanpour M, Farzanegan S, Mir S, Memar M. Multifaceted roles of melatonin in oncology: an insight into its therapeutic potential in cancer management. Inflammopharmacol. 2025;33(5):2477 [Crossref]
388- Huang J, Bao D, Lei C, Tang H, Zhang C, Su H, Zhang C. Selenoprotein T protects against cisplatin‐induced acute kidney injury through suppression of oxidative stress and apoptosis. The FASEB Journal. 2020;34(9):11983 [Crossref]
389- Mansour N, Ghaly M, El-Gohary N. New indolin-2-one and isoindoline-1,3-dione derivatives as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro, in vivo, and in silico evaluation. Bioorganic Chemistry. 2026;180:110187 [Crossref]
390- Omar M, Emam S, Mikhail D, Elmeligie S. Combretastatin A-4 based compounds as potential anticancer agents: A review. Bioorganic Chemistry. 2024;153:107930 [Crossref]
391- Nam H, Jeong S, Pyo M, Ha S, Nam M, Lee K. Methylglyoxal-Derived Advanced Glycation End Products (AGE4) Promote Cell Proliferation and Survival in Renal Cell Carcinoma Cells through the RAGE/Akt/ERK Signaling Pathways. Biological & Pharmaceutical Bulletin. 2021;44(11):1697 [Crossref]
392- Mirković N, Mitrović M, Jevtić M, Pantić K, Čanović P, Nikolić I, Jakovljević S, Kostić M, Živić J, Nešić J, Zornić N, Erić S, Muškinja J, Šorak M, Anđelković M. Selective Cytotoxicity of Sodium Enone Salts Through Mitochondrial Dysfunction and Cell Cycle Arrest in Human Cancer Cells. Molecules. 2026;31(7):1141 [Crossref]
393- Yang H, Chiu L, Lin Y, Pandey S, Vadivalagan C, Liao J, Gowrisankar Y, Chen H, Lin H, Hseu Y. In vitro and in vivo anti-tumor activity of Coenzyme Q0 against TWIST1-overexpressing HNSCC cells: ROS-mediated inhibition of EMT/metastasis and autophagy/apoptosis induction. Toxicology and Applied Pharmacology. 2023;465:116453 [Crossref]
394- P J N, Patil S, Veeraraghavan V, Daniel S, Aileni K, Karobari M. Oral cancer stem cells: A comprehensive review of key drivers of treatment resistance and tumor recurrence. European Journal of Pharmacology. 2025;989:177222 [Crossref]
395- Özgür A, Kaplan Ö, Gökşen Tosun N, Türkekul İ, Gökçe İ. Green synthesis of silver nanoparticles using Macrolepiota procera extract and investigation of their HSP27, HSP70, and HSP90 inhibitory potentials in human cancer cells. Particulate Science and Technology. 2023;41(3):330 [Crossref]
396- Budi H, Farhood B. Tumor microenvironment remodeling in oral cancer: Application of plant derived-natural products and nanomaterials. Environmental Research. 2023;233:116432 [Crossref]
397- Verçosa B, Muniz-Junqueira M, Menezes-Souza D, Mourão Dias Magalhães L, Fujiwara R, Melo M, Vasconcelos A. Enhanced apoptotic index, chemokines and inflammatory recruitment in renal tissues shows relationship with the clinical signs in Leishmania-infected dogs. Veterinary Parasitology. 2021;300:109611 [Crossref]
398- B, Sherapura A, Malojirao V, Malojirao Z, Sharath B, Thirusangu P, Mahmood R, Kumari N, Baliga S, Khanum S, Prabhakar B. Antiproliferative pharmacophore azo-hydrazone analogue BT-1F exerts death signalling pathway targeting STAT3 in solid tumour. Pharmacol Rep. 2022;74(2):353 [Crossref]
399- Badea M, Balas M, Ionita D, Dinischiotu A. Carbon nanotubes conjugated with cisplatin activate different apoptosis signaling pathways in 2D and 3D-spheroid triple-negative breast cancer cell cultures: a comparative study. Arch Toxicol. 2024;98(9):2843 [Crossref]
400- Kumar C P, Kumar C B, Satyanarayan N, Prasad S, Achur R, Prabhakar B. A quinoline derivative exerts antineoplastic efficacy against solid tumour by inducing apoptosis and anti-angiogenesis both in vitro and in vivo. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(7):9161 [Crossref]
401- Gurgul A, Jasielczuk I, Szmatoła T, Semik-Gurgul E, Kucharski M, Mizera-Szpilka K, Ocłoń E. Elucidating the transcriptomic response of adult-derived mHypoA-2/12 mouse hypothalamic neuron cell line to cannabidiol (CBD) exposure. J Appl Genetics. 2025;66(4):1029 [Crossref]
402- Afshari A, Mollazadeh H, Sahebkar A. Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic. Journal of Oncology. 2020;2020:1 [Crossref]
403- Jiang P, Jiang W, Li X, Zhu Q. Combination of Formononetin and Sulforaphane Natural Drug Repress the Proliferation of Cervical Cancer Cells via Impeding PI3K/AKT/mTOR Pathway. Appl Biochem Biotechnol. 2024;196(10):6726 [Crossref]
404- Wu X, Xu W, Huan X, Wu G, Li G, Zhou Y, Najafi M. Mechanisms of cancer cell killing by metformin: a review on different cell death pathways. Mol Cell Biochem. 2023;478(1):197 [Crossref]
405- Bartnik M, Sławińska-Brych A, Mizerska-Kowalska M, Zdzisińska B. Evaluation of the Biological Effect of Non-UV-Activated Bergapten on Selected Human Tumor Cells and the Insight into the Molecular Mechanism of Its Action. IJMS. 2023;24(21):15555 [Crossref]
406- Bansal P, Bansal K, Sharma S, Mazumder A. Role of BMP-7 in Cardiovascular Diseases: From Molecular Mechanisms to Therapeutic Horizons. CDT. 2026;27(4):217 [Crossref]
407- Zhang C, Wang M, Ying Y, Meng F, Gao H, Zeng S, Zhu Y, Liu A, Zhang Z, Xu C. Knockdown of kinesin family member 4A inhibits cell proliferation, migration, and invasion while promoting apoptosis of urothelial bladder carcinoma cells. Cancer Medicine. 2023;12(11):12581 [Crossref]
408- Shoheeduzzaman R, Varghese E, Samuel S, Büsselberg D. Flavonoid-mediated modulation of ferroptosis: therapeutic potential in gastrointestinal cancers. Journal of Advanced Research. 2026;82:821 [Crossref]
409- Mesci S, Yazgan B, Demir Demirel G, Yildirim T, Yenilmez Çiftçi G. In Silico Molecular Docking of 2‐Hydroxyanthraquinone‐Substituted Spiro‐/Ansa Cyclotriphosphazenes: Targeting Apoptosis via Heat Shock Protein Modulation in Breast and Colon Cancer Cells. Biotech and App Biochem. 2025;72(6):1618 [Crossref]
410- Marcinkowska M, Antunes M, Piórecka K, Pinto Reis C, Kurjata J, Stańczyk W, Klajnert‐Maculewicz B. Cisplatin Derivatives and Their Complexes with PAMAM Dendrimers—A Way to Improve the Efficacy of Anticancer Drugs. ChemMedChem. 2026;21(1) [Crossref]
411- Mao S, Zhang X, Yang M, Duan J, Xiao P. A comprehensive review on the antitumor mechanisms of polysaccharides and their structure-activity relationships—Current insights and future directions. International Journal of Biological Macromolecules. 2025;319:145355 [Crossref]
412- Tian R, Liu X, Luo Y, Jiang S, Liu H, You F, Zheng C, Wu J. Apoptosis Exerts a Vital Role in the Treatment of Colitis-Associated Cancer by Herbal Medicine. Front Pharmacol. 2020;11 [Crossref]
413- Shirazian S, Mohseni A, Pourshahidi S, Alaeddini M, Etemad‐Moghadam S, Vatanpour M. The effect of different parameters of low‐level laser used in the treatment of oral mucositis, on the viability and apoptosis of oral squamous cell carcinoma cells: In vitro study. Photochem & Photobiology. 2025;101(2):330 [Crossref]
414- Darafsheh M, Osgoei L, Eslamimahmoudabadi M, Aghayan S, Ghaleh H. Comparison of the Cytotoxic Effects of Lactobacillus casei Extract with Newcastle Disease Virus in Human Colorectal Cancer. RJMM. 2026;129(1):38 [Crossref]
415- Ebrahimi M, Abtahi-Evari S, Brazvan B, Shokoohi M, Soltani M, Rostamian M, Fani M, Moghimian M. Safranal Ameliorates Ischemic/Reperfusion Injury Induced by Testicular Torsion in Rat. Physiol Pharmacol. 2023;27(4):403 [Crossref]
416- Ali M, Kaleem N, Ali A, Khan N, Khaliq M, Arif N, Almarhoon Z, Habtemariam S, Setzer W, Calina D, Sharifi-Rad J. Pterostilbene as a Multifaceted Anticancer Agent: Molecular Mechanisms, Therapeutic Potential and Future Directions. Med Oncol. 2025;42(7) [Crossref]
417- Heshmati Z, Amiri-Yekta A, Khosravifar M, Akbarian F, Moini A, Eftekhari-Yazdi P, Hafezi M, Afsharian P. Administration of N-acetylcysteine influence the expression of apoptotic genes in the granulosa cells of infertile women diagnosed with endometriosis. Sci Rep. 2026;16(1) [Crossref]
418- Zarrin P, Ates-Alagoz Z. Targeting Bcl-2 with Indole Scaffolds: Emerging Drug Design Strategies for Cancer Treatment. MRMC. 2025;25(4):293 [Crossref]
419- Vladimirskaja T, Adzeriho I, Ustemchuk A. Assessment of endothelial apoptosis in the pulmonary arteries of rats with monocrotaline-induced pulmonary arterial hypertension. jour. 2024;(2):37 [Crossref]
420- Sutiningsi D, Ginandjar P, Dian Saras L, Mubarika H S. Anticancer Activity of Pasak Bumi Root Extract (Eurycoma longifolia Jack) on Raji Cells. Pakistan J of Biological Sciences. 2021;24(12):1226 [Crossref]
421- Fijałkowski P, Pryshchepa O, van Eldik R, Pomastowski P. Ovotransferrin – Multifunctional protein: Structure, bioactivity, and industrial potential. International Journal of Biological Macromolecules. 2025;317:144810 [Crossref]
422- Messeha S, Zarmouh N, Asiri A, Soliman K. Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. European Journal of Pharmacology. 2020;885:173419 [Crossref]
423- Afzali M, Sadat Shandiz S, Keshtmand Z. Preparation of biogenic silver chloride nanoparticles from microalgae Spirulina Platensis extract: anticancer properties in MDA-MB231 breast cancer cells. Mol Biol Rep. 2024;51(1) [Crossref]
424- Speidel J, Affandi T, Jones D, Ferrara S, Reyland M. Functional proteomic analysis reveals roles for PKCδ in regulation of cell survival and cell death: Implications for cancer pathogenesis and therapy. Advances in Biological Regulation. 2020;78:100757 [Crossref]
425- Egorova A, Shtykalova S, Maretina M, Freund S, Selutin A, Shved N, Selkov S, Kiselev A. Serum-Resistant Ternary DNA Polyplexes for Suicide Gene Therapy of Uterine Leiomyoma. IJMS. 2023;25(1):34 [Crossref]
426- Cavalu S, Saber S, Hamad R, Abdel-Reheim M, Elmorsy E, Youssef M. Orexins in apoptosis: a dual regulatory role. Front Cell Neurosci. 2024;18 [Crossref]
427- Griffith A, Holmes W. Fine Tuning: Effects of Post-Translational Modification on Hsp70 Chaperones. IJMS. 2019;20(17):4207 [Crossref]
428- Schmidt A, Rokhsary S, Hübner L, Miebach L, Bekeschus S. Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues. Advanced NanoBiomed Research. 2026;6(9) [Crossref]
429- Mahbub A, Le Maitre C, Cross N, Jordan-Mahy N. The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines. Sci Rep. 2022;12(1) [Crossref]
430- Pason P, Tachaapaikoon C, Suyama W, Waeonukul R, Shao R, Wongwattanakul M, Limpaiboon T, Chonanant C, Ngernyuang N. Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro. Toxicology Reports. 2024;12:82 [Crossref]
431- Gharib E, Robichaud G. From Crypts to Cancer: A Holistic Perspective on Colorectal Carcinogenesis and Therapeutic Strategies. IJMS. 2024;25(17):9463 [Crossref]
432- Serban R, Niculae D, Manda G, Neagoe I, Dobre M, Niculae D, Temelie M, Mustăciosu C, Leonte R, Chilug L, Cornoiu M, Cocioabă D, Stan M, Dinischiotu A. Modifications in cellular viability, DNA damage and stress responses inflicted in cancer cells by copper-64 ions. Front Med. 2023;10 [Crossref]
433- Runa F, Ortiz-Soto G, de Barros N, Kelber J. Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors. Pharmaceuticals. 2024;17(3):326 [Crossref]
