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Adv Pharm Bull. 2019;9(3): 470-480. doi: 10.15171/apb.2019.056
PMID: 31592121        PMCID: PMC6773944

Research Article

Positive Effects of PI3K/Akt Signaling Inhibition on PTEN and P53 in Prevention of Acute Lymphoblastic Leukemia Tumor Cells

Elahe Naderali 1,2 ORCID, Behnaz Valipour 1 ORCID, Amir Afshin Khaki 2 ORCID, Jafar Soleymani Rad 2, Alireza Alihemmati 2 ORCID, Mohammad Rahmati 3 ORCID, Hojjatollah Nozad Charoudeh 1 * ORCID

Cited by CrossRef: 20


1- Richter A, Fischer E, Holz C, Schulze J, Lange S, Sekora A, Knuebel G, Henze L, Roolf C, Murua Escobar H, Junghanss C. Combined Application of Pan-AKT Inhibitor MK-2206 and BCL-2 Antagonist Venetoclax in B-Cell Precursor Acute Lymphoblastic Leukemia. IJMS. 2021;22(5):2771 [Crossref]
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4- Yang Q, Yu H, Du S, Li Q. Overexpression of CDC42 causes accumulation of DNA damage leading to failure of oogenesis in triploid Pacific oyster Crassostrea gigas. International Journal of Biological Macromolecules. 2024;282:136769 [Crossref]
5- Basu A, Upadhyay P, Ghosh A, Bose A, Gupta P, Chattopadhyay S, Chattopadhyay D, Adhikary A. Hyaluronic acid engrafted metformin loaded graphene oxide nanoparticle as CD44 targeted anti-cancer therapy for triple negative breast cancer. Biochimica et Biophysica Acta (BBA) - General Subjects. 2021;1865(3):129841 [Crossref]
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8- Yoo M, Choi J, Jang Y, Park S, Seol J. Anti-cancer effect of palmatine through inhibition of the PI3K/AKT pathway in canine mammary gland tumor CMT-U27 cells. BMC Vet Res. 2023;19(1) [Crossref]
9- Wang C, Wang Y, Zuo N, Fang S, Shi J. CD44–fibrinogen binding promotes bleeding in acute promyelocytic leukemia by in situ fibrin(ogen) deposition. 2022;6(15):4617 [Crossref]
10- Holz C, Lange S, Sekora A, Knuebel G, Krohn S, Murua Escobar H, Junghanss C, Richter A. Combined BCL-2 and PI3K/AKT Pathway Inhibition in KMT2A-Rearranged Acute B-Lymphoblastic Leukemia Cells. IJMS. 2023;24(2):1359 [Crossref]
11- Chen Y, Li J, Zhao Z. Redox Control in Acute Lymphoblastic Leukemia: From Physiology to Pathology and Therapeutic Opportunities. Cells. 2021;10(5):1218 [Crossref]
12- Li Y, Jia Z, Kong X, Zhao H, Liu X, Cui G, Luo J. Effect of 5-Aza-2’-deoxycytidine on T-cell acute lymphoblastic leukemia cell biological behaviors and PTEN expression. Cytojournal. 2024;21:36 [Crossref]
13- Abdo A, Kopecki Z. Comparing Redox and Intracellular Signalling Responses to Cold Plasma in Wound Healing and Cancer. CIMB. 2024;46(5):4885 [Crossref]
14- Gao D, Wang P, Zhi L, Sun S, Qiu X, Liu Y. Expression of TMEM59L associated with radiosensitive in glioblastoma. 2023;64(5):833 [Crossref]
15- Shi X, Li S, Tang S, Lu Y. Anlotinib Inhibits Proliferation and Induces Apoptosis in B-cell Acute Lymphoblastic Leukemia by Targeting the BTK and AKT/mTOR Pathway. ACAMC. 2023;23(12):1397 [Crossref]
16- Perry J, Genenger B, Thind A, Ashford B, Ranson M. PIK Your Poison: The Effects of Combining PI3K and CDK Inhibitors against Metastatic Cutaneous Squamous Cell Carcinoma In Vitro. Cancers. 2024;16(2):370 [Crossref]
17- Constantin M, Chifiriuc M, Bleotu C, Vrancianu C, Cristian R, Bertesteanu S, Grigore R, Bertesteanu G. Molecular pathways and targeted therapies in head and neck cancers pathogenesis. Front Oncol. 2024;14 [Crossref]
18- Sun C, Wen K, Zhang B, Dong Y, Chen C, Neo S, Leng B, Gao T, Wu J. DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway. Aging. 2023;15(13):6380 [Crossref]
19- Sommariva S, Caviglia G, Ravera S, Frassoni F, Benvenuto F, Tortolina L, Castagnino N, Parodi S, Piana M. Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells. Sci Rep. 2021;11(1) [Crossref]