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Adv Pharm Bull. 2019;9(4): 578-583. doi: 10.15171/apb.2019.066
PMID: 31857961        PMCID: PMC6912181

Research Article

Niosomal Benzoyl Peroxide and Clindamycin Lotion Versus Niosomal Clindamycin Lotion in Treatment of Acne Vulgaris: A Randomized Clinical Trial

Saman Mohammadi 1 ORCID, Abbas Pardakhty 2 ORCID, Maryam Khalili 1 ORCID, Reza Fathi 1 ORCID, Maryam Rezaeizadeh 2 ORCID, Saeedeh Farajzadeh 3, Azadeh Mohebbi 1 ORCID, Mahin Aflatoonian 1 * ORCID

Cited by CrossRef: 18


1- Rezaeizadeh M, Eskanlou A, Soltani H, Pardakhty A, Moshafi M, Hosseini-Nejad F. Preparation of Stable Clindamycin Phosphate Niosomes by Combination of Sorbitan Esters and their Ethoxylaed Derivatives. J Pharm Innov. 2022;17(4):1189 [Crossref]
2- Dhingra P, Garg U, Jain N, Kaul S, Nagaich U. Exploring the Potential of Nanocarriers for Targeted Delivery of Anti-acne Agents: A Review. NANOASIA. 2023;13(5) [Crossref]
3- Abdelrazik Y, Ali F, Salek M, Finlay A. Clinical experience and psychometric properties of the Cardiff Acne Disability Index (CADI)*. Br J Dermatol. 2021;185(4):711 [Crossref]
4- Jorgaqi E, Savo I, Koraqi A, Doci X, Cela R, Vasili E, Jafferany M. Efficacy of acne vulgaris treatment protocols according to its clinical forms. Dermatologic Therapy. 2020;33(4) [Crossref]
5- Abu-Huwaij R, Alkarawi A, Salman D, Alkarawi F. Exploring the use of niosomes in cosmetics for efficient dermal drug delivery. Pharmaceutical Development and Technology. 2023;28(7):708 [Crossref]
6- Chakraborty N, Narayanan V, Gautam H. Nano-Therapeutics to Treat Acne Vulgaris. Indian J Microbiol. 2022;62(2):167 [Crossref]
7- AJRIN M, ANJUM F. Proniosome: A Promising Approach for Vesicular Drug Delivery. tjps. 2022;19(4):462 [Crossref]
8- Zhou L, Chen L, Liu X, Huang Y, Xu Y, Xiong X, Deng Y. The influence of benzoyl peroxide on skin microbiota and the epidermal barrier for acne vulgaris. Dermatologic Therapy. 2022;35(3) [Crossref]
9- Rezaeizadeh M, Eskanlou A, Pardakhty A, Pournamdari M, Daneshpajooh M. Preparation and Physicochemical Characterizations of Niosomal Benzoyl Peroxide and Clindamycin Phosphate Formulation for Acne Vulgaris. J Pharm Innov. 2024;19(1) [Crossref]
10- Stuart B, Maund E, Wilcox C, Sridharan K, Sivaramakrishnan G, Regas C, Newell D, Soulsby I, Tang K, Finlay A, Bucher H, Little P, Layton A, Santer M. Topical preparations for the treatment of mild‐to‐moderate acne vulgaris: systematic review and network meta‐analysis*. Br J Dermatol. 2021;185(3):512 [Crossref]
11- Amiri R, Khalili M, Mohammadi S, Iranmanesh B, Aflatoonian M. Treatment protocols and efficacy of light and laser treatments in post‐acne erythema. J of Cosmetic Dermatology. 2022;21(2):648 [Crossref]
12- Mehrarya M, Gharehchelou B, Haghighi Poodeh S, Jamshidifar E, Karimifard S, Farasati Far B, Akbarzadeh I, Seifalian A. Niosomal formulation for antibacterial applications. Journal of Drug Targeting. 2022;30(5):476 [Crossref]
13- Salem A, Mohamed E, Zohdy M, Elsaed W, Abdelghani G, Saleh N. New insights from the integration of dapsone, flutamide, tea tree oil, and rose oil as a topical combined microemulsion for the management of Acne Vulgaris: Design, development, and in vitro/in vivo characterization. Journal of Drug Delivery Science and Technology. 2024;101:106276 [Crossref]
14- Podwojniak A, Tan I, Sauer J, Parikh A, Cohen B, Heath C. Updates on Topical Dyad and Triple Combination Therapies Approved for Acne Vulgaris. 2024; [Crossref]
15- Ghasemiyeh P, Mohammadi-Samani S, Noorizadeh K, Zadmehr O, Rasekh S, Mohammadi-Samani S, Dehghan D. Novel topical drug delivery systems in acne management: Molecular mechanisms and role of targeted delivery systems for better therapeutic outcomes. Journal of Drug Delivery Science and Technology. 2022;74:103595 [Crossref]
16- Fan D, Ma J, Liu X, Zhang S, Sun J, Li Y, Jiang B, Zhang L. The safety and efficiency of benzoyl peroxide for reducing Cutibacterium acnes in the shoulder: An updated systematic review and meta-analysis. Front Surg. 2023;10 [Crossref]
17- Bae W, Jung W, Lee Y, Shin S, An Y, Kim T, Sohn M. Heat‐treated Pediococcus acidilactici LM1013‐mediated inhibition of biofilm formation by Cutibacterium acnes and its application in acne vulgaris: A single‐arm clinical trial. J of Cosmetic Dermatology. 2023;22(11):3125 [Crossref]
18- do Nascimento T, de Abreu Garófalo D, de Souza Bustamante Monteiro M, Santos-Oliveira R, dos Santos Matos A, Ricci-Júnior E. Drug Encapsulation: Review of Niosomes for Promoting Antimicrobial Activity. J Nanopart Res. 2022;24(12) [Crossref]
19- Ly S, Miller J, Tong L, Blake L, Mostaghimi A, Barbieri J. Use of Patient-Reported Outcomes in Acne Vulgaris and Rosacea Clinical Trials From 2011 to 2021. JAMA Dermatol. 2022;158(12):1419 [Crossref]