434- Park G, Baniya M, Cha E, Sim S, Choi J, Chun K. Domperidone Induces Apoptosis through Suppression of STAT3 Signaling in Human Renal Cancer Caki-2 Cells. J Cancer Prev. 2025;30(1):24 [Crossref]
435- Hossam A, Abdallah I, El-Sebakhy N, Alnajjar R, Mohyeldin M. Discovery of natural scaffolds as HER2 inhibitors for breast cancer: virtual screening, molecular dynamics, and biological characterization with selectivity profiling. Sci Rep. 2025;15(1) [Crossref]
436- Mohamed R, Ahmed N, Mohsin I. Prevalence and Immunological Markers of Entameba Complex Infection in Patients with Amebiasis Symptoms. Med J Babylon. 2026;23(2):1271 [Crossref]
437- Lotfinejad P, Kazemi T, Safaei S, Amini M, Roshani asl E, Baghbani E, Sandoghchian Shotorbani S, Jadidi Niaragh F, Derakhshani A, Abdoli Shadbad M, Silvestris N, Baradaran B. PD-L1 silencing inhibits triple-negative breast cancer development and upregulates T-cell-induced pro-inflammatory cytokines. Biomedicine & Pharmacotherapy. 2021;138:111436 [Crossref]
438- Mohamed H, Borai M, Mosaad S, Osman A, Elsewedy A, Zaki H, Diab A, Safwat G. Bioactive glass nanoparticles induce intrinsic p53-dependent apoptosis and promote genomic instability via ROS overproduction and mitochondrial depolarization in triple-negative breast cancer cells. Sci Rep. 2026;16(1) [Crossref]
439- Farghadani R, Naidu R. Curcumin: Modulator of Key Molecular Signaling Pathways in Hormone-Independent Breast Cancer. Cancers. 2021;13(14):3427 [Crossref]
440- Cai Z, Zeng Y, Liu Z, Zhu R, Wang W. Curcumin Alleviates Epidermal Psoriasis-Like Dermatitis and IL-6/STAT3 Pathway of Mice. CCID. 2023;Volume 16:2399 [Crossref]
441- Samavarchi Tehrani S, Esmaeili F, Shirzad M, Goodarzi G, Yousefi T, Maniati M, Taheri‐Anganeh M, Anushiravani A. The critical role of circular RNAs in drug resistance in gastrointestinal cancers. Med Oncol. 2023;40(4) [Crossref]
442- Cieślak M, Napiórkowska M, Kaźmierczak-Barańska J, Królewska-Golińska K, Hawrył A, Wybrańska I, Nawrot B. New Succinimides with Potent Anticancer Activity: Synthesis, Activation of Stress Signaling Pathways and Characterization of Apoptosis in Leukemia and Cervical Cancer Cells. IJMS. 2021;22(9):4318 [Crossref]
443- Chimento A, De Luca A, Avena P, De Amicis F, Casaburi I, Sirianni R, Pezzi V. Estrogen Receptors-Mediated Apoptosis in Hormone-Dependent Cancers. IJMS. 2022;23(3):1242 [Crossref]
444- Surówka A, Żołnierczuk M, Prowans P, Grabowska M, Kupnicka P, Markowska M, Szlosser Z, Kędzierska-Kapuza K. The Effect of Chronic Immunosuppressive Regimen Treatment on Apoptosis in the Heart of Rats. Pharmaceuticals. 2024;17(9):1188 [Crossref]
445- Eity T, Bhuia M, Chowdhury R, Ahmmed S, Ahmmed S, Akter R, Islam M, Huang Z. Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms. Journal of Tropical Medicine. 2024;2024(1) [Crossref]
446- Abdel-Wahab W, Daifalla N, Essawy A. L-Methionine attenuates methotrexate-induced cardiotoxicity by modulating oxidative stress, inflammation, and dyslipidemia in rats. Toxicology Reports. 2026;16:102233 [Crossref]
447- Park C, Cha H, Hong S, Kim H, Leem S, Shim J, Kim G, Kang K, Hyun J, Choi Y. Combination Therapy with Betulinic Acid and TRAIL Increases ROS-Dependent Cytotoxicity and Inhibits PI3K/Akt Signaling in Human Bladder Cancer Cells. Biomol Ther (Seoul). 2026;34(3):641 [Crossref]
448- Cao Q, Wang Q, Wu X, Zhang Q, Huang J, Chen Y, You Y, Qiang Y, Huang X, Qin R, Cao G. A literature review: mechanisms of antitumor pharmacological action of leonurine alkaloid. Front Pharmacol. 2023;14 [Crossref]
449- Wang W, Zhao Z, Bai Y, Li Y, Gao X, Zhang S, Sun Y. Sevoflurane preconditioning prevents acute renal injury caused by ischemia‑reperfusion in mice via activation of the Nrf2 signaling pathway. Exp Ther Med. 2022;23(4) [Crossref]
450- Cândido M, dos Santos Jesus V, Vieira P, Campos A, Raniero L. Chemical and cellular characterization of SPIONs stabilized with sodium citrate. Res Biomed Eng. 2025;41(1) [Crossref]
451- Masood S, Nawaz B, Javed K, Rashid Z, Sumrra S, Chaudhry G, Zafar M. Biological effects of p-PYA ligands on certain trace elements of group-12 towards DNA binding and cytotoxicity potency. Biometals. 2026;39(1):297 [Crossref]
452- Milan A, Mioc M, Mioc A, Marangoci N, Racoviceanu R, Mardale G, Bălan-Porcărașu M, Rotunjanu S, Şoica I, Șoica C. Exploring the Antimelanoma Potential of Betulinic Acid Esters and Their Liposomal Nanoformulations. Processes. 2024;12(2):416 [Crossref]
453- Aldawsari M, Anwer M. Synthesis of acalabrutinib loaded β-cyclodextrin-based metal–organic frameworks as a potential material for breast cancer therapy. Results in Chemistry. 2025;16:102512 [Crossref]
454- Choi E, Kim M, Park S. Targeting Mitochondrial Dysfunction and Reactive Oxygen Species for Neurodegenerative Disease Treatment. IJMS. 2024;25(14):7952 [Crossref]
455- Rabbani S, Sharma S, El-Tanani M, Khurana S, Saini M, Yadav M, Kumar R, El-Tanani Y. Plant-Derived Polyphenols in Cancer Therapy: Bridging Molecular Mechanisms and Bioavailability Toward Clinical Translation. Pharmaceutics. 2026;18(6):737 [Crossref]
456- Zou Y, Xu L, Wang W, Zhu X, Lin J, Li H, Chen J, Xu W, Gao H, Wu X, Yin Z, Wang Q. Muscone restores anoikis sensitivity in TMZ-resistant glioblastoma cells by suppressing TOP2A via the EGFR/Integrin β1/FAK signaling pathway. Phytomedicine. 2024;129:155714 [Crossref]
457- Tahir M, Ali S, Zhang W, Lv B, Qiu W, Wang J. Aloperine: A Potent Modulator of Crucial Biological Mechanisms in Multiple Diseases. Biomedicines. 2022;10(4):905 [Crossref]
458- Pradhan B, Rout L, Ki J. Immunomodulatory and anti-inflammatory and anticancer activities of porphyran, a sulfated galactan. Carbohydrate Polymers. 2023;301:120326 [Crossref]
459- Lin S, Qin H, Li Z, Zhu H, Long L, Xu L. Gallic acid suppresses the progression of triple-negative breast cancer HCC1806 cells via modulating PI3K/AKT/EGFR and MAPK signaling pathways. Front Pharmacol. 2022;13 [Crossref]
460- Saleh T, Al Shboul S, Awad H, El-Sadoni M, Alhesa A, Alsharaiah E, Abu Shahin N, Alotaibi M, Battah A, Azab B. Characterization of BCL-XL, MCL-1, and BAX Protein Expression in Response to Neoadjuvant Chemotherapy in Breast Cancer. 2024;32(4):189 [Crossref]
461- Sharma S. Unraveling the role of long non-coding RNAs in therapeutic resistance in acute myeloid leukemia: New prospects & challenges. Non-coding RNA Research. 2024;9(4):1203 [Crossref]
462- Rajakrishna N, Lim S, Wang X, Wong T. Caspase-mediated pathways in retinal ganglion cell injury: a novel therapeutic target for glaucoma. Front Cell Dev Biol. 2025;13 [Crossref]
463- Nejadi Orang F, Abdoli Shadbad M. CircRNA and lncRNA-associated competing endogenous RNA networks in medulloblastoma: a scoping review. Cancer Cell Int. 2024;24(1) [Crossref]
464- Nashed M, Hassanen E, Issa M, Tohamy A, Prince A, Hussien A, Soliman M. The mollifying effect of Sambucus nigra extract on StAR gene expression, oxidative stress, and apoptosis induced by fenpropathrin in male rats. Food and Chemical Toxicology. 2024;189:114744 [Crossref]
465- Pourbagher-Shahri A, Sahab-Negah S, Moghbeli M, Saburi E, Forouzanfar F. A Review of the Anticancer Properties of Cedrol and its Molecular Mechanisms. ACAMC. 2026;26(11):1029 [Crossref]
466- Chamani R, Saberi O, Fathinejad F. An arresten-derived anti-angiogenic peptide triggers apoptotic cell death in endothelial cells. Mol Biol Rep. 2024;51(1) [Crossref]
467- Nashaat S, Henen M, El-Messery S, Eisa H. New Benzimidazoles Targeting Breast Cancer: Synthesis, Pin1 Inhibition, 2D NMR Binding, and Computational Studies. Molecules. 2022;27(16):5245 [Crossref]
468- Keshari A, Singh V, Patni T, Mishra T, Mishra A, Gupta R. A new frontier: Terpenes in the fight against colon cancer. ASPET Discovery. 2025;1:100016 [Crossref]
469- Almalki Z, Algregri M, Alhosin M, Alkhaled M, Damiati S, Zamzami M. In vitro cytotoxicity of curcuminoids against head and neck cancer HNO97 cell line. Braz J Biol. 2023;83 [Crossref]
470- Nascimento F, Viktor de Paula Barros Baeta J, Prado de França A, Braga Rocha e Oliveira M, Pizziolo V, Aparecida dos Santos A, Antônio de Oliveira Mendes T, Diaz-Muñoz G, Nogueira Diaz M. Dibenzoylmethane derivative inhibits melanoma cancer in vitro and in vivo through induction of intrinsic and extrinsic apoptotic pathways. Chemico-Biological Interactions. 2022;351:109734 [Crossref]
471- Joha Z, Öztürk A, Yulak F, Karataş Ö, Ataseven H. Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma. Med Oncol. 2023;40(9) [Crossref]
472- Salahuddin M, Omran G, Helmy M, Houssen M. Effect of Regorafenib on P2X7 Receptor Expression and Different Oncogenic Signaling Pathways in a Human Breast Cancer Cell Line: A Potential of New Insight of the Antitumor Effects of Regorafenib. CIMB. 2021;43(3):2199 [Crossref]
473- Madkour M, Sebastian A, Ramadan W, Menon V, Lozon L, Srikanth G, Tarazi H, El-Gamal M, Al-Tel T, El-Awady R. Synthesis and biological evaluation of new Camptothecin-like compounds as anticancer agents. Journal of Molecular Structure. 2025;1328:141271 [Crossref]
474- Mantri S, Doshi G. Reactivating apoptotic pathways in cancer: A review of novel therapeutic approaches. European Journal of Pharmacology. 2025;1003:177965 [Crossref]
475- Alherz F, El-Masry T, Oriquat G, Elekhnawy E, Al-Shaalan N, Gaballa M, El Zahaby E, El-Nagar M. Hesperidin Nanoformulation: A Potential Strategy for Reducing Doxorubicin-Induced Renal Damage via the Sirt-1/HIF1-α/VEGF/NF-κB Signaling Cascade. Pharmaceuticals. 2024;17(9):1144 [Crossref]
476- Balusamy S, Samad A, Singh P, Sunderraj S, Elsadek M, Altwaijry N, Sukweenadhi J, Perumalsamy H. Comparative anti-cancer properties of carene isoforms induced apoptotic cell death in stomach and lung cancer cell lines. Naunyn-Schmiedeberg's Arch Pharmacol. 2026;399(1):329 [Crossref]
477- Chaudhry G, Jan R, Akim A, Zafar M, Sung Y, Muhammad T. Breast Cancer: a Global Concern, Diagnostic and Therapeutic Perspectives, Mechanistic Targets in Drug Development. Adv Pharm Bull. 2020;11(4):580 [Crossref]
478- Luo Y, Song L, Wang X, Huang Y, Liu Y, Wang Q, Hong M, Yuan Z. Uncovering the Mechanisms of Cryptotanshinone as a Therapeutic Agent Against Hepatocellular Carcinoma. Front Pharmacol. 2020;11 [Crossref]
479- Mary S, Veeravarmal V, Thankappan P, Arumugam P, Augustine P, Franklin R. Anti-cancer effects of green synthesized gold nanoparticles using leaf extract of Annona muricata. L against squamous cell carcinoma cell line 15 through apoptotic pathway. 2024;21(1) [Crossref]
480- Barzegari R, Mohammadzadeh M, Mahdavi M. In Vitro Assessment of Novel Ciprofloxacin Derivative Effects on Cell Proliferation, Cell Cycle and Oxidative Stress–Induced Apoptosis in Chronic Myeloid Leukemia K562 Cell Line. J of Applied Toxicology. 2026; [Crossref]
481- Chavan P, Pandey R, Patil B, Murti K, Kumar N. Unravelling key signaling pathways for the therapeutic targeting of non-small cell lung cancer. European Journal of Pharmacology. 2025;998:177494 [Crossref]
