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Freq.: Quarterly

eISSN: 2251-7308 
pISSN: 2228-5881 

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Adv Pharm Bull. 2019;9(3): 453-461. doi: 10.15171/apb.2019.054
PMID: 31592434        PMCID: PMC6773929

Research Article

Cell Cycle Modulation of CHO-K1 Cells Under Genistein Treatment Correlates with Cells Senescence, Apoptosis and ROS Level but in a Dose-Dependent Manner

Riris Istighfari Jenie 1,2 ORCID, Nur Dina Amalina 2, Gagas Pradani Nur Ilmawati 2, Rohmad Yudi Utomo 1,2 ORCID, Muthi Ikawati 1,2 ORCID, Annisa Khumaira 2, Jun- Ya Kato 3, Edy Meiyanto 1,2 * ORCID

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2- Hermansyah D, Syarifah S, Muhar A, Putra A. Unveiling Paclitaxel-Induced Mesenchymal Stem Cells: orchestrating Nrf2 Modulation and Apoptosis in CD44+/CD24- Cancer Stem Cells. BCTT. 2024;Volume 16:319 [Crossref]
3- Amalina N, Salsabila I, Zulfin U, Jenie R, Meiyanto E. In vitro synergistic effect of hesperidin and doxorubicin downregulates epithelial-mesenchymal transition in highly metastatic breast cancer cells. J Egypt Natl Canc Inst. 2023;35(1) [Crossref]
4- Haitamy M, Kariosentono H, Prayitno A, Setiamika M, Setiamika S, Nurwati I, Riswiyanto R, Brahmadi A. Exploring the anti-inflammatory effects of Nigella sativa on cyclooxygenase-2 through the nuclear factor-kappa B pathway in an Aspergillus niger-induced otitis externa mouse model. 2024;15(4):341 [Crossref]
5- Della Vedova L, Baron G, Morazzoni P, Aldini G, Gado F. The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action. Pharmaceuticals. 2025;18(2):138 [Crossref]
6- Kaufman‐Szymczyk A, Jalmuzna J, Lubecka‐Gajewska K. Soy‐derived isoflavones as chemo‐preventive agents targeting multiple signalling pathways for cancer prevention and therapy. British J Pharmacology. 2025;182(10):2259 [Crossref]
7- Mursiti S, Amalina N, Marianti A. Inhibition of breast cancer cell development using Citrus maxima extract through increasing levels of Reactive Oxygen Species (ROS). J Phys: Conf Ser. 2021;1918(5):052005 [Crossref]
8- Jenie R, Amalina N, Hermawan A, Suzery M, Putra A, Meiyanto E. Caesalpinia sappan reduces the stemness of breast cancer stem cells involving the elevation of intracellular reactive oxygen species. 2023;18(6):708 [Crossref]
9- Ran Q, Su Y, Zhang W, Zhang X, Zhao L, Chen M, Wan Y, Tan W, Ye Q. Influence of Cell Physiological Status on the Intensified Fed‐Batch Cultures at Ultra‐High Seeding Density. Biotech and App Biochem. 2025; [Crossref]
10- Peng S, Dong S, Gong C, Chen X, Du H, Zhan Y, Ye C. Identification of Breast-Cancer-Associated Properties of Drinking Water under a Composite-Toxicity Perspective of Mixed Contaminants: A Case Study in a High-Prevalence Area of China. Water. 2024;16(5):702 [Crossref]
11- Ivashkevich A. The role of isoflavones in augmenting the effects of radiotherapy. Front Oncol. 2023;12 [Crossref]
12- Sutejo I, Hasanah A, Sudarko F. Ethanolic extract of Edamame (Glycine max L. merril) enhance second degree burn wound healing trough modulating of hydroxiproline levels and increasing epithelial thickness. 2022;68(2):55 [Crossref]
13- Hermansyah D, Paramita D, Muhar A, Amalina N. Curcuma longa extract inhibits migration by reducing MMP-9 and Rac-1 expression in highly metastatic breast cancer cells. 2024;19(2):157 [Crossref]
14- Hermansyah D, Putra A, Munir D, Lelo A, Amalina N, Alif I. Synergistic Effect of Curcuma longa Extract in Combination with Phyllanthus niruri Extract in Regulating Annexin A2, Epidermal Growth Factor Receptor, Matrix Metalloproteinases, and Pyruvate Kinase M1/2 Signaling Pathway on Breast Cancer Stem Cell. Open Access Maced J Med Sci. 2021;9(A):271 [Crossref]
15- Suzery M, Cahyono B, Amalina N. Citrus sinensis (L) Peels Extract Inhibits Metastasis of Breast Cancer Cells by Targeting the Downregulation Matrix Metalloproteinases-9. Open Access Maced J Med Sci. 2021;9(B):464 [Crossref]
16- Chan L, Pang Y, Wang Y, Zhu D, Taledaohan A, Jia Y, Zhao L, Wang W. Genistein-induced mitochondrial dysfunction and FOXO3a/PUMA expression in non-small lung cancer cells. Pharmaceutical Biology. 2022;60(1):1876 [Crossref]