The Effects of Thymoquinone on Viability, and Anti-apoptotic Factors (BCL-XL, BCL-2, MCL-1) in Prostate Cancer (PC3) Cells: An In Vitro and Computer-Simulated Environment Study

Javad Saffari_Chaleshtori ¹ , Ehsan Heidari-Sureshjani ², Fahimeh Moradi ³, Esfandiar Heidarian ⁴ *

Cited by CrossRef: 9

1- Pal R, Rajpal V, Singh P, Saraf S. Recent Findings on Thymoquinone and Its Applications as a Nanocarrier for the Treatment of Cancer and Rheumatoid Arthritis. Pharmaceutics. 2021;13(6):775 [Crossref]

2- Messias Monteiro A, da Silva F, Rodrigues T, Ramos C, Scotti M, Scotti L. In silico Studies on Natural Products and Derivatives against Different Types of Cancer. CMC. 2024;31(7):825 [Crossref]

3- Martinucci B, Cucielo M, Minatel B, Cury S, Caxali G, Aal M, Felisbino S, Pinhal D, Carvalho R, Delella F. Fibronectin Modulates the Expression of miRNAs in Prostate Cancer Cell Lines. Front Vet Sci. 2022;9 [Crossref]

4- Dai Q, Peng Y, He P, Wu X. Interactions and communications in the prostate tumour microenvironment: evolving towards effective cancer therapy. Journal of Drug Targeting. 2024;:1 [Crossref]

5- Jamali N, Soureshjani E, Mobini G, Samare-Najaf M, Clark C, Saffari-Chaleshtori J. Medicinal plant compounds as promising inhibitors of coronavirus (COVID-19) main protease: anin silicostudy. Journal of Biomolecular Structure and Dynamics. 2022;40(17):8073 [Crossref]

6- Mirzaei S, Paskeh M, Saghari Y, Zarrabi A, Hamblin M, Entezari M, Hashemi M, Aref A, Hushmandi K, Kumar A, Rabiee N, Ashrafizadeh M, Samarghandian S. Transforming growth factor-beta (TGF-β) in prostate cancer: A dual function mediator?. International Journal of Biological Macromolecules. 2022;206:435 [Crossref]

7- Basati G, Saffari-Chaleshtori J, Abbaszadeh S, Asadi-Samani M, Ashrafi-Dehkordi K. Molecular Dynamics Mechanisms of the Inhibitory Effects of Abemaciclib, Hymenialdisine, and Indirubin on CDK-6. CDRR. 2019;11(2):135 [Crossref]

8- Mahmoudi Gomari M, Rostami N, Ghodrati A, Hernandez Y, Fadaie M, Sadegh Eslami S, Tarighi P. Implementation of docking, molecular dynamics and free energy to investigate drug potency of novel BCR-ABLT315I inhibitors as an alternative to ponatinib. Computational Toxicology. 2021;20:100180 [Crossref]

9- Osorio-Pérez S, Estrada-Meza C, Ruiz-Manriquez L, Arvizu-Espinosa M, Srivastava A, Sharma A, Paul S. Thymoquinone Potentially Modulates the Expression of Key Onco- and Tumor Suppressor miRNAs in Prostate and Colon Cancer Cell Lines: Insights from PC3 and HCT-15 Cells. Genes. 2023;14(9):1730 [Crossref]