482- Chamani R, Zamani F. Novel Anti-angiogenic Peptide Derived from Canstatin Induces Apoptosis In Vitro and In Vivo. Int J Pept Res Ther. 2022;28(5) [Crossref]
483- Mustafa M, Ahmad R, Tantry I, Ahmad W, Siddiqui S, Alam M, Abbas K, Abbas M, Hassan M, Habib S, Islam S. Apoptosis: A Comprehensive Overview of Signaling Pathways, Morphological Changes, and Physiological Significance and Therapeutic Implications. Cells. 2024;13(22):1838 [Crossref]
484- Xiang Y, Xu L, Lin Z, Zhu M, He Z. USP4‐Deubiquitinated PGAM5 Regulates Mitochondrial Dynamics in the Progression of Esophageal Squamous Cell Carcinoma. Molecular Carcinogenesis. 2026;65(1):106 [Crossref]
485- Sripetthong S, Nalinbenjapun S, Basit A, Surassmo S, Sajomsang W, Ovatlarnporn C. Preparation of Self-Assembled, Curcumin-Loaded Nano-Micelles Using Quarternized Chitosan–Vanillin Imine (QCS-Vani Imine) Conjugate and Evaluation of Synergistic Anticancer Effect with Cisplatin. JFB. 2023;14(10):525 [Crossref]
486- Ferreira R, Duarte S, de Sousa V, de Souza R, Marques K, de Abrantes R, do Nascimento Y, de Sousa N, Scotti M, Scotti L, Tavares J, Gonçalves J, da Silva M, Sobral M. The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways. Pharmaceuticals. 2023;16(11):1553 [Crossref]
487- Gök Korucu D, Uysal E, Akkuş F, Tombaklar P, Doğru Ş, Günenç O. The Role of Immature Granulocyte Percentage and Other Inflammatory Hematological Markers in Predicting In Vitro Fertilization Success. Biomedicines. 2025;13(11):2819 [Crossref]
488- Küçükbağrıaçık Y, Elmusa M, Elmusa F, Yılmaz H, Kasımoğulları R, Dastourı M. Assessment of Anticancer Properties of Synthesized Pyrazole-Acridine Derivative on SH-SY5Y Human Neuroblastoma Cells. 2025;27(1):1 [Crossref]
489- Pandey R, Bisht P, Wal P, Murti K, Ravichandiran V, Kumar N. SMAC Mimetics for the Treatment of Lung Carcinoma: Present Development and Future Prospects. MRMC. 2024;24(14):1334 [Crossref]
490- Yang L, Hou H, Lu L, Sun Y, Chen R, Deng Q, Chen H. Effects of natural source polysaccharides on neurological diseases: A review. International Journal of Biological Macromolecules. 2025;296:139697 [Crossref]
491- Constantinescu D, Sorop A, Ghionescu A, Lixandru D, Herlea V, Bacalbasa N, Dima S. EM-transcriptomic signature predicts drug response in advanced stages of high-grade serous ovarian carcinoma based on ascites-derived primary cultures. Front Pharmacol. 2024;15 [Crossref]
492- Tahmasvand R, Dehghani S, Kooshafar Z, Emami Najafi S, Almasirad A, Salimi M. In vitro and in vivo activity of a novel oxamide-hydrazone hybrid derivative against triple-negative breast cancer. Naunyn-Schmiedeberg's Arch Pharmacol. 2024;397(7):5119 [Crossref]
493- Mohammed R, Khosravi M, Rahman H, Adili A, Kamali N, Soloshenkov P, Thangavelu L, Saeedi H, Shomali N, Tamjidifar R, Isazadeh A, Aslaminabad R, Akbari M. Anastasis: cell recovery mechanisms and potential role in cancer. Cell Commun Signal. 2022;20(1) [Crossref]
494- Salazar-Garcés L, Velastegui-Hernandez D, Leiva Suero L. Evaluating the immunogenic potential of BAX protein isoforms as therapeutic targets in oncology: brief report. Salud, Ciencia y Tecnología - Serie de Conferencias. 2023;2:587 [Crossref]
495- Pasupuleti S, Vanguru R, Manyam R, Siripurapu S, Alapati N, Salwaji S. Viral Carcinogenesis: A Concise Review. 2023;18(4):889 [Crossref]
496- Wawrowski T, Surówka A, Żołnierczuk M, Prowans P, Grabowska M, Kupnicka P, Markowska M, Kaczmarkiewicz M, Sych W, Zagrodnik E, Kędzierska-Kapuza K. The Role of the SLC1A5 Transporter on Glutathione Homeostasis and Enterocyte Apoptosis in Chronic Treatment of Rats with Immunosuppressive Drugs. IJMS. 2025;26(17):8330 [Crossref]
497- Niu J, Fang D, Chen J, Xiong Y, Liu J, Min W. SpaBatch: Deep Learning‐Based Cross‐Slice Integration and 3D Spatial Domain Identification in Spatial Transcriptomics. Advanced Science. 2025;12(44) [Crossref]
498- Gomes D, Yaduvanshi S, Silvestre S, Duarte A, Santos A, Soares C, Kumar V, Passarinha L, Sousa Â. Taxifolin and Lucidin as Potential E6 Protein Inhibitors: p53 Function Re-Establishment and Apoptosis Induction in Cervical Cancer Cells. Cancers. 2022;14(12):2834 [Crossref]
499- Ćorović K, Stojković D, Petrović Đ, Jovičić Milić S, Đukić M, Radojević I, Raković I, Jurišević M, Gajović N, Jovanović M, Marinković J, Jovanović I, Stojanović B. Newly synthesized palladium(ii) complexes with dialkyl esters of (S,S)-propylenediamine-N,N′-di-(2,2′-di-(4-hydroxy-benzil))acetic acid: in vitro investigation of biological activities and HSA/DNA binding. Dalton Trans. 2024;53(18):7922 [Crossref]
500- Sarfraz A, Rasul A, Sarfraz I, Shah M, Hussain G, Shafiq N, Masood M, Adem Ş, Sarker S, Li X. RETRACTED: Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways. Environmental Research. 2020;190:110017 [Crossref]
501- Iacopetta D, Costabile C, La Chimia M, Mariconda A, Ceramella J, Scumaci D, Catalano A, Rosano C, Cuda G, Sinicropi M, Longo P. NHC-Ag(I) and NHC-Au(I) Complexes with N-Boc-Protected α-Amino Acidate Counterions Powerfully Affect the Growth of MDA-MB-231 Cells. ACS Med Chem Lett. 2023;14(11):1567 [Crossref]
502- Zhang Q, Huang Q, Cheng Z, Xue W, Liu S, Liao Y, Li X, Chen X, Han Y, Zhu D, Su Z, Yang X, Luo Z, Guo H. Exploring the mechanism of Xiaoaiping Injection inhibiting autophagy in prostate cancer based on proteomics. Chinese Journal of Natural Medicines. 2025;23(1):64 [Crossref]
503- Duan Y, Zhang W, Liu H, Wang M, Zhong L, Liu J, Chen X, Zhang S. Insights into the molecular response mechanisms of fasting stress and refeeding in channel catfish (Ictalurus punctatus) through transcriptome and histological analysis. Journal of Fish Biology. 2025;107(5):1714 [Crossref]
504- Wu Y, Liu J, Shao M, Zhang P, Song S, Yang G, Liu X, Liu Z. Cyclometalated iridium(III) dithioformic acid complexes as mitochondria-targeted imaging and anticancer agents. Journal of Inorganic Biochemistry. 2022;233:111855 [Crossref]
505- Abbas J, Hasoon B, Jabir M. Insights into the apoptosis induction in colon cancer cells by Ag-Cu bimetallic nanocomposite: 2D tissue culture model and insilico study. Inorganic Chemistry Communications. 2025;174:114019 [Crossref]
506- Kalındemirtaş F, Kaya B, Sert E, Şahin O, Kuruca S, Ülküseven B. New oxovanadium(IV) complexes overcame drug resistance and increased in vitro cytotoxicity by an apoptotic pathway in breast cancer cells. Chemico-Biological Interactions. 2022;363:109997 [Crossref]
507- Dakal T, Dhabhai B, Pant A, Moar K, Chaudhary K, Yadav V, Ranga V, Sharma N, Kumar A, Maurya P, Maciaczyk J, Schmidt‐Wolf I, Sharma A. Oncogenes and tumor suppressor genes: functions and roles in cancers. MedComm. 2024;5(6) [Crossref]
508- Bispo I, Granger H, Almeida P, Nishiyama P, de Freitas L. Systems biology and OMIC data integration to understand gastrointestinal cancers. World J Clin Oncol. 2022;13(10):762 [Crossref]
509- Karam-Palos S, Andrés-Blasco I, Campos-Borges C, Zanón-Moreno V, Gallego-Martínez A, Alegre-Ituarte V, García-Medina J, Pastor-Idoate S, Sellés-Navarro I, Vila-Arteaga J, Lleó-Perez A, Pinazo-Durán M. Oxidative Stress Mediates Epigenetic Modifications and the Expression of miRNAs and Genes Related to Apoptosis in Diabetic Retinopathy Patients. JCM. 2023;13(1):74 [Crossref]
510- Kiruthiga C, Jafni S, Preethi S, Kannan N, Pandima Devi K. Oral toxicity assessment and the mitigation of lung carcinogenesis by phytol and α-bisabolol combination treatment in swiss albino mice: insights into redox enzyme modulation and caspase-dependent cell death mechanisms. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(4):3881 [Crossref]
511- Aengwanich W, Wandee J. The effect of increased ambient temperature on Hsp70, superoxide dismutase, nitric oxide, malondialdehyde, and caspase activity in relation to the intrinsic and extrinsic apoptosis pathway of broiler blood cells. Journal of Thermal Biology. 2022;105:103211 [Crossref]
512- Abdullah H, Ismail I, Suppian R, Zakaria N. Natural Gallic Acid and Methyl Gallate Induces Apoptosis in Hela Cells through Regulation of Intrinsic and Extrinsic Protein Expression. IJMS. 2023;24(10):8495 [Crossref]
513- Ahmed T, Milibary G, Almehmady A, Alahmadi A, Ali E, El-Say K. Improving the Cytotoxic Activity of Hinokitiol from Drug-Loaded Phytosomal Formulation Against Breast Cancer Cell Lines. IJN. 2024;Volume 19:10321 [Crossref]
514- Kalyniukova A, Ahmed S, Ak G, Saka E, Duran T, Abul N, Gulcin I, Senkardes I, Cetiz M, Zengin G. Comprehensive Metabolomic Profiling and Biological Activity Analysis of Eschscholzia californica Extracts Using LC‐ESI‐QTOF‐MS. Food Science & Nutrition. 2025;13(9) [Crossref]
515- Wang S, Liang J, Zhang J, Ji D, Huang Z, Li D. Down-Regulation of Oncogene c-myb Specifically by Carbazole Derivative Through Opposing Effects on Different Quadruplex Structures of Gene Promoter for Cancer Treatment. IJMS. 2025;26(17):8299 [Crossref]
516- Motofei I. Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation. Seminars in Cancer Biology. 2022;86:600 [Crossref]
517- ASDEMİR A, ÖZGÜR A. Combination of navitoclax (Bcl-2 and Bcl-xL inhibitor) and Debio-0932 (Hsp90 inhibitor) suppresses the viability of prostate cancer cells via induction of apoptotic signaling pathway. Med Oncol. 2024;41(4) [Crossref]
518- Šeklić D, Jovanović M, Nikolić D, Đukić T. Application of Biphasic Numerical Model for the Prediction of Colorectal Carcinoma Cell Response to Co-Treatments. MCA. 2026;31(3):109 [Crossref]
519- Ganjayi M, Krauss T, Willis C, Baumann C. Chronic alcohol-related myopathy: a closer look at the role of lipids. Front Physiol. 2024;15 [Crossref]
520- Beilankouhi E, Yousefi B, Hadian N, Safaralizadeh R, Valilo M. The cross-talk between NRF2 and apoptosis in cancer. Med Mol Morphol. 2025;58(3):155 [Crossref]
521- Sitarek P, Merecz-Sadowska A, Śliwiński T, Zajdel R, Kowalczyk T. An In Vitro Evaluation of the Molecular Mechanisms of Action of Medical Plants from the Lamiaceae Family as Effective Sources of Active Compounds against Human Cancer Cell Lines. Cancers. 2020;12(10):2957 [Crossref]
522- Bhat E, Sajjad N. Human Pannexin 1 channel: Insight in structure–function mechanism and its potential physiological roles. Mol Cell Biochem. 2021;476(3):1529 [Crossref]
523- Valencia-Chan L, Estrada-Alfaro N, Ceballos-Cruz J, Torres-Tapia L, Peraza-Sánchez S, Moo-Puc R. Lupane Triterpene Derivatives Improve Antiproliferative Effect on Leukemia Cells through Apoptosis Induction. Molecules. 2022;27(23):8263 [Crossref]
524- Ji J, Jiang X, Liao X, Du F, Wang G, Huang H, Mei M, He Y, Tan X, Javid B, Li H. A Monovalent SMAC Mimetic as a Potential Host-Directed Therapy for Tuberculosis. 2026;233(4):777 [Crossref]
525- Uthra C, Nagaraj K, Muralitharan G, Al-Ansari M, Velmurugan G. Synthesis, characterization and apoptosis induction by cyanobacteria-derived neurotoxins: evaluating L-BMAA, 2,4-DAB, and AEG as potential anticancer agents against brain and breast cancer cells. Chem Pap. 2025;79(12):8971 [Crossref]
526- Ahmed K, Rahman M, Islam M, Fahim M, Rahman M, Kim B. Antioxidants activities of phytochemicals perspective modulation of autophagy and apoptosis to treating cancer. Biomedicine & Pharmacotherapy. 2024;174:116497 [Crossref]
527- Smith A, Hergenrother P. Raptinal: a powerful tool for rapid induction of apoptotic cell death. Cell Death Discov. 2024;10(1) [Crossref]
528- Chen C, Wu N, Tsai T. How Cells Die in Psoriasis?. IJMS. 2025;26(8):3747 [Crossref]
529- Bahr H, Ibrahiem A, Gabr A, Elbahaie A, Elmahdi H, Soliman N, Youssef A, El-Sherbiny M, Zaitone S. Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on JNK signaling. Toxicology Mechanisms and Methods. 2021;31(2):138 [Crossref]
530- El-Shafey H, Gomaa R, El-Messery S, Goda F. Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent. Bioorganic Chemistry. 2020;101:103987 [Crossref]
531- Zhang S, Ren H, Sun H, Cao S. Dieckol exerts anticancer activity in human osteosarcoma (MG-63) cells through the inhibition of PI3K/AKT/mTOR signaling pathway. Saudi Journal of Biological Sciences. 2021;28(9):4908 [Crossref]
532- El-Sapagh S, El-Zawawy N, Elshobary M, Alquraishi M, Zabed H, Nouh H. Harnessing the power of Neobacillus niacini AUMC-B524 for silver oxide nanoparticle synthesis: optimization, characterization, and bioactivity exploration. Microb Cell Fact. 2024;23(1) [Crossref]
533- Safavi-Naeini S, Nasehi M, Zarrindast M, Safavi-Naeini S. Exploring the effects of naringenin on cell functioning and energy synthesis in the hippocampus of male Wistar rats with chronic tinnitus, by examining genetic indicators such as Bax, Bcl-2, Tfam, and Pgc-1α. Gene. 2025;933:148980 [Crossref]
534- XIE J, LI B, ZHOU T, WANG X. The water content, apoptosis, and proliferation of the brain in marine medaka affected by seawater acidification. Integr Zool. 2025;20(6):1306 [Crossref]
535- Fonseca R, Zhu Y, Bruins L, Ahmann J, de Bonolo Campos C, Braggio E, Chen X, Arribas M, Darvish S, Welsh S, Meermeier E, Mangalaparthi K, Kandasamy R, Ahmann G, Wiedmeier-Nutor J, Pandey A, Chesi M, Bergsagel P, Fonseca R. Exploring BCL2 regulation and upstream signaling transduction in venetoclax resistance in multiple myeloma: potential avenues for therapeutic intervention. Blood Cancer J. 2025;15(1) [Crossref]
536- Shen Y, Gao Y, Yang G, Zhao Z, Zhao Y, Gao L, Li S. Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota. Front Pharmacol. 2025;15 [Crossref]
537- Shojaei‐Zarghani S, Rafraf M, Yari‐Khosroushahi A. Theanine and cancer: A systematic review of the literature. Phytotherapy Research. 2021;35(9):4782 [Crossref]
538- Shehata M, Abu-Serie M, Abd El-Aziz N, El-Sohaimy S. Nutritional, phytochemical, and in vitro anticancer potential of sugar apple (Annona squamosa) fruits. Sci Rep. 2021;11(1) [Crossref]
539- Kamran S, Sinniah A, Chik Z, Nelli G, Alshawsh M. Synergistic anti-tumorigenic effect of diosmetin in combination with 5-fluorouracil on human colon cancer xenografts in nude mice. Biochemical and Biophysical Research Communications. 2024;735:150677 [Crossref]
540- Famurewa A, Akhigbe R, George M, Adekunle Y, Oyedokun P, Akhigbe T, Fatokun A. Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical studies. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(5):4747 [Crossref]
541- Cavalu S, Saber S, Amer A, Hamad R, Abdel‐Reheim M, Elmorsy E, Abdelhamid A. The multifaceted role of beta‐blockers in overcoming cancer progression and drug resistance: Extending beyond cardiovascular disorders. The FASEB Journal. 2024;38(13) [Crossref]
542- Mohd Nor M, Nik Mohd Kamal N, Khairuddean M, Chear N, Tong W, Leong C, Tan W. Nanotechnology-based combination approach using essential oils and chemotherapeutic drugs for targeting cancer cells. International Journal of Polymeric Materials and Polymeric Biomaterials. 2025;74(16):1529 [Crossref]
543- Varghese R, Ramamoorthy S. Deciphering the effects of bixin on pulmonary alveolar adenocarcinoma migration and proliferation via targeting BAX/BCL-2 and Cyclin D1. Sci Rep. 2025;15(1) [Crossref]
544- Gomes G, Zubieta C, Weber S, de Lima D, Reddy T, Guerrero A, de Fatima Cepa Matos M, Parisotto E, Perdomo R. Thiopyrimidine derivatives induce cytotoxicity, cell cycle arrest and oxidative stress in breast cancer 3D-spheroids. Chem Pap. 2021;75(3):1211 [Crossref]
545- Özgür A, Kara A, Gökşen Tosun N, Tekin Ş, Gökçe İ. Debio-0932, a second generation oral Hsp90 inhibitor, induces apoptosis in MCF-7 and MDA-MB-231 cell lines. Mol Biol Rep. 2021;48(4):3439 [Crossref]
546- Muttiah B, Muhammad Fuad N, Jaafar F, Abdullah N. Extracellular Vesicles in Ovarian Cancer: From Chemoresistance Mediators to Therapeutic Vectors. Biomedicines. 2024;12(8):1806 [Crossref]
547- Danışman-Kalındemirtaş F, Sert E, Tan E, Akyüz E, Karakuş S. Potential multifaceted applications of cisplatin-loaded Camellia sinensis extract/CuO nanoparticles in cytotoxic and apoptotic effects. Biomass Conv Bioref. 2024;14(17):20261 [Crossref]
548- Jan N, Sofi S, Mir A, Masoodi G, Mir M. Balancing senescence and apoptosis: therapeutic insights into aging and cancer. Mol Cell Biochem. 2025;480(11):5821 [Crossref]
549- Staehlke S, Mahajan S, Thieme D, Trosan P, Fuchsluger T. Suppressing Pro-Apoptotic Proteins by siRNA in Corneal Endothelial Cells Protects against Cell Death. Biomedicines. 2024;12(7):1439 [Crossref]
550- Dashti A, Shokrzadeh M, Karami M, Habibi E. Phytochemical identification, acute and subchronic oral toxicity assessments of hydroalcoholic extract of Acroptilon repens in BALB/c mice: A toxicological and mechanistic study. Heliyon. 2022;8(2):e08940 [Crossref]
551- Gursoy G, Esmekaya M, Cicek Z. Treatment of cervical cancer by electrochemotherapy with bleomycin, cisplatin, and calcium: an in vitro experimental study. Med Oncol. 2022;40(1) [Crossref]
552- Silva S, Machado F, Santos L, de Castro M, Nogueira M, Soares M, Rocha S, Araújo R, Dias R, Bezerra D, Araújo A, Marinho Filho J. Cordiaquinone B induces cytotoxicity and oxidative stress-mediated apoptosis in human colorectal cancer cells in vitro and in vivo. Chemico-Biological Interactions. 2025;421:111764 [Crossref]
553- Abulkhair H, Turky A, Ghiaty A, Ahmed H, Bayoumi A. Novel triazolophthalazine-hydrazone hybrids as potential PCAF inhibitors: Design, synthesis, in vitro anticancer evaluation, apoptosis, and molecular docking studies. Bioorganic Chemistry. 2020;100:103899 [Crossref]
554- Hafeez A, Khan Z, Armaghan M, Khan K, Sönmez Gürer E, Abdull Razis A, Modu B, Almarhoon Z, Setzer W, Sharifi-Rad J. Exploring the therapeutic and anti-tumor properties of morusin: a review of recent advances. Front Mol Biosci. 2023;10 [Crossref]
555- Goya L, Mateos R. Antioxidant and Anti-inflammatory Effects of Marine Phlorotannins and Bromophenols Supportive of Their Anticancer Potential. 2025;83(3):e1225 [Crossref]
556- Agena R, de Jesús Cortés-Sánchez A, Hernández-Sánchez H, Jaramillo-Flores M. Pro-Apoptotic Activity of Bioactive Compounds from Seaweeds: Promising Sources for Developing Novel Anticancer Drugs. Marine Drugs. 2023;21(3):182 [Crossref]
557- Lee Y, Pan Y, Park S, Sin S, Park K. Anticancer Effects in HT-29 Cells and Anti-Inflammatory Effects on Mouse Splenocytes of Broccoli Cultivated with Deep Sea Water Minerals in Organic Farming. Applied Sciences. 2023;13(17):9684 [Crossref]
558- Attique I, Haider Z, Khan M, Hassan S, Soliman M, Ibrahim W, Anjum S. Reactive Oxygen Species: From Tumorigenesis to Therapeutic Strategies in Cancer. Cancer Medicine. 2025;14(10) [Crossref]
559- Palma C, McIntyre H, Salomon C. Extracellular Vesicles—New Players in Cell-to-Cell Communication in Gestational Diabetes Mellitus. Biomedicines. 2022;10(2):462 [Crossref]
560- Hou Z, Vanecek A, Tepe J, Odom A. Synthesis, structure, properties, and cytotoxicity of a (quinoline)RuCp+ complex. Dalton Trans. 2023;52(3):721 [Crossref]
561- Kattan S, Nafie M, Elmgeed G, Alelwani W, Badar M, Tantawy M. Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR pathway. The Journal of Steroid Biochemistry and Molecular Biology. 2020;198:105604 [Crossref]
562- Gervasi F, Pojero F. Use of Oleuropein and Hydroxytyrosol for Cancer Prevention and Treatment: Considerations about How Bioavailability and Metabolism Impact Their Adoption in Clinical Routine. Biomedicines. 2024;12(3):502 [Crossref]
563- Sudaarsan A, Ghosh A. Appraisal of postbiotics in cancer therapy. Front Pharmacol. 2024;15 [Crossref]
564- Cui T, Yue Y, Yan S. Current evidence for Banxia Xiexin decoction in gastrointestinal tumors and future research perspectives. Journal of Ethnopharmacology. 2025;351:119972 [Crossref]
565- Thombre K, Masram R, Pandhare V, Potbhare R, Gupta K, Umekar M. Rutin and human health: Chemistry, bioactivity, and translational challenges. PharmaNutrition. 2026;38:100532 [Crossref]
566- Shabani M, Hosseini H, Tajik M, Meshkani R, Sadeghi A. Resveratrol relieves HFD-induced insulin resistance in skeletal muscle tissue through antioxidant capacity enhancement and the Nrf2-Keap1 signaling pathway. Mol Biol Rep. 2024;51(1) [Crossref]
567- Marques K, Formiga A, de Souza R, Castro I, Alexandre H, Ramalho I, Melquiades Pereira É, Carvalho L, Sobral M, Júnior F, Gonçalves J. Development and Characterization of Copaiba Oil‐Loaded Polymeric Nanocapsules With Enhanced Antitumor Activity Against Breast Cancer Cells. Part & Part Syst Charact. 2026;43(1) [Crossref]
568- Yıldırım M, Binzet G, Binzet R, Yabalak E. A natural approach to breast cancer treatment: investigation of chemical features of aerial parts of endemic Onosma sintenisii Hausskn. ex Bornm and its antioxidant properties, in vitro cytotoxic and apoptosis induction on MCF-7 cells . International Journal of Environmental Health Research. 2024;34(11):3784 [Crossref]
569- Rok J, Rzepka Z, Kowalska J, Banach K, Beberok A, Wrześniok D. The Anticancer Potential of Doxycycline and Minocycline—A Comparative Study on Amelanotic Melanoma Cell Lines. IJMS. 2022;23(2):831 [Crossref]
570- Jang E, Yu H, Kim E, Hwang J, Yoo J, Choi J, Jeong H, Jang S. The Therapeutic Effects of Blueberry-Treated Stem Cell-Derived Extracellular Vesicles in Ischemic Stroke. IJMS. 2024;25(12):6362 [Crossref]
571- Cândido M, Vieira P, Campos A, Soares C, Raniero L. Gold-Coated Superparamagnetic Iron Oxide Nanoparticles Functionalized to EGF and Ce6 Complexes for Breast Cancer Diagnoses and Therapy. Pharmaceutics. 2022;15(1):100 [Crossref]
572- Kim S, Kim Y, Han G, Kim S, Kim B, Moon S, Shin S, Ryu B. Elucidating the mechanisms and mitigation strategies for six-phthalate-induced toxicity in male germ cells. Front Cell Dev Biol. 2024;12 [Crossref]
573- Kim E, Park S, Bae O. Cardiovascular Toxicity of Metal-Based Nanoparticles. IJMS. 2025;26(12):5816 [Crossref]
574- Aidy E, Elmongy E, Ahmed A, El Sayed I, Henidi H, EL‐Gendy S, EL‐Gendy Y, El‐Tantawy A, Effat H. Anti‐Proliferative and Apoptotic Evaluation of a Novel Synthesized Acridine Hybrid With Anticipated Synergistic Effect to Paclitaxel on Breast Cancer Cells. Chem Biol Drug Des. 2026;107(2) [Crossref]
575- Ponnapakkam T, Saulsberry T, Hill-Odom M, Beamon T, Hooks R, Goyal N, Shaik S, Anbalagan M, Foroozesh M. Anti-cancer effectiveness of a novel ceramide analog on chemo-sensitive and chemo-resistant breast cancers. 2024;35(1):12 [Crossref]
576- Drill M, Kan L, Sequeira R, Jayakrishnan P, Hunn M, Jones N, O’Brien T, Monif M, Bobé P. Purinergic P2X receptor 7 (P2X7R) inhibition induced cytotoxicity in glioblastoma. PLoS One. 2025;20(9):e0332212 [Crossref]
577- Dey C, Pal P, Ghosh R, Dey S. Copper-Aβ and cytochrome c: a potential Janus in Alzheimer's disease. Dalton Trans. 2025;54(32):12235 [Crossref]
578- Li J, Wang Z, Wang Y, Lin J, Tang N, Zheng C, Xu Q. The essential oil from the rhizomes of Stahlianthus involucratus attenuates the progression of vascular aging and atherosclerosis by regulating Nrf2-mediated mitochondrial quality. Front Pharmacol. 2025;16 [Crossref]
579- Chaudhry G, Jan R, Mohamad H, Tengku Muhammad T. Vitex rotundifolia fractions induce apoptosis in human breast cancer cell line, MCF-7, via extrinsic and intrinsic pathways. Res Pharma Sci. 2019;14(3):273 [Crossref]
580- Vasall P, Sheelmarevaa F, Permadi N, Setiawan F, Amalia R, Rukayadi Y, Julaeha E. Exploring the anticancer potential of Citrus spp. essential oils against various human cancer cell lines. Phytomedicine Plus. 2026;6(2):100990 [Crossref]
581- Shen X, Gao C, Li H, Liu C, Wang L, Li Y, Liu R, Sun C, Zhuang J. Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer. Front Pharmacol. 2023;14 [Crossref]
582- Wang L, Fu H, Lin J, Zhao M, Chen C, Liao H, Duan Y. Harnessing the Biological Responses Induced by Nanomaterials for Enhanced Cancer Therapy. Aggregate. 2025;6(9) [Crossref]
583- Park J, Kim S, Lee S, Park S, Kim J. Cucurbitacin-I exhibits anticancer activity by inducing apoptosis in SKOV3 human ovarian cancer cells. Mol Cell Toxicol. 2025;21(1):271 [Crossref]
584- Talib W, Alsayed A, Abuawad A, Daoud S, Mahmod A. Melatonin in Cancer Treatment: Current Knowledge and Future Opportunities. Molecules. 2021;26(9):2506 [Crossref]
585- Badmus J, Ekpo O, Sharma J, Sibuyi N, Meyer M, Hussein A, Hiss D. An Insight into the Mechanism of Holamine- and Funtumine-Induced Cell Death in Cancer Cells. Molecules. 2020;25(23):5716 [Crossref]
586- Kiflu A. The Immune Escape Strategy of Rabies Virus and Its Pathogenicity Mechanisms. Viruses. 2024;16(11):1774 [Crossref]
587- Irfan M, Javed Z, Khan K, Khan N, Docea A, Calina D, Sharifi-Rad J, Cho W. Apoptosis evasion via long non-coding RNAs in colorectal cancer. Cancer Cell Int. 2022;22(1) [Crossref]
588- Bułakowska A, Sławiński J, Hering A, Gucwa M, Ochocka J, Hałasa R, Balewski Ł, Stefanowicz-Hajduk J. New Chalcone Derivatives Containing 2,4-Dichlorobenzenesulfonamide Moiety with Anticancer and Antioxidant Properties. IJMS. 2023;25(1):274 [Crossref]
589- Chand P, Ambwani S, Kumar R, Garzoli S. Phytochemical Investigation and In Vitro Assessment of Antioxidant, Anti‐Inflammatory and Immunomodulatory Properties of Melia azedarach Linn. Extract in Chicken Lymphocyte Model. Flavour & Fragrance J. 2026; [Crossref]
590- Malayil D, House N, Puthenparambil D, Job J, Narayanankutty A. Borassus flabellifer haustorium extract prevents pro-oxidant mediated cell death and LPS-induced inflammation . Drug and Chemical Toxicology. 2022;45(4):1716 [Crossref]
591- Solares M, Kelly D. Complete Models of p53 Better Inform the Impact of Hotspot Mutations. IJMS. 2022;23(23):15267 [Crossref]
592- Potdar M, Bhamare R, Agrawal Y, Belgamwar A. Crosstalk Between Signaling Stroke Cascade and Therapeutic Receptors PPAR-γ, ROCK, CB1R, and CB2R: From Mechanism to Therapies. Transl Stroke Res. 2025;16(5):1884 [Crossref]
593- Zhang Q, Huang Q, Cheng Z, Xue W, Liu S, Liao Y, Hao J, Chen X, Li X, Han Y, Zhu D, Su Z, Yang X, Luo Z, Guo H. WITHDRAWN: Marsdenia tenacissima extract activates FoxO3a nuclear translocation to promote apoptosis via inhibiting autophagy in prostate cancer. Phytomedicine. 2022;:154560 [Crossref]
594- Magdy O, Eshra M, Rashed L, Maher M, Hosny S, ShamsEldeen A. Amelioration of cisplatin-induced neurodegenerative changes in rats and restoration of mitochondrial biogenesis by 6-bromoindirubin-3′-oxime: The implication of the GSK-3β/PGC1-α axis. Tissue and Cell. 2024;88:102393 [Crossref]
595- Moraes-Lacerda T, de Jesus M. Mechanisms of solid lipid nanoparticles-triggered signaling pathways in eukaryotic cells. Colloids and Surfaces B: Biointerfaces. 2022;220:112863 [Crossref]
596- Bala R, Madaan R, Chauhan S, Gupta M, Dubey A, Zahoor I, Brijesh H, Calina D, Sharifi-Rad J. Revitalizing allicin for cancer therapy: advances in formulation strategies to enhance bioavailability, stability, and clinical efficacy. Naunyn-Schmiedeberg's Arch Pharmacol. 2024;397(2):703 [Crossref]
597- Putra A, Putra A, Winarto H, Prijanti A, Prijanti L, Pakasi T, Gandamihardja S, Wirasugianto J, Wirasugianto A, Syariatin L. Investigating LATS1 and NF-κB as Predictors of Radiotherapy Response in Cervical Cancer. CIMB. 2025;47(5):365 [Crossref]
598- Pedrão L, Medeiros P, Leandro E, Falquetto B. Parkinson’s disease models and death signaling: what do we know until now?. Front Neuroanat. 2024;18 [Crossref]
599- Adu-Amankwaah F, Februarie C, Nyambo K, Maarman G, Tshililo N, Mabasa L, Mavumengwana V, Baatjies L. Cytotoxic properties, glycolytic effects and high-resolution respirometry mitochondrial activities of Eriocephalus racemosus against MDA-MB 231 triple-negative breast cancer. BMC Complement Med Ther. 2024;24(1) [Crossref]
600- Duan G, Zahid Piracha Z, Saeed U, Tian Y. In vitro Multi-targeted Anti-cancer Effects of Bavachinin in Papillary Thyroid Carcinoma Cell Line: Dual Pathway Inhibition and Cytokine Downregulation. Iran J Pharm Res. 2025;24(1) [Crossref]
601- Laurindo L, Rodrigues V, Guiguer E, Laurindo L, de Campos Zuccari D, Detregiachi C, Araújo A, da Silva Camarinha Oliveira J, Maria D, Dias J, Rici R, Lamas C, Direito R, Barbalho S. Catalpol: An Iridoid Glycoside With Potential in Combating Cancer Development and Progression—A Comprehensive Review. Phytotherapy Research. 2025;39(10):4950 [Crossref]
602- Ma X, Lu J, Yang P, Huang B, Li R, Ye R. Synthesis, Characterization and Antitumor Mechanism Investigation of Heterometallic Ru(Ⅱ)-Re(Ⅰ) Complexes. Front Chem. 2022;10 [Crossref]
603- Alqarni A, Hosmani J, Assiri K, Alassiri S, Alqahtani A. Cisplatin in Combination with Apigenin Inhibits Human Osteosarcoma Cells Proliferation by Promoting Osteogenic Differentiation: A Mechanistic Insight. Pharmacognosy Magazine. 2025;21(3):818 [Crossref]
604- El-Shafey E, Elsherbiny E. Therapeutic potential of a 2,2’-bipyridine-based vanadium(IV) complex on HepG2 cells: cytotoxic effects and molecular targeting. Egyptian Journal of Basic and Applied Sciences. 2023;10(1):204 [Crossref]
605- Sarwar A, Zhu M, Su Q, Zhu Z, Yang T, Chen Y, Peng X, Zhang Y. Targeting mitochondrial dysfunctions in pancreatic cancer evokes new therapeutic opportunities. Critical Reviews in Oncology/Hematology. 2022;180:103858 [Crossref]
606- Strzelecka M, Wiatrak B, Jawień P, Czyżnikowska Ż, Świątek P. New Schiff bases derived from dimethylpyridine-1,2,4-triazole hybrid as cytotoxic agents targeting gastrointestinal cancers: Design, synthesis, biological evaluation and molecular docking studies. Bioorganic Chemistry. 2023;139:106758 [Crossref]
607- Ghosh-Mitra A, Patel M, Das S. The Role of MicroRNAs Carried by Extracellular Vesicles in Tumorigenesis Through Reprogramming the Mitochondrial Information Processing System. IJMS. 2026;27(11):5112 [Crossref]
608- Renukadevi J, Mridula D, Nimithasree K, Sanjay V. Cofilin in Cancer: A Molecular Review of Its Role in Tumor Plasticity and Progression. J Bio-X Res. 2025;8 [Crossref]
609- Turchi R, Tortolici F, Benvenuto M, Punziano C, De Luca A, Rufini S, Faraonio R, Bei R, Lettieri-Barbato D, Aquilano K. Low Sulfur Amino Acid, High Polyunsaturated Fatty Acid Diet Inhibits Breast Cancer Growth. IJMS. 2022;24(1):249 [Crossref]
610- Zhao P, Tang Z, Lin H, Djuanda D, Zhu Z, Niu Q, Zhao L, Qian Y, Cao G, Shen J, Fu B. VEGF aptamer/i-motif-based drug co-delivery system for combined chemotherapy and photodynamic therapy. Photodiagnosis and Photodynamic Therapy. 2021;36:102547 [Crossref]
611- Chan W, Urandur S, Li H, Goudar V. Recent Advances in Copper Sulfide Nanoparticles for Phototherapy of Bacterial Infections and Cancer. Nanomedicine (Lond). 2023;18(30):2185 [Crossref]
612- Ezzat R. Anti-carcinogenic effects and mechanisms of actions of Citrus limon fruit peel hydroethanolic extract and limonene in diethylnitrosmine/2-acetylaminofluorene-induced hepatocellular carcinoma in Wistar rats. Am J Cancer Res. 2024;14(11):5193 [Crossref]
613- Olivares-Urbano M, Griñán-Lisón C, Marchal J, Núñez M. CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer. Cells. 2020;9(7):1651 [Crossref]
614- Akim A, Chaudhry G, Chaudhry Z, Ken T, Sung Y, Tengku Muhammad T. Cytotoxic effect and apoptotic induction of tricyclohexyltin p-methoxycinnamate on HT-29 colorectal cancer cells: Implications for anticancer therapeutics. 2025;16(1):1 [Crossref]
615- Mathew N, Park K. Long non-coding RNAs: Emerging regulators of diverse programmed cell death pathways in neurons. 2026;21(9):4020 [Crossref]
616- Laka K, Mdee L, Mbita Z. Drimia calcarata Bulb Extracts Deactivate the PI3K Signalling Pathway in Cervical HPV-18 Positive HeLa Cells. Clinical Complementary Medicine and Pharmacology. 2022;2(4):100054 [Crossref]
617- Singh A, Kushwaha P, Singh A, Pandey A. Overcoming cancer drug resistance: insights into Apoptotic pathway modulation by plant-based nanoparticle and natural products. Front Oncol. 2025;15 [Crossref]
618- Li H, Chen F, Qin M, Liao C, Shi Y, Wu S, Rong K, Zhang X. Short-term dietary teprenone improved thermal tolerance and mitigated liver damage caused by heat stress in juvenile largemouth bass (Micropterus salmoides). Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology. 2024;273:110984 [Crossref]
619- X, Ji J, Rui X, Chen X, Jiang M, Zhang Q, Dong M, Li W. Exopolysaccharide (LHEPS-1) from Lactobacillus helveticus MB2-1 Induced Apoptosis and G2/M Arrest in Human Liver Cancer HepG-2 Cells. Russ J Bioorg Chem. 2023;49(4):849 [Crossref]
620- Vahdati E, Rabbani-Chadegani A, Fallah Kohan S, Zeynali B, Davoodi J. Compromised Integrity of the Initial Stage of the Intrinsic Apoptosis Pathway in HEK293T and A549 but not HeLa Cells. Iran J Sci. 2026;50(2):373 [Crossref]
621- Jassem A, Hassan S, Hussein K, Ismael S, Almashal F, Jabir H. Ultrasonic-promoted green synthesis of new 1, 3, 4-oxadiazoles: Anti-esophageal cancer evaluation, apoptosis morphology, DFT-calculations, in silico ADME, and molecular docking study. Journal of the Indian Chemical Society. 2025;102(11):102178 [Crossref]
622- Živković M, Stanisavljević I, Gajović N, Pavlović S, Simović Marković B, Jovanović I, Cupara S, Tadić V, Žugić A, Milenković M, Barjaktarević A. Comprehensive Phytochemical Analysis and Evaluation of Antioxidant, Antimicrobial, Cytotoxic, and Immunomodulatory Activities of Commercial Cinnamon Bark Essential Oil (Cinnamomum zeylanicum L.). IJMS. 2025;26(13):6482 [Crossref]
623- You G, Cheng A, Shen E, Fan K, Huang Y, Huang Y, Chang K, Chang J. MiR-630 Promotes Radioresistance by Induction of Anti-Apoptotic Effect via Nrf2–GPX2 Molecular Axis in Head–Neck Cancer. Cells. 2023;12(24):2853 [Crossref]
624- Forma E, Bryś M. Anticancer Activity of Propolis and Its Compounds. Nutrients. 2021;13(8):2594 [Crossref]
625- He L, Wu H, Sun Z, Zhang J. Inhibition of Multiple Myeloma Growth by Wogonin Involves Mitochondrial Apoptosis and G2/M Cycle Arrest. International J of Pharmacology. 2024;20(2):166 [Crossref]
626- Ryczkowska M, Maciejewska N, Olszewski M, Witkowska M, Makowiec S. Tetrahydroquinolinone derivatives exert antiproliferative effect on lung cancer cells through apoptosis induction. Sci Rep. 2022;12(1) [Crossref]
627- Liu Q, Chen Q, Wei H, Tang B, Tian B, Ma Z, Gu Q, Su X, Dong Y, Shi W, Luo C. Targeting the BAG2/CHIP axis promotes gastric cancer apoptosis by blocking apoptosome assembly. Front Immunol. 2025;16 [Crossref]
628- Lu K, Lin R, Tsai M, Su S, Yang S. Flavones in osteosarcoma: Molecular mechanisms, antitumor activity, and translational challenges. Drug Discovery Today. 2026;31(6):104801 [Crossref]
629- S. Y, K.L. M, Harithpriya K, Zong C, Sahabudeen S, Ichihara G, Ramkumar K. Disruptive multiple cell death pathways of bisphenol-A. Toxicology Mechanisms and Methods. 2025;35(4):430 [Crossref]
630- Rostamabadi H, Samandari Bahraseman M, Esmaeilzadeh-Salestani K. Froriepia subpinnata Leaf Extract-Induced Apoptosis in the MCF-7 Breast Cancer Cell Line by Increasing Intracellular Oxidative Stress. Iran J Pharm Res. 2023;In Press(In Press) [Crossref]
631- Fikry H, Saleh L, Sadek D, Alkhalek H. The possible protective effect of luteolin on cardiovascular and hepatic changes in metabolic syndrome rat model. Cell Tissue Res. 2025;399(1):27 [Crossref]
632- Nosalova N, Keselakova A, Kello M, Martinkova M, Fabianova D, Pilatova M. Involvement of Both Extrinsic and Intrinsic Apoptotic Pathways in Tridecylpyrrolidine-Diol Derivative-Induced Apoptosis In Vitro. IJMS. 2023;24(14):11696 [Crossref]
633- Li Z, Xu B, Sun Y, Zhou L, Tao Y, Hou W, Bao J, Liu J, Fan W. 1α,25(OH) 2 D 3 (VD3) promotes Raddeanin A-induced anti-proliferative effects on HeLa cell apoptosis and autophagy through negative regulation of HPV18E6-E7/PD-L1/VDR axis . Bioengineered. 2022;13(1):357 [Crossref]
634- Seshadri V. Brucine promotes apoptosis in cervical cancer cells (ME‐180) via suppression of inflammation and cell proliferation by regulating PI3K/AKT/mTOR signaling pathway. Environmental Toxicology. 2021;36(9):1841 [Crossref]
635- Derakhshani A, Silvestris N, Hajiasgharzadeh K, Mahmoudzadeh S, Fereidouni M, Paradiso A, Brunetti O, Atarod D, Safarpour H, Baradaran B. Expression and characterization of a novel recombinant cytotoxin II from Naja naja oxiana venom: A potential treatment for breast cancer. International Journal of Biological Macromolecules. 2020;162:1283 [Crossref]
636- Han K, Kwak M, Lee T, Park M, Jeong I, Kim M, Jin J, Lee P. USP14 Inhibition Regulates Tumorigenesis by Inducing Autophagy in Lung Cancer In Vitro. IJMS. 2019;20(21):5300 [Crossref]
637- Alapati K, Handanahal S. Cytotoxic activity of cholesterol oxidase produced by Streptomyces sp. AKHSS against cancerous cell lines: mechanism of action in HeLa cells. World J Microbiol Biotechnol. 2021;37(8) [Crossref]
638- Ismail N. Propolis Nanoparticles Combined with Gamma-Irradiation Enhance the Potency of Anticancer Against HepG2 Cell Lines: Invitro Investigation. BioNanoSci. 2024;14(3):2457 [Crossref]
639- Maldonado-Cano Y, Rojas-Flores A, López-Álvarez G, Luzardo-Ocampo I, Kuri-García A, Cuéllar-Núñez M, Vergara-Castañeda H. Bioaccessible compounds generated during human colonic fermentation of Myrtillocactus geometrizans exert anticancer effects in colon cancer cells. Food Funct. 2026;17(15):6969 [Crossref]
640- El-Sawy W, El‐Bahrawy A, Messiha B, Hemeida R, Khalaf M. The impact of PPAR-γ/Nrf-2/HO-1, NF-κB/IL-6/ Keap-1, and Bcl-2/caspase-3/ATG-5 pathways in mitigation of DOX-induced cardiotoxicity in an animal model: The potential cardioprotective role of oxyresveratrol and/or dapagliflozin. Food and Chemical Toxicology. 2024;191:114863 [Crossref]
641- Aghaei-Zarch S, Nia A, Nouri M, Mousavinasab F, Najafi S, Bagheri-Mohammadi S, Aghaei-Zarch F, Toolabi A, Rasoulzadeh H, Ghanavi J, Moghadam M, Talebi M. The impact of particulate matters on apoptosis in various organs: Mechanistic and therapeutic perspectives. Biomedicine & Pharmacotherapy. 2023;165:115054 [Crossref]
642- Pekince Özöner M, Seker U, Sert C, Tuysuz M, Yüksel M, Gökçe Y. Extremely low-frequency pulsed electromagnetic fields induce apoptotic, oxidative stress, inflammatory and aquaporin-related kidney alteration. J Mol Histol. 2026;57(4) [Crossref]
643- Amini P, Moazamiyanfar R, Dakkali M, Jafarzadeh E, Ganjizadeh M, Rastegar-Pouyani N, Moloudi K, Khodamoradi E, Taeb S, Najafi M. Induction of Cancer Cell Death by Apigenin: A Review on Different Cell Death Pathways. MRMC. 2023;23(14):1461 [Crossref]
644- Al-Khafaji K, Taskin Tok T. Understanding the mechanism of amygdalin’s multifunctional anti-cancer action using computational approach. Journal of Biomolecular Structure and Dynamics. 2021;39(5):1600 [Crossref]
645- Bhat A, Afzal M, Moglad E, Thapa R, Ali H, Almalki W, Kazmi I, Alzarea S, Gupta G, Subramaniyan V. lncRNAs as prognostic markers and therapeutic targets in cuproptosis-mediated cancer. Clin Exp Med. 2024;24(1) [Crossref]
646- Maleki N, Yavari N, Ebrahimi M, Faisal Faiz A, Khosh Ravesh R, Sharbati A, Panji M, Lorian K, Gravand A, Abbasi M, Abazari O, Shafiee Mehr M, Eskandari Y. Silibinin exerts anti-cancer activity on human ovarian cancer cells by increasing apoptosis and inhibiting epithelial-mesenchymal transition (EMT). Gene. 2022;823:146275 [Crossref]
647- Viji M, Yasiha K, Subramanian Sathiya J, Aishwariya S, Ireen C, Indu S, Hinduja S, Rajalakshmi M. In-silico Study: The role of myricitrin from the leaves of Syzygium cumini in breast cancer treatment through apoptosis pathway. Journal of Medico Informatics. 2025;1(1):1 [Crossref]
648- Hjazi A, Alissa M, Alqasem A, Alghamdi A, Alghamdi S. Cynaropicrin, a sesquiterpene lactone, triggers apoptotic cell death in triple negative breast cancer cells. Mol Biol Rep. 2024;51(1) [Crossref]
649- Tarlan M, Moradi S, Heidarizade N, Tavallaei O, Khazayel S, Farzaei M, Echeverría J. The protective role of curcumin in mitigating drug-induced toxicity in male reproductive system. Front Pharmacol. 2025;16 [Crossref]
650- Silva J, Beserra Filho J, Acha B, Almeida F, Batista E, Silva V, Bomfim L, Soares M, Bezerra D, dos Santos A, de Andrade F, Mendes A, Arcanjo D, Ferreira P. Promising Effects of Casearins in Tumor-Bearing Mice and Antinociceptive Action against Oncologic Pain: Molecular Docking and In Vivo Findings. Pharmaceuticals. 2024;17(5):633 [Crossref]
651- Sułkowska-Ziaja K, Korczyński M, Trepa M, Galanty A, Lazur J, Kubica P, Kała K, Paśko P, Muszyńska B. A Comparative Study on the Mycelium and Fruiting Body of Meripilus giganteus: Chemical Composition and Biological Activity. CIMB. 2025;47(5):302 [Crossref]
652- Yulak F. Investigation of The Antiproliferative Effect of Colchicine on SNU-1 Gastric Cancer Cells. 2023;44(2):263 [Crossref]
653- Moses L, Abu Bakar M, Mamat H, Aziz Z, Tebyanian H. Unfermented Freeze-Dried Leaf Extract of Tongkat Ali (Eurycoma longifolia Jack.) Induced Cytotoxicity and Apoptosis in MDA-MB-231 and MCF-7 Breast Cancer Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2021;2021:1 [Crossref]
654- Chakraborty S, Banerjee M, Jayaraman G, Rajeswari V D. Evaluation of the health impacts and deregulation of signaling pathways in humans induced by microplastics. Chemosphere. 2024;369:143881 [Crossref]
655- Singh S, Bhaskar R, Ghosh S, Yarlagadda B, Singh K, Verma P, Sengupta S, Mladenov M, Hadzi-Petrushev N, Stojchevski R, Sinha J, Avtanski D. Exploring the Genetic Orchestra of Cancer: The Interplay Between Oncogenes and Tumor-Suppressor Genes. Cancers. 2025;17(7):1082 [Crossref]
656- Mohammed M, Adil B, Obaid A, Al-Shammari A. Plasma Jet Prepared Gold and Silver Nanoparticles to Induce Caspase-Independent Apoptosis in Digestive System Cancers. MSF. 2022;1050:51 [Crossref]
657- Sanlier N, Ozler E. Coffee Consumption and Its Potential Implications for Digestive Tract Carcinogenesis. Curr Nutr Rep. 2026;15(1) [Crossref]
658- Gómez-Apo E, Mondragón-Maya A, Ferrari-Díaz M, Silva-Pereyra J, Weller A. Structural Brain Changes Associated with Overweight and Obesity. Journal of Obesity. 2021;2021:1 [Crossref]
659- Cai H, Meng Z, Yu F. The involvement of ROS-regulated programmed cell death in hepatocellular carcinoma. Critical Reviews in Oncology/Hematology. 2024;197:104361 [Crossref]
660- Nezhadi S, Norouzi P, Rasouli A, Akbari Javar H, Ostad S, Dorkoosh F. Co-delivery of paclitaxel and regorafenib by F127/TPGS mixed micelles for triple negative breast cancer treatment. Journal of Drug Delivery Science and Technology. 2023;86:104673 [Crossref]
661- Wang Y, He J, Lian S, Zeng Y, He S, Xu J, Luo L, Yang W, Jiang J. Targeting Metabolic–Redox Nexus to Regulate Drug Resistance: From Mechanism to Tumor Therapy. Antioxidants. 2024;13(7):828 [Crossref]
662- Xu M, Xu B. Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics. Mol Cancer. 2025;24(1) [Crossref]
663- Jaswal P, Bansal S, Chaudhary R, Basu J, Bansal N, Kumar S. Nitric oxide: Potential therapeutic target in Heat Stress–induced Multiple Organ Dysfunction. Naunyn-Schmiedeberg's Arch Pharmacol. 2025;398(3):2535 [Crossref]
664- Ahmed N, Mohamed M, Awad S, El-tawab N, Gaballah M, Said A. Design, synthesis, molecular modelling and biological evaluation of novel 6-amino-5-cyano-2-thiopyrimidine derivatives as potent anticancer agents against leukemia and apoptotic inducers. Journal of Enzyme Inhibition and Medicinal Chemistry. 2024;39(1) [Crossref]
665- Lee W, Lee R, Park H. Tebuconazole Induces ER-Stress-Mediated Cell Death in Bovine Mammary Epithelial Cell Lines. Toxics. 2023;11(4):397 [Crossref]
666- del Val C, Díaz de la Guardia-Bolívar E, Zwir I, Mishra P, Mesa A, Salas R, Poblete G, de Erausquin G, Raitoharju E, Kähönen M, Raitakari O, Keltikangas-Järvinen L, Lehtimäki T, Cloninger C. Gene expression networks regulated by human personality. Mol Psychiatry. 2024;29(7):2241 [Crossref]
667- Shenoy U, Adiga D, Kabekkodu S, Hunter K, Radhakrishnan R. Molecular implications of HOX genes targeting multiple signaling pathways in cancer. Cell Biol Toxicol. 2022;38(1):1 [Crossref]
668- Lantvit D, Unterberger C, Lazar M, Arneson P, Longhurst C, Swanson S, Marker P. Mammary Tumors Growing in the Absence of Growth Hormone Are More Sensitive to Doxorubicin Than Wild-Type Tumors. 2021;162(4) [Crossref]
669- Sahu M, Jain U. ROS-mediated therapeutic approach through oxidative stress and cell signalling modulation. Critical Reviews in Oncology/Hematology. 2026;220:105168 [Crossref]
670- Karuppaiya V, Annamalai A, Krishnamurthy S, Soundarapandian K. RETRACTED: Dieckol prevents prostate cancer cell proliferation by transcriptionally attenuating JAK/STAT3 signaling pathway. Environmental Toxicology. 2024;39(3):1187 [Crossref]
671- Putta S, Chinnaiyan S, Korni R, Gadela V. Revolutionizing cancer treatment: ROS-induced apoptosis via nanoformulated alkaloids. Journal of Drug Delivery Science and Technology. 2025;104:106556 [Crossref]
672- Zavadinack M, Mazepa E, Quadrado R, Zhai Z, da Silva Milhorini S, Gomes D, Martinez G, Cordeiro L, Edgar K, Iacomini M. Hydroxypropylation confers cytotoxic activity to (1→3), (1→6)-β-D-glucans against B16-F10 murine melanoma cells. Carbohydrate Polymers. 2026;391:125797 [Crossref]
673- Saleh A, Eldehna W, Elnagar M, Elmasry G, Abdelrahman M, El-Zahabi M, Abou-Seri S. Design of 4-(Piperazin-1-yl)thieno[2,3-d]pyrimidine derivatives Targeting the DFG-out Conformation of VEGFR-2: Synthesis, Biological Evaluations, and Molecular modeling approaches. European Journal of Medicinal Chemistry. 2026;:119401 [Crossref]
674- Chota A, Sarbadhikary P, Abrahamse H, George B. Emerging Advances in Nanomedicine for Targeted Cancer Photoimmunotherapy and Photo‐Immunometabolic Therapy. WIREs Nanomed Nanobiotechnol. 2025;17(6) [Crossref]
675- Chota A, George B, Abrahamse H. Interactions of multidomain pro-apoptotic and anti-apoptotic proteins in cancer cell death. Oncotarget. 2021;12(16):1615 [Crossref]
676- Yao Z, Wang L, Cai D, Jiang X, Sun J, Wang Y, Bai W. Warangalone Induces Apoptosis in HeLa Cells via Mitochondria‐Mediated Endogenous Pathway. eFood. 2021;2(5):259 [Crossref]
677- Askary M, Behdani M, Mollaei H, Fallahi H, Azarmi-Atajan F, Mokhtari Macinaei H. Bioactive compounds and apoptotic effects of saffron (Crocus sativus L.) in different fertilizer conditions. Biochemical Systematics and Ecology. 2024;114:104806 [Crossref]
678- Wang X, Zang S, Ban Z, Zhang Y, Hou L, Zhang X, Wang Y, Li D, An F, Liu Y, Jia Y, Gao Y. Norisoboldine inhibits endoplasmic reticulum stress and alleviates depressive behaviors in CUMS mice by activating growth hormone secretagogue receptor type 1a in the hippocampus. European Journal of Pharmacology. 2026;1030:179056 [Crossref]
679- Eldehna W, Elsayed Z, Elnagar M, El-Said A, Majrashi T, Negmeldin A, Saleh A, Elrayess R, Elnahriry K, Chen Z, Elagawany M, Tawfik H. Discovery of Novel Piperidinyl-Based Benzoxazole Derivatives as Anticancer Agents Targeting VEGFR-2 and c-Met Kinases. Pharmaceuticals. 2025;18(12):1875 [Crossref]
680- Abi Zamer B, Rah B, Jayakumar M, Abumustafa W, Hamad M, Muhammad J. DNA methylation-mediated epigenetic regulation of oncogenic RPS2 as a novel therapeutic target and biomarker in hepatocellular carcinoma. Biochemical and Biophysical Research Communications. 2024;696:149453 [Crossref]
681- Hong J, Chung K, Shin J, Lee J, Gil H, Lee H, Choi E, Choi J, Hassan A, Lee Y, Lee K. The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation. Cancers. 2019;11(12):1927 [Crossref]
682- Elmimehr R, Motamed‐Sanaye A, Brazvan B, Abtahi‐Eivary S, Moghimian M, Fani M. Effects of hypothermia and pentoxifylline on the adnexal torsion/detorsion injuries in a rat testis model. Andrologia. 2021;53(8) [Crossref]
683- Mod Razif M, Chan S, Chew Y, Hassan M, Ahmad Hisham S, Abdul Rahman S, Mai C, Teo M, Kee P, Khoo K, Lee S, Liew K. Recent Developments in Luteolin-Loaded Nanoformulations for Enhanced Anti-Carcinogenic Activities: Insights from In Vitro and In Vivo Studies. Sci. 2024;6(4):68 [Crossref]
684- Erpel F, Mateos R, Pérez-Jiménez J, Pérez-Correa J. Phlorotannins: From isolation and structural characterization, to the evaluation of their antidiabetic and anticancer potential. Food Research International. 2020;137:109589 [Crossref]
685- Karademir D, Özgür A. The effects of STA-9090 (Ganetespib) and venetoclax (ABT-199) combination on apoptotic pathways in human cervical cancer cells. Med Oncol. 2023;40(8) [Crossref]
686- Jiménez-Salazar J, Damian-Ferrara R, Arteaga M, Batina N, Damián-Matsumura P. Non-Genomic Actions of Estrogens on the DNA Repair Pathways Are Associated With Chemotherapy Resistance in Breast Cancer. Front Oncol. 2021;11 [Crossref]
687- Ahuja R, Singh M, Dutt Konar A. 12-Hydroxy-Lauric Acid Tethered Self-Assembled Heterochiral Diphenylalanine-Based Mechanoresponsive and Proteolytically Stable Hydrogel: A Dual Player for Handling Cancer and Bacterial Challenges. ACS Appl Bio Mater. 2025;8(2):1108 [Crossref]
688- Eladwy R, Fares M, Alsherbiny M, Chang D, Li C, Bhuyan D. Postbiotics Combination Synergises the Antiproliferative Effects of Doxorubicin in Gastric Cancer Cells: A Cellular and Molecular Deep Dive. IJMS. 2025;27(1):362 [Crossref]
689- Shenoy T, Abdul Salam A. Therapeutic potential of dietary bioactive compounds against anti-apoptotic Bcl-2 proteins in breast cancer. Critical Reviews in Food Science and Nutrition. 2025;65(25):4915 [Crossref]
690- Baviskar T, Momin M, Liu J, Guo B, Bhatt L. Target Genetic Abnormalities for the Treatment of Colon Cancer and Its Progression to Metastasis. CDT. 2021;22(7):722 [Crossref]
691- Leveille E, Johnson N. Genetic Events Inhibiting Apoptosis in Diffuse Large B Cell Lymphoma. Cancers. 2021;13(9):2167 [Crossref]
692- Behl T, Kaur G, Sehgal A, Singh S, Bhatia S, Al-Harrasi A, Zengin G, Bungau S, Munteanu M, Brisc M, Andronie-Cioara F, Brisc C. Elucidating the Multi-Targeted Role of Nutraceuticals: A Complementary Therapy to Starve Neurodegenerative Diseases. IJMS. 2021;22(8):4045 [Crossref]
693- Mlyczyńska E, Zaobidna E, Rytelewska E, Dawid M, Kopij G, Kieżun M, Dobrzyń K, Smolińska N, Kamiński T, Rak A. Visfatin Modulates Angiogenesis and Apoptosis in Porcine Luteal Cells via INSR, MAPK, and AKT Pathways. Molecular Reproduction Devel. 2025;92(9) [Crossref]
694- El-Banna M, Hendawy O, El-Nekeety A, Abdel-Wahhab M. Efficacy of ginsenoside Rg3 nanoparticles against Ehrlich solid tumor growth in mice. Environ Sci Pollut Res. 2022;29(29):43814 [Crossref]
695- Keflee R, Leong K, Abdulwahab M, Ariffin A, Kong K. A new anilinoquinazoline derivative, F307 induces autophagy and differential apoptosis in wild-type and mutated-epidermal growth factor receptor non-small cell lung cancer cell lines. 2026;37(1):1 [Crossref]
696- Chen R, Li R, Jiang J, Zhou L, Zhao S, Zhang Y, Xia Q, Yang Z. Coconut oil derived medium-chain triglycerides ameliorated memory deficits via promoting neurite outgrowth and maintaining gut homeostasis in 5×FAD mice. Front Nutr. 2025;12 [Crossref]
697- Han Q, Dong J, Ren W, Qu Y, Wei F. Preparation and evaluation of multi-functional Nimbolide-loaded PLGA/chitosan nanoparticles as a potential therapy for renal cell carcinoma through activation of intrinsic apoptotic pathway. International Journal of Biological Macromolecules. 2026;337:149088 [Crossref]
698- Dilip P, Daksh R, Sharma P, Khanna S, Bojja S, Singh A, Nampoothiri M. Repressor Element 1 Silencing Transcription Factor as a central regulator of autophagy and neuroinflammation in Alzheimer's disease. European Journal of Pharmacology. 2026;1030:179168 [Crossref]
699- Verçosa B, Muniz-Junqueira M, Mineiro A, Melo M, Vasconcelos A. Enhanced apoptosis and inflammation allied with autophagic and apoptotic Leishmania amastigotes in the seemingly undamaged ear skin of clinically affected dogs with canine visceral Leishmaniasis. Cellular Immunology. 2025;408:104909 [Crossref]
700- Hosseindoost S, Mousavi S, Dehpour A, Javadi S, Arjmand B, Fallah A, Hadjighassem M. β2-Adrenergic receptor agonist enhances the bystander effect of HSV-TK/GCV gene therapy in glioblastoma multiforme via upregulation of connexin 43 expression. Molecular Therapy - Oncolytics. 2022;26:76 [Crossref]
701- Čižmáriková M, Michalková R, Mirossay L, Mojžišová G, Zigová M, Bardelčíková A, Mojžiš J. Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence. Biomolecules. 2023;13(11):1653 [Crossref]
702- Mannaperuma D, Stratton D, Lange S, Inal J. Extracellular Vesicles from the Myocyte Secretome Contribute In Vitro to Creating an Unfavourable Environment for Migrating Lung Carcinoma Cells. Biology. 2025;14(11):1578 [Crossref]
703- Pradhan B, Ki J. Seaweed-derived laminarin and alginate as potential chemotherapeutical agents: An updated comprehensive review considering cancer treatment. International Journal of Biological Macromolecules. 2025;293:136593 [Crossref]
704- Mattioli L, Stella R, Peggion C, Cagnin S, Pifferi A, Miraldi E, Cappellucci G, Baini G, Camarda L, Budriesi R, Frosini M. Magnolia officinalis (L.) Bark Extract Counteracts Oxidative Brain Injury: A Proteomic Investigation into Neuroprotective Mechanisms. IJMS. 2026;27(8):3350 [Crossref]
705- Rahmati-Dehkordi F, Khanifar H, Zare-Hoseinabadi A, Dadgostar E, Jafarpour H, Aschner M, Mirzaei H, Tamtaji O, Nabavizadeh F. Potential of Edaravone Dexborneol in the treatment of cerebral ischemia: focus on cell death-related signaling pathways. Mol Biol Rep. 2024;51(1) [Crossref]
706- Nair A, Kaushik D, Kumar A, Singh J, Oz E, Sharma A, Jebreen A, Proestos C, Oz F, Kumar M. Deciphering the Effect of Ginsenoside Rk3 on Gut Microbiota and Its Applications. The FASEB Journal. 2025;39(13) [Crossref]
707- Mandal M, Samanta D, Manna D, Bharadwaj D, Majumder R, Banerjee I, Mukherjee B, Mandal M. Modified PAMAM Dendrimer-Based Carboplatin Delivery in Glioblastoma: In Vitro and In Vivo Studies. 2025;8(11):10393 [Crossref]
708- Aung K, Zin S, Wu X, Myint Z, Karanth S, Estus S, Norris C, Nelson P, Fardo D, Abner E, Katsumata Y. Disentangling the inverse relationship between cancer and Alzheimer's or Parkinson's disease: A systematic review on Mendelian randomization studies. Neurobiology of Disease. 2025;217:107190 [Crossref]
709- Kaplan Ö, Gökşen Tosun N, İmamoğlu R, Türkekul İ, Gökçe İ, Özgür A. Biosynthesis and characterization of silver nanoparticles from Tricholoma ustale and Agaricus arvensis extracts and investigation of their antimicrobial, cytotoxic, and apoptotic potentials. Journal of Drug Delivery Science and Technology. 2022;69:103178 [Crossref]
710- D’Amico M, De Amicis F. Challenges of Regulated Cell Death: Implications for Therapy Resistance in Cancer. Cells. 2024;13(13):1083 [Crossref]
711- Radovanović M, Petrović M, Šantrić V, Milojević B, Zubelić A, Isaković A. P53 and survivin expression in renal cell carcinoma. 2023;15(2):186 [Crossref]
712- Nandi S, Nag A, Khatua S, Sen S, Chakraborty N, Naskar A, Acharya K, Calina D, Sharifi‐Rad J. Anticancer activity and other biomedical properties of β‐sitosterol: Bridging phytochemistry and current pharmacological evidence for future translational approaches. Phytotherapy Research. 2024;38(2):592 [Crossref]
713- Chaudhry G, Md Akim A, Sung Y, Sifzizul T. Cancer and apoptosis: The apoptotic activity of plant and marine natural products and their potential as targeted cancer therapeutics. Front Pharmacol. 2022;13 [Crossref]
714- Modeel S, Siwach S, Dolkar P, Chaurasia M, Yadav P, Atri A, Yadav A, Negi T, Negi R. Emerging risk factors and the role of gut microbiota in immunomodulation and therapeutic implications in colorectal cancer. Cancer Pathogenesis and Therapy. 2026;4(1):14 [Crossref]
715- Hu H, Zhang H, Zhong R, Yang Y, Huang C, Chen J, Liang L, Chen Y, Liu Y. Synthesis, RNA-sequence and evaluation of anticancer efficacy of ruthenium(II) polypyridyl complexes toward HepG2 cells. Journal of Inorganic Biochemistry. 2023;244:112230 [Crossref]
716- Kokaçya Ö, Pazarci P, Kaplan H. Alpha-Lipoic Acid Modulates Melanoma Survival Networks via ER Stress Induction, Mitochondrial Apoptosis, and Kinase Pathway Suppression in B16F10 Cells. CIMB. 2026;48(7):690 [Crossref]
717- Baggio C, Luisetto R, Boscaro C, Scanu A, Ramonda R, Albiero M, Sfriso P, Oliviero F. Leucocyte Abnormalities in Synovial Fluid of Degenerative and Inflammatory Arthropathies. IJMS. 2023;24(6):5450 [Crossref]
718- Al Mamun A, Geng P, Wang S, Shao C. Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation. JIR. 2024;Volume 17:7037 [Crossref]
719- Behroozi Z, Ramezani F, Nasirinezhad F. Human umbilical cord blood-derived platelet -rich plasma: a new window for motor function recovery and axonal regeneration after spinal cord injury. Physiology & Behavior. 2022;252:113840 [Crossref]
720- Bai H, Kang C, Sun Z, Li X, Dai X, Huang R, Zhao J, Bei Y, Huang X, Lu Z, Wu S, Lu J, Ping B, Wang Q, Hu Y. TTDA inhibited apoptosis by regulating the p53-Bax/Bcl2 axis in glioma. Experimental Neurology. 2020;331:113380 [Crossref]
721- Wang Z, Liu Y, Asemi Z. Quercetin and microRNA Interplay in Apoptosis Regulation: A New Therapeutic Strategy for Cancer?. CMC. 2025;32(5):939 [Crossref]
722- Wu T, Chen C, Lin J. Caffeic acid and 5-caffeoylquinic acid inhibit HT-29 colorectal cancer cell growth through immunotherapy by inducing the Bax/Bcl-2 apoptotic pathway in vitro. Bioorganic Chemistry. 2025;163:108723 [Crossref]
723- Chen F, Zhong X, Dai Q, Li K, Zhang W, Wang J, Zhao Y, Shen J, Xiao Z, Xing H, Li J. Human Umbilical Cord MSC Delivered-Soluble TRAIL Inhibits the Proliferation and Promotes Apoptosis of B-ALL Cell In Vitro and In Vivo. Pharmaceuticals. 2022;15(11):1391 [Crossref]
724- Sharma R, Sharma S, Mazumder A, Kumar R, Chauhan A, Ahsan M, Yar M, Maqsood R, Singh S. Pyrazoline Derivatives: Exploring the Synthesis and Development of New Ligands for Anti-Cancer Therapy. MC. 2025;21(9):938 [Crossref]
725- Wei R, Pan X, Cai D, Pan L. Synergistic Inhibition of Breast Carcinoma Cell Proliferation by Quercetin and Sulforaphane via Activation of the ERK/MAPK Pathway. Cell Biochem Biophys. 2025;83(2):2533 [Crossref]
726- Han H, Chen J, Li J, Correia A, Bártolo R, Shahbazi M, Teesalu T, Wang S, Cui W, Santos H. Enhancing Apoptosome Assembly via Mito‐Biomimetic Lipid Nanocarrier for Cancer Therapy. Adv Funct Materials. 2023;33(46) [Crossref]
727- Hashem M, Mohandesi Khosroshahi E, Aliahmady M, Ghanei M, Soofi Rezaie Y, alsadat Jafari Y, rezaei F, Khodaparast eskadehi R, Kia Kojoori K, jamshidian F, Nabavi N, Rashidi M, Hasani Sadi F, Taheriazam A, Entezari M. Non-coding RNA transcripts, incredible modulators of cisplatin chemo-resistance in bladder cancer through operating a broad spectrum of cellular processes and signaling mechanism. Non-coding RNA Research. 2024;9(2):560 [Crossref]
728- Ay E, Caner A, Özsoy Hepokur C, Danişman Kalindemirtaş F, Özen Eroğlu G, Kariper İ. Propolis nanoparticles synthesis and characterization with cytotoxic and apoptotic effects on breast cancer cells. Journal of Taibah University for Science. 2023;17(1) [Crossref]
729- Hajla A, Al-Khuraiji A, El-Nagar D, Al-Malahi N, Alanazi I, Abdel-Gaber R. Anti-Cancer Efficacy of Acacia nilotica Nanoparticles: Apoptosis Induction and Tumor Regression in a DMBA-induced Breast Cancer Rat Model . Pharmacognosy Magazine. 2025;21(4):1390 [Crossref]
730- Chaudhry G, Chaudhry Z, Sharifi-Rad J, Calina D. Hispidulin: a promising anticancer agent and mechanistic breakthrough for targeted cancer therapy. Naunyn-Schmiedeberg's Arch Pharmacol. 2024;397(4):1919 [Crossref]
731- Wan W, Tufail M, Jiang C, Li N. Metabolism, autophagy, and cell death: The triangular axis in tumor survival and therapeutic resistance. Redox Biology. 2026;95:104269 [Crossref]
732- Chiang S, Chen S, Chang L. The Role of HO-1 and Its Crosstalk with Oxidative Stress in Cancer Cell Survival. Cells. 2021;10(9):2401 [Crossref]
733- Dembowski M, Burigk L, Baumgärtner W, Hansmann F. Occurrence of neuronal dysfunction in mice with virus- or toxic-induced lesions in the central nervous system. Molecular and Cellular Neuroscience. 2026;137:104096 [Crossref]
734- Guan Y, Zhao X, Song N, Cui Y, Chang Y. Albicanol antagonizes Cd-induced apoptosis through a NO/iNOS-regulated mitochondrial pathway in chicken liver cells. Food Funct. 2021;12(4):1757 [Crossref]
735- Aderinto N, Babawale E, Olatunji G, Kokori E, Babarinde F, Donaldy W, Oyesiji O, Vande-Pallen F, Andibanbang F, Obaje A, Olaomi O, Entonu A, Alabi B, Ikeoluwa A, Fagbolade O, Jojo K, Abraham I, Udojike C. RNA-based approaches for neuroprotection and recovery in ischemic stroke: current evidence and future directions. Egypt J Neurol Psychiatry Neurosurg. 2026;62(1) [Crossref]
736- Kahraman E, Göker E. Anticancer effects of imidazole nucleus in hepatocellular carcinoma cell lines via the inhibition of AKT and ERK1/2 signaling pathways. Mol Biol Rep. 2022;49(6):4377 [Crossref]
737- Zhou H, Xu L, Shi Y, Gu S, Wu N, Liu F, Huang Y, Qian Z, Xue W, Wang X, Chen F. A Novel Myricetin Derivative with Anti-cancer Properties Induces Cell Cycle Arrest and Apoptosis in A549 Cells. Biological & Pharmaceutical Bulletin. 2023;46(1):42 [Crossref]
738- Ghilane F, El Omari N, Goh K, Bourais I, Bakri Y, El Btaouri H, Bouyahya A. Mechanistic insights and clinical perspectives on anticancer natural compounds from dietary polyphenols. Journal of Functional Foods. 2025;133:106991 [Crossref]
739- Alamoudi S, Saad A, Alsubhi N, Alrefaei G, Al-Quwaie D, Binothman N, Aljadani M, Alharbi M, Alanazi H, Babalghith A, Almuhayawi M, Gattan H, Alruhaili M, Selim S. Upgrading the physiochemical and sensory quality of yogurt by incorporating polyphenol-enriched citrus pomaces with antioxidant, antimicrobial, and antitumor activities. Front Nutr. 2022;9 [Crossref]
740- Hashemi M, Mirdamadi M, Talebi Y, Khaniabad N, Banaei G, Daneii P, Gholami S, Ghorbani A, Tavakolpournegari A, Farsani Z, Zarrabi A, Nabavi N, Zandieh M, Rashidi M, Taheriazam A, Entezari M, Khan H. Pre-clinical and clinical importance of miR-21 in human cancers: Tumorigenesis, therapy response, delivery approaches and targeting agents. Pharmacological Research. 2023;187:106568 [Crossref]
741- BEYHAN YILMAZ M, MUZ D. Apoptosis in cancer. 2022;6(2):85 [Crossref]
742- Tarawneh N, Hussein S, Abdalla S. Repurposing Antiepileptic Drugs for Cancer: A Promising Therapeutic Strategy. JCM. 2025;14(8):2673 [Crossref]
743- Huang M, Yu G. Cycloastragenol inhibits Aβ1–42-induced blood-brain barrier disruption and enhances soluble Aβ efflux in vitro. Journal of Asian Natural Products Research. 2021;23(6):556 [Crossref]
744- Eshkelani S, Hassankiadeh A, Hajitabar M, Balasbaneh Z, Kazemi T, Dafchahi H, Shahriarinour M, Nikpassand M, Ranji N, Varma R. Anti-Invasion and Apoptotic Induction Effects of Quercetin-Functionalized Silver Oxide (Ag2O) Nanoparticles on DU-145 Prostate Carcinoma Cells via Modulation of miR-34a, miR-181a, and Their Potential Targets. Russ J Bioorg Chem. 2025;51(6):2443 [Crossref]
745- Nakamori Y, Park E, Shimaoka M. Immune Deregulation in Sepsis and Septic Shock: Reversing Immune Paralysis by Targeting PD-1/PD-L1 Pathway. Front Immunol. 2021;11 [Crossref]
746- Martins R, Gomes C, Carvalho M, Souza J, Souza T, Farias D. A network toxicology and molecular docking-based approach revealed shared hepatotoxic mechanisms and targets between the herbicide 2,4-D and its metabolite 2,4-DCP. Toxicology. 2025;513:154086 [Crossref]
747- Zhang M, Ji X, Li Y, Chen X, Wu X, Tan R, Jiang H. Anthriscus sylvestris: An overview on Bioactive Compounds and Anticancer Mechanisms from a Traditional Medicinal Plant to Modern Investigation. MRMC. 2024;24(12):1162 [Crossref]
748- Korkmaz N, Kısa D, Ceylan Y, Güçlü E, Şen F. Biogenic synthesis of silica nanoparticles from industrial hemp waste for sustainable applications: Characterization and potential environmental benefits. Inorganic Chemistry Communications. 2024;167:112750 [Crossref]
749- Wasnis N, Ilyas S, Hutahaean S, Silaban R, Situmorang P. Analysis of Apoptotic Cells and Lung Inflammation after Given by Vitis gracilis. Pakistan J of Biological Sciences. 2022;25(11):1033 [Crossref]
750- Alabi F, Okpalanwaka I, Oyegbesan A, Okoyeocha E, Oladejo M, Imodoye S. Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress. MedComm – Oncology. 2025;4(3) [Crossref]
751- Vučelj S, Hasić R, Ašanin D, Šmit B, Caković A, Bogojeski J, Serafinović M, Marković B, Stojanović B, Pavlović S, Stanisavljević I, Ćorović I, Stojanović M, Jovanović I, Soldatović T, Stojanović B. Modes of Interactions with DNA/HSA Biomolecules and Comparative Cytotoxic Studies of Newly Synthesized Mononuclear Zinc(II) and Heteronuclear Platinum(II)/Zinc(II) Complexes toward Colorectal Cancer Cells. IJMS. 2024;25(5):3027 [Crossref]
752- Gabr B, Shalabi A, Said M, George R. 3,5-Disubstituted pyrazoline as a promising core for anticancer agents: mechanisms of action and therapeutic potentials. Future Medicinal Chemistry. 2025;17(6):725 [Crossref]
753- Sartori Assuncao L, Kretzer I, Sierra Restrepo J, de Mello Junior L, Rocha Barbosa F, Ferreira M, Mandolesi Sa M, Creczynski-Pasa T. Methyl (Z)-2-(Isothioureidomethyl)-2-pentenoate Hydrobromide Induces Cell Cycle Arrest and Disrupts Mitosis in a Melanoma Cell Line. ACAMC. 2025;25(20):1597 [Crossref]
754- Ahmad A, Tiwari R, Ansari I. Targeting the interplay between human papillomavirus oncoproteins and hedgehog signaling: assessment of chemopreventive potential of carvacrol in cervical cancer. 3 Biotech. 2025;15(4) [Crossref]
755- Ahmadpour E, Spotin A, Moghimi A, Shahrivar F, Jadidi-Niaragh F, Hajizadeh F, Mehrani S, Mazhab-Jafari K, Ali A. Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model. PLoS ONE. 2023;18(10):e0292434 [Crossref]
756- Phillips R. Diet, Mitochondrial Dysfunction, Vascular Endothelial Damage, and the Microbiome: Drivers of Ocular Degenerative and Inflammatory Diseases. Ophthalmol Ther. 2025;14(7):1429 [Crossref]